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1. An Automatic Cascaded Model for Hemorrhagic Stroke Segmentation and Hemorrhagic Volume Estimation

Author

Xu, Weijin, Sha, Zhuang, Yang, Huihua, Jiang, Rongcai, Li, Zhanying, Liu, Wentao, and Su, Ruisheng

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition
Abstract

Hemorrhagic Stroke (HS) has a rapid onset and is a serious condition that poses a great health threat. Promptly and accurately delineating the bleeding region and estimating the volume of bleeding in Computer Tomography (CT) images can assist clinicians in treatment planning, leading to improved treatment outcomes for patients. In this paper, a cascaded 3D model is constructed based on UNet to perform a two-stage segmentation of the hemorrhage area in CT images from rough to fine, and the hemorrhage volume is automatically calculated from the segmented area. On a dataset with 341 cases of hemorrhagic stroke CT scans, the proposed model provides high-quality segmentation outcome with higher accuracy (DSC 85.66%) and better computation efficiency (6.2 second per sample) when compared to the traditional Tada formula with respect to hemorrhage volume estimation., Comment: Accepted by SWITCH2023: Stroke Workshop on Imaging and Treatment CHallenges, a workshop at MICCAI 2023

Published
2024

8. A meta-analysis of cognitive and functional outcomes in severe brain trauma cases

Author

Zhang Shuanglong, Yuan Jiangyuan, Nie Meng, Wang Zheng, Zhang Yunshui, Sun Wei, Qiao Li, and Jiang Rongcai

Subjects
brain trauma, severe TBI, depression, verbal and visual disabilities, learning and memory impairment, cognitive disabilities, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

BackgroundSevere traumatic brain injuries (TBIs) are an important health issue worldwide, which are associated with harmful side effects. This meta-analysis investigates the cognitive and functional outcomes in severe brain trauma cases. It assesses the impact on memory, verbal and visual abilities, attention, learning, and the presence of depression. The study provides a comprehensive overview of the consequences of severe brain trauma injury on cognitive and functional domains.ObjectiveThe main objective of the current comprehensive meta-analysis study is to assess and analyze the impact of severe TBI on functional and cognitive outcomes, including verbal, visual, attention, learning, memory, and emotional stability.MethodsWe collected data from three online databases, including PubMed, Cochrane Library, and Embase. Case–control trials related to severe TBI association with cognitive and functional outcomes were included. Verbal strength, visual functions, learning abilities, attention, memory, and depression were considered primary outcomes.ResultsWe have included 13 case–control studies with 1,442 subjects in this meta-analysis, which provide adequate data to determine the pooled effect size for targeted outcomes. The effect of severe TBI on the inducement of depression and impairment of memory, verbal, visual, attention, and learning abilities compared to the control group showed statistically significant outcomes (p

Published
2024
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11. Multimodality management for chronic subdural hematoma in China: protocol and characteristics of an ambidirectional, nationwide, multicenter registry study

Author

Liu, Tao, Zhao, Zhihao, Huang, Jinhao, Zhu, Xide, Chen, Weiliang, Lin, Kun, Yu, Yunhu, Li, Zhanying, Fan, Yibing, Liu, Mingqi, Nie, Meng, Liu, Xuanhui, Gao, Chuang, Quan, Wei, Qian, Yu, Wu, Chenrui, Yuan, Jiangyuan, Wu, Di, Lv, Chuanxiang, Dong, Shiying, Mi, Liang, Tian, Yu, Tian, Ye, Zhang, Jianning, and Jiang, Rongcai

Published
2024
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12. The third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3): an international, stepped wedge cluster randomised controlled trial

