25 results on '"Jiang, Jipu"'
Search Results
2. Birth Weight in Different Etiologies of Disorders of Sex Development
- Author
-
Poyrazoglu, Sukran, Darendeliler, Feyza, Ahmed, S. Faisal, Hughes, Ieuan, Bryce, Jillian, Jiang, Jipu, Rodie, Martina, Hiort, Olaf, Hannema, Sabine E., Bertelloni, Silvano, Lisa, Lidka, Guran, Tulay, Cools, Martine, Desloovere, An, Claahsen-van der Grinten, Hedi L., Nordenstrom, Anna, Holterhus, Paul-Martin, Kohler, Birgit, Niedziela, Marek, and Krone, Nils
- Published
- 2017
3. User-oriented Security Supporting Inter-disciplinary Life Science Research across the Grid
- Author
-
Sinnott, Richard, Ajayi, Oluwafemi, Jiang, Jipu, Stell, Anthony, and Watt, John
- Published
- 2007
- Full Text
- View/download PDF
4. Novel Associations in Disorders of Sex Development: Findings From the I-DSD Registry
- Author
-
Cox, Kathryn, Bryce, Jillian, Jiang, Jipu, Rodie, Martina, Sinnott, Richard, Alkhawari, Mona, Arlt, Wiebke, Audi, Laura, Balsamo, Antonio, Bertelloni, Silvano, Cools, Martine, Darendeliler, Feyza, Drop, Stenvert, Ellaithi, Mona, Guran, Tulay, Hiort, Olaf, Holterhus, Paul-Martin, Hughes, Ieuan, Krone, Nils, Lisa, Lidka, Morel, Yves, Soder, Olle, Wieacker, Peter, and Ahmed, S. Faisal
- Published
- 2014
5. A New International Registry Highlights the Differences in Practice for Reaching a Diagnosis of CAH - On Behalf of the I-CAH/I-DSD Registry User Group
- Author
-
Kourime, Mariam, Bryce, Jillian, Jiang, Jipu, Karunasena, Nayananjani, Guran, Tulay, Hannema, Sabine Elisabeth, Cools, Martine, Grinten, Hedi L. Claahsen, Krone, Nils, Darendeliler, Feyza, Balsamo, Antonio, Bonfig, Walter, Nordenstrom, Anna, Hiort, Olaf, Dagmar, Lallemand, Ross, Richard, Ahmed, Syed Faisal, Koehler, Birgit, Acerini, Carlo, Berenice Mendonca, Bertelloni, Silvano, Lisa, Lidka, Elsedfy, Heba, and Marginean, Otilia
- Published
- 2016
6. Adrenal crisis and sick day episodes among CAH patients: preliminary report based on international CAH (I-CAH) registry
- Author
-
Karunasena, Nayananjani, primary, Daniel, Eleni, additional, Bryce, Jillian, additional, Jiang, Jipu, additional, Faisal, Ahmed S, additional, Guran, Tulay, additional, Mendonca, Berenice B, additional, Bachega, Tania A, additional, Blankenstein, Oliver, additional, Koehler, Birgit, additional, Neumann, Uta, additional, Acerini, Carlo, additional, Krone, Nils, additional, Bonfig, Walter, additional, Mohnike, Klaus, additional, Elsedfy, Heba, additional, and Ross, Richard, additional
- Published
- 2016
- Full Text
- View/download PDF
7. Changes Over Time in Sex Assignment for Disorders of Sex Development
- Author
-
Kolesinska, Zofia, primary, Ahmed, S. Faisal, additional, Niedziela, Marek, additional, Bryce, Jillian, additional, Molinska-Glura, Marta, additional, Rodie, Martina, additional, Jiang, Jipu, additional, Sinnott, Richard O., additional, Hughes, Ieuan A., additional, Darendeliler, Feyza, additional, Hiort, Olaf, additional, van der Zwan, Yvonne, additional, Cools, Martine, additional, Guran, Tulay, additional, Holterhus, Paul-Martin, additional, Bertelloni, Silvano, additional, Lisa, Lidka, additional, Arlt, Wiebke, additional, Krone, Nils, additional, Ellaithi, Mona, additional, Balsamo, Antonio, additional, Mazen, Inas, additional, Nordenstrom, Anna, additional, Lachlan, Katherine, additional, Alkhawari, Mona, additional, Chatelain, Pierre, additional, and Weintrob, Naomi, additional
- Published
- 2014
- Full Text
- View/download PDF
8. The spectrum of associated congenital anomalies in disorders of sex development: a review of the I-DSD Registry
- Author
-
Cox, Kathryn, primary, Bryce, Jillian, additional, Jiang, Jipu, additional, Rodie, Martina, additional, Sinnott, Richard, additional, Alkhawari, Mona, additional, Arlt, Wiebke, additional, Audi, Laura, additional, Balsamo, Antonio, additional, Bertelloni, Silvano, additional, Cools, Martine, additional, Darendeliler, Feyza, additional, Drop, Stenvert, additional, Ellaithi, Mona, additional, Hiort, Olaf, additional, Hughes, Ieuan, additional, Lisa, Lidka, additional, Morel, Yves, additional, Soder, Olle, additional, and Ahmed, S Faisal, additional
