Author: "Jiang, L. H." - Searchworks@Jio Institute Digital Library Search Results

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225 results on '"Jiang, L. H."'

1. Retraction Note to: SYNTHESIS, CRYSTAL STRUCTURE, AND ANTI-GASTRIC CANCER ACTIVITY OF A Zn(II) COORDINATION POLYMER WITH A 4,4′-BIS(1-IMIDAZOLYL)BIPHENYL LIGAND

Author: Zhai, J. -B., Jiang, L. -H., and Jiang, Y.
Published: 2024
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2. Insight-HXMT observations of Swift J0243.6+6124: the evolution of RMS pulse fractions at super-Eddington luminosity

Author: Wang, P. J., Kong, L. D., Zhang, S., Chen, Y. P., Zhang, S. N., Qu, J. L., Ji, L., Tao, L., Ge, M. Y., Lu, F. J., Chen, L., Song, L. M., Li, T. P., Xu, Y. P., Cao, X. L., Chen, Y., Liu, C. Z., Bu, Q. C., Cai, C., Chang, Z., Chen, G., Chen, T. X., Chen, Y. B., Cui, W., Cui, W. W., Deng, J. K., Dong, Y. W., Du, Y. Y., Fu, M. X., Gao, G. H., Gao, H., Gao, M., Gu, Y. D., Guan, J., Guo, C. C., Han, D. W., Huang, Y., Huo, J., Jia, S. M., Jiang, L. H., Jiang, W. C., Jin, J., Jin, Y. J., Li, B., Li, C. K., Li, G., Li, M. S., Li, W., Li, X., Li, X. B., Li, X. F., Li, Y. G., Li, Z. W., Liang, X. H., Liao, J. Y., Liu, B. S., Liu, G. Q., Liu, H. W., Liu, X. J., Liu, Y. N., Lu, B., Lu, X. F., Luo, Q., Luo, T., Ma, X., Meng, B., Nang, Y., Nie, J. Y., Ou, G., Sai, N., Shang, R. C., Song, X. Y., Sun, L., Tan, Y., Tuo, Y. L., Wang, C., Wang, G. F., Wang, J., Wang, L. J., Wang, W. S., Wang, Y. S., Wen, X. Y., Wu, B. Y., Wu, B. B., Wu, M., Xiao, G. C., Xiao, S., Xiong, S. L., Yang, J. W., Yang, S., Yang, Yan Ji, Yang, Yi Jung, Yi, Q. B., Yin, Q. Q., You, Y., Zhang, A. M., Zhang, C. M., Zhang, F., Zhang, H. M., Zhang, J., Zhang, T., Zhang, W. C., Zhang, W., Zhang, W. Z., Zhang, Y., Zhang, Y. F., Zhang, Y. J., Zhang, Zhao, Zhang, Zhi, Zhang, Z. L., Zhao, H. S., Zhao, X. F., Zheng, S. J., Zheng, Y. G., Zhou, D. K., Zhou, J. F., Zhu, Y. X., Zhu, Y., and Zhuang, R. L.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: Based on Insight-HXMT data, we report on the pulse fraction evolution during the 2017-2018 outburst of the newly discovered first Galactic ultraluminous X-ray source (ULX) Swift J0243.6+6124. The pulse fractions of 19 observation pairs selected in the rising and fading phases with similar luminosity are investigated. The results show a general trend of the pulse fraction increasing with luminosity and energy at super-critical luminosity. However, the relative strength of the pulsation between each pair evolves strongly with luminosity. The pulse fraction in the rising phase is larger at luminosity below $7.71\times10^{38}$~erg~s$^{-1}$, but smaller at above. A transition luminosity is found to be energy independent. Such a phenomena is firstly confirmed by Insight-HXMT observations and we speculate it may have relation with the radiation pressure dominated accretion disk.
Published: 2020
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3. Insight-HXMT firm detection of the highest energy fundamental cyclotron resonance scattering feature in the spectrum of GRO J1008-57

Author: Ge, M. Y., Ji, L., Zhang, S. N., Santangelo, A., Liu, C. Z., Doroshenko, V., Staubert, R., Qu, J. L., Zhang, S., Lu, F. J., Song, L. M., Li, T. P., Tao, L., Xu, Y. P., Cao, X. L., Chen, Y., Bu, Q. C., Cai, C., Chang, Z., Chen, G., Chen, L., Chen, T. X., Chen, Y. B., Chen, Y. P., Cui, W., Cui, W. W., Deng, J. K., Dong, Y. W., Du, Y. Y., Fu, M. X., Gao, G. H., Gao, H., Gao, M., Gu, Y. D., Guan, J., Guo, C. C., Han, D. W., Huang, Y., Huo, J., Jia, S. M., Jiang, L. H., Jiang, W. C., Jin, J., Jin, Y. J., Kong, L. D., Li, B., Li, C. K., Li, G., Li, M. S., Li, W., Li, X., Li, X. B., Li, X. F., Li, Y. G., Li, Z. W., Liang, X. H., Liao, J. Y., Liu, B. S., Liu, G. Q., Liu, H. W., Liu, X. J., Liu, Y. N., Lu, B., Lu, X. F., Luo, Q., Luo, T., Ma, X., Meng, B., Nang, Y., Nie, J. Y., Ou, G., Sai, N., Shang, R. C., Song, X. Y., Sun, L., Tan, Y., Tuo, Y. L., Wang, C., Wang, G. F., Wang, J., Wang, L. J., Wang, W. S., Wang, Y. D., Wang, Y. S., Wen, X. Y., Wu, B. B., Wu, B. Y., Wu, M., Xiao, G. C., Xiao, S., Xiong, S. L., Xu, H., Yang, J. W., Yang, S., Yang, Y. J., Yi, Q. B., Yin, Q. Q., You, Y., Zhang, A. M., Zhang, C. M., Zhang, F., Zhang, H. M., Zhang, J., Zhang, T., Zhang, W. C., Zhang, W., Zhang, W. Z., Zhang, Y., Zhang, Y. F., Zhang, Y. J., Zhang, Z., Zhang, Z. L., Zhao, H. S., Zhao, X. F., Zheng, S. J., Zheng, Y. G., Zhou, D. K., Zhou, J. F., Zhuang, R. L., Zhu, Y. X., and Zhu, Y.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We report on the observation of the accreting pulsar GRO J1008-57 performed by Insight-HXMT at the peak of the source's 2017 outburst. Pulsations are detected with a spin period of 93.283(1) s. The pulse profile shows double peaks at soft X-rays, and only one peak above 20 keV. The spectrum is well described by the phenomenological models of X-ray pulsars. A cyclotron resonant scattering feature is detected with very high statistical significance at a centroid energy of $E_{\rm cyc}=90.32_{-0.28}^{+0.32}$ keV, for the reference continuum and line models, HIGHECUT and GABS respectively. Detection is very robust with respect to different continuum models. The line energy is significantly higher than what suggested from previous observations, which provided very marginal evidence for the line. This establishes a new record for the centroid energy of a fundamental cyclotron resonant scattering feature observed in accreting pulsars. We also discuss the accretion regime of the source during the Insight-HXMT observation., Comment: 8 pages, 3 figures, accepted for publication in ApJL
Published: 2020
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4. HXMT Identification of a non-thermal X-ray burst from SGR J1935+2154 and with FRB 200428

Author: Li, C. K., Lin, L., Xiong, S. L., Ge, M. Y., Li, X. B., Li, T. P., Lu, F. J., Zhang, S. N., Tuo, Y. L., Nang, Y., Zhang, B., Xiao, S., Chen, Y., Song, L. M., Xu, Y. P., Liu, C. Z., Jia, S. M., Cao, X. L., Qu, J. L., Zhang, S., Gu, Y. D., Liao, J. Y., Zhao, X. F., Tan, Y., Nie, J. Y., Zhao, H. S., Zheng, S. J., Zheng, Y. G., Luo, Q., Cai, C., Li, B., Xue, W. C., Bu, Q. C., Chang, Z., Chen, G., Chen, T. X., Chen, Y. B., Chen, Y. P., Cui, W., Cui, W. W., Deng, J. K., Dong, Y. W., Du, Y. Y., Fu, M. X., Gao, G. H., Gao, H., Gao, M., Guan, J., Guo, C. C., Han, D. W., Huang, Y., Huo, J., Jiang, L. H., Jiang, W. C., Jin, J., Jin, Y. J., Kong, L. D., Li, G., Li, M. S., Li, W., Li, X., Li, X. F., Li, Y. G., Li, Z. W., Liang, X. H., Liu, B. S., Liu, G. Q., Liu, H. W., Liu, X. J., Liu, Y. N., Lu, B., Lu, X. F., Luo, T., Ma, X., Meng, B., Ou, G., Sai, N., Shang, R. C., Song, X. Y., Sun, L., Tao, L., Wang, C., Wang, G. F., Wang, J., Wang, W. S., Wang, Y. S., Wen, X. Y., Wu, B. B., Wu, B. Y., Wu, M., Xiao, G. C., Xu, H., Yang, J. W., Yang, S., Yang, Y. J., Yang, Yi-Jung, Yi, Q. B., Yin, Q. Q., You, Y., Zhang, A. M., Zhang, C. M., Zhang, F., Zhang, H. M., Zhang, J., Zhang, T., Zhang, W., Zhang, W. C., Zhang, W. Z., Zhang, Y., Zhang, Yue, Zhang, Y. F., Zhang, Y. J., Zhang, Z., Zhang, Zhi, Zhang, Z. L., Zhou, D. K., Zhou, J. F., Zhu, Y., Zhu, Y. X., and Zhuang, R. L.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: Fast radio bursts (FRBs) are short pulses observed in radio band from cosmological distances. One class of models invoke soft gamma-ray repeaters (SGRs), or magnetars, as the sources of FRBs. Some radio pulses have been observed from some magnetars, however, no FRB-like events had been detected in association any magnetar burst, including one giant flare. Recently, a pair of FRB-like bursts (FRB 200428 hereafter) separated by milliseconds (ms) were detected from the general direction of the Galactic magnetar SGR J1935+2154. Here we report the detection of a non-thermal X-ray burst in the 1-250 keV energy band with the Insight-HXMT satellite, which we identify as emitted from SGR J1935+2154. The burst showed two hard peaks with a separation of 34 ms, broadly consistent with that of the two bursts in FRB 200428. The delay time between the double radio and X-ray peaks is about 8.57 s, fully consistent with the dispersion delay of FRB 200428. We thus identify the non-thermal X-ray burst is associated with FRB 200428 whose high energy counterpart is the two hard peaks in X-ray. Our results suggest that the non-thermal X-ray burst and FRB 200428 share the same physical origin in an explosive event from SGR J1935+2154., Comment: 24 pages, 9 figures, 6 tables; initial submission to a journal on May 9th, 2020. Significant changes include updated localization and detailed spectral evolution of the X-ray burst, and better determination of the two narrow X-ray peaks corresponding to the two radio pulses. Conclusions are strengthened. Nature Astronomy online on Feb. 18, 2021
Published: 2020
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5. Insight-HXMT insight into switch of the accretion mode: the case of the X-ray pulsar 4U 1901+03

Author: Tuo, Y. L., Ji, L., Tsygankov, S. S., Mihara, T., Song, L. M., Ge, M. Y., Nabizadeh, A., Tao, L., Qu, J. L., Zhang, Y., Zhang, S., Zhang, S. N., Bu, Q. C., Chen, L., Xu, Y. P., Cao, X. L., Chen, Y., Liu, C. Z., Cai, C., Chang, Z., Chen, G., Chen, T. X., Chen, Y. B., Chen, Y. P., Cui, W., Cui, W. W., Deng, J. K., Dong, Y. W., Du, Y. Y., Fu, M. X., Gao, G. H., Gao, H., Gao, M., Gu, Y. D., Guan, J., Guo, C. C., Han, D. W., Huang, Y., Huo, J., Jia, S. M., Jiang, L. H., Jiang, W. C., Jin, J., Jin, Y. J., Kong, L. D., Li, B., Li, C. K., Li, G., Li, M. S., Li, T. P., Li, W., Li, X., Li, X. B., Li, X. F., Li, Y. G., Li, Z. W., Liang, X. H., Liao, J. Y., Liu, B. S., Liu, G. Q., Liu, H. W., Liu, X. J., Liu, Y. N., Lu, B., Lu, F. J., Lu, X. F., Luo, Q., Luo, T., Ma, X., Meng, B., Nang, Y., Nie, J. Y., Ou, G., Sai, N., Shang, R. C., Song, X. Y., Sun, L., Tan, Y., Wang, C., Wang, G. F., Wang, J., Wang, W. S., Wang, Y. S., Wen, X. Y., Wu, B. Y., Wu, B. B., Wu, M., Xiao, G. C., Xiao, S., Xiong, S. L., Yang, J. W., Yang, S., Yang, Y. J., Yi, Q. B., Yin, Q. Q., You, Y., Zhang, A. M., Zhang, C. M., Zhang, F., Zhang, H. M., Zhang, J., Zhang, T., Zhang, W., Zhang, W. C., Zhang, W. Z., Zhang, Y. F., Zhang, Y. J., Zhang, Y. H., Zhang, Z., Zhang, Z. L., Zhao, H. S., Zhao, X. F., Zheng, S. J., Zheng, Y. G., Zhou, D. K., Zhou, J. F., Zhu, Y. X., Zhu, Y., and Zhuang, R. L.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We use the In data collected during the 2019 outburst from X-ray pulsar 4U 1901+03 to complement the orbital parameters reported by Fermi/GBM. Using the Insight-HXMT, we examine the correlation between the derivative of the intrinsic spin frequency and bolometric flux based on accretion torque models. It was found that the pulse profiles significantly evolve during the outburst. The existence of two types of the profile's pattern discovered in the Insight-HXMT data indicates that this source experienced transition between a super-critical and a sub-critical accretion regime during its 2019 outburst. Based on the evolution of the pulse profiles and the torque model, we derive the distance to 4U 1901+03 as 12.4+-0.2 kpc., Comment: 8 pages, 5 figures, accepted by JHEAP
Published: 2020