Author

Robinson, Thompson, Miranda, J. Jaime, Anderson, Craig S., You, Chao, Song, Lili, Parry-Jones, Adrian, Sprigg, Nikola, Durrans, Sophie, Harris, Caroline, Bamford, Ann, Smith, Olivia, Herbert, Robert, Chen, Christopher, Whiteley, William, Hu, Rong, Billot, Laurent, Li, Qiang, Mysore, Jayanthi, Hu, Xin, Zhang, Yao, Liu, Feifeng, Sakamoto, Yuki, You, Shoujiang, Han, Qiao, Crutzen, Bernard, Li, Yunke, Cheung, Emily, Jan, Stephen, Liu, Hueiming, Ouyang, Menglu, Sun, Lingli, Chu, Honglin, Anjum, Anila, Gonzalez Mc Cawley, Francisca, Del Rio, Alejandra, Rimoli, Bruna, Cerantola, Rodrigo, Jeevarajah, Thanushanthan, Kannangara, Madhushani, Joseph, Andrene, Nanayakkara, Chamath, Chen, Xiaoying, Malavera, Alejandra, Zhang, Chunmiao, Yang, Zhao, Li, Brook, Meng, Zhuo, Liu, Leibo, Ning, Yi, Dong, Le, Armenis, Manuela, Lim, Joyce, Monaghan, Helen, Ma, Lu, Li, Xi, Luo, Rui, Cheng, Guojuan, Dong, Yilin, Liu, Ziqin, Wang, Shuihong, Zhang, Ying, Cheng, Jipeng, Shi, Hui, Li, Wenjing, Mou, Langming, Yi, Ping, Chen, Chen, Chen, Xue, Weerawardena, Shalomi, Ellawala, Poornima, Ranasinghe, Enalee, Rodrigo, Chrishmi, Wahab, Kolawala, Adeniyi, Sunday, Pandian, Jeyaraj, Khanna, Megha, Muñoz Venturelli, Paula, González, Francisca, Urrutia Goldsack, Francisca, Wasay, Mohammad, Begum, Dilshad, Pontes-Neto, Octavio, Camilo, Millene, Dias, Francisco, Vincenzi, Octavio, Moro, Carla, Santos, Renata, Texeira, Nara, Longo, Alexandre, Liberato, Rafaela, Martins, Sheila, Pille, Arthur, Chwal, Bruna, Silva, Isabel, Titton, Natacha, Weiss, Gustavo, Mora, Daissy, Ouriques, Magda, Carbonera, Leonardo, Bazan, Rodrigo, Modolo, Gabriel, Winckler, Fernanda, Miranda, Luana, Souza, Juli, Rojo, Alexis, Uslar, Wilhelm, Medel, Lorena, Lopez, Javiera, Herrero, Diego, Lavados, Pablo, Vargas Latorre, Barbara, Conejan, Nathalie, Esparza, Tomas, Sotomayor, Patricio, Wenger, Denisse, Gigoux, Juan Pablo, Letelier, Aldo, Acevedo, Lilian, Moya, Vivianne, Figueroa, Cristian, Vallejos, Nicol, Guerrero, Rodrigo, Velasquez, Mauricio, Vallejos, Jose, Pallauta, Kimerly, Santibanez, Tamara, Queirolo, Angelo, Lobos, Andrea, Jiang, Yongming, Li, Weimin, Huang, Wei, Luo, Ke, Liu, Gangying, Tang, Guanghai, Yang, Guang, Jiang, Hongtao, Zhang, Xu, Jing, Hongyan, Zhu, Sheng, Pu, Bo, Lv, Dong, Kang, Hui, Hu, Qiuping, She, Xiaochun, Jiang, Xiaoming, Chen, Yanli, Yang, Shenghua, He, Jianjun, Li, Zongping, Cheng, Gang, Huang, Hailin, Wang, Xiaoyi, Lin, Jianqiong, Chen, Minhui, Yang, Chenghao, Ding, Hao, Deng, Yunliang, Luo, Fei, Zhang, Rongjun, Wang, Xiaofeng, Zhang, Hongbing, Yang, Xiaoliang, Zhang, Yang, Yang, Chengyi, He, Yu, Liu, Feng, Wang, Rongjie, Zhang, Yuhui, Xin, Xiaodong, Feng, Bin, Hao, Wanru, Song, Chang, Guo, Yun, Jiang, Dehua, Chen, Jie, Tang, Changtong, Zhu, Hongliang, Li, Xin, Cui, Jin, Xu, Haidong, Li, Boyang, Tang, Fusheng, Li, Yuanbin, Gao, Min, Yang, Bo, Xu, Xuejun, Deng, Bing, Zheng, Yi, Ge, Yuanhong, Chen, Keyu, Liu, Yang, Li, Xinshen, Zhong, Tingting, Xu, Jianfeng, Zhang, Hai, Wang, Jiyue, Zhu, Jianxin, Sun, Hanyu, Yu, Fuhua, Zhang, Xueguang, Xu, Jianguo, Zhang, Mingsen, Wang, Bin, Ma, Yiming, Jiang, Donglin, Zhou, Jun, Liu, Cong, Nie, Wenhong, Li, Mingguo, Tian, Tao, Li, Yong, He, Mingfang, Tu, Xiaolong, Wu, Zhengjun, Liu, Hong, Zhong, Dongsheng, Jiang, Rongcai, Sun, Jian, Tian, Ye, Wei, Yingsheng, An, Shuo, Wei, Pingbo, Luo, Le, Lin, Bin, Liu, Gang, Wen, Yan, Cai, Qiang, Chen, Qianxue, Lei, Pan, Li, Zhiyang, Zhang, Meifang, He, Jiaquan, Chen, Yan, Liu, Jun, Liu, Xinghai, Li, Junyan, Chen, Min, Wang, Jing, Zhou, Bingzhi, Ye, Baichun, Zhang, Jiancheng, Zhang, Manyuan, Pan, Xuming, Yu, Xiaoxiang, Xu, Jian, Xiao, Qingbao, Wang, Yuefei, Tao, Liang, Shi, Lin, Zheng, Niandong, You, Guoliang, Lei, Bo, Chen, Shu, Wu, Honggang, Hu, Jin, Zhao, Jianlan, Yu, Jian, Yuan, Qiang, Du, Zhuoying, Tang, Xielin, Li, Qianke, Liu, Shenghua, Yang, Feilong, Xiao, Kui, Luo, Chao, Wang, Guang, Che, Xudong, Teng, Zhipeng, Wan, Wenwu, Li, Jun, Liu, Yu, Fan, Mingbo, Zhang, Tao, Cai, Lun, Ma, Yuan, Ma, Zhifeng, Li, Bin, He, Linlin, Li, Jinghui, Zhang, Weibing, Zhang, Shuxin, Zhang, Hongzhen, Dai, Yingguang, Lei, Jun, Mao, Lei, Huang, Yiyang, Zhou, Zhi, Chen, Ping, Chen, Fang, Wei, Pan, Li, Tiangui, Chen, Honglin, Zeng, Mengfei, Mou, Kejie, Xue, Jun, Jiang, Yong, Tang, Xiaoping, Chen, Tao, Zhang, Yalan, Xu, Yanbing, Gu, Yuchen, Chen, Lei, Zhao, Yujun, Yang, Bin, Kuai, Peng, Wang, Xi, Yang, Yuwang, Hu, Xueling, Zhang, Huitian, Yang, Yintao, Wang, Weifeng, Zhang, Junyi, Cheng, Wei, Zhang, Xiaoxue, Ma, Xiaowen, He, Qin, Zhang, Li, Gao, Rong, Liu, Huixiang, Ye, Jingwei, Xu, Ping, Wu, Xin, Yuan, Yuan, Zou, Peng, Zhang, Zhen, Cheng, Jiyong, Zhou, Zhangming, Zeng, Yijun, Liang, Zhang, Du, Deming, Yu, Shui, Cao, Yongjun, Xu, Jiaping, Huang, Zhichao, Chen, Dongqin, Xiao, Wenfeng, Zhu, Li, Yuan, Miao, Wang, Yuhai, Shi, Dongliang, Hu, Xu, Xiang, Dingchao, Shi, Like, Wang, Hongqin, Yang, Liu, Miao, Wang, Hu, Yiyi, Zhao, Yuchun, Hu, Xi, Zhou, Weiduo, Sun, Chao, Tang, Dong, Yao, Kun, You, Jin, Chen, Shishi, Yao, Jianmin, Li, Huanmei, Liu, Jinmei, Bai, Ailin, Yi, Yong, Deng, Qingshan, Luo, Peng, Wang, Han, Jiang, Jingcheng, Yang, Qingwei, He, Shunpo, Wang, Jun, Chen, Yu, He, Hua, Deng, Yuyang, Cao, Zhikai, Yi, Xuxia, Luo, Jinbiao, Luo, Shuang, Gong, Min, Liu, Li, Gao, Xuejun, Liu, Jia, Wu, Li'e, Zhang, Jia, Sun, Hongying, Li, Xinhui, Jia, Lu, Wu, Jianbing, Zhang, Jie, Zhang, Huajun, Du, Chunfu, Li, Shun, Yang, Xiaobin, He, Jie, Liao, Lei, Zhou, Gezhi, Dong, Wentao, Chen, Yunxiang, Lin, Xiaofeng, Shui, Xujian, Zhang, Peng, Zhao, Yuan, Yang, Hongli, Zhao, Wenbin, Zhang, Xiaoyi, Chen, Jincao, Wu, Qian, Dai, Xuan, Tang, Baogui, Wang, Yinjuan, Liu, Tao, Zhang, Haixia, Duan, Faliang, Luo, Ming, Jiao, Qingfang, Lei, Guoliang, Wang, Dong, Song, Chunwang, Tan, Haopeng, Ye, Feng, Qin, Xinghu, Liang, Xiaolong, Liu, Junling, Yang, Lang, Yang, Jie, Lin, Yapeng, Yang, Qian, Ma, Xuntai, Qi, Yinkuang, Pan, Baogen, Jiang, Caixia, Ye, Zhanying, Dong, Ce, Yue, Xiongfei, Yang, Xiaopeng, Maimaitiyiming, Tuoheti, Dong, Jun, Wu, Yonggang, Gao, Feng, Zhao, Deqiang, Zhang, Xinghai, Wang, PengJun, Jiang, Hongbo, Li, Jianping, Zhang, Wei, Chen, Jing, Tong, Haibo, Wang, Yonghong, Qiao, Kaipeng, Guo, Fuyou, Zhang, Mingchu, Hu, Yan, Feng, Mengzhao, Song, Dengpan, Zuo, Yi, Chen, Shangjun, Qian, Chao, Li, Baoming, Ma, Jingku, Zhang, Sunfu, Kong, Bin, Dong, Xingyu, Fang, Sheng, Lu, Bin, Li, Yang, Yang, Yongling, Yu, Hong, Sun, Huaiyu, Wang, Yue, Wang, Weimin, Li, Tong, Li, Shengli, Xu, Zhiming, Wang, Yongyi, Dong, Qiang, Tang, Yuping, Chu, Heling, Lu, Ying, Wang, Zhong, Sun, Xiaoou, Zhao, Jianhua, Yang, Shuaifeng, Qian, Xiying, Saroja, Aralikatte Onkarappa, Naik k, Ravishankar, Chindhi, Sandip, Pampaniya, Nakul, Amaresh, Kurubara, Iype, Thomas, R, Dileep, Rajan, Reeja, Panicker, Praveen, Das, Rupjyoti, Choudhury, Nupur, Gohain, Pankaja, Webster, Jemin, Pakma, Biyol, Sangi, Lalbiak, Sebastian, Ivy, Aggrawal, Gaurav, Raj, Komal, Rajoura, Deepankshi, Singh, Sulena, Aggrawal, Varun, Narang, Amit, Arauz, Antonio, Cano-Nigenda, Vanesa, López-Mena, Diego, Valdez-Ruvalcaba, Héctor, Toledo-Treviño, Roberto, Obiako, Reginald, Abubakar, Sani, Emeka, Oguike, Olayemi, Balogun, Lois, Melika, Philip, Ibinaiye, Comfort O, Olurishe, Okubadejo, Njideka, Agabi, Osigwe, Ojo, Oluwadamilola, Wahab, Kolawole, Bello, Abiodun, Ibukun, Oyinloye, Sanayaolu, Olufemi, Jimoh, Abdulraheem, Waheed, Shahid, Kamal, Dr.Ayeesha, Shoaib, Raja Farhat, Orooj, Fizza, Majid, Sadaf, Zehra, Taskeen, Khan, Abdus Salam, Shanker, Ravi, Syed, Nadir Ali, Ahmad, Nashwa, Abanto, Carlos, Valencia, Ana, Barrientos, Danny, Ramirez, Jorge, Calle, Pilar, Palliyeguruge, Dilum, Muthucumarana, Sumudu, Ratnayaka, Shiroma, Ganihiarachchi, Dilhara, Bandaranayake, Arundathi, Somaratne, S.D.B, Narayana, Saumya, Gallage, Sithara, Senanayake, Bimsara, Samarasiri, Udari, Luke, Dunya, Sivapathasundaram, Mythily, Sahadevan, Vithoosan, Rasmi, Amani, Deshaka, Yuran, Fernando, Nilukshi, Munasinghe, Aruna, Rathnapriya, Kapilanga, Nissanka, A.S, Karunathilake, Kanchana, Gayan, Isuru, Wijenayake, Kaminda, Gunasekara, Hasitha, Vidyarathne, Jagath, Keshavaraj, Ajantha, Janarthanan, Kanagasabapathy, Gerald Jeevathasan, Arhivalaky, Sivamainthan, Sivaram, John Priyanth, Mathyamuthan, John Priyanth, Abirami, Rajendiran, Thambippillai, Alwis, Sanjeewa, Gunasekare, Nushara, Liyanarachchi, Vasundara, Dissanayake, Athula, Uluwattage, Wimalasiri Mewa, Ratnayake, Gimhani, Rajinee, Charika, Jayawardana, Sakura, Peiris, Janaka, Wicramasinghe, Ranjith, Fernando, Chamila, Abbas, Jessie, Withanage, Nethmini, Bandara, Makaranda, Mai, Duy Ton, Nguyen, Van Chi, Dao, Viet Phuong, Vuong, Xuan Trung, Nguyen, Tien Dung, Dinh, Trung Hieu, Phan, Ha Quan, Bui, Quoc Viet, Phung, Dinh Tho, Pham, Quang Tho, Pham, Dinh Dai, Do, Duc Thuan, Dang, Phuc Duc, Dang, Minh Duc, Nguyen, Dang Hai, Nguyen, Thi Phuong Nga, Nguyen, Quoc Huy, Pham, Quoc Dai, Chau, Quoc Vinh, Tai, Vinh Thy Van, Le, Tran Vinh, Le, Cong Tri, Tran, Ha Mai Khuong, Nguyen, Huu Khanh, Ngyen, Hoang Minh Thao, Vo, Duc Chien, Nguyen, Thai My Phuong, Tran, Trung Thanh, Vo, Thi Hanh Vi, Cao, Hao Nhien, Nguyen, Ba Thang, Le, Thi Ngoc Suong, La, Thien Duc, Pham, Chi Duc, Thai, Huy, Muñoz-Venturelli, Paula, de Silva, Asita, Thang, Nguyen Huy, Wahab, Kolawole W, Pandian, Jeyaraj D, Pontes-Neto, Octavio M, Shi, Haiping, Wang, Xia, Zhao, Yang, Li, Hao, Liu, Yi, Jiang, Yan, Wu, Bo, Liu, Ming, and Anderson, Craig S