- Published
- 2013
- Full Text
- View/download PDF
9. Development and Support of Platforms for Research into Rare Diseases
- Author
-
Sinnott, Richard O., primary, Jiang, Jipu, additional, Stell, Anthony, additional, and Watt, John, additional
- Published
- 2010
- Full Text
- View/download PDF
10. A federated data collection application for the prediction of adverse hypotensive events
- Author
-
Stell, Anthony, primary, Sinnott, Richard, additional, and Jiang, Jipu, additional
- Published
- 2009
- Full Text
- View/download PDF
11. Tool Support for Security-Oriented Virtual Research Collaborations
- Author
-
Watt, John, primary, Sinnott, Richard, additional, Jiang, Jipu, additional, Doherty, Tom, additional, Higgins, Chris, additional, and Koutroumpas, Michael, additional
- Published
- 2009
- Full Text
- View/download PDF
12. A Clinical Grid Infrastructure Supporting Adverse Hypotensive Event Prediction
- Author
-
Stell, Anthony, primary, Sinnott, Richard, additional, and Jiang, Jipu, additional
- Published
- 2009
- Full Text
- View/download PDF
13. Designing Privacy for Scalable Electronic Healthcare Linkage
- Author
-
Stell, Anthony, primary, Sinnott, Richard, additional, Ajayi, Oluwafemi, additional, and Jiang, Jipu, additional
- Published
- 2009
- Full Text
- View/download PDF
14. Towards a Virtual Research Environment for Paediatric Endocrinology across Europe
- Author
-
Jiang, Jipu, primary, Sinnott, Richard, additional, Stell, Anthony, additional, Watt, John, additional, and Ahmed, Faisal, additional
- Published
- 2009
- Full Text
- View/download PDF
15. Security Oriented e-Infrastructures Supporting Neurological Research and Clinical Trials
- Author
-
Stell, Anthony, primary, Sinnott, Richard, additional, Ajayi, Oluwafemi, additional, and Jiang, Jipu, additional
- Published
- 2007
- Full Text
- View/download PDF
16. Enabling Secure, Distributed Collaborations for Adrenal Tumor Research.
- Author
-
Solomonides, Tony, Blanquer, Ignacio, Breton, Vincent, Glatard, Tristan, Legré, Yannick, Stell, Anthony, Sinnott, Richard, and Jiang, Jipu
- Abstract
Many e-Health strategies rely on the secure integration of datasets that have previously resided in isolated locations, but can now in principle be accessed over the Internet. Of paramount importance in the health domain is the need for the security and privacy of data that is transmitted across these networks. One such collaboration, which spans several specialist centres across France, Germany, Italy and the UK, is ENSAT – the European Network for the Study of Adrenal Tumors. The rarity of the tumors under study means the value of accessing, aggregating and comparing data from many centres is great indeed. However this is especially challenging given that ENSAT require clinical and genomic data to be seamlessly linked, but in such a way that the information governance, ethics and privacy concerns of the patients and associated stakeholders involved are visibly satisfied. Key to this is the clear separation of clinical and genomic data sets and support for rigorous patient-identity protecting access control. This is especially challenging when such data sets exist across different organisational boundaries. In this paper we describe a prototype solution offering a security-oriented tailored portal supported by a layered encryption-driven linkage technology (VANGUARD) that offers precisely such patient-privacy protecting capabilities. We describe the architecture, implementation and use to date of this facility to support the ENSAT adrenal cancer research network. [ABSTRACT FROM AUTHOR]