6. The evolution of the broadband temporal features observed in the black-hole transient MAXI J1820+070 with Insight-HXMT

Author: Wang, Yanan, Ji, Long, Zhang, S. N., Méndez, Mariano, Qu, J. L., Maggi, Pierre, Ge, M. Y., Qiao, Erlin, Tao, L., Zhang, S., Altamirano, Diego, Zhang, L., Ma, X., Lu, F. J., Li, T. P., Huang, Y., Zheng, S. J., Chen, Y. P., Chang, Z., Tuo, Y. L., Gungor, C., Song, L. M., Xu, Y. P., Cao, X. L., Chen, Y., Liu, C. Z., Bu, Q. C., Cai, C., Chen, G., Chen, L., Chen, T. X., Chen, Y. B., Cui, W., Cui, W. W., Deng, J. K., Dong, Y. W., Du, Y. Y., Fu, M. X., Gao, G. H., Gao, H., Gao, M., Gu, Y. D., Guan, J., Guo, C. C., Han, D. W., Huo, J., Jia, S. M., Jiang, L. H., Jiang, W. C., Jin, J., Jin, Y. J., Kong, L. D., Li, B., Li, C. K., Li, G., Li, M. S., Li, W., Li, X., Li, X. B., Li, X. F., Li, Y. G., Li, Z. W., Liang, X. H., Liao, J. Y., Liu, G. Q., Liu, H. W., Liu, X. J., Liu, Y. N., Lu, B., Lu, X. F., Luo, Q., Luo, T., Meng, B., Nang, Y., Nie, J. Y., Ou, G., Sai, N., Shang, R. C., Song, X. Y., Sun, L., Tan, Y., Wang, G. F., Wang, J., Wang, W. S., Wang, Y. D., Wang, Y. S., Wen, X. Y., Wu, B. B., Wu, B. Y., Wu, M., Xiao, G. C., Xiao, S., Xiong, S. L., Yang, J. W., Yang, S., Yang, Y. J., Yi, Q. B., Yin, Q. Q., You, Y., Zhang, A. M., Zhang, C. M., Zhang, F., Zhang, H. M., Zhang, J., Zhang, T., Zhang, W. C., Zhang, W., Zhang, W. Z., Zhang, Y., Zhang, Y. F., Zhang, Y. J., Zhang, Z., Zhang, Z. L., Zhao, H. S., Zhao, X. F., Zhou, D. K., Zhou, J. F., Zhuang, R. L., Zhu, Y. X., and Zhu, Y.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We study the evolution of the temporal properties of MAXI 1820+070 during the 2018 outburst in its hard state from MJD 58190 to 58289 with Insight-HXMT in a broad energy band 1-150 keV. We find different behaviors of the hardness ratio, the fractional rms and time lag before and after MJD 58257, suggesting a transition occurred at around this point. The observed time lags between the soft photons in the 1-5 keV band and the hard photons in higher energy bands, up to 150 keV, are frequency-dependent: the time lags in the low-frequency range, 2-10 mHz, are both soft and hard lags with a timescale of dozens of seconds but without a clear trend along the outburst; the time lags in the high-frequency range, 1-10 Hz, are only hard lags with a timescale of tens of milliseconds; first increase until around MJD 58257 and decrease after this date. The high-frequency time lags are significantly correlated to the photon index derived from the fit to the quasi-simultaneous NICER spectrum in the 1-10 keV band. This result is qualitatively consistent with a model in which the high-frequency time lags are produced by Comptonization in a jet., Comment: Accepted for publication in ApJ
Published: 2020
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7. Discovery of delayed spin-up behavior following two large glitches in the Crab pulsar, and the statistics of such processes

Author: Ge, M. Y., Zhang, S. N., Lu, F. J., Li, T. P., Yuan, J. P., Zheng, X. P., Huang, Y., Zheng, S. J., Chen, Y. P., Chang, Z., Tuo, Y. L., Cheng, Q., Güngör, C., Song, L. M., Xu, Y. P., Cao, X. L., Chen, Y., Liu, C. Z., Zhang, S., Qu, J. L., Bu, Q. C., Cai, C., Chen, G., Chen, L., Chen, M. Z., Chen, T. X., Chen, Y. B., Cui, W., Cui, W. W., Deng, J. K., Dong, Y. W., Du, Y. Y., Fu, M. X., Gao, G. H., Gao, H., Gao, M., Gu, Y. D., Guan, J., Guo, C. C., Han, D. W., Hao, L. F., Huo, J., Jia, S. M., Jiang, L. H., Jiang, W. C., Jin, C. J., Jin, J., Jin, Y. J., Kong, L. D., Li, B., Li, D., Li, C. K., Li, G., Li, M. S., Li, W., Li, X., Li, X. B., Li, X. F., Li, Y. G., Li, Z. W., Li, Z. X., Liu, Z. Y., Liang, X. H., Liao, J. Y., Liu, G. Q., Liu, H. W., Liu, X. J., Liu, Y. N., Lu, B., Lu, X. F., Luo, Q., Luo, T., Ma, X., Meng, B., Nang, Y., Nie, J. Y., Ou, G., Sai, N., Shang, R. C., Song, X. Y., Sun, L., Tan, Y., Tao, L., Wang, C., Wang, G. F., Wang, J., Wang, J. B., Wang, M., Wang, N., Wang, W. S., Wang, Y. D., Wang, Y. S., Wen, X. Y., Wen, Z. G., Wu, B. B., Wu, B. Y., Wu, M., Xiao, G. C., Xiao, S., Xiong, S. L., Xu, Y. H., Yan, W. M., Yang, J. W., Yang, S., Yang, Y. J., Yi, Q. B., Yin, Q. Q., You, Y., Yue, Y. L., Zhang, A. M., Zhang, C. M., Zhang, D. P., Zhang, F., Zhang, H. M., Zhang, J., Zhang, T., Zhang, W. C., Zhang, W., Zhang, W. Z., Zhang, Y., Zhang, Y. F., Zhang, Y. J., Zhang, Z., Zhang, Z. L., Zhao, H. S., Zhao, X. F., Zheng, W., Zhou, D. K., Zhou, J. F., Zhou, X., Zhuang, R. L., Zhu, Y. X., and Zhu, Y.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: Glitches correspond to sudden jumps of rotation frequency ($\nu$) and its derivative ($\dot{\nu}$) of pulsars, the origin of which remains not well understood yet, partly because the jump processes of most glitches are not well time-resolved. There are three large glitches of the Crab pulsar, detected in 1989, 1996 and 2017, which were found to have delayed spin-up processes before the normal recovery processes. Here we report two additional glitches of the Crab pulsar occurred in 2004 and 2011 for which we discovered delayed spin up processes, and present refined parameters of the largest glitch occurred in 2017. The initial rising time of the glitch is determined as $<0.48$ hour. We also carried out a statistical study of these five glitches with observed spin-up processes. The two glitches occurred in 2004 and 2011 have delayed spin-up time scales ($\tau_{1}$) of $1.7\pm0.8$\,days and $1.6\pm0.4$\,days, respectively. We find that the $\Delta{\nu}$ vs. $|\Delta{\dot\nu}|$ relation of these five glitches is similar to those with no detected delayed spin-up process, indicating that they are similar to the others in nature except that they have larger amplitudes. For these five glitches, the amplitudes of the delayed spin-up process ($|\Delta{\nu}_{\rm d1}|$) and recovery process ($\Delta{\nu}_{\rm d2}$), their time scales ($\tau_{1}$, $\tau_{2}$), and permanent changes in spin frequency ($\Delta{\nu}_{\rm p}$) and total frequency step ($\Delta{\nu}_{\rm g}$) have positive correlations. From these correlations, we suggest that the delayed spin-up processes are common for all glitches, but are too short and thus difficult to be detected for most glitches., Comment: 25 pages, 8 figures
Published: 2020
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8. A search for prompt gamma-ray counterparts to fast radio bursts in the Insight-HXMT data

Author: Guidorzi, C., Marongiu, M., Martone, R., Nicastro, L., Xiong, S. L., Liao, J. Y., Li, G., Zhang, S. N., Amati, L., Frontera, F., Orlandini, M., Rosati, P., Virgilli, E., Zhang, S., Bu, Q. C., Cai, C., Cao, X. L., Chang, Z., Chen, G., Chen, L., Chen, T. X., Chen, Y. B., Chen, Y. P., Cui, W., Cui, W. W., Deng, J. K., Dong, Y. W., Du, Y. Y., Fu, M. X., Gao, G. H., Gao, H., Gao, M., Ge, M. Y., Gu, Y. D., Guan, J., Guo, C. C., Han, D. W., Huang, Y., Huo, J., Jia, S. M., Jiang, L. H., Jiang, W. C., Jin, J., Jin, Y. J., Kong, L. D., Li, B., Li, C. K., Li, M. S., Li, T. P., Li, W., Li, X., Li, X. B., Li, X. F., Li, Y. G., Li, Z. W., Liang, X. H., Liu, B. S., Liu, C. Z., Liu, G. Q., Liu, H. W., Liu, X. J., Liu, Y. N., Lu, B., Lu, F. J., Lu, X. F., Luo, Q., Luo, T., Ma, R. C., Ma, X., Meng, B., Nang, Y., Nie, J. Y., Oui, G., Qu, J. L, Sai, N., Shang, R. C., Song, L. M., Song, X. Y., Sun, L., Tani, Y., Tao, L., Tuo, Y. L., Wang, C., Wang, G. F., Wang, J., Wang, W. S., Wang, Y. S., Wen, X. Y., Wu, B. Y., Wu, B. B., Wu, M., Xiao, G. C., Xiao, S., Xu, Y. P., Yang, J. W., Yang, S., Yang, Y. J., Yi, Q. B., Yin, Q. Q., You, Y., Zhang, A. M. Zhang C. M., Zhang, F., Zhang, H. M., Zhang, J., Zhang, T., Zhang, W. C., Zhang, W., Zhang, W. Z., Zhang, Y., Zhang, Y. F., Zhang, Y. J., Zhang, Z., Zhang, Z. L., Zhang, H. S., Zhang, X. F., Zheng, S. J., Zhou, D. K., Zhou, J. F., Zhu, Y. X., Zhu, Y., and Zhuang, R. L.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: No robust detection of prompt electromagnetic counterparts to fast radio bursts (FRBs) has yet been obtained, in spite of several multi-wavelength searches carried out so far. Specifically, X/gamma-ray counterparts are predicted by some models. We planned on searching for prompt gamma-ray counterparts in the Insight-Hard X-ray Modulation Telescope (Insight-HXMT) data, taking advantage of the unique combination of large effective area in the keV-MeV energy range and of sub-ms time resolution. We selected 39 FRBs that were promptly visible from the High-Energy (HE) instrument aboard Insight-HXMT. After calculating the expected arrival times at the location of the spacecraft, we searched for a significant excess in both individual and cumulative time profiles over a wide range of time resolutions, from several seconds down to sub-ms scales. Using the dispersion measures in excess of the Galactic terms, we estimated the upper limits on the redshifts. No convincing signal was found and for each FRB we constrained the gamma-ray isotropic-equivalent luminosity and the released energy as a function of emission timescale. For the nearest FRB source, the periodic repeater FRB180916.J0158+65, we find $L_{\gamma,iso}<5.5\times 10^{47}$ erg/s over 1 s, whereas $L_{\gamma,iso}<10^{49}-10^{51}$ erg/s for the bulk of FRBs. The same values scale up by a factor of ~100 for a ms-long emission. Even on a timescale comparable with that of the radio pulse itself no keV-MeV emission is observed. A systematic association with either long or short GRBs is ruled out with high confidence, except for subluminous events, as is the case for core-collapse of massive stars (long) or binary neutron star mergers (short) viewed off axis. Only giant flares from extra-galactic magnetars at least ten times more energetic than Galactic siblings are ruled out for the nearest FRB., Comment: 15 pages, 3 figures, 6 tables, accepted by A&A
Published: 2020
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9. Switches between accretion structures during flares in 4U 1901+03

