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Cancer has evolved into a substantial public health concern as the second-leading cause of mortality globally. Radiotherapy and chemotherapy have been the two most widely used cancer therapies in recent years; however, both have drawbacks. Therefore, the focus has shifted to the creation of herbal medicines, the extraction of active ingredients, replacement therapy, and the adverse effects of these medications. Ginsenoside Rh2, which is extracted from ginseng, has been identified in many cancer cells. The immune system of the body is strengthened by ginsenoside Rh2, which can also cause the proliferation, death, and differentiation of tumor cells through various pathways. For instance, it inhibits the expression of the NF- κ B signaling pathway and induces cell apoptosis, affects the expression levels of mitochondrial apoptosis proteins Bcl-2 and Bax, and cooperates with the PD-1 blockade to reactivate T cells to promote an antitumor immune response. Furthermore, ginsenosides Rh2 has the effect of reversing the toxic effect of chemotherapy drugs on normal cells, reducing myocardial damage, and relieving bone marrow function suppression. For clinical applications, it is mainly used as an adjuvant drug for preoperative neoadjuvant chemotherapy, postoperative adjuvant chemotherapy, and rescue treatment of advanced cancer. This paper summarizes the pharmacological action and mechanism of ginsenosides Rh2 in all kinds of cancer and looks forward to its future development and application. [ABSTRACT FROM AUTHOR]

The Baihetan super-high arch dam is constructed under complicated geological conditions, including large-scale columnar jointed basalt (CJB) with closely spaced joints and multiple interlayer and intralayer shear belts at the lower part of dam base, which may increase a risk of seepage in adjacent dam foundations. Therefore, curtain grouting is used to reduce the permeability of dam foundations. Lugeon and grouting field tests and geological exploration were carried out to investigate curtain grouting characteristics of the dam foundation. The findings were as follows: (1) the permeability coefficient of the first type of CJB and breccia lava without unloading is 2 × 10−5 ~ 5 × 10−5 cm/s; that of the second type of CJB without unloading is 2.5 × 10−5 ~ 5 × 10−5 cm/s; and that of the unloaded third type of massive basalt is 1 × 10−5 ~ 3 × 10−5 cm/s. (2) The rock core shows that the slurry caused repeated splitting of the rock mass and widened the cracks of the rock mass, which resulted in plastic deformation of the rock mass. The P ~ Q curve of the five-point Lugeon test shows that the curve shape is turbulent and that the maximum Lugeon value appears at the highest pressure. (3) The phenomenon of low-permeability conditions with a large grout take can be frequently observed. The proportion of the hole stages with a water permeability less than 1 LU and grout take greater than 50 kg/m ranges from 12.5 to 37.5%. The proportion of holes with permeability greater than 10 Lu and grout take greater than 50 kg/m is 0 to 12.5%. The findings from this case study can provide a reference for engineering construction. [ABSTRACT FROM AUTHOR]

The dam foundation rock mass, at the Baihetan hydropower station on the Jinsha River, is mainly columnar jointed basalt, with faults and fissures developed. Considering adverse factors such as the unloading relaxation or the opening of the fissures due to excavation blasting, consolidation grouting is needed to improve the integrity of the dam foundation rock mass. According to the physical and mechanical properties of columnar jointed basalt and the continuity of construction, the effectiveness of overburden consolidation grouting is experimentally studied. The results show that this grouting technology can obviously improve the integrity and uniformity of a dam foundation rock mass and reduce the permeability of the rock mass. After grouting, the average increase in the wave velocity of the rock mass is 7.3%. The average improvement in the deformation modulus after grouting is 13.5%. After grouting, the permeability of 99% of the inspection holes in the Lugeon test section had Lugeon values of no more than 3 LU. This improvement is considerable and provides a case to engineering application. [ABSTRACT FROM AUTHOR]