- Published
- 2010
17. BioNessieG – A Grid Enabled Biochemical Networks Simulation Environment.
- Author
-
Solomonides, Tony, Silverstein, Jonathan C., Saltz, Joel, Legré, Yannick, Kratz, Mary, Foster, Ian, Breton, Vincent, Beck, J. Robert, Liu, Xuan, Jiang, Jipu, Ajayi, Oluwafemi, Gu, Xu, Gilbert, David, and Sinnott, Richard
- Abstract
The simulation of biochemical networks provides insight and understanding about the underlying biochemical processes and pathways used by cells and organisms. BioNessie is a biochemical network simulator which has been developed at the University of Glasgow. This paper describes the simulator and focuses in particular on how it has been extended to benefit from a wide variety of high performance compute resources across the UK through Grid technologies to support larger scale simulations. [ABSTRACT FROM AUTHOR]
- Published
- 2008
18. Security-oriented Data Grids for Microarray Expression Profiles.
- Author
-
Jacq, Nicolas, Müller, Henning, Blanquer, Ignacio, Legré, Yannick, Breton, Vincent, Hausser, Dominique, Hernández, Vicente, Solomonides, Tony, Hofmann-Apitius, Martin, Sinnott, Richard, Bayliss, Christopher, and Jiang, Jipu
- Abstract
Microarray experiments are one of the key ways in which gene activity can be identified and measured thereby shedding light and understanding for example on biological processes. The BBSRC funded Grid enabled Microarray Expression Profile Search (GEMEPS) project has developed an infrastructure which allows post-genomic life science researchers to ask and answer the following questions: who has undertaken microarray experiments that are in some way similar or relevant to mine; and how similar were these relevant experiments? Given that microarray experiments are expensive to undertake and may possess crucial information for future exploitation (both academically and commercially), scientists are wary of allowing unrestricted access to their data by the wider community until fully exploited locally. A key requirement is thus to have fine grained security that is easy to establish and simple (or ideally transparent) to use across inter-institutional virtual organisations. In this paper we present an enhanced security-oriented data Grid infrastructure that supports the definition of these kinds of queries and the analysis and comparison of microarray experiment results. [ABSTRACT FROM AUTHOR]
- Published
- 2007
19. Novel Associations in Disorders of Sex Development: Findings From the I-DSD Registry
- Author
-
Tulay Guran, Martina Rodie, Silvano Bertelloni, Yves Morel, Lidka Lisa, Feyza Darendeliler, Kathryn Cox, Mona Ellaithi, Paul-Martin Holterhus, Olle Söder, Richard O. Sinnott, Nils Krone, S Faisal Ahmed, Antonio Balsamo, Laura Audí, Jipu Jiang, Mona Alkhawari, Stenvert L. S. Drop, Peter Wieacker, Jillian Bryce, Martine Cools, Wiebke Arlt, Ieuan A. Hughes, Olaf Hiort, K. Cox, J. Bryce, J. Jiang, M. Rodie, R. Sinnott, M. Alkhawari, W. Arlt, L. Audi, A. Balsamo, S. Bertelloni, M. Cool, F. Darendeliler, S. Drop, M. Ellaithi, T. Guran, O. Hiort, P.-M. Holterhu, I. Hughe, N. Krone, L. Lisa, Y. Morel, O. Soder, P. Wieacker, S. F. Ahmed, Cox, Kathryn, Bryce, Jillian, Jiang, Jipu, Rodie, Martina, Sinnott, Richard, Alkhawari, Mona, Arlt, Wiebke, Audi, Laura, Balsamo, Antonio, Bertelloni, Silvano, Cools, Martine, Darendeliler, Feyza, Drop, Stenvert, Ellaithi, Mona, Guran, Tulay, Hiort, Olaf, Holterhus, Paul-Martin, Hughes, Ieuan, Krone, Nils, Lisa, Lidka, Morel, Yves, Soder, Olle, Wieacker, Peter, Ahmed, S. Faisal, Molecular Genetics, Pathology, and Pediatrics
- Subjects