Author: Ji, L., Ducci, L., Santangelo, A., Zhang, S., Suleimanov, V., Tsygankov, S., Doroshenko, V., Nabizadeh, A., Zhang, S. N., Ge, M. Y., Tao, L., Bu, Q. C., Qu, J. L., Lu, F. J., Chen, L., Song, L. M., Li, T. P., Xu, Y. P., Cao, X. L., Chen, Y., Liu, C. Z., Cai, C., Chang, Z., Chen, G., Chen, T. X., Chen, Y. B., Chen, Y. P., Cui, W., Cui, W. W., Deng, J. K., Dong, Y. W., Du, Y. Y., Fu, M. X., Gao, G. H., Gao, H., Gao, M., Gu, Y. D., Guan, J., Guo, C. C., Han, D. W., Huang, Y., Huo, J., Jia, S. M., Jiang, L. H., Jiang, W. C., Jin, J., Kong, L. D., Li, B., Li, C. K., Li, G., Li, M. S., Li, W., Li, X., Li, X. B., Li, X. F., Li, Y. G., Li, Z. W., Liang, X. H., Liao, J. Y., Liu, G. Q., Liu, H. X., Liu, H. W., Liu, X. J., Liu, Y. N., Lu, B., Lu, X. F., Luo, Q., Luo, T., Ma, X., Meng, B., Nang, Y., Nie, J. Y., Ou, G., Ren, X. Q., Sai, N., Song, X. Y., Sun, L., Tan, Y., Tuo, Y. L., Wang, C., Wang, G. F., Wang, J., Wang, P. J., Wang, W. S., Wang, Y. S., Wen, X. Y., Wu, B. Y., Wu, B. B., Wu, M., Xiao, G. C., Xiao, S., Xiong, S. L., Yang, J. W., Yang, S., Yang, Yan-Ji, Yang, Yi-Jung, Yi, Q. B., Yin, Q. Q., You, Y., Zhang, A. M., Zhang, C. M., Zhang, F., Zhang, H. M., Zhang, J., Zhang, P., Zhang, T., Zhang, W., Zhang, W. C., Zhang, W. Z., Zhang, Yi, Zhang, Y. F., Zhang, Y. J., Zhang, Y. H., Zhang, Yue, Zhang, Z., Zhang, Z. L., Zhao, H. S., Zhao, X. F., Zheng, S. J., Zhou, D. K., Zhou, J. F., Zhu, Y. X., and Zhu, Y.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We report on our analysis of the 2019 outburst of the X-ray accreting pulsar 4U 1901+03 observed with Insight-HXMT and NICER. Both spectra and pulse profiles evolve significantly in the decaying phase of the outburst. Dozens of flares are observed throughout the outburst. They are more frequent and brighter at the outburst peak. We find that the flares, which have a duration from tens to hundreds of seconds, are generally brighter than the persistent emission by a factor of $\sim$ 1.5. The pulse profile shape during the flares can be significantly different than that of the persistent emission. In particular, a phase shift is clearly observed in many cases. We interpret these findings as direct evidence of changes of the pulsed beam pattern, due to transitions between the sub- and super-critical accretion regimes on a short time scale. We also observe that at comparable luminosities the flares' pulse profiles are rather similar to those of the persistent emission. This indicates that the accretion on the polar cap of the neutron star is mainly determined by the luminosity, i.e., the mass accretion rate., Comment: 11 pages, 8 figures, accepted for publication in MNRAS
Published: 2020
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10. Joint Analysis of Energy and RMS Spectra from MAXI J1535-571 with Insight-HXMT

Author: Kong, L. D., Zhang, S., Chen, Y. P., Ji, L., Zhang, S. N., Yang, Y. R., Tao, L., Ma, X., Qu, J. L., Lu, F. J., Bu, Q. C., Chen, L., Song, L. M., Li, T. P., Xu, Y. P., Cao, X. L., Chen, Y., Liu, C. Z., Cai, C., Chang, Z., Chen, G., Chen, T. X., Chen, Y. B., Cui, W., Cui, W. W., Deng, J. K., Dong, Y. W., Du, Y. Y., Fu, M. X., Gao, G. H., Gao, H., Gao, M., Ge, M. Y., Gu, Y. D., Guan, J., Guo, C. C., Han, D. W., Huang, Y., Huo, J., Jia, S. M., Jiang, L. H., Jiang, W. C., Jin, J., Li, B., Li, C. K., Li, G., Li, M. S., Li, W., Li, X., Li, X. B., Li, X. F., Li, Y. G., Li, Z. W., Liang, X. H., Liao, J. Y., Liu, G. Q., Liu, H. X., Liu, H. W., Liu, S. Z., Liu, X. J., Liu, Y. N., Lu, B., Lu, X. F., Luo, Q., Luo, T., Meng, B., Nang, Y., Nie, J. Y., Ou, G., Ren, X. Q., Sai, N., Song, X. Y., Sun, L., Tan, Y., Tuo, Y. L., Wang, C., Wang, G. F., Wang, J., Wang, P. J., Wang, W. S., Wang, Y. S., Wen, X. Y., Wu, B. Y., Wu, B. B., Wu, M., Xiao, G. C., Xiao, S., Xiong, S. L., Xu, H., Yang, J. W., Yang, S., Yang, Y. J., Yi, Q. B., You, Y., Zhang, A. M., Zhang, C. M., Zhang, F., Zhang, H. M., Zhang, J., Zhang, P., Zhang, T., Zhang, W., Zhang, W. C., Zhang, W. Z., Zhang, Y., Zhang, Y. F., Zhang, Y. J., Zhang, Y. H., Zhang, Z., Zhang, Z. L., Zhao, H. S., Zhao, X. F., Zheng, S. J., Zheng, Y. G., Zhou, D. K., Zhou, J. F., Zhu, Y. X., and Zhu, Y.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: A new black hole X-ray binary (BHXRB) MAXI J1535-571 was discovered by MAXI during its outburst in 2017. Using observations taken by the first Chinese X-ray satellite, the Hard X-ray Modulation Telescope (dubbed as Insight-HXMT), we perform a joint spectral analysis (2-150 keV) in both energy and time domains. The energy spectra provide the essential input for probing the intrinsic Quasi-Periodic Oscillation (QPO) fractional rms spectra (FRS). Our results show that during the intermediate state, the energy spectra are in general consistent with those reported by Swift/XRT and NuSTAR. However, the QPO FRS become harder and the FRS residuals may suggest the presence of either an additional power-law component in the energy spectrum or a turn-over in the intrinsic QPO FRS at high energies.
Published: 2020

11. Diagnostic of the spectral properties of Aquila X-1 by Insight-HXMT snapshots during the early propeller phase

Author: Güngör, C., Ge, M. Y., Zhang, S., Santangelo, A., Zhang, S. N., Lu, F. J., Zhang, Y., Chen, Y. P., Tao, L., Yang, Y. J., Bu, Q. C., Cai, C., Cao, X. L., Chang, Z., Chen, G., Chen, L., Chen, T. X., Chen, Y., Chen, Y. B., Cui, W., Cui, W. W., Deng, J. K., Dong, Y. W., Du, Y. Y., Fu, M. X., Gao, G. H., Gao, H., Gao, M., Gu, Y. D., Guan, J., Guo, C. C., Han, D. W., Huang, Y., Huo, J., Ji, L., Jia, S. M., Jiang, L. H., Jiang, W. C., Jin, J., Kong, L. D., Li, B., Li, C. K., Li, G., Li, M. S., Li, T. P., Li, W., Li, X., Li, X. B., Li, X. F., Li, Y. G., Li, Z. W., Liang, X. H., Liao, J. Y., Liu, C. Z., Liu, G. Q., Liu, H. W., Liu, X. J., Liu, Y. N., Lu, B., Lu, X. F., Luo, T., Luo, Q., Ma, X., Meng, B., Nang, Y., Nie, J. Y., Ou, G., Sai, N., Song, L. M., Song, X. Y., Sun, L., Tan, Y., Tuo, Y. L., Wang, C., Wang, G. F., Wang, J., Wang, W. S., Wang, Y. S., Wen, X. Y., Wu, B. B., Wu, B. Y., Wu, M., Xiao, G. C., Xiao, S., Xiong, S. L., Xu, Y. P., Yang, J. W., Yang, S., Yi, Q. B., Yin, Q. Q., You, Y., Zhang, A. M., Zhang, C. M., Zhang, F., Zhang, H. M., Zhang, J., Zhang, T., Zhang, W., Zhang, W. C., Zhang, W. Z., Zhang, Y. F., Zhang, Y. J., Zhang, Z., Zhang, Z. L., Zhao, H. S., Zhao, X. F., Zheng, S. J., Zhou, D. K., Zhou, J. F., Zhu, Y., and Zhu, Y. X.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We study the 2018 outburst of Aql X-1 via the monitor of all sky X-ray image (MAXI) data. We show that the outburst starting in February 2018 is a member of short-low class in the frame of outburst duration and the peak count rate although the outburst morphology is slightly different from the other fast-rise-exponential-decay (FRED) type outbursts with a milder rising stage. We study the partial accretion in the weak propeller stage of Aql X-1 via the MAXI data of the 2018 outburst. We report on the spectral analysis of 3 observations of Aquila X-1 obtained by Insight - hard X-ray modulation telescope (Insight-HXMT) during the late decay stage of the 2018 outburst. We discuss that the data taken by Insight-HXMT is just after the transition to the weak propeller stage. Our analysis shows the necessity of a comptonization component to take into account the existence of an electron cloud resulting photons partly up-scattered., Comment: 8 pages, 4 figures, accepted for publication in JHEAp
Published: 2019

12. $Insight$-HXMT study of the timing properties of Sco X-1

Author: Jia, S. M., Bu, Q. C., Qu, J. L., Lu, F. J., Zhang, S. N., Huang, Y., Ma, X., Tao, L., Xiao, G. C., Zhang, W., Chen, L., Song, L. M., Zhang, S., Li, T. B., Xu, Y. P., Cao, X. L., Chen, Y., Liu, C. Z., Cai, C., Chang, Z., Chen, G., Chen, T. X., Chen, Y. B., Chen, Y. P., Cui, W., Cui, W. W., Deng, J. K., Dong, Y. W., Du, Y. Y., Fu, M. X., Gao, G. H., Gao, H., Gao, M., Ge, M. Y., Gu, Y. D., Guan, J., Guo, C. C., Han, D. W., Huo, J., Jiang, L. H., Jiang, W. C., Jin, J., Kong, L. D., Li, B., Li, C. K., Li, G., Li, M. S., Li, W., Li, X., Li, X. B., Li, X. F., Li, Y. G., Li, Z. W., Liang, X. H., Liao, J. Y., Liu, G. Q., Liu, H. W., Liu, X. J., Liu, Y. N., Lu, B., Lu, X. F., Luo, Q., Luo, T., Meng, B., Nang, Y., Nie, J. Y., Ou, G., Sai, N., Song, X. Y., Sun, L., Tan, Y., Tuo, Y. L., Wang, C., Wang, G. F., Wang, J., Wang, W. S., Wang, Y. S., Wen, X. Y., Wu, B. Y., Wu, B. B., Wu, M., Xiao, S., Xiong, S. L., Yang, J. W., Yang, S., Yang, Y. J., Yin, Q. Q., Yi, Q. B., You, Y., Zhang, A. M., Zhang, C. M., Zhang, F., Zhang, H. M., Zhang, J., Zhang, T., Zhang, W. C., Zhang, W. Z., Zhang, Y., Zhang, Y. F., Zhang, Y. J., Zhang, Z., Zhang, Z. L., Zhao, H. S., Zhao, X. F., Zheng, S. J., Zhou, D. K., Zhou, J. F., Zhu, Y. X., and Zhu, Y.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Phenomenology
Abstract: We present a detailed timing study of the brightest persistent X-ray source Sco X-1 using the data collected by the Hard X-ray Modulation Telescope ($Insight$-HXMT) from July 2017 to August 2018. A complete $Z$-track hardness-intensity diagram (HID) is obtained. The normal branch oscillations (NBOs) at $\sim$ 6 Hz in the lower part of the normal branch (NB) and the flare branch oscillations (FBOs) at $\sim$ 16 Hz in the beginning part of the flaring branch (FB) are found in observations with the Low Energy X-ray Telescope (LE) and the Medium Energy X-ray Telescope (ME) of $Insight$-HXMT, while the horizontal branch oscillations (HBOs) at $\sim$ 40 Hz and the kilohertz quasi-periodic oscillations (kHz QPOs) at $\sim$ 800 Hz are found simultaneously up to 60 keV for the first time on the horizontal branch (HB) by the High Energy X-ray Telescope (HE) and ME. We find that for all types of the observed QPOs, the centroid frequencies are independent of energy, while the root mean square (rms) increases with energy; the centroid frequencies of both the HBOs and kHz QPOs increase along the $Z$-track from the top to the bottom of the HB; and the NBOs show soft phase lags increasing with energy. A continuous QPO transition from the FB to NB in $\sim$ 200 s are also detected. Our results indicate that the non-thermal emission is the origin of all types of QPOs, the innermost region of the accretion disk is non-thermal in nature, and the corona is nonhomogeneous geometrically.
Published: 2019

13. Insight-HXMT observation on 4U~1608--52: evolving spectral properties of a bright type-I X-ray burst

Author: Chen, Y. P., Zhang, S., Zhang, S. N., Ji, L., Kong, L. D., Santangelo, A., Qu, J. L., Lu, F. J., Li, T. P., Song, L. M., Xu, Y. P., Cao, X. L., Chen, Y., Liu, C. Z., Bu, Q. C., Cai, C., Chang, Z., Chen, G., Chen, L., Chen, T. X., Chen, Y. B., Cui, W., Cui, W. W., Deng, J. K., Dong, Y. W., Du, Y. Y., Fu, M. X., Gao, G. H., Gao, H., Gao, M., Ge, M. Y., Gu, Y. D., Guan, J., Guo, C. C., Han, D. W., Huang, Y., Huo, J., Jia, S. M., Jiang, L. H., Jiang, W. C., Jin, J., Li, B., Li, C. K., Li, G., Li, M. S., Li, W., Li, X., Li, X. B., Li, X. F., Li, Y. G., Li, Z. W., Liang, X. H., Liu, J. Y. Liao G. Q., Liu, H. W., Liu, X. J., Liu, Y. N., Lu, B., Lu, X. F., Luo, Q., Luo, T., Ma, X., Meng, B., Nang, Y., Nie, J. Y., Ou, G., Sai, N., Sun, L., Tan, Y., Tao, L., Tuo, Y. L., Wang, C., Wang, G. F., Wang, J., Wang, W. S., Wang, Y. S., Wen, X. Y., Wu, B. Y., Wu, B. B., Wu, M., Xiao, G. C., Xiao, S., Xiong, S. L., Yang, J. W., Yang, S., Yang, Yang-Ji, Yang, Yi-Jung, Yi, Q. B., Yin, Q. Q., You, Y., Zhang, A. M., Zhang, C. L., Zhang, C. M., Zhang, F., Zhang, H. M., Zhang, J., Zhang, T., Zhang, W. C., Zhang, W., Zhang, W. Z., Zhang, Yi., Zhang, Y. F., Zhang, Y. J., Zhang, Yue., Zhang, Z., Zhang, Z. L., Zhao, H. S., Zhao, X. F., Zheng, S. J., Zhou, D. K., Zhou, J. F., Zhu, Y., and Zhu, Y. X.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: The evidences for the influence of thermonuclear (type-I) X-ray bursts upon the surrounding environments in neutron star low-mass X-ray binaries (LMXB) were detected previously via spectral and timing analyses. Benefitting from a broad energy coverage of Insight-HXMT, we analyze one photospheric radius expansion (PRE) burst, and find an emission excess at soft X-rays. Our spectral analysis shows that, such an excess is not likely relevant to the disk reflection induced by the burst emission and can be attributed to an enhanced pre-burst/persistent emission. We find that the burst and enhanced persistent emissions sum up to exceed Eddington luminosity by $\sim$ 40 percentages. We speculate that the enhanced emission is from a region beyond the PRE radius, or through the Comptonization of the corona., Comment: accepted by JHEA(Journal of High Energy Astrophysics)
Published: 2019

