14 results on '"Jiang, Wun Kai"'
Search Results
2. Effect of long-term exposure to fine particulate matter on lung function decline and risk of chronic obstructive pulmonary disease in Taiwan: a longitudinal, cohort study
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Guo, Cui, Zhang, Zilong, Lau, Alexis K H, Lin, Chang Qing, Chuang, Yuan Chieh, Chan, Jimmy, Jiang, Wun Kai, Tam, Tony, Yeoh, Eng-Kiong, Chan, Ta-Chien, Chang, Ly-Yun, and Lao, Xiang Qian
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- 2018
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3. Long-term exposure to ambient fine particulate matter (PM2.5) and incident type 2 diabetes: a longitudinal cohort study
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Lao, Xiang Qian, Guo, Cui, Chang, Ly-yun, Bo, Yacong, Zhang, Zilong, Chuang, Yuan Chieh, Jiang, Wun Kai, Lin, Changqing, Tam, Tony, Lau, Alexis K. H., Lin, Chuan-Yao, and Chan, Ta-Chien
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- 2019
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4. Long-Term Exposure to Fine Particulate Matter, Blood Pressure, and Incident Hypertension in Taiwanese Adults
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Zhang, Zilong, Guo, Cui, Lau, Alexis K.H., Chan, Ta-Chien, Chuang, Yuan Chieh, Lin, Changqing, Jiang, Wun Kai, Yeoh, Eng- kiong, Tam, Tony, Woo, Kam S., Yan, Bryan P., Chang, Ly-yun, Wong, Martin C.S., and Lao, Xiang Qian
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Hypertension -- Risk factors ,Air pollution -- Health aspects ,Particulate matter -- Health aspects ,Blood pressure -- Health aspects ,Cardiovascular diseases -- Risk factors ,Environmental issues ,Health - Abstract
Background: Long-term exposure to particulate matter (PM) air pollution may increase blood pressure and the risk of hypertension. However, epidemiological evidence is scarce and inconsistent. Objectives: We investigated the associations between long-term exposure to PM with an aerodynamic diameter Methods: We studied 361,560 adults [greater than or equal to]18 y old from a large cohort who participated in a standard medical examination program during 2001 to 2014. Among this group, 125,913 nonhypertensive participants were followed up. A satellite-based spatiotemporal model was used to estimate the 2-y average P[M.sub.2.5] concentrations at each participant's address. Multivariable linear regression was used in the cross-sectional data analysis with the 361,560 participants to investigate the associations between P[M.sub.2.5] and systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse pressure (PP), and Cox proportional hazard regression was used in the cohort data analysis with the 125,913 participants to investigate the associations between P[M.sub.2.5] and incident hypertension. Results: Each 10-[micro]g/[m.sup.3] increment in the 2-y average P[M.sub.2.5] concentration was associated with increases of 0.45 mmHg [95% confidence interval (CI): 0.40, 0.50], 0.07 mmHg (95% CI: 0.04, 0.11), and 0.38 mmHg (95% CI: 0.33, 0.42) in SBP, DBP, and PP, respectively, after adjusting for a wide range of covariates and possible confounders. Each 10-[micro]g/[m.sup.3] increment in the 2-y average P[M.sub.2.5] concentration was associated with an increase of 3% in the risk of developing hypertension [hazard ratio = 1.03 (95% CI: 1.01, 1.05)]. Stratified and sensitivity analyses yielded similar results. Conclusions: Long-term exposure to P[M.sub.2.5] air pollution is associated with higher blood pressure and an increased risk of hypertension. These findings reinforce the importance of air pollution mitigation strategies to reduce the risk of cardiovascular disease. https://doi.org/10.1289/EHP2466, Introduction Cardiovascular disease (CVD) is a leading cause of death worldwide, contributing to 17.7 million deaths in 2015 (WHO 2017). Many epidemiological studies have shown that long-term exposure to particulate [...]