Male ,medicine.medical_specialty ,GENES ,Endocrinology, Diabetes and Metabolism ,Clinical Biochemistry ,Karyotype ,Disorders of Sex Development ,STEROIDOGENESIS ,Context (language use) ,Biology ,Biochemistry ,HYPOSPADIAS ,Endocrinology ,KIDNEY ,Internal medicine ,Epidemiology ,medicine ,MANAGEMENT ,Humans ,associated conditions ,EPIDEMIOLOGY ,MALFORMATIONS ,Disorders of sex development ,Registries ,JCEM Online: Advances in Genetics ,Biochemistry (medical) ,Biology and Life Sciences ,medicine.disease ,3. Good health ,I-DSD registry ,DISORDER OF SEXUAL DEVELOPMENT ,LEMLI-OPITZ-SYNDROME ,Hypospadias ,ANDROGEN INSENSITIVITY SYNDROME ,Mutation ,Etiology ,Small for gestational age ,GENITAL ANOMALIES ,Androgen insensitivity syndrome ,Female - Abstract
Context:\ud The focus of care in disorders of sex development (DSD) is often directed to issues related to sex and gender development. In addition, the molecular etiology remains unclear in the majority of cases.\ud Objective:\ud To report the range of associated conditions identified in the international DSD (I-DSD) Registry.\ud Design, Setting, and Patients:\ud Anonymized data were extracted from the I-DSD Registry for diagnosis, karyotype, sex of rearing, genetic investigations, and associated anomalies. If necessary, clarification was sought from the reporting clinician.\ud Results:\ud Of 649 accessible cases, associated conditions occurred in 168 (26%); 103 (61%) cases had one condition, 31 (18%) had two conditions, 20 (12%) had three conditions, and 14 (8%) had four or more conditions. Karyotypes with most frequently reported associations included 45,X with 6 of 8 affected cases (75%), 45,X/46,XY with 19 of 42 cases (45%), 46,XY with 112 of 460 cases (24%), and 46,XX with 27 of 121 cases (22%). In the 112 cases of 46,XY DSD, the commonest conditions included small for gestational age in 26 (23%), cardiac anomalies in 22 (20%), and central nervous system disorders in 22 (20%), whereas in the 27 cases of 46,XX DSD, skeletal and renal anomalies were commonest at 12 (44%) and 8 (30%), respectively. Of 170 cases of suspected androgen insensitivity syndrome, 19 (11%) had reported anomalies and 9 of these had confirmed androgen receptor mutations.\ud Conclusions:\ud Over a quarter of the cases in the I-DSD Registry have an additional condition. These associations can direct investigators toward novel genetic etiology and also highlight the need for more holistic care of the affected person.
- Published
- 2014
20. Birth weight in different etiologies of disorders of sex development
- Author
-
Jipu Jiang, Hannema Se, Silvano Bertelloni, Jillian Bryce, Marek Niedziela, Nils Krone, S Faisal Ahmed, Feyza Darendeliler, Paul Martin Holterhus, Olaf Hiort, Lidka Lisa, An Desloovere, Tulay Guran, Martina Rodie, Hedi L Claahsen-van der Grinten, Martine Cools, Anna Nordenström, Ieuan A. Hughes, Sukran Poyrazoglu, Birgit Köhler, Pediatric surgery, Poyrazoglu, Sukran, Darendeliler, Feyza, Ahmed, S. Faisal, Hughes, Ieuan, Bryce, Jillian, Jiang, Jipu, Rodie, Martina, Hiort, Olaf, Hannema, Sabine E., Bertelloni, Silvano, Lisa, Lidka, Guran, Tulay, Cools, Martine, Desloovere, An, Grinten, Hedi L. Claahsen-van der, Nordenstrom, Anna, Holterhus, Paul-Martin, Kohler, Birgit, Niedziela, Marek, and Krone, Nils
- Subjects
Male ,BOYS ,Endocrinology, Diabetes and Metabolism ,Clinical Biochemistry ,Disorders of Sex Development ,Androgen Excess ,Biochemistry ,0302 clinical medicine ,Endocrinology ,Testis ,LENGTH ,Birth Weight ,Registries ,Disorders of sex development ,Sex Characteristics ,Fetal Growth Retardation ,Vascular damage Radboud Institute for Molecular Life Sciences [Radboudumc 16] ,Androgen-Insensitivity Syndrome ,3. Good health ,Europe ,RECEPTOR GENE-MUTATIONS ,ANDROGEN INSENSITIVITY SYNDROME ,HEAD CIRCUMFERENCE ,Infant, Small for Gestational Age ,Androgens ,Female ,Androgen insensitivity syndrome ,medicine.medical_specialty ,Birth weight ,Gestational Age ,030209 endocrinology & metabolism ,Biology ,HYPOSPADIAS ,03 medical and health sciences ,030225 pediatrics ,Internal medicine ,Androgen deficiency ,medicine ,Humans ,COHORT ,Disorder of Sex Development, 46,XY ,Biochemistry (medical) ,Hyperandrogenism ,Infant, Newborn ,medicine.disease ,Androgen receptor ,MATERNAL RISK ,DIMORPHISM ,FETAL-GROWTH ,Small for gestational age - Abstract