14. Insight-HXMT observations of 4U~1636-536: Corona cooling revealed with single short type-I X-ray burst

Author: Chen, Y. P., Zhang, S., Zhang, S. N., Ji, L., Kong, L. D., Cao, X. L., Chang, Z., Chen, G., Chen, L., Chen, T. X., Chen, Y., Chen, Y. B., Cui, W., Cui, W. W., Deng, J. K., Dong, Y. W., Du, Y. Y., Fu, M. X., Gao, G. H., Gao, H., Gao, M., Ge, M. Y., Gu, Y. D., Guan, J., Guo, C. C., Han, D. W., Hu, W., Huang, Y., Huo, J., Jia, S. M., Jiang, L. H., Jiang, W. C., Jin, J., Jin, Y. J., Li, B., Li, C. K., Li, G., Li, M. S., Li, T. P., Li, W., Li, X., Li, X. B., Li, X. F., Li, Y. G., Li, Z. J., Li, Z. W., Liang, X. H., Liao, J. Y., Liu, C. Z., Liu, G. Q., Liu, H. W., Liu, S. Z., Liu, X. J., Liu, Y., Liu, Y. N., Lu, B., Lu, F. J., Lu, X. F., Luo, T., Ma, X., Meng, B., Nang, Y., Nie, J. Y., Ou, G., Qu, J. L., Sai, N., Song, L. M., Sun, L., Tan, Y., Tao, L., Tao, W. H., Tuo, Y. L., Wang, G. F., Wang, H. Y., Wang, J., Wang, W. S., Wang, Y. S., Wen, X. Y., Wu, B. B., Wu, M., Xiao, G. C., Xiong, S. L., Xu, H., Xu, Y. P., Yan, L. L., Yang, J. W., Yang, S., Yang, Y. J., Zhang, A. M., Zhang, C. L., Zhang, C. M., Zhang, F., hang, H. M., Zhang, J., Zhang, Q., Zhang, T., Zhang, W., Zhang, W. C., Zhang, W. Z., Zhang, Y., Zhang, Y. F., Zhang, Y. J., Zhang, Z., Zhang, Z. L., Zhao, H. S., Zhao, J. L., Zhao, X. F., Zheng, S. J., Zhu, Y., Zhu, Y. X., and Zou, C. L.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: Corona cooling was detected previously from stacking a series of short type-I bursts occurred during the low/had state of atoll outburst. Type-I bursts are hence regarded as sharp probe to our better understanding on the basic property of the corona. The launch of the first Chinese X-ray satellite Insight-HXMT has large detection area at hard X-rays which provide almost unique chance to move further in this research field. We report the first detection of the corona cooling by Insight-HXMT from single short type-I burst showing up during {\bf flare} of 4U 1636-536. This type-I X-ray burst has a duration of $\sim$13 seconds and hard X-ray shortage is detected with significance 6.2~$\sigma$ in 40-70 keV. A cross-correlation analysis between the lightcurves of soft and hard X-ray band, shows that the corona shortage lag the burst emission by 1.6 $\pm$1.2~s. These results are consistent with those derived previously from stacking a large amount of bursts detected by RXTE/PCA within a series of {\bf flares} of 4U 1636-536. Moreover, the broad bandwidth of Insight-HXMT allows as well for the first time to infer the burst influence upon the continuum spectrum via performing the spectral fitting of the burst, which ends up with the finding that hard X-ray shortage appears at around 40 keV in the continuum spectrum. These results suggest that the evolution of the corona along with the outburst{\bf /flare} of NS XRB may be traced via looking into a series of embedded type-I bursts by using Insight-HXMT., Comment: published in 2018, ApJL,864, L30
Published: 2019
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15. Timing analysis of 2S 1417-624 observed with NICER and Insight-HXMT

Author: Ji, L., Doroshenko, V., Santangelo, A., Gungor, C., Zhang, S., Ducci, L., Zhang, S. -N., Ge, M. -Y., Qu, L. J., Chen, Y. P., Bu, Q. C., Cao, X. L., Chang, Z., Chen, G., Chen, L., Chen, T. X., Chen, Y., Chen, Y. B., Cui, W., Cui, W. W., Deng, J. K., Dong, Y. W., Du, Y. Y., Fu, M. X., Gao, G. H., Gao, H., Gao, M., Gu, Y. D., Guan, J., Guo, C. C., Han, D. W., Hu, W., Huang, Y., Huo, J., Jia, S. M., Jiang, L. H., Jiang, W. C., Jin, J., Jin, Y. J., Kong, L. D., Li, B., Li, C. K., Li, G., Li, M. S., Li, T. P., Li, W., Li, X., Li, X. B., Li, X. F., Li, Y. G., Li, Z. J., Li, Z. W., Liang, X. H., Liao, J. Y., Liu, C. Z., Liu, G. Q., Liu, H. W., Liu, S. Z., Liu, X. J., Liu, Y., Liu, Y. N., Lu, B., Lu, F. J., Lu, X. F., Luo, T., Ma, X., Meng, B., Nang, Y., Nie, J. Y., Ou, G., Sai, N., Song, L. M., Song, X. Y., Sun, L., Tan, Y., Tao, L., Tuo, Y. L., Wang, G. F., Wang, J., Wang, W. S., Wang, Y. S., Wen, X. Y., Wu, B. B., Wu, M., Xiao, G. C., Xiong, S. L., Xu, H., Xu, Y. P., Yang, Y. R., Yang, J. W., Yang, S., Yang, Y. J., Zhang, A. M., Zhang, C. L., Zhang, C. M., Zhang, F., Zhang, H. M., Zhang, J., Zhang, Q., Zhang, T., Zhang, W., Zhang, W. C., Zhang, W. Z., Zhang, Y., Zhang, Y. F., Zhang, Y. J., Zhang, Z., Zhang, Z. L., Zhao, H. S., Zhao, J. L., Zhao, X. F., Zheng, S. J., Zhu, Y., Zhu, Y. X., and Zou, C. L.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We present a study of timing properties of the accreting pulsar 2S 1417-624 observed during its 2018 outburst, based on Swift/BAT, Fermi/GBM, Insight-HXMT and NICER observations. We report a dramatic change of the pulse profiles with luminosity. The morphology of the profile in the range 0.2-10.0keV switches from double to triple peaks at $\sim2.5$ $\rm \times 10^{37}{\it D}_{10}^2\ erg\ s^{-1}$ and from triple to quadruple peaks at $\sim7$ $\rm \times 10^{37}{\it D}_{10}^2\ erg\ s^{-1}$. The profile at high energies (25-100keV) shows significant evolutions as well. We explain this phenomenon according to existing theoretical models. We argue that the first change is related to the transition from the sub to the super-critical accretion regime, while the second to the transition of the accretion disc from the gas-dominated to the radiation pressure-dominated state. Considering the spin-up as well due to the accretion torque, this interpretation allows to estimate the magnetic field self-consistently at $\sim7\times 10^{12}$G., Comment: 7 pages, 4 figures, 1 tables, accepted for publication in MNRAS
Published: 2019
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16. Constant cyclotron line energy in Hercules X-1 -- Joint Insight-HXMT and NuSTAR observations

Author: Xiao, G. C., Ji, L., Staubert, R., Ge, M. Y., Zhang, S., Zhang, S. N., Santangelo, A., Ducci, L., Liao, J. Y., Guo, C. C., Li, X. B., Zhang, W., Qu, J. L., Lu, F. J., Li, T. P., Song, L. M., Xu, Y. P., Bu, Q. C., Cai, C., Cao, X. L., Chang, Z., Chen, G., Chen, L., Chen, T. X., Chen, Y. B., Chen, Y., Chen, Y. P., Cui, W., Cui, W. W., Deng, J. K., Dong, Y. W., Du, Y. Y., Fu, M. X., Gao, G. H., Gao, H., Gao, M., Gu, Y. D., Guan, J., Gungor, C., Han, D. W., Huang, Y., Huo, J., Jia, S. M., Jiang, L. H., Jiang, W. C., Jin, J., Kong, L. D., Li, B., Li, C. K., Li, G., Li, M. S., Li, W., Li, X., Li, X. F., Li, Y. G., Li, Z. W., Liang, X. H., Liu, C. Z., Liu, G. Q., Liu, H. W., Liu, X. J., Liu, Y. N., Lu, B., Lu, X. F., Luo, Q., Luo, T., Ma, X., Meng, B., Nang, Y., Nie, J. Y., Ou, G., Sai, N., Song, S. X., Sun, L., Tan, Y., Tao, L., Tuo, Y. L., Wang, C., Wang, G. F., Wang, J., Wang, W. S., Wang, Y. S., Wen, X. Y., Wu, B. B., Wu, B. Y., Wu, M., Xiong, S. L., Yang, J. W., Yang, S., Yang, Y. J., Yin, Q. B., Yin, Q. Q., Zhang, A. M., Zhang, C. M., Zhang, F., Zhang, H. M., Zhang, J., Zhang, T., Zhang, W. C., Zhang, W. Z., Zhang, Y., Zhang, Y. F., Zhang, Y. J., Zhang, Z., Zhang, Z. L., Zhao, H. S., Zhao, X. F., Zheng, S. J., Zhou, J. F., Zhu, Y., and Zhu, Y. X.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: The long-term evolution of the centroid energy of the CRSF in Her X-1 is still a mystery. We report a new measurement from a campaign between {\sl Insight}-HXMT and {\sl NuSTAR} performed in February 2018. Generally, the two satellites show well consistent results of timing and spectral properties. The joint spectral analysis confirms that the previously observed long decay phase has ended, and that the line energy instead keeps constant around 37.5 keV after flux correction.
Published: 2019

17. Hot disk of the Swift J0243.6+6124 revealed by Insight-HXMT

Author: Doroshenko, V., Zhang, S. N., Santangelo, A., Ji, L., Tsygankov, S., Mushtukov, A., Qu, L. J., Zhang, S., Ge, M. Y., Chen, Y. P., Bu, Q. C., Cao, X. L., Chang, Z., Chen, G., Chen, L., Chen, T. X., Chen, Y., Chen, Y. B., Cui, W., Cui, W. W., Deng, J. K., Dong, Y. W., Du, Y. Y., Fu, M. X., Gao, G. H., Gao, H., Gao, M., Gu, Y. D., Guan, Guo, C. C., Han, D. W., Hu, W., Huang, Y., Huo, J., Jia, S. M., Jiang, L. H., Jiang, W. C., Jin, J., Jin, Y. J., Kong, L. D., Li, B., Li, C. K., Li, G., Li, M. S., Li, T. P., Li, W., Li, X., Li, X. B., Li, X. F., Li, Y. G., Li, Z. J., Li, Z. W., Liang, X. H., Liao, J. Y., Liu, C. Z., Liu, G. Q., Liu, H. W., Liu, S. Z., Liu, X. J., Liu, Y., Liu, Y. N., Lu, B., Lu, F. J., Lu, X. F., Luo, T., Ma, X., Meng, B., Nang, Y., Nie, J. Y., Ou, G., Sai, N., Song, L. M., Song, X. Y., Sun, L., Tan, Y., Tao, L., Tuo, Y. L., Wang, G. F., Wang, J., Wang, W. S., Wang, Y. S., Wen, X. Y., Wu, B. B., Wu, M., Xiao, G. C., Xiong, S. L., Xu, H., Xu, Y. P., Yang, Y. R., Yang, J. W., Yang, S., Yang, Y. J., Zhang, A. M., Zhang, C. L., Zhang, C. M., Zhang, F., Zhang, H. M., Zhang, J., Zhang, Q., Zhang, T., Zhang, W., Zhang, W. C., Zhang, W. Z., Zhang, Y., Zhang, Y. F., Zhang, Y. J., Zhang, Z., Zhang, Z. L., Zhao, H. S., Zhao, J. L., Zhao, X. F., Zheng, S. J., Zhu, Y., Zhu, Y. X., and Zou, C. L.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We report on analysis of observations of the bright transient X-ray pulsar \src obtained during its 2017-2018 giant outburst with Insight-HXMT, \emph{NuSTAR}, and \textit{Swift} observatories. We focus on the discovery of a sharp state transition of the timing and spectral properties of the source at super-Eddington accretion rates, which we associate with the transition of the accretion disk to a radiation pressure dominated (RPD) state, the first ever directly observed for magnetized neutron star. This transition occurs at slightly higher luminosity compared to already reported transition of the source from sub- to super-critical accretion regime associate with onset of an accretion column. We argue that this scenario can only be realized for comparatively weakly magnetized neutron star, not dissimilar to other ultra-luminous X-ray pulsars (ULPs), which accrete at similar rates. Further evidence for this conclusion is provided by the non-detection of the transition to the propeller state in quiescence which strongly implies compact magnetosphere and thus rules out magnetar-like fields., Comment: Submitted to MNRAS
Published: 2019
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18. In-orbit demonstration of X-ray pulsar navigation with the Insight-HXMT satellite

