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34 results on '"Jiang, Jiamiao"'

6. Self‐Propelled Proteomotors with Active Cell‐Free mtDNA Clearance for Enhanced Therapy of Sepsis‐Associated Acute Lung Injury (Adv. Sci. 27/2023)

Author

Huang, Weichang, primary, Wen, Lihong, additional, Tian, Hao, additional, Jiang, Jiamiao, additional, Liu, Meihuan, additional, Ye, Yicheng, additional, Gao, Junbin, additional, Zhang, Ruotian, additional, Wang, Fei, additional, Li, Huaan, additional, Shen, Lihan, additional, Peng, Fei, additional, and Tu, Yingfeng, additional

Published
2023
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7. Nanorobot-Mediated Synchronized Neuron Activation

Author

Chen, Bin, primary, Tan, Haixin, additional, Ding, Miaomiao, additional, Liu, Lu, additional, Wang, Shuanghu, additional, Peng, Xiuyun, additional, Tian, Hao, additional, Jiang, Jiamiao, additional, Gao, Junbin, additional, Huang, Weichang, additional, Li, Huaan, additional, Ye, Yicheng, additional, Wang, Fei, additional, Wilson, Daniela A., additional, Tu, Yingfeng, additional, and Peng, Fei, additional

Published
2023
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12. Mobile mechanical signal generator for macrophage polarization

Author

Jiang, Jiamiao, primary, Wang, Fei, additional, Huang, Weichang, additional, Sun, Jia, additional, Ye, Yicheng, additional, Ou, Juanfeng, additional, Liu, Meihuan, additional, Gao, Junbin, additional, Wang, Shuanghu, additional, Fu, Dongmei, additional, Chen, Bin, additional, Liu, Lu, additional, Peng, Fei, additional, and Tu, Yingfeng, additional

Published
2023
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18. Correction to Control the Neural Stem Cell Fate with Biohybrid Piezoelectrical Magnetite Micromotors

Author

Liu, Lu, primary, Wu, Juanyan, additional, Wang, Shuanghu, additional, Liu, Kun, additional, Gao, Junbin, additional, Chen, Bin, additional, Ye, Yicheng, additional, Wang, Fei, additional, Tong, Fei, additional, Jiang, Jiamiao, additional, Ou, Juanfeng, additional, Wilson, Daniela A., additional, Tu, Yingfeng, additional, and Peng, Fei, additional

Published
2021
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19. Apoptotic Tumor DNA Activated Nanomotor Chemotaxis

Author

Ye, Yicheng, primary, Tong, Fei, additional, Wang, Shuanghu, additional, Jiang, Jiamiao, additional, Gao, Junbin, additional, Liu, Lu, additional, Liu, Kun, additional, Wang, Fei, additional, Wang, Zhen, additional, Ou, Juanfeng, additional, Chen, Bin, additional, Wilson, Daniela A., additional, Tu, Yingfeng, additional, and Peng, Fei, additional

Published
2021
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20. MnO2-Based Nanomotors with Active Fenton-like Mn2+ Delivery for Enhanced Chemodynamic Therapy

Author

Ou, Juanfeng, primary, Tian, Hao, additional, Wu, Juanyan, additional, Gao, Junbin, additional, Jiang, Jiamiao, additional, Liu, Kun, additional, Wang, Shuanghu, additional, Wang, Fei, additional, Tong, Fei, additional, Ye, Yicheng, additional, Liu, Lu, additional, Chen, Bin, additional, Ma, Xing, additional, Chen, Xuncai, additional, Peng, Fei, additional, and Tu, Yingfeng, additional

Published
2021
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21. Minimally Invasive Therapy: Hydrogen‐Powered Microswimmers for Precise and Active Hydrogen Therapy Towards Acute Ischemic Stroke (Adv. Funct. Mater. 19/2021)

Author

Wang, Shuanghu, primary, Liu, Kun, additional, Zhou, Quan, additional, Xu, Cong, additional, Gao, Junbin, additional, Wang, Zhen, additional, Wang, Fei, additional, Chen, Bin, additional, Ye, Yicheng, additional, Ou, Juanfeng, additional, Jiang, Jiamiao, additional, Wilson, Daniela A., additional, Liu, Shuwen, additional, Peng, Fei, additional, and Tu, Yingfeng, additional