Item does not contain fulltext Context: It is well established that boys are heavier than girls at birth. Although the cause of birth weight (BW) difference is unknown, it has been proposed that it could be generated from prenatal androgen action. Objective: The aim of the current study was to determine the BW of children with disorders of sex development (DSD) of different etiologies and to evaluate the effects of androgen action on BW. Methods: Data regarding diagnosis, BW, gestational age, karyotype, and concomitant conditions were collected from the International Disorders of Sex Development (I-DSD) Registry (www.i-dsd). BW standard deviation score was calculated according to gestational age. Cases were evaluated according to disorder classification in I-DSD (i.e., disorders of gonadal development, androgen excess, androgen synthesis, androgen action, nonspecific disorder of undermasculinization groups, and Leydig cell defect). Results: A total of 533 cases were available; 400 (75%) cases were 46,XY, and 133 (25%) cases were 46,XX. Eighty cases (15%) were born small for gestational age (SGA). Frequency of SGA was higher in the 46,XY group (17.8%) than in the 46,XX (6.7%) group (P = 0.001). Mean BW standard deviation scores of cases with androgen excess and androgen deficiency [in disorders of gonadal development, androgen synthesis, and Leydig cell defect groups and androgen receptor gene (AR) mutation-positive cases in disorders of androgen action groups] were similar to normal children with the same karyotype. SGA birth frequency was higher in the AR mutation-negative cases in disorders of androgen action group and in the nonspecific disorders of the undermasculinization group. Conclusions: BW dimorphism is unlikely to be explained by fetal androgen action per se. 46,XY DSDs due to nonspecific disorders of undermasculinization are more frequently associated with fetal growth restriction, SGA, and concomitant conditions.
- Published
- 2017
- Full Text
- View/download PDF
21. Changes over time in sex assignment for disorders of sex development
- Author
-
Marek Niedziela, Feyza Darendeliler, Martine Cools, Anna Nordenström, Tulay Guran, Katherine Lachlan, Wiebke Arlt, Antonio Balsamo, Mona Ellaithi, Ieuan A. Hughes, Jipu Jiang, Mona Alkhawari, Martina Rodie, Zofia Kolesinska, Yvonne G. van der Zwan, Olaf Hiort, Pierre Chatelain, Marta Molińska-Glura, Silvano Bertelloni, Paul-Martin Holterhus, Richard O. Sinnott, Naomi Weintrob, Jillian Bryce, Nils Krone, Inas Mazen, S Faisal Ahmed, Lidka Lisa, Kolesinska, Zofia, Ahmed, S. Faisal, Niedziela, Marek, Bryce, Jillian, Molinska-Glura, Marta, Rodie, Martina, Jiang, Jipu, Sinnott, Richard O., Hughes, Ieuan A., Darendeliler, Feyza, Hiort, Olaf, Van Der Zwan, Yvonne, Cools, Martine, Guran, Tulay, Holterhus, Paul-Martin, Bertelloni, Silvano, Lisa, Lidka, Arlt, Wiebke, Krone, Nil, Ellaithi, Mona, Balsamo, Antonio, Mazen, Ina, Nordenstrom, Anna, Lachlan, Katherine, Alkhawari, Mona, Chatelain, Pierre, and Weintrob, Naomi
- Subjects
Adult ,Male ,Registrie ,medicine.medical_specialty ,Percentile ,Time Factors ,Adolescent ,Time Factor ,Sex assignment ,Disorders of Sex Development ,DSD ,Health outcomes ,Follow-Up Studie ,Cohort Studies ,Young Adult ,Arts and Humanities (miscellaneous) ,Internal medicine ,medicine ,Humans ,Disorders of sex development ,Registries ,Genitalia ,Young adult ,Partial androgen insensitivity syndrome ,business.industry ,Gender ,Gender Identity ,Cloacal exstrophy ,medicine.disease ,Endocrinology ,Difference ,Pediatrics, Perinatology and Child Health ,Intersex ,Female ,Cohort Studie ,business ,Atypical ,Demography ,Cohort study ,Follow-Up Studies ,Human - Abstract