Author: Zheng, S. J., Zhang, S. N., Lu, F. J., Wang, W. B., Gao, Y., Li, T. P., Song, L. M., Ge, M. Y., Han, D. W., Chen, Y., Xu, Y. P., Cao, X. L., Liu, C. Z., Zhang, S., Qu, J. L., Chang, Z., Chen, G., Chen, L., Chen, T. X., Chen, Y. B., Chen, Y. P., Cui, W., Cui, W. W., Deng, J. K., Dong, Y. W., Du, Y. Y., Fu, M. X., Gao, G. H., Gao, H., Gao, M., Gu, Y. D., Guan, J., Gungor, C., Guo, C. C., Hu, W., Huang, Y., Huo, J., Ji, J. F., Jia, S. M., Jiang, L. H., Jiang, W. C., Jin, J., Jin, Y. J., Li, B., Li, C. K., Li, G., Li, M. S., Li, W., Li, X., Li, X. B., Li, X. F., Li, Y. G., Li, Z. J., Li, Z. W., Liang, X. H., Liao, J. Y., Liu, G. Q., Liu, H. W., Liu, S. Z., Liu, X. J., Liu, Y., Liu, Y. N., Lu, B., Lu, X. F., Luo, T., Ma, X., Meng, B., Nang, Y., Nie, J. Y., Ou, G, Sai, N., Shang, R. C., Sun, L., Tan, Y., Tao, L., Tao, W., Tuo, Y. L., Wang, G. F., Wang, J., Wang, W. S., Wang, Y. S., Wen, X. Y., Wu, B. B., Wu, M., Xiao, G. C., Xiong, S. L., Xu, H., Yan, L. L., Yang, J. W., Yang, S., Yang, Y. J., Zhang, A. M., Zhang, C. L., Zhang, C. M., Zhang, F., Zhang, H. M., Zhang, J., Zhang, Q., Zhang, T., Zhang, W., Zhang, W. C., Zhang, W. Z., Zhang, Y., Zhang, Y. F., Zhang, Y. J., Zhang, Z., Zhang, Z. L., Zhao, H. S., Zhao, J. L., Zhao, X. F., Zhu, Y., Zhu, Y. X., and Zou, C. L.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: In this work, we report the in-orbit demonstration of X-ray pulsar navigation with Insight-Hard X-ray Modulation Telescope (Insight-HXMT), which was launched on Jun. 15th, 2017. The new pulsar navigation method 'Significance Enhancement of Pulse-profile with Orbit-dynamics' (SEPO) is adopted to determine the orbit with observations of only one pulsar. In this test, the Crab pulsar is chosen and observed by Insight-HXMT from Aug. 31th to Sept. 5th in 2017. Using the 5-day-long observation data, the orbit of Insight-HXMT is determined successfully with the three telescopes onboard - High Energy X-ray Telescope (HE), Medium Energy X-ray Telescope (ME) and Low Energy X-ray Telescope (LE) - respectively. Combining all the data, the position and velocity of the Insight-HXMT are pinpointed to within 10 km (3 sigma) and 10 m/s (3 sigma), respectively., Comment: Accepted by the Astrophysical Journal Supplement
Published: 2019
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19. Insight-HXMT observations of the New Black Hole Candidate MAXI J1535-571: timing analysis

Author: Huang, Y., Qu, J. L., Zhang, S. N., Bu, Q. C., Chen, Y. P., Tao, L., Zhang, S., Lu, F. J., Li, T. P., Song, L. M., Xu, Y. P., Cao, X. L., Chen, Y., Liu, C. Z., Chang, H. -K., Yu, W. f., Weng, S. S., Hou, X., Kong, A. K. H., Xie, F. G., Zhang, G. B., ZHOU, J. F., Chang, Z., Chen, G., Chen, L., Chen, T. X., Chen, Y. B., Cui, W., Cui, W. W., Deng, J. K., Dong, Y. W., Du, Y. Y., Fu, M. X., Gao, G. H., Gao, H., Gao, M., Ge, M. Y., Gu, Y. D., Guan, J., Gungor, C., Guo, C. C., Han, D. W., Hu, W., Huo, J., Ji, J. F., Jia, S. M., Jiang, L. H., Jiang, W. C., Jin, J., Jin, Y. J., Li, B., Li, C. K., Li, G., Li, M. S., Li, W., Li, X., Li, X. B., Li, X. F., Li, Y. G., Li, Z. J., Li, Z. W., Liang, X. H., Liao, J. Y., Liu, G. Q., Liu, H. W., Liu, S. Z., Liu, X. J., Liu, Y., Liu, Y. N., Lu, B., Lu, X. F., Luo, T., Ma, X., Meng, B., Nang, Y., Nie, J. Y., Ou, G, Sai, N., Shang, R. C., Sun, L., Tan, Y., Tao, W., Tuo, Y. L., Wang, G. F., Wang, H. Y., Wang, J., Wang, W. S., Wang, Y. S., Wen, X. Y., Wu, B. B., Wu, M., Xiao, G. C., Xiong, S. L., Xu, H., Yan, L. L., Yang, J. W., Yang, S., Yang, Y. J., Zhang, A. M., Zhang, C. L., Zhang, C. M., Zhang, F., Zhang, H. M., Zhang, J., Zhang, Q., Zhang, T., Zhang, W., Zhang, W. C., Zhang, W. Z., Zhang, Y., Zhang, Y. F., Zhang, Y. J., Zhang, Z., Zhang, Z. L., Zhao, H. S., Zhao, J. L., Zhao, X. F., Zheng, S. J., Zhu, Y., Zhu, Y. X., and Zou, C. L.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We present the X-ray timing results of the new black hole candidate (BHC) MAXI J1535-571 during its 2017 outburst from Hard X-ray Modulation Telescope (\emph{Insight}-HXMT) observations taken from 2017 September 6 to 23. Following the definitions given by \citet{Belloni2010}, we find that the source exhibits state transitions from Low/Hard state (LHS) to Hard Intermediate state (HIMS) and eventually to Soft Intermediate state (SIMS). Quasi-periodic oscillations (QPOs) are found in the intermediate states, which suggest different types of QPOs. With the large effective area of \emph{Insight}-HXMT at high energies, we are able to present the energy dependence of the QPO amplitude and centroid frequency up to 100 keV which is rarely explored by previous satellites. We also find that the phase lag at the type-C QPOs centroid frequency is negative (soft lags) and strongly correlated with the centroid frequency. By assuming a geometrical origin of type-C QPOs, the source is consistent with being a high inclination system., Comment: 12 pages, 11 figures, Sumbitted to ApJ
Published: 2018
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20. HXMT identification of a non-thermal X-ray burst from SGR J1935+2154 and with FRB 200428

Author: Li, C. K., Lin, L., Xiong, S. L., Ge, M. Y., Li, X. B., Li, T. P., Lu, F. J., Zhang, S. N., Tuo, Y. L., Nang, Y., Zhang, B., Xiao, S., Chen, Y., Song, L. M., Xu, Y. P., Liu, C. Z., Jia, S. M., Cao, X. L., Qu, J. L., Zhang, S., Gu, Y. D., Liao, J. Y., Zhao, X. F., Tan, Y., Nie, J. Y., Zhao, H. S., Zheng, S. J., Zheng, Y. G., Luo, Q., Cai, C., Li, B., Xue, W. C., Bu, Q. C., Chang, Z., Chen, G., Chen, L., Chen, T. X., Chen, Y. B., Chen, Y. P., Cui, W., Cui, W. W., Deng, J. K., Dong, Y. W., Du, Y. Y., Fu, M. X., Gao, G. H., Gao, H., Gao, M., Gu, Y. D., Guan, J., Guo, C. C., Han, D. W., Huang, Y., Huo, J., Jiang, L. H., Jiang, W. C., Jin, J., Jin, Y. J., Kong, L. D., Li, G., Li, M. S., Li, W., Li, X., Li, X. F., Li, Y. G., Li, Z. W., Liang, X. H., Liu, B. S., Liu, G. Q., Liu, H. W., Liu, X. J., Liu, Y. N., Lu, B., Lu, X. F., Luo, T., Ma, X., Meng, B., Ou, G., Sai, N., Shang, R. C., Song, X. Y., Sun, L., Tao, L., Wang, C., Wang, G. F., Wang, J., Wang, W. S., Wang, Y. S., Wen, X. Y., Wu, B. B., Wu, B. Y., Wu, M., Xiao, G. C., Xu, H., Yang, J. W., Yang, S., Yang, Y. J., Yang, Yi-Jung, Yi, Q. B., Yin, Q. Q., You, Y., Zhang, A. M., Zhang, C. M., Zhang, F., Zhang, H. M., Zhang, J., Zhang, T., Zhang, W., Zhang, W. C., Zhang, W. Z., Zhang, Y., Zhang, Yue, Zhang, Y. F., Zhang, Y. J., Zhang, Z., Zhang, Zhi, Zhang, Z. L., Zhou, D. K., Zhou, J. F., Zhu, Y., Zhu, Y. X., and Zhuang, R. L.
Published: 2021
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21. RETRACTED ARTICLE: SYNTHESIS, CRYSTAL STRUCTURE, AND ANTI-GASTRIC CANCER ACTIVITY OF A Zn(II) COORDINATION POLYMER WITH A 4,4′-BIS(1-IMIDAZOLYL)BIPHENYL LIGAND

Author: Zhai, J B, Jiang, L H, and Jiang, Y
Published: 2020
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22. Bone tissue engineering using 3D silk scaffolds and human dental pulp stromal cells epigenetic reprogrammed with the selective histone deacetylase inhibitor MI192

Author: Man, K, Joukhdar, H, Manz, XD, Brunet, MY, Jiang, L-H, Rnjak-Kovacina, J, Yang, XB, Pulmonary medicine, and ACS - Pulmonary hypertension & thrombosis
Subjects: Histology, Tissue Engineering, Tissue Scaffolds, fungi, Silk, Mice, Nude, Cell Biology, Isoquinolines, Epigenesis, Genetic, Pathology and Forensic Medicine, Histone Deacetylase Inhibitors, Mice, Osteogenesis, Benzamides, Animals, Humans, Stromal Cells, Cells, Cultured, Dental Pulp
Abstract: Epigenetics plays a critical role in regulating mesenchymal stem cells’ (MSCs) fate for tissue repair and regeneration. There is increasing evidence that the inhibition of histone deacetylase (HDAC) isoform 3 can enhance MSC osteogenesis. This study investigated the potential of using a selective HDAC2 and 3 inhibitor, MI192, to promote human dental pulp stromal cells (hDPSCs) bone-like tissue formation in vitro and in vivo within porous Bombyx Mori silk scaffolds. Both 2 and 5 wt% silk scaffolds were fabricated and characterised. The 5 wt% scaffolds possess thicker internal lamellae, reduced scaffold swelling and degradation rates, whilst increased compressive modulus in comparison to the 2 wt% silk scaffold. MI192 pre-treatment of hDPSCs on 5 wt% silk scaffold significantly enhanced hDPSCs alkaline phosphatase activity (ALP). The expression of osteoblast-related genes (RUNX2, ALP, Col1a, OCN) was significantly upregulated in the MI192 pre-treated cells. Histological analysis confirmed that the MI192 pre-treated hDPSCs-silk scaffold constructs promoted bone extracellular matrix (ALP, Col1a, OCN) deposition and mineralisation compared to the untreated group. Following 6 weeks of subcutaneous implantation in nude mice, the MI192 pre-treated hDPSCs-silk scaffold constructs enhanced the vascularisation and extracellular matrix mineralisation compared to untreated control. In conclusion, these findings demonstrate the potential of using epigenetic reprogramming and silk scaffolds to promote hDPSCs bone formation efficacy, which provides evidence for clinical translation of this technology for bone augmentation. Graphical abstract
Published: 2022

23. YO-BYNet: multi-object tracking of fish based on YOLOv8 and BYTE association method

Author: Tong, X., primary, Long, W., additional, Jiang, L. H., additional, Huang, Z. Z., additional, and Xu, L. H., additional
Published: 2023
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24. Tyrosine 288 in the extracellular domain of the human P2X7 receptor is critical for receptor function revealed by structural modeling and site-directed mutagenesis

Author: Caseley, EA, Muench, SP, and Jiang, L-H
Abstract: The P2X7 receptor (P2X7R) is a calcium-permeable cation channel activated by high concentrations of extracellular ATP. It plays a role in vital physiological processes, particularly in innate immunity, and is dysregulated in pathological conditions such as inflammatory diseases, neurodegenerative diseases, mood disorders, and cancers. Structural modeling of the human P2X7R (hP2X7R) based on the recently available structures of the rat P2X7 receptor (rP2XR) in conjunction with molecular docking predicts the orientation of tyrosine at position 288 (Y288) in the extracellular domain to face ATP. In this short communication, we combined site-directed mutagenesis and whole-cell patch-clamp recording to investigate the role of this residue in the hP2X7R function. Mutation of this extracellular residue to amino acids with different properties massively impaired current responses to both ATP and BzATP, suggesting that Y288 is important for normal receptor function. Such a finding facilitates development of an in-depth understanding of the molecular basis of hP2X7R structure–function relationships.
Published: 2022

25. Litter priming and trenching greatly affect soil respiration in a mature subtropical evergreen broadleaf forest in Southwestern China

Author: Wang, J. J., Lai, L. M., Zhao, X. C., Jiang, L. H., Wang, Y. J., Zhou, J. H., Wang, F., Zhang, C., and Zheng, Y. R.
Published: 2015
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26. Role of the store-operated Ca2+ channel in ATP-induced Ca2+ signalling in mesenchymal stem cells and regulation of cell functions