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- 2018
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5. Exposure to ambient fine particulate matter and semen quality in Taiwan
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Lao, Xiang Qian, Zhang, Zilong, Lau, Alexis K H, Chan, Ta-Chien, Chuang, Yuan Chieh, Chan, Jimmy, Lin, Changqing, Guo, Cui, Jiang, Wun Kai, Tam, Tony, Hoek, Gerard, Kan, Haidong, Yeoh, Eng-Kiong, Chang, Ly-Yun, One Health Chemisch, dIRAS RA-2, dIRAS RA-I&I RA, One Health Chemisch, dIRAS RA-2, and dIRAS RA-I&I RA
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Adult ,Male ,Adolescent ,Fine particulate ,Population ,Taiwan ,Environment ,010501 environmental sciences ,Semen analysis ,complex mixtures ,01 natural sciences ,Toxicology ,Young Adult ,03 medical and health sciences ,Semen quality ,semen quality ,0302 clinical medicine ,Air Pollution ,Humans ,Medicine ,education ,Sperm motility ,0105 earth and related environmental sciences ,Air Pollutants ,education.field_of_study ,030219 obstetrics & reproductive medicine ,Sperm Count ,medicine.diagnostic_test ,sperm morphology ,business.industry ,Confounding ,Public Health, Environmental and Occupational Health ,Environmental Exposure ,Environmental exposure ,Middle Aged ,Sperm ,Semen Analysis ,Cross-Sectional Studies ,Logistic Models ,fine particulate matter ,Sperm Motility ,Particulate Matter ,business - Abstract
ObjectivesEnvironmental exposure to chemicals has been considered a potential factor contributing to deteriorated semen quality. However, previous literature on exposure to air pollution and semen quality is inconsistent. We therefore investigated the health effects of short-term and long-term exposure to fine particulate matter (PM2.5) on semen quality in Taiwanese men from the general population.MethodsA cross-sectional study was conducted among 6475 male participants aged 15–49 years who participated in a standard medical examination programme in Taiwan between 2001 and 2014. Semen quality was assessed according to the WHO 1999 guidelines, including sperm concentration, total motility, progressive motility and morphology. Three-month and 2-year average PM2.5concentrations were estimated at each participant’s address using a spatiotemporal model based on satellite-derived aerosol optical depth data. Multivariable linear and logistic regressions were used to examine the associations between PM2.5and semen quality.ResultsA robust association was observed between exposure to PM2.5and decreased normal morphology. Every increment of 5 µg/m3in 2-year average PM2.5was significantly associated with a decrease of 1.29% in sperm normal morphology and a 26% increased risk of having the bottom 10% of sperm normal morphology, after adjusting for a wide range of potential confounders (p3in 2-year average PM2.5was associated with an increase of 1.03×106/mL in sperm concentration and a 10% decreased risk of being the bottom 10% of sperm concentration (both p2.5.ConclusionsExposure to ambient PM2.5air pollution is associated with a lower level of sperm normal morphology and a higher level of sperm concentration.
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- 2017
6. Long-Term Exposure to Ambient Fine Particulate Matter and Chronic Kidney Disease: A Cohort Study
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Chan, Ta-Chien, Zhang, Zilong, Lin, Bo-Cheng, Lin, Changqing, Deng, Han-Bing, Chuang, Yuan Chieh, Chan, Jimmy W M, Jiang, Wun Kai, Tam, Tony, Chang, Ly-Yun, Hoek, Gerard, Lau, Alexis K H, Lao, Xiang Qian, One Health Chemisch, dIRAS RA-2, dIRAS RA-I&I RA, One Health Chemisch, dIRAS RA-2, and dIRAS RA-I&I RA
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Adult ,Male ,medicine.medical_specialty ,Fine particulate ,Health, Toxicology and Mutagenesis ,Taiwan ,010501 environmental sciences ,urologic and male genital diseases ,01 natural sciences ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Air Pollution ,Environmental health ,Humans ,Medicine ,Longitudinal Studies ,030212 general & internal medicine ,Particle Size ,Renal Insufficiency, Chronic ,Proportional Hazards Models ,0105 earth and related environmental sciences ,business.industry ,Research ,Public health ,Public Health, Environmental and Occupational Health ,Environmental Exposure ,Middle Aged ,medicine.disease ,female genital diseases and pregnancy complications ,Female ,Particulate Matter ,business ,Cohort study ,Kidney disease - Abstract
BACKGROUND: Chronic kidney disease (CKD) is a serious global public health challenge, but there is limited information on the connection between air pollution and risk of CKD. OBJECTIVE: The aim of this study was to investigate the association between long-term exposure to particulate matter (PM) with an aerodynamic diameter of less than [Formula: see text] ([Formula: see text]) and the development of CKD in a large cohort. METHODS: A total of 100,629 nonCKD Taiwanese residents age 20 y or above were included in this study between 2001 and 2014. Ambient [Formula: see text] concentration was estimated at each participant's address using a satellite-based spatiotemporal model. Incident CKD cases were identified by an estimated glomerular filtration rate (eGFR) of less than [Formula: see text]. We collected information on a wide range of potential confounders/modifiers during the medical examinations. Cox proportional hazard regression was applied to calculate hazard ratios (HRs). RESULTS: During the follow-up, 4,046 incident CKD cases were identified, and the incidence rate was 6.24 per 1,000 person-years. In contrast with participants with the first quintile exposure of [Formula: see text], participants with the fourth and fifth quintiles exposure of [Formula: see text] had increased risk of CKD development, adjusting for age, sex, educational level, smoking, drinking, body mass index, systolic blood pressure, fasting glucose, total cholesterol, and self-reported heart disease or stroke, with an HR [95% confidence interval (CI)] of 1.11 (1.02, 1.22) and 1.15 (1.05, 1.26), respectively. A significant concentration-response trend was observed ([Formula: see text]). Every [Formula: see text] increment in the [Formula: see text] concentration was associated with a 6% higher risk of developing CKD (HR: 1.06, 95% CI: 1.02, 1.10). Sensitivity and stratified analyses yielded similar results. CONCLUSIONS: Long-term exposure to ambient [Formula: see text] was associated with an increased risk of CKD development. Our findings reinforce the urgency to develop global strategies of air pollution reduction to prevent CKD. https://doi.org/10.1289/EHP3304.