Published
2021
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23. Hydrogen‐Powered Microswimmers for Precise and Active Hydrogen Therapy Towards Acute Ischemic Stroke

Author

Wang, Shuanghu, primary, Liu, Kun, additional, Zhou, Quan, additional, Xu, Cong, additional, Gao, Junbin, additional, Wang, Zhen, additional, Wang, Fei, additional, Chen, Bin, additional, Ye, Yicheng, additional, Ou, Juanfeng, additional, Jiang, Jiamiao, additional, Wilson, Daniela A., additional, Liu, Shuwen, additional, Peng, Fei, additional, and Tu, Yingfeng, additional

Published
2021
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27. Drug Delivery Systems: Hyperthermia‐Triggered On‐Demand Biomimetic Nanocarriers for Synergetic Photothermal and Chemotherapy (Adv. Sci. 11/2020)

Author

Gao, Junbin, primary, Wang, Fei, additional, Wang, Shuanghu, additional, Liu, Lu, additional, Liu, Kun, additional, Ye, Yicheng, additional, Wang, Zhen, additional, Wang, Hong, additional, Chen, Bin, additional, Jiang, Jiamiao, additional, Ou, Juanfeng, additional, Hest, Jan C. M., additional, Peng, Fei, additional, and Tu, Yingfeng, additional

Published
2020
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28. Hyperthermia‐Triggered On‐Demand Biomimetic Nanocarriers for Synergetic Photothermal and Chemotherapy

Author

Gao, Junbin, primary, Wang, Fei, additional, Wang, Shuanghu, additional, Liu, Lu, additional, Liu, Kun, additional, Ye, Yicheng, additional, Wang, Zhen, additional, Wang, Hong, additional, Chen, Bin, additional, Jiang, Jiamiao, additional, Ou, Juanfeng, additional, Hest, Jan C. M., additional, Peng, Fei, additional, and Tu, Yingfeng, additional

Published
2020
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31. Photoelectrochemical TiO2‐Au‐Nanowire‐Based Motor for Precise Modulation of Single‐Neuron Activities.

Author

Chen, Bin, Liu, Lu, Liu, Kun, Tong, Fei, Wang, Shuanghu, Fu, Dongmei, Gao, Junbin, Jiang, Jiamiao, Ou, Juanfeng, Ye, Yicheng, Wilson, Daniela A., Tu, Yingfeng, and Peng, Fei

Subjects
RETINAL ganglion cells, ELECTRIC fields, BRAIN-computer interfaces, ION channels, CALCIUM ions
Abstract

Micro/nanomotors are revolutionary miniaturized robotic systems capable of converting diverse energy sources, including light, ultrasound, and thermal heat, into mechanical motion. This fascinating research area is emerging and developing at a rapid pace, demonstrating potential in multiple fields. While their locomotion and momentum capabilities have been explored in medical treatments, including microsurgery and diagnosis, the aspect of converting their intrinsic energies into usable forms remains unexplored. Here, we proposed a novel motor based on composite TiO2‐Au nanowires (NWs), powered by a local electric field generated from ultra‐low ultraviolet (UV) irradiation, to serve as an interactive bioelectric interface with a neural cell. Under a light field, the NW motor achieved highly controllable motion in biological environments and reached the targeted neuronal retinal ganglion cells (RGCs) with notable precision. Next, the locally generated electric field was utilized as an electrical stimulus to activate the targeted cell through the calcium ion channel. This is the first study to report on the photoelectric conversion capabilities of a motor being used to provide propulsion force and interactive cues in a biosystem. This motor‐based strategy represents a new approach for the precise and non‐invasive delivery of bioelectrical signals and neuronal activity modulation. [ABSTRACT FROM AUTHOR]

Published
2021
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32. MnO2-Based Nanomotors with Active Fenton-like Mn2+Delivery for Enhanced Chemodynamic Therapy

Author

Ou, Juanfeng, Tian, Hao, Wu, Juanyan, Gao, Junbin, Jiang, Jiamiao, Liu, Kun, Wang, Shuanghu, Wang, Fei, Tong, Fei, Ye, Yicheng, Liu, Lu, Chen, Bin, Ma, Xing, Chen, Xuncai, Peng, Fei, and Tu, Yingfeng