BACKGROUND AND OBJECTIVE: It is unclear whether the proportion of infants with a disorder of sex development who are raised as male or female has changed over time. The temporal trends in sex assignment of affected cases entered in the International Disorder of Sex Development (I-DSD) Registry were studied. METHODS: Cases of disorders of sex development reported as partial androgen insensitivity syndrome (PAIS; n = 118), disorder of gonadal development (DGD; n = 232), and disorder of androgen synthesis (DAS; n = 104) were divided into those who were born before 1990, 1990–1999, and after 1999. External appearance of the genitalia was described by the external masculinization score. RESULTS: The median (5th–95th percentile) external masculinization scores of those infants with PAIS, DGD, and DAS who were raised as boys were 6 (2–9), 6 (3–9), and 6 (1–12), respectively, and were significantly higher than in those raised as girls (2 [0–6], 2 [0–7], and 0 [0–5], respectively); this difference was maintained in the 3 temporal birth cohorts (P < .01). Of the 118 cases in the pre-1990 cohort, 41 (35%) were raised as boys; of the 148 cases in the 1990–1999 cohort, 60 (41%) were raised as boys; and of the 188 cases in the post-1999 cohort, 128 (68%) were raised as boys. CONCLUSIONS: Although there is an association between the external appearance of the genitalia and the choice of sex assignment, there are clear temporal trends in this practice pointing toward an increased likelihood of affected infants being raised as boys. The impact of this change in practice on long-term health outcomes requires additional focus.
- Published
- 2014
22. Clinical value of miR-216a-5p and miR-34a in early screening for cervical cancer.
- Author
-
Li F, Ma Q, Jiang M, Jiang J, Yang H, Ma H, Zhou N, Li C, Luo Y, Wang Z, Jiang H, and Zhao N
- Abstract
Objective: To investigate the clinical value of miR-216a-5p and miR-34a in early screening for cervical cancer (CC)., Methods: 99 patients were selected and classified into a cervical cancer group, a precancerous lesion group, and a chronic cervicitis group, with 33 patients in each group. The miR-216a-5p and miR-34a levels in the morning urine samples of patients in the three groups were detected. Additionally, the urine samples of CC patients were analyzed and their cervical tissues examined to confirm the presence of Human Papilloma Virus (HPV) infection. The differences in the levels of miR-216a-5p and miR-34a in CC patients exhibiting varying clinical features and the clinical values of the two biomarkers in identifying CC were analyzed. Patients in the cervical cancer group were divided into a recurrence group and a non-recurrence group, after which their levels of miR-216a-5p and miR-34a were analyzed. These patients were subsequently divided into a high-expression group and a low-expression group with the aforementioned biomarker levels in the non-recurrence group as cutoff values. The progression-free survival was compared between the low- and high-expression groups., Results: Sensitivity and specificity of the urine sample test for HPV infection were 85.19% and 93.33%, respectively. Compared to chronic cervicitis group and precancerous lesion groups, or the non-recurrence group, the levels of miR-216a-5p and miR-34a in both the cervical cancer group and recurrence group were significantly lower (P < 0.05). CC patients with moderately to poorly differentiated tumor cells, an infiltration depth of the muscle layer > 1/2, lymph node metastasis, parametrial infiltration, or vascular invasion had significantly lower levels of miR-216a-5p and miR-34a than those without these risk factors (P < 0.05). The AUC for the application of the two biomarkers in diagnosing CC individually or in combination, or in forecasting recurrence, was greater than 0.8. Additionally, the cumulative progression-free survival was shorter in the low-expression group compared to the high-expression group., Conclusion: Use of morning urine samples for testing HPV infection shows high sensitivity and specificity. Moreover, the miR-216a-5p and miR-34a levels were closely associated with the progression and recurrence of CC., Competing Interests: None., (AJTR Copyright © 2025.)