Published
2023
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15. Cannabidiol alleviates neurological deficits after traumatic brain injury by improving intracranial lymphatic drainage

Author

Dong, Shiying, primary, Zhao, Hongwei, additional, Nie, Meng, additional, Sha, Zhuang, additional, Feng, Jiancheng, additional, Liu, Mingqi, additional, Lv, Chuanxiang, additional, Chen, Yupeng, additional, Jiang, Weiwei, additional, Yuan, Jiangyuan, additional, Qian, Yu, additional, Wan, Honggang, additional, Gao, Chuang, additional, and Jiang, Rongcai, additional

Published
2024
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16. CD4+CD11b+ T cells infiltrate and aggravate the traumatic brain injury depending on brain‐to‐cervical lymph node signaling

Author

Jiang, Weiwei, primary, Liu, Xuanhui, additional, Chen, Yupeng, additional, Liu, Mingqi, additional, Yuan, Jiangyuan, additional, Nie, Meng, additional, Fan, Yibing, additional, Wu, Di, additional, Qian, Yu, additional, Sha, Zhuang, additional, Dong, Shiying, additional, Wu, Chenrui, additional, Liu, Tao, additional, Huang, Jinhao, additional, Zhang, Jianning, additional, Gao, Chuang, additional, and Jiang, Rongcai, additional

Published
2024
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18. Effect of L‐oxiracetam and oxiracetam on memory and cognitive impairment in mild‐to‐moderate traumatic brain injury patients: Study protocol for a randomized controlled trial.