Abstract

Chemodynamic therapy (CDT) is an emerging strategy for cancer treatment based on Fenton chemistry, which can convert endogenous H2O2into toxic ·OH. However, the limited endocytosis of passive CDT nanoagents with low penetrating capability resulted in unsatisfactory anticancer efficacy. Herein, we propose the successful fabrication of a self-propelled biodegradable nanomotor system based on hollow MnO2nanoparticles with catalytic activity for active Fenton-like Mn2+delivery and enhanced CDT. Compared with the passive counterparts, the significantly improved penetration of nanomotors with enhanced diffusion is demonstrated in both the 2D cell culture system and 3D tumor multicellular spheroids. After the intracellular uptake of nanomotors, toxic Fenton-like Mn2+is massively produced by consuming overexpressed intracellular glutathione (GSH), which has a strong scavenging effect on ·OH, thereby leading to enhanced cancer CDT. The as-developed MnO2-based nanomotor system with enhanced penetration and endogenous GSH scavenging capability shows much promise as a potential platform for cancer treatment in the near future.

Published
2021
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33. Microenvironment Mechanical Torque from ZnFe 2 O 4 (ZFO) Micromotors Inhibiting Tumor Migration.

Author

Jiang T, Feng Y, Gao C, Jiang J, Chen B, Liu S, Du D, Ding M, Rong J, Liao Z, Li W, Wilson DA, Tu Y, Song S, Wang Y, and Peng F

Abstract

Mechanical force attracts booming attention with the potential to tune the tumor cell behavior, especially in cell migration. However, the current approach for introducing mechanical input is difficult to apply in vivo. How the mechanical force affects cell behavior in situ also remains unclear. In this work, an intelligent miniaturized platform is constructed with magnetic ZnFe 2 O 4 (ZFO) micromotors. The wireless ZFO can self-assemble in situ and rotate to generate mechanical torque of biologically relevant piconewton-scale at the target tumor site. It is observed unexpectedly that enhanced in situ mechanical rotating torque from ZFO micromotors and the active fluid inhibit the migration of highly invasive A549 tumor cells. The down-regulation of the Piezo1 channel and the suppressed signaling of ROCK1 in mechano-adaptive tumor cells is found to be related to the inhibition effect. With effectiveness confirmed with the zebrafish xenograft model, this platform provides a valuable toolkit for mechanobiology and force-associated non-invasive tumor therapy., (© 2025 Wiley‐VCH GmbH.)

Published
2025
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34. MnO 2 -Based Nanomotors with Active Fenton-like Mn 2+ Delivery for Enhanced Chemodynamic Therapy.

Author

Ou J, Tian H, Wu J, Gao J, Jiang J, Liu K, Wang S, Wang F, Tong F, Ye Y, Liu L, Chen B, Ma X, Chen X, Peng F, and Tu Y

Subjects
Animals, Antineoplastic Agents pharmacology, Cell Line, Tumor, Melanoma, Experimental therapy, Mice, Hydrogen Peroxide pharmacology, Iron pharmacology, Manganese Compounds pharmacology, Nanoparticles therapeutic use, Neoplasms therapy
Abstract

Chemodynamic therapy (CDT) is an emerging strategy for cancer treatment based on Fenton chemistry, which can convert endogenous H 2 O 2 into toxic ·OH. However, the limited endocytosis of passive CDT nanoagents with low penetrating capability resulted in unsatisfactory anticancer efficacy. Herein, we propose the successful fabrication of a self-propelled biodegradable nanomotor system based on hollow MnO 2 nanoparticles with catalytic activity for active Fenton-like Mn 2+ delivery and enhanced CDT. Compared with the passive counterparts, the significantly improved penetration of nanomotors with enhanced diffusion is demonstrated in both the 2D cell culture system and 3D tumor multicellular spheroids. After the intracellular uptake of nanomotors, toxic Fenton-like Mn 2+ is massively produced by consuming overexpressed intracellular glutathione (GSH), which has a strong scavenging effect on ·OH, thereby leading to enhanced cancer CDT. The as-developed MnO 2 -based nanomotor system with enhanced penetration and endogenous GSH scavenging capability shows much promise as a potential platform for cancer treatment in the near future.

Published
2021
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