Author: Wang, L, Roger, S, Yang, XB, and Jiang, L-H
Abstract: It is well-known that extracellular ATP acts as an autocrine/paracrine signal to regulate cell functions by inducing intracellular Ca2+ signalling through its cognate receptors, namely, the ligand-gated ion channel P2X receptors that mediate Ca2+ influx and/or the Gq/11-coupled P2Y receptors that link to Ca2+ release from the ER. The reduction in ER Ca2+ can trigger further extracellular Ca2+ entry by activating the store-operated Ca2+ (SOC) channel. Mesenchymal stem cells (MSC) play an important role in the homeostasis of residing tissues and have promising applications in regenerative medicines. MSC can release ATP spontaneously or in response to diverse stimuli, and express multiple P2X and Gq/11-coupled P2Y receptors that participate in ATP-induced Ca2+ signalling and regulate cell function. There is increasing evidence to show the contribution of the SOC channel in ATP-induced Ca2+ signalling in MSC. In this mini-review, we discuss the current understanding of the expression of the SOC channel in MSC and its potential role in mediating ATP-induced Ca2+ signalling and regulation of MSC differentiation, proliferation and migration.
Published: 2021

27. MI192 induced epigenetic reprogramming enhances the therapeutic efficacy of human bone marrows stromal cells for bone regeneration

Author: Man, K, Mekhileri, NV, Lim, KS, Jiang, L-H, Woodfield, TBF, and Yang, XB
Abstract: Human bone marrow stromal cells (hBMSCs) have been extensively utilised for bone tissue engineering applications. However, they are associated with limitations that hinder their clinical utility for bone regeneration. Cell fate can be modulated via altering their epigenetic functionality. Inhibiting histone deacetylase (HDAC) enzymes have been reported to promote osteogenic differentiation, with HDAC3 activity shown to be causatively associated with osteogenesis. Therefore, this study aimed to investigate the potential of using an HDAC2 & 3 selective inhibitor - MI192 to induce epigenetic reprogramming of hBMSCs and enhance its therapeutic efficacy for bone formation. Treatment with MI192 caused a time-dose dependant reduction in hBMSCs viability. MI192 was also found to substantially alter hBMSCs epigenetic function through reduced HDAC activity and increased histone acetylation. hBMSCs were pre-treated with MI192 (50 μM) for 48 h prior to osteogenic induction. MI192 pre-treatment significantly upregulated osteoblast-related gene/protein expression (Runx2, ALP, Col1a and OCN) and enhanced alkaline phosphatase specific activity (ALPSA) (1.43-fold) (P ≤ 0.001). Moreover, MI192 substantially increased hBMSCs extracellular matrix calcium deposition (1.4-fold) (P ≤ 0.001) and mineralisation when compared to the untreated control. In 3D microtissue culture, MI192 significantly promoted hBMSCs osteoblast-related gene expression and ALPSA (> 2.41-fold) (P ≤ 0.001). Importantly, MI192 substantially enhanced extracellular matrix deposition (ALP, Col1a, OCN) and mineralisation (1.67-fold) (P ≤ 0.001) within the bioassembled-microtissue (BMT) construct. Following 8-week intraperitoneal implantation within nude mice, MI192 treated hBMSCs exhibited enhanced extracellular matrix deposition and mineralisation (2.39-fold) (P ≤ 0.001) within the BMT when compared to the untreated BMT construct. Taken together, these results demonstrate that MI192 effectively altered hBMSCs epigenetic functionality and is capable of promoting hBMSCs osteogenic differentiation in vitro and in vivo, indicating the potential of using epigenetic reprogramming to enhance the therapeutic efficacy of hBMSCs for bone augmentation strategies.
Published: 2021

28. Structural basis for the functional properties of the P2X7 receptor for extracellular ATP

Author: Jiang, L-H, Caseley, EA, Muench, SP, and Roger, S
Abstract: The P2X7 receptor, originally known as the P2Z receptor due to its distinctive functional properties, has a structure characteristic of the ATP-gated ion channel P2X receptor family. The P2X7 receptor is an important mediator of ATP-induced purinergic signalling and is involved the pathogenesis of numerous conditions as well as in the regulation of diverse physiological functions. Functional characterisations, in conjunction with site-directed mutagenesis, molecular modelling, and, recently, structural determination, have provided significant insights into the structure–function relationships of the P2X7 receptor. This review discusses the current understanding of the structural basis for the functional properties of the P2X7 receptor.
Published: 2021

29. TRPM2 channel-mediated cell death: an important mechanism linking oxidative stress-inducing pathological factors to associated pathological conditions

Author: Malko, P and Jiang, L-H
Abstract: Oxidative stress resulting from the accumulation of high levels of reactive oxygen species is a salient feature of, and a well-recognised pathological factor for, diverse pathologies. One common mechanism for oxidative stress damage is via the disruption of intracellular ion homeostasis to induce cell death. TRPM2 is a non-selective Ca2+-permeable cation channel with a wide distribution throughout the body and is highly sensitive to activation by oxidative stress. Recent studies have collected abundant evidence to show its important role in mediating cell death induced by miscellaneous oxidative stress-inducing pathological factors, both endogenous and exogenous, including ischemia/reperfusion and the neurotoxicants amyloid-β peptides and MPTP/MPP+ that cause neuronal demise in the brain, myocardial ischemia/reperfusion, proinflammatory mediators that disrupt endothelial function, diabetogenic agent streptozotocin and diabetes risk factor free fatty acids that induce loss of pancreatic β-cells, bile acids that damage pancreatic acinar cells, renal ischemia/reperfusion and albuminuria that are detrimental to kidney cells, acetaminophen that triggers hepatocyte death, and nanoparticles that injure pericytes. Studies have also shed light on the signalling mechanisms by which these pathological factors activate the TRPM2 channel to alter intracellular ion homeostasis leading to aberrant initiation of various cell death pathways. TRPM2-mediated cell death thus emerges as an important mechanism in the pathogenesis of conditions including ischemic stroke, neurodegenerative diseases, cardiovascular diseases, diabetes, pancreatitis, chronic kidney disease, liver damage and neurovascular injury. These findings raise the exciting perspective of targeting the TRPM2 channel as a novel therapeutic strategy to treat such oxidative stress-associated diseases.
Published: 2020

30. Chemical activation of the Piezo1 channel drives mesenchymal stem cell migration via inducing ATP release and activation of P2 receptor purinergic signaling

Author: Mousawi, F, Peng, H, Li, J, Sreenivasan, P, Roger, S, Zhao, H, Yang, X, and Jiang, L-H
Abstract: Here we examined the Ca2+‐permeable Piezo1 channel, a newly‐identified mechanosensing ion channel, in human dental pulp‐derived mesenchymal stem cells (MSC) and hypothesized that activation of the Piezo1 channel regulates MSC migration via inducing ATP release and activation of the P2 receptor purinergic signalling. The Piezo1 mRNA and protein were readily detected in hDP‐MSC from multiple donors and, consistently, brief exposure to Yoda1, the Piezo1 channel‐specific activator, elevated intracellular Ca2+ concentration. Yoda1‐induced Ca2+ response was inhibited by ruthenium red or GsMTx4, two Piezo1 channel inhibitors, and also by Piezo1‐specific siRNA. Brief exposure to Yoda1 also induced ATP release. Persistent exposure to Yoda1 stimulated MSC migration, which was suppressed by Piezo1‐specific siRNA, and also prevented by apyrase, an ATP scavenger, or PPADS, a P2 generic antagonist. Furthermore, stimulation of MSC migration induced by Yoda1 as well as ATP was suppressed by PF431396, a PYK2 kinase inhibitor, or U0126, an inhibitor of the mitogen‐activated protein kinase MEK/ERK signaling pathway. Collectively, these results suggest that activation of the Piezo1 channel stimulates MSC migration via inducing ATP release and subsequent activation of the P2 receptor purinergic signalling and downstream PYK2 and MEK/ERK signaling pathways, thus revealing novel insights into the molecular and signalling mechanisms regulating MSC migration. Such findings provide useful information for evolving a full understanding of MSC migration and homing and developing strategies to improve MSC‐based translational applications.
Published: 2020

31. Predisposition to Alzheimer’s and age-related brain pathologies by PM2.5 exposure: perspective on the roles of oxidative stress and TRPM2 channel

Author: Wang, L, Wei, L, Ding, R, Feng, Y, Li, D, Zhang, L, Li, C, Malko, P, Syed Mortadza, SA, Wu, W, Yin, Y, and Jiang, L-H
Abstract: Accumulating epidemiological evidence supports that chronic exposure to ambient fine particular matters of
Published: 2020

32. Targeting the P2X7 receptor in microglial cells to prevent brain inflammation

Author: Jiang, L-H and Roger, S
Published: 2020

33. Automated Planar Patch-Clamp Recording of P2X Receptors.

Author: Milligan, CJ, Jiang, L-H, Milligan, CJ, and Jiang, L-H
Abstract: P2X receptors are a structurally and functionally distinctive family of ligand-gated ion channels that play important roles in mediating extracellular adenosine 5'-triphosphate (ATP) signaling in diverse physiological and pathophysiological processes. For several decades, the "manual" patch-clamp technique was regarded as the gold standard assay for investigating ion channel properties. More recently, breakthroughs in the development of automated patch-clamp technologies are enabling the study of ion channels, with much greater throughput capacities. These automated platforms, of which there are many, generate consistent, reliable, high-fidelity data. This chapter demonstrates the versatility of one of these technologies for ligand-gated ion channels, with a particular emphasis on protocols that address some of the issues of receptor desensitization that are commonly associated with P2X receptor-mediated currents.
Published: 2020

34. Diagnostic of the spectral properties of Aquila X-1 by Insight-HXMT snapshots during the early propeller phase

Author: G��ng��r, C., Ge, M. Y., Zhang, S., Santangelo, A., Zhang, S. N., Lu, F. J., Zhang, Y., Chen, Y. P., Tao, L., Yang, Y. J., Bu, Q. C., Cai, C., Cao, X. L., Chang, Z., Chen, G., Chen, L., Chen, T. X., Chen, Y., Chen, Y. B., Cui, W., Cui, W. W., Deng, J. K., Dong, Y. W., Du, Y. Y., Fu, M. X., Gao, G. H., Gao, H., Gao, M., Gu, Y. D., Guan, J., Guo, C. C., Han, D. W., Huang, Y., Huo, J., Ji, L., Jia, S. M., Jiang, L. H., Jiang, W. C., Jin, J., Kong, L. D., Li, B., Li, C. K., Li, G., Li, M. S., Li, T. P., Li, W., Li, X., Li, X. B., Li, X. F., Li, Y. G., Li, Z. W., Liang, X. H., Liao, J. Y., Liu, C. Z., Liu, G. Q., Liu, H. W., Liu, X. J., Liu, Y. N., Lu, B., Lu, X. F., Luo, T., Luo, Q., Ma, X., Meng, B., Nang, Y., Nie, J. Y., Ou, G., Sai, N., Song, L. M., Song, X. Y., Sun, L., Tan, Y., Tuo, Y. L., Wang, C., Wang, G. F., Wang, J., Wang, W. S., Wang, Y. S., Wen, X. Y., Wu, B. B., Wu, B. Y., Wu, M., Xiao, G. C., Xiao, S., Xiong, S. L., Xu, Y. P., Yang, J. W., Yang, S., Yi, Q. B., Yin, Q. Q., You, Y., Zhang, A. M., Zhang, C. M., Zhang, F., Zhang, H. M., Zhang, J., Zhang, T., Zhang, W., Zhang, W. C., Zhang, W. Z., Zhang, Y. F., Zhang, Y. J., Zhang, Z., Zhang, Z. L., Zhao, H. S., Zhao, X. F., Zheng, S. J., Zhou, D. K., Zhou, J. F., Zhu, Y., and Zhu, Y. X.
Subjects: High Energy Astrophysical Phenomena (astro-ph.HE), Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astrophysics::Solar and Stellar Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract: We study the 2018 outburst of Aql X-1 via the monitor of all sky X-ray image (MAXI) data. We show that the outburst starting in February 2018 is a member of short-low class in the frame of outburst duration and the peak count rate although the outburst morphology is slightly different from the other fast-rise-exponential-decay (FRED) type outbursts with a milder rising stage. We study the partial accretion in the weak propeller stage of Aql X-1 via the MAXI data of the 2018 outburst. We report on the spectral analysis of 3 observations of Aquila X-1 obtained by Insight - hard X-ray modulation telescope (Insight-HXMT) during the late decay stage of the 2018 outburst. We discuss that the data taken by Insight-HXMT is just after the transition to the weak propeller stage. Our analysis shows the necessity of a comptonization component to take into account the existence of an electron cloud resulting photons partly up-scattered., 8 pages, 4 figures, accepted for publication in JHEAp
Published: 2019

35. Potent antitumoral efficacy of a novel replicative adenovirus CNHK300 targeting telomerase-positive cancer cells

Author: Su, C.-Q., Sham, J., Xue, H.-B., Wang, X.-H., Chua, D., Cui, Z.-F., Peng, L.-H., Li, L.-F., Jiang, L.-H., Wu, M.-C., and Qian, Q.-J.
Published: 2004
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36. 001 ETHANOL AS METABOLIC PRECURSOR AND FUEL FOR THE BRAIN

Author: Wang, J., Jiang, L. H., Du, H. Y., Behar, K. L., Li, T.-K., and Mason, G. F.
Published: 2013
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37. Two Complete Spectral Transitions of Swift J0243.6+6124 Observed by Insight-HXMT