- Published
- 2025
- Full Text
- View/download PDF
23. Enabling secure, distributed collaborations for adrenal tumor research.
- Author
-
Stell A, Sinnott R, and Jiang J
- Subjects
- Access to Information, Computer Security, Europe, Humans, Adrenal Glands physiopathology, Biomedical Research, Cooperative Behavior, Neoplasms, Public Health Informatics
- Abstract
Many e-Health strategies rely on the secure integration of datasets that have previously resided in isolated locations, but can now in principle be accessed over the Internet. Of paramount importance in the health domain is the need for the security and privacy of data that is transmitted across these networks. One such collaboration, which spans several specialist centres across France, Germany, Italy and the UK, is ENSAT - the European Network for the Study of Adrenal Tumors. The rarity of the tumors under study means the value of accessing, aggregating and comparing data from many centres is great indeed. However this is especially challenging given that ENSAT require clinical and genomic data to be seamlessly linked, but in such a way that the information governance, ethics and privacy concerns of the patients and associated stakeholders involved are visibly satisfied. Key to this is the clear separation of clinical and genomic data sets and support for rigorous patient-identity protecting access control. This is especially challenging when such data sets exist across different organisational boundaries. In this paper we describe a prototype solution offering a security-oriented tailored portal supported by a layered encryption-driven linkage technology (VANGUARD) that offers precisely such patient-privacy protecting capabilities. We describe the architecture, implementation and use to date of this facility to support the ENSAT adrenal cancer research network.
- Published
- 2010
24. BioNessie(G) - a Grid enabled biochemical networks simulation environment.
- Author
-
Liu X, Jiang J, Ajayi O, Gu X, Gilbert D, and Sinnott R
- Subjects
- Databases as Topic, Humans, Software, United Kingdom, Biochemistry organization & administration, Computer Communication Networks organization & administration, Computer Simulation, Systems Biology organization & administration
- Abstract
The simulation of biochemical networks provides insight and understanding about the underlying biochemical processes and pathways used by cells and organisms. BioNessie is a biochemical network simulator which has been developed at the University of Glasgow. This paper describes the simulator and focuses in particular on how it has been extended to benefit from a wide variety of high performance compute resources across the UK through Grid technologies to support larger scale simulations.
- Published
- 2008
25. Security-oriented data grids for microarray expression profiles.
- Author
-
Sinnott R, Bayliss C, and Jiang J
- Subjects
- Access to Information, Humans, United Kingdom, Computer Security, Database Management Systems organization & administration, Medical Informatics, Oligonucleotide Array Sequence Analysis
- Abstract
Microarray experiments are one of the key ways in which gene activity can be identified and measured thereby shedding light and understanding for example on biological processes. The BBSRC funded Grid enabled Microarray Expression Profile Search (GEMEPS) project has developed an infrastructure which allows post-genomic life science researchers to ask and answer the following questions: who has undertaken microarray experiments that are in some way similar or relevant to mine; and how similar were these relevant experiments? Given that microarray experiments are expensive to undertake and may possess crucial information for future exploitation (both academically and commercially), scientists are wary of allowing unrestricted access to their data by the wider community until fully exploited locally. A key requirement is thus to have fine grained security that is easy to establish and simple (or ideally transparent) to use across inter-institutional virtual organisations. In this paper we present an enhanced security-oriented data Grid infrastructure that supports the definition of these kinds of queries and the analysis and comparison of microarray experiment results.
- Published
- 2007
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.