Author

Liu, Tao, Liu, Mingqi, Nie, Meng, Zhao, Zhihao, Liu, Xuanhui, Qian, Yu, Yu, Yunhu, Sha, Zhuang, Wu, Chenrui, Yuan, Jiangyuan, Jiang, Weiwei, Lv, Chuanxiang, Mi, Liang, Tian, Yu, Zhang, Jianning, and Jiang, Rongcai

Subjects
NEUROPROTECTIVE agents, BLIND experiment, RANDOMIZED controlled trials, COGNITION disorders, DRUG efficacy, RESEARCH, MEMORY, BRAIN injuries, MEMORY disorders, COGNITION, EVALUATION, DISEASE complications
Abstract

Objectives: Patients with traumatic brain injury (TBI) often suffer memory and cognitive impairments, and oxiracetam‐like drugs are considered to have a positive impact on these symptoms potentially. However, the efficacy and safety of L‐oxiracetam and oxiracetam in TBI patients have not been sufficiently investigated. Methods: The study adopts a multicenter, randomized, double‐blind, parallel‐group, phase 3 clinical trial design in 74 centers across 51 hospitals in China. A total of 590 TBI patients meeting criteria will be randomly allocated into three groups in a 2:2:1 ratio: L‐oxiracetam group, oxiracetam group, and placebo group. The treatment period is 14 days, with a follow‐up period of 90 days. The primary outcome measure is the change in the Loewenstein Occupational Therapy Cognitive Assessment score at 90 days after treatment. Secondary outcomes include changes in other cognitive assessments, neurological function, activities of daily living, and safety assessments. Discussion: There is no robust evidence to suggest that L‐oxiracetam and oxiracetam can enhance memory and cognitive function in patients with mild to moderate TBI. This study has the potential to answer this crucial clinical question. Trial registration: chinadrugtrials.org.cn, identifier CTR20192539; ClinicalTrials.gov, identifier NCT04205565. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Inactivation of ERK1/2 signaling mediates dysfunction of basal meningeal lymphatic vessels in experimental subdural hematoma

Author

Yuan, Jiangyuan, primary, Liu, Xuanhui, additional, Nie, Meng, additional, Chen, Yupeng, additional, Liu, Mingqi, additional, Huang, Jinhao, additional, Jiang, Weiwei, additional, Gao, Chuang, additional, Quan, Wei, additional, Gong, Zhitao, additional, Xiang, Tangtang, additional, Zhang, Xinjie, additional, Sha, Zhuang, additional, Wu, Chenrui, additional, Wang, Dong, additional, Li, Shenghui, additional, Zhang, Jianning, additional, and Jiang, Rongcai, additional

Published
2024
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23. Fingolimod improves diffuse brain injury by promoting AQP4 polarization and functional recovery of the glymphatic system.

Author

Feng, Dongyi, Liu, Tao, Zhang, Xinjie, Xiang, Tangtang, Su, Wanqiang, Quan, Wei, and Jiang, Rongcai

Subjects
BRAIN injuries, FINGOLIMOD, ENCEPHALITIS, CEREBRAL edema, BRAIN damage
Abstract

Background: Diffuse brain injury (DBI) models are characterized by intense global brain inflammation and edema, which characterize the most severe form of TBI. In a previous experiment, we found that fingolimod promoted recovery after controlled cortical impact injury (CCI) by modulating inflammation around brain lesions. However, it remains unclear whether fingolimod can also attenuate DBI because of its different injury mechanisms. Furthermore, whether fingolimod has additional underlying effects on repairing DBI is unknown. Methods: The impact acceleration model of DBI was established in adult Sprague–Dawley rats. Fingolimod (0.5 mg/kg) was administered 0.5, 24, and 48 h after injury for 3 consecutive days. Immunohistochemistry, immunofluorescence analysis, cytokine array, and western blotting were used to evaluate inflammatory cells, inflammatory factors, AQP4 polarization, apoptosis in brain cells, and the accumulation of APP after DBI in rats. To evaluate the function of the glymphatic system (GS), a fluorescent tracer was injected into the cistern. The neural function of rats with DBI was evaluated using various tests, including the modified neurological severity score (mNSS), horizontal ladder‐crossing test, beam walking test, and tape sensing and removal test. Brain water content was also measured. Results: Fingolimod administration for 3 consecutive days could reduce the levels of inflammatory cytokines, neutrophil recruitment, microglia, and astrocyte activation in the brain following DBI. Moreover, fingolimod reduced apoptotic protein expression, brain cell apoptosis, brain edema, and APP accumulation. Additionally, fingolimod inhibited the loss of AQP4 polarization, improved lymphatic system function, and reduced damage to nervous system function. Notably, inhibiting the GS weakened the therapeutic effect of fingolimod on the neurological function of rats with DBI and increased the accumulation of APP in the brain. Conclusions: In brief, these findings suggest that fingolimod alleviates whole‐brain inflammation and GS system damage after DBI and that inhibiting the GS could weaken the positive effect of fingolimod on nerve function in rats with DBI. Thus, inhibiting inflammation and regulating the GS may be critical for the therapeutic effect of fingolimod on DBI. [ABSTRACT FROM AUTHOR]

Published
2024
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24. CD4+CD11b+ T cells infiltrate and aggravate the traumatic brain injury depending on brain‐to‐cervical lymph node signaling.

Author

Jiang, Weiwei, Liu, Xuanhui, Chen, Yupeng, Liu, Mingqi, Yuan, Jiangyuan, Nie, Meng, Fan, Yibing, Wu, Di, Qian, Yu, Sha, Zhuang, Dong, Shiying, Wu, Chenrui, Liu, Tao, Huang, Jinhao, Zhang, Jianning, Gao, Chuang, and Jiang, Rongcai

Subjects
BRAIN injuries, T cells, LYMPH nodes, CEREBRAL edema, BRAIN damage
Abstract

Aim: We aim to identify the specific CD4+ T‐cell subtype influenced by brain‐to‐CLN signaling and explore their role during the acute phase of traumatic brain injury (TBI). Method: Cervical lymphadenectomy or cervical afferent lymphatic ligation was performed before TBI. Cytokine array and western blot were used to detect cytokines, while the motor function was assessed using mNss and rotarod test. CD4+ T‐cell subtypes in blood, brain, and CLNs were analyzed with Cytometry by time‐of‐flight analysis (CyTOF) or fluorescence‐activated cell sorting (FACS). Brain edema and volume changes were measured by 9.4T MRI. Neuronal apoptosis was evaluated by terminal deoxynucleotidyl transferase‐mediated dUTP nick end labeling (TUNEL) staining. Results: Cervical lymphadenectomy and ligation of cervical lymphatic vessels resulted in a decreased infiltration of CD4+ T cells, specifically CD11b‐positive CD4+ T cells, within the affected region. The population of CD4+CD11b+ T cells increased in ligated CLNs, accompanied by a decrease in the average fluorescence intensity of sphingosine‐1‐phosphate receptor‐1 (S1PR1) on these cells. Administration of CD4+CD11b+ T cells sorted from CLNs into the lateral ventricle reversed the attenuated neurologic deficits, brain edema, and lesion volume following cervical lymphadenectomy. Conclusion: The infiltration of CD4+CD11b+ T cells exacerbates secondary brain damage in TBI, and this process is modulated by brain‐to‐CLN signaling. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Fingolimod Attenuates Lung Injury after Diffuse Brain Injury

Author

Feng, Dongyi, primary, Zhang, Xinjie, additional, Xiang, Tangtang, additional, Su, Wanqiang, additional, Liu, Tao, additional, Li, Fanjian, additional, Qian, Yu, additional, Fan, Yibing, additional, Li, Wanjing, additional, An, Shuo, additional, Tian, Yu, additional, and Jiang, Rongcai, additional

Published
2023
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29. Recombinant Human Erythropoietin Improves the Neurofunctional Recovery of Rats Following Traumatic Brain Injury via an Increase in Circulating Endothelial Progenitor Cells