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- 2018
7. Particulate matter air pollution, physical activity and systemic inflammation in Taiwanese adults
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Zhang, Zilong, Hoek, Gerard, Chang, Ly-Yun, Chan, Ta-Chien, Guo, Cui, Chuang, Yuan Chieh, Chan, Jimmy, Lin, Changqing, Jiang, Wun Kai, Guo, Yuming, Vermeulen, Roel, Yeoh, Eng-Kiong, Tam, Tony, Lau, Alexis K H, Griffiths, Sian, Lao, Xiang Qian, One Health Chemisch, dIRAS RA-2, dIRAS RA-I&I RA, One Health Chemisch, dIRAS RA-2, and dIRAS RA-I&I RA
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Adult ,Male ,medicine.medical_specialty ,Taiwan ,Physical activity ,010501 environmental sciences ,Systemic inflammation ,complex mixtures ,01 natural sciences ,Gastroenterology ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Air Pollution ,Internal medicine ,White blood cell ,medicine ,Humans ,Aerodynamic diameter ,030212 general & internal medicine ,Exercise ,0105 earth and related environmental sciences ,Inflammation ,business.industry ,Confounding ,Public Health, Environmental and Occupational Health ,Middle Aged ,Confidence interval ,Chronic disease ,medicine.anatomical_structure ,Cohort ,Immunology ,Female ,medicine.symptom ,business ,Particulate matter - Abstract
Background The protective effects of physical activity (PA) against chronic disease can be partially ascribed to its anti-inflammatory effects. On the other hand, long-term exposure to particulate matter with an aerodynamic diameter less than 2.5 μm (PM 2.5 ) may induce systemic inflammation. Objective To investigate the joint effects of habitual PA and long-term exposure to PM 2.5 on systemic inflammation in a large cohort of Taiwanese adults. Methods We studied 359,067 adult participants from a cohort consisting of Taiwanese residents who participated in a standard medical examination program from 2001 to 2014. Peripheral white blood cell (WBC) and differential counts were measured as indicators of systemic inflammation. Two-year average concentration of PM 2.5 was estimated at each participant‘s address using a satellite-based spatio-temporal model. Habitual PA level was assessed by questionnaire (inactive, low, moderate and high). Mixed-effects linear regression model was used to examine the associations of WBC counts with PM 2.5 and PA. Results Compared with inactive participants, those with low, moderate or high PA levels had 0.36% [95% confidence interval (CI): 0.31%, 0.41%], 0.70% (95%CI: 0.65%, 0.76%) and 1.16% (95%CI: 1.11%, 1.22%) lower WBC counts, respectively, after adjusting for PM 2.5 exposure and a wide range of confounders. Long-term PM 2.5 exposure was associated with increased WBC counts at all PA levels. Analyses for differential counts generated similar results. No significant interaction was observed between PA and PM 2.5 exposure ( P for interaction = 0.59). Conclusions Habitual PA was associated with statistically significant lower markers of systemic inflammation across different levels of PM 2.5 . Effects of PA and PM 2.5 exposure on systemic inflammation are independent.