Author: Kong, L. D., primary, Zhang, S., additional, Chen, Y. P., additional, Zhang, S. N., additional, Ji, L., additional, Doroshenko, V., additional, Wang, P. J., additional, Tao, L., additional, Ge, M. Y., additional, Liu, C. Z., additional, Song, L. M., additional, Lu, F. J., additional, Qu, J. L., additional, Li, T. P., additional, Xu, Y. P., additional, Cao, X. L., additional, Chen, Y., additional, Bu, Q. C., additional, Cai, C., additional, Chang, Z., additional, Chen, G., additional, Chen, L., additional, Chen, T. X., additional, Chen, Y. B., additional, Cui, W., additional, Cui, W. W., additional, Deng, J. K., additional, Dong, Y. W., additional, Du, Y. Y., additional, Fu, M. X., additional, Gao, G. H., additional, Gao, H., additional, Gao, M., additional, Gu, Y. D., additional, Guan, J., additional, Guo, C. C., additional, Han, D. W., additional, Huang, Y., additional, Huo, J., additional, Jia, S. M., additional, Jiang, L. H., additional, Jiang, W. C., additional, Jin, J., additional, Jin, Y. J., additional, Li, B., additional, Li, C. K., additional, Li, G., additional, Li, M. S., additional, Li, W., additional, Li, X., additional, Li, X. B., additional, Li, X. F., additional, Li, Y. G., additional, Li, Z. W., additional, Liang, X. H., additional, Liao, J. Y., additional, Liu, B. S., additional, Liu, G. Q., additional, Liu, H. W., additional, Liu, X. J., additional, Liu, Y. N., additional, Lu, B., additional, Lu, X. F., additional, Luo, Q., additional, Luo, T., additional, Ma, X., additional, Meng, B., additional, Nang, Y., additional, Nie, J. Y., additional, Ou, G., additional, Sai, N., additional, Shang, R. C., additional, Song, X. Y., additional, Sun, L., additional, Tan, Y., additional, Tuo, Y. L., additional, Wang, C., additional, Wang, G. F., additional, Wang, J., additional, Wang, L. J., additional, Wang, W. S., additional, Wang, Y. S., additional, Wen, X. Y., additional, Wu, B. B., additional, Wu, B. Y., additional, Wu, M., additional, Xiao, G. C., additional, Xiao, S., additional, Xiong, S. L., additional, Xu, H., additional, Yang, J. W., additional, Yang, S., additional, Yang, Y. J., additional, Yi, Q. B., additional, Yin, Q. Q., additional, You, Y., additional, Zhang, A. M., additional, Zhang, C. M., additional, Zhang, F., additional, Zhang, H. M., additional, Zhang, J., additional, Zhang, T., additional, Zhang, W. C., additional, Zhang, W., additional, Zhang, W. Z., additional, Zhang, Y., additional, Zhang, Y. F., additional, Zhang, Y. J., additional, Zhang, Z., additional, Zhang, Z. L., additional, Zhao, H. S., additional, Zhao, X. F., additional, Zheng, S. J., additional, Zheng, Y. G., additional, Zhou, D. K., additional, Zhou, J. F., additional, Zhu, Y. X., additional, and Zhuang, R. L., additional
Published: 2020
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38. Insight-HXMT observations of Swift J0243.6+6124: the evolution of RMS pulse fractions at super-Eddington luminosity

Author: Wang, P J, primary, Kong, L D, additional, Zhang, S, additional, Chen, Y P, additional, Zhang, S N, additional, Qu, J L, additional, Ji, L, additional, Tao, L, additional, Ge, M Y, additional, Lu, F J, additional, Chen, L, additional, Song, L M, additional, Li, T P, additional, Xu, Y P, additional, Cao, X L, additional, Chen, Y, additional, Liu, C Z, additional, Bu, Q C, additional, Cai, C, additional, Chang, Z, additional, Chen, G, additional, Chen, T X, additional, Chen, Y B, additional, Cui, W, additional, Cui, W W, additional, Deng, J K, additional, Dong, Y W, additional, Du, Y Y, additional, Fu, M X, additional, Gao, G H, additional, Gao, H, additional, Gao, M, additional, Gu, Y D, additional, Guan, J, additional, Guo, C C, additional, Han, D W, additional, Huang, Y, additional, Huo, J, additional, Jia, S M, additional, Jiang, L H, additional, Jiang, W C, additional, Jin, J, additional, Jin, Y J, additional, Li, B, additional, Li, C K, additional, Li, G, additional, Li, M S, additional, Li, W, additional, Li, X, additional, Li, X B, additional, Li, X F, additional, Li, Y G, additional, Li, Z W, additional, Liang, X H, additional, Liao, J Y, additional, Liu, B S, additional, Liu, G Q, additional, Liu, H W, additional, Liu, X J, additional, Liu, Y N, additional, Lu, B, additional, Lu, X F, additional, Luo, Q, additional, Luo, T, additional, Ma, X, additional, Meng, B, additional, Nang, Y, additional, Nie, J Y, additional, Ou, G, additional, Sai, N, additional, Shang, R C, additional, Song, X Y, additional, Sun, L, additional, Tan, Y, additional, Tuo, Y L, additional, Wang, C, additional, Wang, G F, additional, Wang, J, additional, Wang, L J, additional, Wang, W S, additional, Wang, Y S, additional, Wen, X Y, additional, Wu, B Y, additional, Wu, B B, additional, Wu, M, additional, Xiao, G C, additional, Xiao, S, additional, Xiong, S L, additional, Yang, J W, additional, Yang, S, additional, Yang, Yan Ji, additional, Yang, Yi Jung, additional, Yi, Q B, additional, Yin, Q Q, additional, You, Y, additional, Zhang, A M, additional, Zhang, C M, additional, Zhang, F, additional, Zhang, H M, additional, Zhang, J, additional, Zhang, T, additional, Zhang, W C, additional, Zhang, W, additional, Zhang, W Z, additional, Zhang, Y, additional, Zhang, Y F, additional, Zhang, Y J, additional, Zhang, Zhao, additional, Zhang, Zhi, additional, Zhang, Z L, additional, Zhao, H S, additional, Zhao, X F, additional, Zheng, S J, additional, Zheng, Y G, additional, Zhou, D K, additional, Zhou, J F, additional, Zhu, Y X, additional, Zhu, Y, additional, and Zhuang, R L, additional
Published: 2020
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39. Insight-HXMT Firm Detection of the Highest-energy Fundamental Cyclotron Resonance Scattering Feature in the Spectrum of GRO J1008-57

Author: Ge, M. Y., primary, Ji, L., additional, Zhang, S. N., additional, Santangelo, A., additional, Liu, C. Z., additional, Doroshenko, V., additional, Staubert, R., additional, Qu, J. L., additional, Zhang, S., additional, Lu, F. J., additional, Song, L. M., additional, Li, T. P., additional, Tao, L., additional, Xu, Y. P., additional, Cao, X. L., additional, Chen, Y., additional, Bu, Q. C., additional, Cai, C., additional, Chang, Z., additional, Chen, G., additional, Chen, L., additional, Chen, T. X., additional, Chen, Y. B., additional, Chen, Y. P., additional, Cui, W., additional, Cui, W. W., additional, Deng, J. K., additional, Dong, Y. W., additional, Du, Y. Y., additional, Fu, M. X., additional, Gao, G. H., additional, Gao, H., additional, Gao, M., additional, Gu, Y. D., additional, Guan, J., additional, Guo, C. C., additional, Han, D. W., additional, Huang, Y., additional, Huo, J., additional, Jia, S. M., additional, Jiang, L. H., additional, Jiang, W. C., additional, Jin, J., additional, Jin, Y. J., additional, Kong, L. D., additional, Li, B., additional, Li, C. K., additional, Li, G., additional, Li, M. S., additional, Li, W., additional, Li, X., additional, Li, X. B., additional, Li, X. F., additional, Li, Y. G., additional, Li, Z. W., additional, Liang, X. H., additional, Liao, J. Y., additional, Liu, B. S., additional, Liu, G. Q., additional, Liu, H. W., additional, Liu, X. J., additional, Liu, Y. N., additional, Lu, B., additional, Lu, X. F., additional, Luo, Q., additional, Luo, T., additional, Ma, X., additional, Meng, B., additional, Nang, Y., additional, Nie, J. Y., additional, Ou, G., additional, Sai, N., additional, Shang, R. C., additional, Song, X. Y., additional, Sun, L., additional, Tan, Y., additional, Tuo, Y. L., additional, Wang, C., additional, Wang, G. F., additional, Wang, J., additional, Wang, L. J., additional, Wang, W. S., additional, Wang, Y. D., additional, Wang, Y. S., additional, Wen, X. Y., additional, Wu, B. B., additional, Wu, B. Y., additional, Wu, M., additional, Xiao, G. C., additional, Xiao, S., additional, Xiong, S. L., additional, Xu, H., additional, Yang, J. W., additional, Yang, S., additional, Yang, Y. J., additional, Yi, Q. B., additional, Yin, Q. Q., additional, You, Y., additional, Zhang, A. M., additional, Zhang, C. M., additional, Zhang, F., additional, Zhang, H. M., additional, Zhang, J., additional, Zhang, T., additional, Zhang, W. C., additional, Zhang, W., additional, Zhang, W. Z., additional, Zhang, Y., additional, Zhang, Y. F., additional, Zhang, Y. J., additional, Zhang, Z., additional, Zhang, Z. L., additional, Zhao, H. S., additional, Zhao, X. F., additional, Zheng, S. J., additional, Zheng, Y. G., additional, Zhou, D. K., additional, Zhou, J. F., additional, Zhuang, R. L., additional, Zhu, Y. X., additional, and Zhu, Y., additional
Published: 2020
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40. SYNTHESIS, CRYSTAL STRUCTURE, AND ANTI-GASTRIC CANCER ACTIVITY OF A Zn(II) COORDINATION POLYMER WITH A 4,4′-BIS(1-IMIDAZOLYL)BIPHENYL LIGAND

Author: Zhai, J B, primary, Jiang, L H, additional, and Jiang, Y, additional
Published: 2020
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41. Discovery of Delayed Spin-up Behavior Following Two Large Glitches in the Crab Pulsar, and the Statistics of Such Processes

Author: Ge, M. Y., primary, Zhang, S. N., additional, Lu, F. J., additional, Li, T. P., additional, Yuan, J. P., additional, Zheng, X. P., additional, Huang, Y., additional, Zheng, S. J., additional, Chen, Y. P., additional, Chang, Z., additional, Tuo, Y. L., additional, Cheng, Q., additional, Güngör, C., additional, Song, L. M., additional, Xu, Y. P., additional, Cao, X. L., additional, Chen, Y., additional, Liu, C. Z., additional, Zhang, S., additional, Qu, J. L., additional, Bu, Q. C., additional, Cai, C., additional, Chen, G., additional, Chen, L., additional, Chen, M. Z., additional, Chen, T. X., additional, Chen, Y. B., additional, Cui, W., additional, Cui, W. W., additional, Deng, J. K., additional, Dong, Y. W., additional, Du, Y. Y., additional, Fu, M. X., additional, Gao, G. H., additional, Gao, H., additional, Gao, M., additional, Gu, Y. D., additional, Guan, J., additional, Guo, C. C., additional, Han, D. W., additional, Hao, L. F., additional, Huo, J., additional, Jia, S. M., additional, Jiang, L. H., additional, Jiang, W. C., additional, Jin, C. J., additional, Jin, J., additional, Jin, Y. J., additional, Kong, L. D., additional, Li, B., additional, Li, D., additional, Li, C. K., additional, Li, G., additional, Li, M. S., additional, Li, W., additional, Li, X., additional, Li, X. B., additional, Li, X. F., additional, Li, Y. G., additional, Li, Z. W., additional, Li, Z. X., additional, Liu, Z. Y., additional, Liang, X. H., additional, Liao, J. Y., additional, Liu, G. Q., additional, Liu, H. W., additional, Liu, X. J., additional, Liu, Y. N., additional, Lu, B., additional, Lu, X. F., additional, Luo, Q., additional, Luo, T., additional, Ma, X., additional, Meng, B., additional, Nang, Y., additional, Nie, J. Y., additional, Ou, G., additional, Sai, N., additional, Shang, R. C., additional, Song, X. Y., additional, Sun, L., additional, Tan, Y., additional, Tao, L., additional, Wang, C., additional, Wang, G. F., additional, Wang, J., additional, Wang, J. B., additional, Wang, M., additional, Wang, N., additional, Wang, W. S., additional, Wang, Y. D., additional, Wang, Y. S., additional, Wen, X. Y., additional, Wen, Z. G., additional, Wu, B. B., additional, Wu, B. Y., additional, Wu, M., additional, Xiao, G. C., additional, Xiao, S., additional, Xiong, S. L., additional, Xu, Y. H., additional, Yan, W. M., additional, Yang, J. W., additional, Yang, S., additional, Yang, Y. J., additional, Yi, Q. B., additional, Yin, Q. Q., additional, You, Y., additional, Yue, Y. L., additional, Zhang, A. M., additional, Zhang, C. M., additional, Zhang, D. P., additional, Zhang, F., additional, Zhang, H. M., additional, Zhang, J., additional, Zhang, T., additional, Zhang, W. C., additional, Zhang, W., additional, Zhang, W. Z., additional, Zhang, Y., additional, Zhang, Y. F., additional, Zhang, Y. J., additional, Zhang, Z., additional, Zhang, Z. L., additional, Zhao, H. S., additional, Zhao, X. F., additional, Zheng, W., additional, Zhou, D. K., additional, Zhou, J. F., additional, Zhou, X., additional, Zhuang, R. L., additional, Zhu, Y. X., additional, and Zhu, Y., additional
Published: 2020
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42. The Evolution of the Broadband Temporal Features Observed in the Black-hole Transient MAXI J1820+070 with Insight-HXMT