Author

Wang, Liang, Wang, Xiaonan, Su, Hua, Han, Zhenying, Yu, Huijie, Wang, Dong, Jiang, Rongcai, Liu, Zhenlin, and Zhang, Jianning

Subjects
Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Stem Cell Research, Traumatic Head and Spine Injury, Physical Injury - Accidents and Adverse Effects, Stem Cell Research - Nonembryonic - Human, Brain Disorders, Regenerative Medicine, Traumatic Brain Injury (TBI), Angiogenesis Inducing Agents, Animals, Brain Injuries, Endothelial Progenitor Cells, Erythropoietin, Hematocrit, Hippocampus, Humans, Male, Rats, Rats, Wistar, Recombinant Proteins, Recovery of Function, Spatial Learning, Traumatic brain injury, Endothelial progenitor cells, Angiogenesis, Public Health and Health Services, Clinical sciences
Abstract

Previous studies show that circulating endothelial progenitor cells (EPCs) promote angiogenesis, which is a process associated with improved recovery in animal models of traumatic brain injury (TBI), and that recombinant human erythropoietin (rhEPO) plays a protective role following stroke. Thus, it was hypothesized that rhEPO would enhance recovery following brain injury in a rat model of TBI via an increase in the mobilization of EPCs and, subsequently, in angiogenesis. Flow cytometry assays using CD34- and CD133-specific antibodies were utilized to identify alterations in EPC levels, CD31 and CD34 antibody-stained brain tissue sections were used to quantify angiogenesis, and the Morris water maze (MWM) test and the modified Neurological Severity Score (mNSS) test were used to evaluate behavioral recovery. Compared with saline treatment, treatment with rhEPO significantly increased the number of circulating EPCs on days 1, 4, 7, and 14 (P

Published
2015

30. Cerebral glucagon‐like peptide‐1 receptor activation alleviates traumatic brain injury by glymphatic system regulation in mice.

Author

Lv, Chuanxiang, Han, Shuai, Sha, Zhuang, Liu, Mingqi, Dong, Shiying, Zhang, Chunyun, Li, Zean, Zhang, Kang, Lu, Shouyong, Xu, Zhiyang, Bie, Li, and Jiang, Rongcai

Subjects
GLUCAGON-like peptide-1 receptor, BRAIN injuries, AQUAPORINS, TIGHT junctions, BASAL lamina
Abstract

Aim: We aimed to assess the effects of cerebral glucagon‐like peptide‐1 receptor (GLP‐1R) activation on the glymphatic system and whether this effect was therapeutic for traumatic brain injury (TBI). Methods: Immunofluorescence was employed to evaluate glymphatic system function. The blood–brain barrier (BBB) permeability, microvascular basement membrane, and tight junction expression were assessed using Evans blue extravasation, immunofluorescence, and western blot. Immunohistochemistry was performed to assess axonal damage. Neuronal apoptosis was evaluated using Nissl staining, terminal deoxynucleotidyl transferase‐mediated dUTP nick end labeling (TUNEL) staining, and western blot. Cognitive function was assessed using behavioral tests. Results: Cerebral GLP‐1R activation restored glymphatic transport following TBI, alleviating BBB disruption and neuronal apoptosis, thereby improving cognitive function following TBI. Glymphatic function suppression by treatment using aquaporin 4 inhibitor TGN‐020 abolished the protective effect of the GLP‐1R agonist against cognitive impairment. Conclusion: Cerebral GLP‐1R activation can effectively ameliorate neuropathological changes and cognitive impairment following TBI; the underlying mechanism could involve the repair of the glymphatic system damaged by TBI. [ABSTRACT FROM AUTHOR]

Published
2023
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33. miR-539 mediates osteoblast mineralization by regulating Distal-less genes 2 in MC3T3-E1 cell line

Author

Han Jianguo, Su Li, Zhang Chunyang, and Jiang Rongcai

Subjects
mir-539, distal less genes 2, osteoblast mineralization, Biology (General), QH301-705.5
Abstract

microRNAs (miRNAs) play an important role in osteoblast differentiation. However, the mechanisms of miRNAs regulating osteoblast mineralization still needs to be further cleared. Distal-less genes 2 (Dlx2) plays an important role in osteoblast differentiation. We have found that miR-539 was significantly downregulated and Dlx2 was found to be inversely correlated with miR-539 in MC3T3-E1 cell line during osteoblast mineralization. The overexpression of miR-539 significantly decreased the expression level of Dlx2 and suppressed the osteogenic marker gene expression level, alkaline phosphatase activity and matrix mineralization. Our study showed that miR-539 was a negative regulator in osteoblast mineralization and that the targeting of Dlx2 gene partly contributes to this inhibitory effect exerted by miR-539.

Published
2017
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35. The third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3): an international, stepped wedge cluster randomised controlled trial