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- 2018
8. Association of long-term exposure to fine particulate matter and incident dyslipidaemia: A longitudinal cohort study
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Bo, Yacong, primary, Chang, Ly-Yun, additional, Guo, Cui, additional, Zhang, Zilong, additional, Lin, Changqing, additional, Chuang, Yuan Chieh, additional, Jiang, Wun Kai, additional, Tam, Tony, additional, Chan, Ta-Chien, additional, Lin, Chuan-Yao, additional, Lau, Alexis KH., additional, Lao, Xiang Qian, additional, and Yeoh, Eng-Kiong, additional
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- 2019
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9. Long-term exposure to ambient particulate matter (PM2.5) is associated with platelet counts in adults
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Zhang, Zilong, primary, Chan, Ta-Chien, additional, Guo, Cui, additional, Chang, Ly-yun, additional, Lin, Changqing, additional, Chuang, Yuan Chieh, additional, Jiang, Wun Kai, additional, Ho, Kin Fai, additional, Tam, Tony, additional, Woo, Kam S., additional, Lau, Alexis K.H., additional, and Lao, Xiang Qian, additional
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- 2018
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10. Short and Long-Term Exposure to Ambient Fine Particulate Matter and Semen Quality in Taiwan
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Lao, Xiang Qian, primary, Zhang, Zilong, additional, Lau, Alexis KH, additional, Chan, Ta-Chien, additional, Chuang, Yuan Chieh, additional, Chan, Jimmy, additional, Lin, Changqing, additional, Guo, Cui, additional, Jiang, Wun Kai, additional, Tam, Tony, additional, Hoek, Gerard, additional, Kan, Haidong, additional, Yeoh, Eng-kiong, additional, and Chang, Ly-yun, additional
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- 2018
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11. Liver Fat, Hepatic Enzymes, Alkaline Phosphatase and the Risk of Incident Type 2 Diabetes: A Prospective Study of 132,377 Adults
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Chen, Sean Chun-Chang, primary, Tsai, Shan Pou, additional, Jhao, Jing-Yun, additional, Jiang, Wun-Kai, additional, Tsao, Chwen Keng, additional, and Chang, Ly-Yun, additional
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- 2017
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12. Long-term exposure to ambient fine particulate matter (PM2.5) and incident type 2 diabetes: a longitudinal cohort study.
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Lao, Xiang Qian, Guo, Cui, Chang, Ly-yun, Bo, Yacong, Zhang, Zilong, Chuang, Yuan Chieh, Jiang, Wun Kai, Lin, Changqing, Tam, Tony, Lau, Alexis K. H., Lin, Chuan-Yao, and Chan, Ta-Chien
- Abstract
Aims/hypothesis: Information on the associations of long-term exposure to fine particulate matter (with an aerodynamic diameter less than 2.5 μm; PM
2.5 ) with the development of type 2 diabetes is scarce, especially for south-east Asia, where most countries are experiencing serious air pollution. This study aimed to investigate the long-term effects of exposure to ambient PM2.5 on the incidence of type 2 diabetes in a population of Taiwanese adults. Methods: A total of 147,908 participants without diabetes, at least 18 years of age, were recruited in a standard medical examination programme between 2001 and 2014. They were encouraged to take medical examinations periodically and underwent at least two measurements of fasting plasma glucose (FPG). Incident type 2 diabetes was identified as FPG ≥7 mmol/l or self-reported physician-diagnosed diabetes in the subsequent medical visits. The PM2.5 concentration at each participant's address was estimated using a satellite-based spatiotemporal model with a resolution of 1 × 1 km2 . The 2 year average of PM2.5 concentrations (i.e. the year of and the year before the medical examination) was treated as an indicator of long-term exposure to ambient PM2.5 air pollution. We performed Cox regression models with time-dependent covariates to analyse the long-term effects of exposure to PM2.5 on the incidence of type 2 diabetes. A wide range of covariates were introduced in the models to control for potential effects, including age, sex, education, season, year, smoking status, alcohol drinking, physical activity, vegetable intake, fruit intake, occupational exposure, BMI, hypertension and dyslipidaemia (all were treated as time-dependent covariates except for sex). Results: Compared with the participants exposed to the first quartile of ambient PM2.5 , participants exposed to the second, third and fourth quartiles of ambient PM2.5 had HRs of 1.28 (95% CI 1.18, 1.39), 1.27 (95% CI 1.17, 1.38) and 1.16 (95% CI 1.07, 1.26), respectively, for the incidence of type 2 diabetes. Participants who drank occasionally or regularly (more than once per week) or who had a lower BMI (<23 kg/m2 ) were more sensitive to the long-term effects of exposure to ambient PM2.5 . Conclusions/interpretation: Long-term exposure to ambient PM2.5 appears to be associated with a higher risk of developing type 2 diabetes in this Asian population experiencing high levels of air pollution. [ABSTRACT FROM AUTHOR]- Published
- 2019
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13. Long-term exposure to ambient particulate matter (PM 2.5 ) is associated with platelet counts in adults.
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Zhang Z, Chan TC, Guo C, Chang LY, Lin C, Chuang YC, Jiang WK, Ho KF, Tam T, Woo KS, Lau AKH, and Lao XQ
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- Adult, Aged, Air Pollution analysis, Biomarkers analysis, Cardiovascular Diseases chemically induced, Cardiovascular Diseases epidemiology, Cohort Studies, Environmental Exposure analysis, Female, Humans, Linear Models, Male, Middle Aged, Air Pollutants analysis, Air Pollution statistics & numerical data, Environmental Exposure statistics & numerical data, Particulate Matter analysis, Platelet Count
- Abstract
Background: The prothrombotic effects of particulate matter (PM) may underlie the association of air pollution with increased risks of cardiovascular disease. This study aimed to investigate the association between long-term exposure to PM with an aerodynamic diameter ≤2.5 μm (PM
2.5 ) and platelet counts, a marker of coagulation profiles., Methods: The study participants were from a cohort consisting of 362,396 Taiwanese adults who participated in a standard medical examination program between 2001 and 2014. Platelet counts were measured through Complete Blood Count tests. A satellite-based spatio-temporal model was used to estimate 2-year average ambient PM2.5 concentration at each participant's address. Mixed-effects linear regression models were used to investigate the association between PM2.5 exposure and platelet counts., Results: This analysis included 175,959 men with 396,248 observations and 186,437 women with 397,877 observations. Every 10-μg/m3 increment in the 2-year average PM2.5 was associated with increases of 0.42% (95% CI: 0.38%, 0.47%) and 0.49% (95% CI: 0.44%, 0.54%) in platelet counts in men and women, respectively. A series of sensitivity analyses, including an analysis in participants free of cardiometabolic disorders, confirmed the robustness of the observed associations. Baseline data analyses showed that every 10-μg/m3 increment in PM2.5 was associated with higher risk of 17% and 14% of having elevated platelet counts (≥90th percentile) in men and women, respectively., Conclusions: Long-term exposure to PM2.5 appears to be associated with increased platelet counts, indicating potential adverse effects on blood coagulability., (Copyright © 2018 Elsevier Ltd. All rights reserved.)- Published
- 2018
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14. Particulate matter air pollution, physical activity and systemic inflammation in Taiwanese adults.
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Zhang Z, Hoek G, Chang LY, Chan TC, Guo C, Chuang YC, Chan J, Lin C, Jiang WK, Guo Y, Vermeulen R, Yeoh EK, Tam T, Lau AKH, Griffiths S, and Lao XQ
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- Adult, Cohort Studies, Female, Humans, Inflammation etiology, Male, Middle Aged, Taiwan epidemiology, Air Pollution adverse effects, Exercise, Inflammation epidemiology, Particulate Matter adverse effects
- Abstract
Background: The protective effects of physical activity (PA) against chronic disease can be partially ascribed to its anti-inflammatory effects. On the other hand, long-term exposure to particulate matter with an aerodynamic diameter less than 2.5μm (PM
2.5 ) may induce systemic inflammation., Objective: To investigate the joint effects of habitual PA and long-term exposure to PM2.5 on systemic inflammation in a large cohort of Taiwanese adults., Methods: We studied 359,067 adult participants from a cohort consisting of Taiwanese residents who participated in a standard medical examination program from 2001 to 2014. Peripheral white blood cell (WBC) and differential counts were measured as indicators of systemic inflammation. Two-year average concentration of PM2.5 was estimated at each participant's address using a satellite-based spatio-temporal model. Habitual PA level was assessed by questionnaire (inactive, low, moderate and high). Mixed-effects linear regression model was used to examine the associations of WBC counts with PM2.5 and PA., Results: Compared with inactive participants, those with low, moderate or high PA levels had 0.36% [95% confidence interval (CI): 0.31%, 0.41%], 0.70% (95%CI: 0.65%, 0.76%) and 1.16% (95%CI: 1.11%, 1.22%) lower WBC counts, respectively, after adjusting for PM2.5 exposure and a wide range of confounders. Long-term PM2.5 exposure was associated with increased WBC counts at all PA levels. Analyses for differential counts generated similar results. No significant interaction was observed between PA and PM2.5 exposure (P for interaction=0.59)., Conclusions: Habitual PA was associated with statistically significant lower markers of systemic inflammation across different levels of PM2.5 . Effects of PA and PM2.5 exposure on systemic inflammation are independent., (Copyright © 2017 Elsevier GmbH. All rights reserved.)- Published
- 2018
- Full Text
- View/download PDF
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