Author: Wang, Yanan, primary, Ji, Long, additional, Zhang, S. N., additional, Méndez, Mariano, additional, Qu, J. L., additional, Maggi, Pierre, additional, Ge, M. Y., additional, Qiao, Erlin, additional, Tao, L., additional, Zhang, S., additional, Altamirano, Diego, additional, Zhang, L., additional, Ma, X., additional, Lu, F. J., additional, Li, T. P., additional, Huang, Y., additional, Zheng, S. J., additional, Chen, Y. P., additional, Chang, Z., additional, Tuo, Y. L., additional, Güngör, C., additional, Song, L. M., additional, Xu, Y. P., additional, Cao, X. L., additional, Chen, Y., additional, Liu, C. Z., additional, Bu, Q. C., additional, Cai, C., additional, Chen, G., additional, Chen, L., additional, Chen, T. X., additional, Chen, Y. B., additional, Cui, W., additional, Cui, W. W., additional, Deng, J. K., additional, Dong, Y. W., additional, Du, Y. Y., additional, Fu, M. X., additional, Gao, G. H., additional, Gao, H., additional, Gao, M., additional, Gu, Y. D., additional, Guan, J., additional, Guo, C. C., additional, Han, D. W., additional, Huo, J., additional, Jia, S. M., additional, Jiang, L. H., additional, Jiang, W. C., additional, Jin, J., additional, Jin, Y. J., additional, Kong, L. D., additional, Li, B., additional, Li, C. K., additional, Li, G., additional, Li, M. S., additional, Li, W., additional, Li, X., additional, Li, X. B., additional, Li, X. F., additional, Li, Y. G., additional, Li, Z. W., additional, Liang, X. H., additional, Liao, J. Y., additional, Liu, G. Q., additional, Liu, H. W., additional, Liu, X. J., additional, Liu, Y. N., additional, Lu, B., additional, Lu, X. F., additional, Luo, Q., additional, Luo, T., additional, Meng, B., additional, Nang, Y., additional, Nie, J. Y., additional, Ou, G., additional, Sai, N., additional, Shang, R. C., additional, Song, X. Y., additional, Sun, L., additional, Tan, Y., additional, Wang, G. F., additional, Wang, J., additional, Wang, W. S., additional, Wang, Y. D., additional, Wang, Y. S., additional, Wen, X. Y., additional, Wu, B. B., additional, Wu, B. Y., additional, Wu, M., additional, Xiao, G. C., additional, Xiao, S., additional, Xiong, S. L., additional, Yang, J. W., additional, Yang, S., additional, Yang, Y. J., additional, Yi, Q. B., additional, Yin, Q. Q., additional, You, Y., additional, Zhang, A. M., additional, Zhang, C. M., additional, Zhang, F., additional, Zhang, H. M., additional, Zhang, J., additional, Zhang, T., additional, Zhang, W. C., additional, Zhang, W., additional, Zhang, W. Z., additional, Zhang, Y., additional, Zhang, Y. F., additional, Zhang, Y. J., additional, Zhang, Z., additional, Zhang, Z. L., additional, Zhao, H. S., additional, Zhao, X. F., additional, Zhou, D. K., additional, Zhou, J. F., additional, Zhuang, R. L., additional, Zhu, Y. X., additional, Zhu, Y., additional, and Wang, Lingjun, additional
Published: 2020
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43. A search for promptγ-ray counterparts to fast radio bursts in the Insight-HXMT data

Author: Guidorzi, C., primary, Marongiu, M., additional, Martone, R., additional, Nicastro, L., additional, Xiong, S. L., additional, Liao, J. Y., additional, Li, G., additional, Zhang, S. N., additional, Amati, L., additional, Frontera, F., additional, Orlandini, M., additional, Rosati, P., additional, Virgilli, E., additional, Zhang, S., additional, Bu, Q. C., additional, Cai, C., additional, Cao, X. L., additional, Chang, Z., additional, Chen, G., additional, Chen, L., additional, Chen, T. X., additional, Chen, Y. B., additional, Chen, Y. P., additional, Cui, W., additional, Cui, W. W., additional, Deng, J. K., additional, Dong, Y. W., additional, Du, Y. Y., additional, Fu, M. X., additional, Gao, G. H., additional, Gao, H., additional, Gao, M., additional, Ge, M. Y., additional, Gu, Y. D., additional, Guan, J., additional, Guo, C. C., additional, Han, D. W., additional, Huang, Y., additional, Huo, J., additional, Jia, S. M., additional, Jiang, L. H., additional, Jiang, W. C., additional, Jin, J., additional, Jin, Y. J., additional, Kong, L. D., additional, Li, B., additional, Li, C. K., additional, Li, M. S., additional, Li, T. P., additional, Li, W., additional, Li, X., additional, Li, X. B., additional, Li, X. F., additional, Li, Y. G., additional, Li, Z. W., additional, Liang, X. H., additional, Liu, B. S., additional, Liu, C. Z., additional, Liu, G. Q., additional, Liu, H. W., additional, Liu, X. J., additional, Liu, Y. N., additional, Lu, B., additional, Lu, F. J., additional, Lu, X. F., additional, Luo, Q., additional, Luo, T., additional, Ma, R. C., additional, Ma, X., additional, Meng, B., additional, Nang, Y., additional, Nie, J. Y., additional, Ou, G., additional, Qu, J. L., additional, Sai, N., additional, Shang, R. C., additional, Song, L. M., additional, Song, X. Y., additional, Sun, L., additional, Tan, Y., additional, Tao, L., additional, Tuo, Y. L., additional, Wang, C., additional, Wang, G. F., additional, Wang, J., additional, Wang, W. S., additional, Wang, Y. S., additional, Wen, X. Y., additional, Wu, B. Y., additional, Wu, B. B., additional, Wu, M., additional, Xiao, G. C., additional, Xiao, S., additional, Xu, Y. P., additional, Yang, J. W., additional, Yang, S., additional, Yang, Y. J., additional, Yi, Q. B., additional, Yin, Q. Q., additional, You, Y., additional, Zhang, A. M., additional, Zhang, C. M., additional, Zhang, F., additional, Zhang, H. M., additional, Zhang, J., additional, Zhang, T., additional, Zhang, W. C., additional, Zhang, W., additional, Zhang, W. Z., additional, Zhang, Y., additional, Zhang, Y. F., additional, Zhang, Y. J., additional, Zhang, Z., additional, Zhang, Z. L., additional, Zhang, H. S., additional, Zhang, X. F., additional, Zheng, S. J., additional, Zhou, D. K., additional, Zhou, J. F., additional, Zhu, Y. X., additional, Zhu, Y., additional, and Zhuang, R. L., additional
Published: 2020
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44. Switches between accretion structures during flares in 4U 1901+03

Author: Ji, L, primary, Ducci, L, primary, Santangelo, A, primary, Zhang, S, primary, Suleimanov, V, primary, Tsygankov, S, primary, Doroshenko, V, primary, Nabizadeh, A, primary, Zhang, S N, primary, Ge, M Y, primary, Tao, L, primary, Bu, Q C, primary, Qu, J L, primary, Lu, F J, primary, Chen, L, primary, Song, L M, primary, Li, T P, primary, Xu, Y P, primary, Cao, X L, primary, Chen, Y, primary, Liu, C Z, primary, Cai, C, primary, Chang, Z, primary, Chen, G, primary, Chen, T X, primary, Chen, Y B, primary, Chen, Y P, primary, Cui, W, primary, Cui, W W, primary, Deng, J K, primary, Dong, Y W, primary, Du, Y Y, primary, Fu, M X, primary, Gao, G H, primary, Gao, H, primary, Gao, M, primary, Gu, Y D, primary, Guan, J, primary, Guo, C C, primary, Han, D W, primary, Huang, Y, primary, Huo, J, primary, Jia, S M, primary, Jiang, L H, primary, Jiang, W C, primary, Jin, J, primary, Jin, Y J, primary, Kong, L D, primary, Li, B, primary, Li, C K, primary, Li, G, primary, Li, M S, primary, Li, W, primary, Li, X, primary, Li, X B, primary, Li, X F, primary, Li, Y G, primary, Li, Z W, primary, Liang, X H, primary, Liao, J Y, primary, Liu, B S, primary, Liu, G Q, primary, Liu, H X, primary, Liu, H W, primary, Liu, X J, primary, Liu, Y N, primary, Lu, B, primary, Lu, X F, primary, Luo, Q, primary, Luo, T, primary, Ma, X, primary, Meng, B, primary, Nang, Y, primary, Nie, J Y, primary, Ou, G, primary, Sai, N, primary, Shang, R C, primary, Song, X Y, primary, Sun, L, primary, Tan, Y, primary, Tuo, Y L, primary, Wang, C, primary, Wang, G F, primary, Wang, J, primary, Wang, P J, primary, Wang, W S, primary, Wang, Y S, primary, Wen, X Y, primary, Wu, B Y, primary, Wu, B B, primary, Wu, M, primary, Xiao, G C, primary, Xiao, S, primary, Xiong, S L, primary, Xu, H, primary, Yang, J W, primary, Yang, S, primary, Yang, Yan-Ji, primary, Yang, Yi-Jung, primary, Yi, Q B, primary, Yin, Q Q, primary, You, Y, primary, Zhang, A M, primary, Zhang, C M, primary, Zhang, F, primary, Zhang, H M, primary, Zhang, J, primary, Zhang, P, primary, Zhang, T, primary, Zhang, W, primary, Zhang, W C, primary, Zhang, W Z, primary, Zhang, Yi, primary, Zhang, Y F, primary, Zhang, Y J, primary, Zhang, Y H, primary, Zhang, Yue, primary, Zhang, Zhao, primary, Zhang, Zhi, primary, Zhang, Z L, primary, Zhao, H S, primary, Zhao, X F, primary, Zheng, S J, primary, Zhou, D K, primary, Zhou, J F, primary, Zhu, Y X, primary, Zhu, Y, primary, and Zhuang, R L, primary
Published: 2020
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45. Synthesis, crystal structure and anti-gastric cancer activity of a Zn(II) coordination polymer with a 4,4'-bis(1-imidazolyl)biphenyl ligand

Author: Zhai, J.-B., primary, Jiang, L.-H., additional, and Jiang, Y., additional
Published: 2020
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46. Identification of the amino acid residues in the extracellular domain of rat P2X7 receptor involved in functional inhibition by acidic pH

Author: Liu, X, Ma, W, Surprenant, A, and Jiang, L H
Published: 2009
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47. Automated Planar Patch-Clamp Recording of P2X Receptors

Author: Milligan, CJ, Jiang, L-H, and Pelegrín, P
Abstract: P2X receptors are a structurally and functionally distinctive family of ligand-gated ion channels that play important roles in mediating extracellular adenosine 5′-triphosphate (ATP) signaling in diverse physiological and pathophysiological processes. For several decades, the “manual” patch-clamp technique was regarded as the gold standard assay for investigating ion channel properties. More recently, breakthroughs in the development of automated patch-clamp technologies are enabling the study of ion channels, with much greater throughput capacities. These automated platforms, of which there are many, generate consistent, reliable, high-fidelity data. This chapter demonstrates the versatility of one of these technologies for ligand-gated ion channels, with a particular emphasis on protocols that address some of the issues of receptor desensitization that are commonly associated with P2X receptor-mediated currents.
Published: 2019

48. Heterologous Expression and Patch-Clamp Recording of P2X Receptors in HEK293 Cells

Author: Jiang, L-H and Roger, S
Abstract: P2X receptors (P2XRs) are ligand-gated ion channels gated by extracellular adenosine 5′-triphosphate (ATP) and play a critical role in mediating ATP-induced purinergic signaling in physiological and pathological processes. Heterologous expression of P2XR in human embryonic kidney 293 (HEK293) cells and measurement of P2XR-mediated currents using patch-clamp recording technique have been widely used to study the biophysical and pharmacological properties of these receptors. Combination of electrophysiology with site-directed mutagenesis and structural information has shed light on the molecular basis for receptor activation and mechanisms of actions by receptor antagonists and modulators. It is anticipated that such methodologies will continue helping us to provide more mechanistic understanding of P2XRs and to test novel receptor antagonists and allosteric modulators for therapeutical purposes. In this chapter, we describe protocols of transiently or stably expressing the P2XR in HEK293 cells and measuring P2XR-mediated currents by using whole-cell recording.
Published: 2019

49. TRPM2 Channel in Microglia as a New Player in Neuroinflammation Associated With a Spectrum of Central Nervous System Pathologies

Author: Malko, P, Mortadza, SAS, McWilliam, J, and Jiang, L-H
Abstract: Microglial cells in the central nervous system (CNS) are crucial in maintaining a healthy environment for neurons to function properly. However, aberrant microglial cell activation can lead to excessive generation of neurotoxic proinflammatory mediators and neuroinflammation, which represents a contributing factor in a wide spectrum of CNS pathologies, including ischemic stroke, traumatic brain damage, Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, psychiatric disorders, autism spectrum disorders, and chronic neuropathic pain. Oxidative stress is a salient and common feature of these conditions and has been strongly implicated in microglial cell activation and neuroinflammation. The transient receptor potential melastatin-related 2 (TRPM2) channel, an oxidative stress-sensitive calcium-permeable cationic channel, is highly expressed in microglial cells. In this review, we examine the recent studies that provide evidence to support an important role for the TRPM2 channel, particularly TRPM2-mediated Ca2+ signaling, in mediating microglial cell activation, generation of proinflammatory mediators and neuroinflammation, which are of relevance to CNS pathologies. These findings lead to a growing interest in the TRPM2 channel, a new player in neuroinflammation, as a novel therapeutic target for CNS diseases.
Published: 2019

50. Characterization of a selective and potent antagonist of human P2X7 receptors, AZ11645373

Author: Stokes, L, Jiang, L-H, Alcaraz, L, Bent, J, Bowers, K, Fagura, M, Furber, M, Mortimore, M, Lawson, M, Theaker, J, Laurent, C, Braddock, M, and Surprenant, A
Published: 2006
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