Author

Ma, Lu, primary, Hu, Xin, additional, Song, Lili, additional, Chen, Xiaoying, additional, Ouyang, Menglu, additional, Billot, Laurent, additional, Li, Qiang, additional, Malavera, Alejandra, additional, Li, Xi, additional, Muñoz-Venturelli, Paula, additional, de Silva, Asita, additional, Thang, Nguyen Huy, additional, Wahab, Kolawole W, additional, Pandian, Jeyaraj D, additional, Wasay, Mohammad, additional, Pontes-Neto, Octavio M, additional, Abanto, Carlos, additional, Arauz, Antonio, additional, Shi, Haiping, additional, Tang, Guanghai, additional, Zhu, Sheng, additional, She, Xiaochun, additional, Liu, Leibo, additional, Sakamoto, Yuki, additional, You, Shoujiang, additional, Han, Qiao, additional, Crutzen, Bernard, additional, Cheung, Emily, additional, Li, Yunke, additional, Wang, Xia, additional, Chen, Chen, additional, Liu, Feifeng, additional, Zhao, Yang, additional, Li, Hao, additional, Liu, Yi, additional, Jiang, Yan, additional, Chen, Lei, additional, Wu, Bo, additional, Liu, Ming, additional, Xu, Jianguo, additional, You, Chao, additional, Anderson, Craig S, additional, Robinson, Thompson, additional, Miranda, J. Jaime, additional, Anderson, Craig S., additional, Parry-Jones, Adrian, additional, Sprigg, Nikola, additional, Durrans, Sophie, additional, Harris, Caroline, additional, Bamford, Ann, additional, Smith, Olivia, additional, Herbert, Robert, additional, Chen, Christopher, additional, Whiteley, William, additional, Hu, Rong, additional, Mysore, Jayanthi, additional, Zhang, Yao, additional, Jan, Stephen, additional, Liu, Hueiming, additional, Sun, Lingli, additional, Chu, Honglin, additional, Anjum, Anila, additional, Gonzalez Mc Cawley, Francisca, additional, Del Rio, Alejandra, additional, Rimoli, Bruna, additional, Cerantola, Rodrigo, additional, Jeevarajah, Thanushanthan, additional, Kannangara, Madhushani, additional, Joseph, Andrene, additional, Nanayakkara, Chamath, additional, Zhang, Chunmiao, additional, Yang, Zhao, additional, Li, Brook, additional, Meng, Zhuo, additional, Ning, Yi, additional, Dong, Le, additional, Armenis, Manuela, additional, Lim, Joyce, additional, Monaghan, Helen, additional, Ma, Lu, additional, Luo, Rui, additional, Cheng, Guojuan, additional, Dong, Yilin, additional, Liu, Ziqin, additional, Wang, Shuihong, additional, Zhang, Ying, additional, Cheng, Jipeng, additional, Shi, Hui, additional, Li, Wenjing, additional, Mou, Langming, additional, Yi, Ping, additional, Chen, Xue, additional, Weerawardena, Shalomi, additional, Ellawala, Poornima, additional, Ranasinghe, Enalee, additional, Rodrigo, Chrishmi, additional, Wahab, Kolawala, additional, Adeniyi, Sunday, additional, Pandian, Jeyaraj, additional, Khanna, Megha, additional, Muñoz Venturelli, Paula, additional, González, Francisca, additional, Urrutia Goldsack, Francisca, additional, Begum, Dilshad, additional, Pontes-Neto, Octavio, additional, Camilo, Millene, additional, Dias, Francisco, additional, Vincenzi, Octavio, additional, Moro, Carla, additional, Santos, Renata, additional, Texeira, Nara, additional, Longo, Alexandre, additional, Liberato, Rafaela, additional, Martins, Sheila, additional, Pille, Arthur, additional, Chwal, Bruna, additional, Silva, Isabel, additional, Titton, Natacha, additional, Weiss, Gustavo, additional, Mora, Daissy, additional, Ouriques, Magda, additional, Carbonera, Leonardo, additional, Bazan, Rodrigo, additional, Modolo, Gabriel, additional, Winckler, Fernanda, additional, Miranda, Luana, additional, Souza, Juli, additional, Rojo, Alexis, additional, Uslar, Wilhelm, additional, Medel, Lorena, additional, Lopez, Javiera, additional, Herrero, Diego, additional, Lavados, Pablo, additional, Vargas Latorre, Barbara, additional, Conejan, Nathalie, additional, Esparza, Tomas, additional, Sotomayor, Patricio, additional, Wenger, Denisse, additional, Gigoux, Juan Pablo, additional, Letelier, Aldo, additional, Acevedo, Lilian, additional, Moya, Vivianne, additional, Figueroa, Cristian, additional, Vallejos, Nicol, additional, Guerrero, Rodrigo, additional, Velasquez, Mauricio, additional, Vallejos, Jose, additional, Pallauta, Kimerly, additional, Santibanez, Tamara, additional, Queirolo, Angelo, additional, Lobos, Andrea, additional, Jiang, Yongming, additional, Li, Weimin, additional, Huang, Wei, additional, Luo, Ke, additional, Liu, Gangying, additional, Yang, Guang, additional, Jiang, Hongtao, additional, Zhang, Xu, additional, Jing, Hongyan, additional, Pu, Bo, additional, Lv, Dong, additional, Kang, Hui, additional, Hu, Qiuping, additional, Jiang, Xiaoming, additional, Chen, Yanli, additional, Yang, Shenghua, additional, He, Jianjun, additional, Li, Zongping, additional, Cheng, Gang, additional, Huang, Hailin, additional, Wang, Xiaoyi, additional, Lin, Jianqiong, additional, Chen, Minhui, additional, Yang, Chenghao, additional, Ding, Hao, additional, Deng, Yunliang, additional, Luo, Fei, additional, Zhang, Rongjun, additional, Wang, Xiaofeng, additional, Zhang, Hongbing, additional, Yang, Xiaoliang, additional, Zhang, Yang, additional, Yang, Chengyi, additional, He, Yu, additional, Liu, Feng, additional, Wang, Rongjie, additional, Zhang, Yuhui, additional, Xin, Xiaodong, additional, Feng, Bin, additional, Hao, Wanru, additional, Song, Chang, additional, Guo, Yun, additional, Jiang, Dehua, additional, Chen, Jie, additional, Tang, Changtong, additional, Zhu, Hongliang, additional, Li, Xin, additional, Cui, Jin, additional, Xu, Haidong, additional, Li, Boyang, additional, Tang, Fusheng, additional, Li, Yuanbin, additional, Gao, Min, additional, Yang, Bo, additional, Xu, Xuejun, additional, Deng, Bing, additional, Zheng, Yi, additional, Ge, Yuanhong, additional, Chen, Keyu, additional, Liu, Yang, additional, Li, Xinshen, additional, Zhong, Tingting, additional, Xu, Jianfeng, additional, Zhang, Hai, additional, Wang, Jiyue, additional, Zhu, Jianxin, additional, Sun, Hanyu, additional, Yu, Fuhua, additional, Zhang, Xueguang, additional, Zhang, Mingsen, additional, Wang, Bin, additional, Ma, Yiming, additional, Jiang, Donglin, additional, Zhou, Jun, additional, Liu, Cong, additional, Nie, Wenhong, additional, Li, Mingguo, additional, Tian, Tao, additional, Li, Yong, additional, He, Mingfang, additional, Tu, Xiaolong, additional, Wu, Zhengjun, additional, Liu, Hong, additional, Zhong, Dongsheng, additional, Jiang, Rongcai, additional, Sun, Jian, additional, Tian, Ye, additional, Wei, Yingsheng, additional, An, Shuo, additional, Wei, Pingbo, additional, Luo, Le, additional, Lin, Bin, additional, Liu, Gang, additional, Wen, Yan, additional, Cai, Qiang, additional, Chen, Qianxue, additional, Lei, Pan, additional, Li, Zhiyang, additional, Zhang, Meifang, additional, He, Jiaquan, additional, Chen, Yan, additional, Liu, Jun, additional, Liu, Xinghai, additional, Li, Junyan, additional, Chen, Min, additional, Wang, Jing, additional, Zhou, Bingzhi, additional, Ye, Baichun, additional, Zhang, Jiancheng, additional, Zhang, Manyuan, additional, Pan, Xuming, additional, Yu, Xiaoxiang, additional, Xu, Jian, additional, Xiao, Qingbao, additional, Wang, Yuefei, additional, Tao, Liang, additional, Shi, Lin, additional, Zheng, Niandong, additional, You, Guoliang, additional, Lei, Bo, additional, Chen, Shu, additional, Wu, Honggang, additional, Hu, Jin, additional, Zhao, Jianlan, additional, Yu, Jian, additional, Yuan, Qiang, additional, Du, Zhuoying, additional, Tang, Xielin, additional, Li, Qianke, additional, Liu, Shenghua, additional, Yang, Feilong, additional, Xiao, Kui, additional, Luo, Chao, additional, Wang, Guang, additional, Che, Xudong, additional, Teng, Zhipeng, additional, Wan, Wenwu, additional, Li, Jun, additional, Liu, Yu, additional, Fan, Mingbo, additional, Zhang, Tao, additional, Cai, Lun, additional, Ma, Yuan, additional, Ma, Zhifeng, additional, Li, Bin, additional, He, Linlin, additional, Li, Jinghui, additional, Zhang, Weibing, additional, Zhang, Shuxin, additional, Zhang, Hongzhen, additional, Dai, Yingguang, additional, Lei, Jun, additional, Mao, Lei, additional, Huang, Yiyang, additional, Zhou, Zhi, additional, Chen, Ping, additional, Chen, Fang, additional, Wei, Pan, additional, Li, Tiangui, additional, Chen, Honglin, additional, Zeng, Mengfei, additional, Mou, Kejie, additional, Xue, Jun, additional, Jiang, Yong, additional, Tang, Xiaoping, additional, Chen, Tao, additional, Zhang, Yalan, additional, Xu, Yanbing, additional, Gu, Yuchen, additional, Zhao, Yujun, additional, Yang, Bin, additional, Kuai, Peng, additional, Wang, Xi, additional, Yang, Yuwang, additional, Hu, Xueling, additional, Zhang, Huitian, additional, Yang, Yintao, additional, Wang, Weifeng, additional, Zhang, Junyi, additional, Cheng, Wei, additional, Zhang, Xiaoxue, additional, Ma, Xiaowen, additional, He, Qin, additional, Zhang, Li, additional, Gao, Rong, additional, Liu, Huixiang, additional, Ye, Jingwei, additional, Xu, Ping, additional, Wu, Xin, additional, Yuan, Yuan, additional, Zou, Peng, additional, Zhang, Zhen, additional, Cheng, Jiyong, additional, Zhou, Zhangming, additional, Zeng, Yijun, additional, Liang, Zhang, additional, Du, Deming, additional, Yu, Shui, additional, Cao, Yongjun, additional, Xu, Jiaping, additional, Huang, Zhichao, additional, Chen, Dongqin, additional, Xiao, Wenfeng, additional, Zhu, Li, additional, Yuan, Miao, additional, Wang, Yuhai, additional, Shi, Dongliang, additional, Hu, Xu, additional, Xiang, Dingchao, additional, Shi, Like, additional, Wang, Hongqin, additional, Yang, Liu, additional, Miao, Wang, additional, Hu, Yiyi, additional, Zhao, Yuchun, additional, Hu, Xi, additional, Zhou, Weiduo, additional, Sun, Chao, additional, Tang, Dong, additional, Yao, Kun, additional, You, Jin, additional, Chen, Shishi, additional, Yao, Jianmin, additional, Li, Huanmei, additional, Liu, Jinmei, additional, Bai, Ailin, additional, Yi, Yong, additional, Deng, Qingshan, additional, Luo, Peng, additional, Wang, Han, additional, Jiang, Jingcheng, additional, Yang, Qingwei, additional, He, Shunpo, additional, Wang, Jun, additional, Chen, Yu, additional, He, Hua, additional, Deng, Yuyang, additional, Cao, Zhikai, additional, Yi, Xuxia, additional, Luo, Jinbiao, additional, Luo, Shuang, additional, Gong, Min, additional, Liu, Li, additional, Gao, Xuejun, additional, Liu, Jia, additional, Wu, Li'e, additional, Zhang, Jia, additional, Sun, Hongying, additional, Li, Xinhui, additional, Jia, Lu, additional, Wu, Jianbing, additional, Zhang, Jie, additional, Zhang, Huajun, additional, Du, Chunfu, additional, Li, Shun, additional, Yang, Xiaobin, additional, He, Jie, additional, Liao, Lei, additional, Zhou, Gezhi, additional, Dong, Wentao, additional, Chen, Yunxiang, additional, Lin, Xiaofeng, additional, Shui, Xujian, additional, Zhang, Peng, additional, Zhao, Yuan, additional, Yang, Hongli, additional, Zhao, Wenbin, additional, Zhang, Xiaoyi, additional, Chen, Jincao, additional, Wu, Qian, additional, Dai, Xuan, additional, Tang, Baogui, additional, Wang, Yinjuan, additional, Liu, Tao, additional, Zhang, Haixia, additional, Duan, Faliang, additional, Luo, Ming, additional, Jiao, Qingfang, additional, Lei, Guoliang, additional, Wang, Dong, additional, Song, Chunwang, additional, Tan, Haopeng, additional, Ye, Feng, additional, Qin, Xinghu, additional, Liang, Xiaolong, additional, Liu, Junling, additional, Yang, Lang, additional, Yang, Jie, additional, Lin, Yapeng, additional, Yang, Qian, additional, Ma, Xuntai, additional, Qi, Yinkuang, additional, Pan, Baogen, additional, Jiang, Caixia, additional, Ye, Zhanying, additional, Dong, Ce, additional, Yue, Xiongfei, additional, Yang, Xiaopeng, additional, Maimaitiyiming, Tuoheti, additional, Dong, Jun, additional, Wu, Yonggang, additional, Gao, Feng, additional, Zhao, Deqiang, additional, Zhang, Xinghai, additional, Wang, PengJun, additional, Jiang, Hongbo, additional, Li, Jianping, additional, Zhang, Wei, additional, Chen, Jing, additional, Tong, Haibo, additional, Wang, Yonghong, additional, Qiao, Kaipeng, additional, Guo, Fuyou, additional, Zhang, Mingchu, additional, Hu, Yan, additional, Feng, Mengzhao, additional, Song, Dengpan, additional, Zuo, Yi, additional, Chen, Shangjun, additional, Qian, Chao, additional, Li, Baoming, additional, Ma, Jingku, additional, Zhang, Sunfu, additional, Kong, Bin, additional, Dong, Xingyu, additional, Fang, Sheng, additional, Lu, Bin, additional, Li, Yang, additional, Yang, Yongling, additional, Yu, Hong, additional, Sun, Huaiyu, additional, Wang, Yue, additional, Wang, Weimin, additional, Li, Tong, additional, Li, Shengli, additional, Xu, Zhiming, additional, Wang, Yongyi, additional, Dong, Qiang, additional, Tang, Yuping, additional, Chu, Heling, additional, Lu, Ying, additional, Wang, Zhong, additional, Sun, Xiaoou, additional, Zhao, Jianhua, additional, Yang, Shuaifeng, additional, Qian, Xiying, additional, Saroja, Aralikatte Onkarappa, additional, Naik k, Ravishankar, additional, Chindhi, Sandip, additional, Pampaniya, Nakul, additional, Amaresh, Kurubara, additional, Iype, Thomas, additional, R, Dileep, additional, Rajan, Reeja, additional, Panicker, Praveen, additional, Das, Rupjyoti, additional, Choudhury, Nupur, additional, Gohain, Pankaja, additional, Webster, Jemin, additional, Pakma, Biyol, additional, Sangi, Lalbiak, additional, Sebastian, Ivy, additional, Aggrawal, Gaurav, additional, Raj, Komal, additional, Rajoura, Deepankshi, additional, Singh, Sulena, additional, Aggrawal, Varun, additional, Narang, Amit, additional, Cano-Nigenda, Vanesa, additional, López-Mena, Diego, additional, Valdez-Ruvalcaba, Héctor, additional, Toledo-Treviño, Roberto, additional, Obiako, Reginald, additional, Abubakar, Sani, additional, Emeka, Oguike, additional, Olayemi, Balogun, additional, Lois, Melika, additional, Philip, Ibinaiye, additional, Comfort O, Olurishe, additional, Okubadejo, Njideka, additional, Agabi, Osigwe, additional, Ojo, Oluwadamilola, additional, Wahab, Kolawole, additional, Bello, Abiodun, additional, Ibukun, Oyinloye, additional, Sanayaolu, Olufemi, additional, Jimoh, Abdulraheem, additional, Waheed, Shahid, additional, Kamal, Dr.Ayeesha, additional, Shoaib, Raja Farhat, additional, Orooj, Fizza, additional, Majid, Sadaf, additional, Zehra, Taskeen, additional, Khan, Abdus Salam, additional, Shanker, Ravi, additional, Syed, Nadir Ali, additional, Ahmad, Nashwa, additional, Valencia, Ana, additional, Barrientos, Danny, additional, Ramirez, Jorge, additional, Calle, Pilar, additional, Palliyeguruge, Dilum, additional, Muthucumarana, Sumudu, additional, Ratnayaka, Shiroma, additional, Ganihiarachchi, Dilhara, additional, Bandaranayake, Arundathi, additional, Somaratne, S.D.B, additional, Narayana, Saumya, additional, Gallage, Sithara, additional, Senanayake, Bimsara, additional, Samarasiri, Udari, additional, Luke, Dunya, additional, Sivapathasundaram, Mythily, additional, Sahadevan, Vithoosan, additional, Rasmi, Amani, additional, Deshaka, Yuran, additional, Fernando, Nilukshi, additional, Munasinghe, Aruna, additional, Rathnapriya, Kapilanga, additional, Nissanka, A.S, additional, Karunathilake, Kanchana, additional, Gayan, Isuru, additional, Wijenayake, Kaminda, additional, Gunasekara, Hasitha, additional, Vidyarathne, Jagath, additional, Keshavaraj, Ajantha, additional, Janarthanan, Kanagasabapathy, additional, Gerald Jeevathasan, Arhivalaky, additional, Sivamainthan, Sivaram, additional, John Priyanth, Mathyamuthan, additional, John Priyanth, Abirami, additional, Rajendiran, Thambippillai, additional, Alwis, Sanjeewa, additional, Gunasekare, Nushara, additional, Liyanarachchi, Vasundara, additional, Dissanayake, Athula, additional, Uluwattage, Wimalasiri Mewa, additional, Ratnayake, Gimhani, additional, Rajinee, Charika, additional, Jayawardana, Sakura, additional, Peiris, Janaka, additional, Wicramasinghe, Ranjith, additional, Fernando, Chamila, additional, Abbas, Jessie, additional, Withanage, Nethmini, additional, Bandara, Makaranda, additional, Mai, Duy Ton, additional, Nguyen, Van Chi, additional, Dao, Viet Phuong, additional, Vuong, Xuan Trung, additional, Nguyen, Tien Dung, additional, Dinh, Trung Hieu, additional, Phan, Ha Quan, additional, Bui, Quoc Viet, additional, Phung, Dinh Tho, additional, Pham, Quang Tho, additional, Pham, Dinh Dai, additional, Do, Duc Thuan, additional, Dang, Phuc Duc, additional, Dang, Minh Duc, additional, Nguyen, Dang Hai, additional, Nguyen, Thi Phuong Nga, additional, Nguyen, Quoc Huy, additional, Pham, Quoc Dai, additional, Chau, Quoc Vinh, additional, Tai, Vinh Thy Van, additional, Le, Tran Vinh, additional, Le, Cong Tri, additional, Tran, Ha Mai Khuong, additional, Nguyen, Huu Khanh, additional, Ngyen, Hoang Minh Thao, additional, Vo, Duc Chien, additional, Nguyen, Thai My Phuong, additional, Tran, Trung Thanh, additional, Vo, Thi Hanh Vi, additional, Cao, Hao Nhien, additional, Nguyen, Ba Thang, additional, Le, Thi Ngoc Suong, additional, La, Thien Duc, additional, Pham, Chi Duc, additional, and Thai, Huy, additional

Published
2023
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36. Evaluating the efficiency of a nomogram based on the data of neurosurgical intensive care unit patients to predict pulmonary infection of multidrug-resistant Acinetobacter baumannii

Author

Wu, Di, primary, Sha, Zhuang, additional, Fan, Yibing, additional, Yuan, Jiangyuan, additional, Jiang, Weiwei, additional, Liu, Mingqi, additional, Nie, Meng, additional, Wu, Chenrui, additional, Liu, Tao, additional, Chen, Yupeng, additional, Feng, Jiancheng, additional, Dong, Shiying, additional, Li, Jin, additional, Sun, Jian, additional, Pang, Chongjie, additional, and Jiang, Rongcai, additional

Published
2023
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40. Improvements of the Tada formula in estimating the intracerebral hemorrhage volume based on computed tomography

Author

Sha, Zhuang, primary, Zhang, Xinjie, additional, Li, Zhanying, additional, Feng, Jiancheng, additional, Quan, Wei, additional, Dong, Shiying, additional, Liu, Mingqi, additional, Jiang, Weiwei, additional, Yuan, Jiangyuan, additional, Huang, Jinhao, additional, Gao, Chuang, additional, Tian, Ye, additional, An, Shuo, additional, Li, Chunming, additional, Wang, Yuanquan, additional, and Jiang, Rongcai, additional

Published
2023
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44. Comparison of endoscopic and open surgery in life-threatening large spontaneous supratentorial intracerebral hemorrhage: A propensity-matched analysis.

Author

Lin, Kun, cheng Lin, Zhi, hai Tang, Yin, Wei, De, Gao, Chuang, and Jiang, Rongcai

Subjects
CEREBRAL hemorrhage, ENDOSCOPIC surgery, GLASGOW Coma Scale, PROPENSITY score matching, DECOMPRESSIVE craniectomy
Abstract

Background: Conventionally, open surgery (OS), including standard craniotomy (SC) and decompressive craniectomy (DC) with hematoma evacuation, is adopted to treat life-threatening large spontaneous supratentorial intracerebral hemorrhage (ICH). Recently, endoscopic surgery (ES), a minimally invasive surgical treatment, has gained increased popularity. However, the safety and efficacy of ES for life-threatening large ICH is uncertain. Aim: The aim of this study was to evaluate the effectiveness and safety of ES for life-threatening large ICH and compare it with traditional OS. Methods: We retrospectively analyzed the clinical and imaging data of consecutive supratentorial ICH patients with preoperative Glasgow Coma Scale (GCS) score ⩽ 8, who underwent ES or OS between May 2015 and October 2021. To minimize bias in case selection, propensity score matching was performed (ratio 1:2, caliper o.2). The primary outcome was a prognosis-based dichotomized (favorable or unfavorable) outcome of the 5-point Glasgow Outcome Scale (GOS) at 6 months. Favorable outcome was defined as a GOS score of 4 to 5 at 6 months. Sensitivity analysis was also performed to ensure the robustness of the findings. Results: Of 695 patients who underwent surgical treatment for spontaneous ICH, 191 patients were identified to be eligible, with 58 patients in the ES group and 133 patients in the OS group. Propensity score matching improved covariate balance and generated a comparable cohort (53 ES and 106 OS) for all analyses. The ES group had a higher incidence of the primary outcome of favorable outcome at 6 months (ES 20/53 (37.7%) vs. OS 22/106 (20.8%); propensity score–matched relative risk (RR) (95% CI) = 1.74 (1.13–2.68); p = 0.013). Sensitivity analysis showed the result was stable. Conclusion: ES is a safe treatment for life-threatening large spontaneous supratentorial ICH patients and may achieve better outcomes than OS. [ABSTRACT FROM AUTHOR]

Published
2023
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