Search

Sulpplemental 1 (Fig. S1, Fig. S2 and Fig. S3)

Traditional elevator indicators have been improved for traditional elevator indicators with strict communication requirements, high communication costs, and unsuitable for fieldbus-guided industrial production. That is, the PROFIBUS-DP interface is developed for the traditional hoist multi-level indicator, and the bus bridge is used to complete the communication protocol conversion during the data transmission process, so that it can be added to the field bus production system. This paper deals with the design of the multi-level indicator hardware circuit of the hoist with PROFIBUS-DP interface and the design of the software circuit. Finally, the system test platform was built to verify that the hoist indicator structure is simple and reliable.

Due to the increasing number of private cars in today's society, there are a lot of safety problems in car reversing. This paper proposes a research program of ultrasonic ranging car reversing radar system with higher accuracy and better warning effect. According to the principle of ultrasonic ranging, the AT89C51 single-chip microcomputer is selected as the core circuit, and the anti-interference error processing is adopted in the processing of the single-chip microcomputer to solve the multiple measurement, the transmission time interval and the dead zone measurement problem of the ultrasonic ranging. Car reversing radar system based on ultrasonic ranging adopt transmitting and receiving circuit, will determine the time difference in the single chip microcomputer. the results are sent to the digital display circuit and voice broadcast circuit. Finally, it is verified by experiments that after ultrasonic error measurement adopts error processing, under the complicated environmental conditions, the accuracy of ranging is higher, the number of false alarms is reduced, and the device has high reliability and practicability.

With the factory to power consumption, efficiency, noise, electromagnetic compatibility requirements gradually increasing, brushless dc motor will be more and more widely applied in the new energy electric cars. The paper propose the improvement of the freescale to provide a high level of integration solutions - S12ZVM mixed-signal MCU series and introduce the detail sensorless brushless dc motor control scheme implementation. Based on the freescale semiconductor MC9S12ZVML128 dedicated to auto motor control chip, combining with the FreeMASTER monitoring software user interface, build high integration brushless dc motor control experimental platform. The experimental results show the applicability and advantage of S12ZVM series control scheme on the new energy automobile motor control.

Random skin flaps have been widely applied in reconstructive and plastic surgery; however, necrosis usually happens due to insufficient blood supply in the ischemic area of flaps. Curcumin (CUR) is a primary bioactive compound of turmeric (Curcuma longa, L.), which has been proven to be effective on anticancer, decreasing oxidative stress and apoptosis through activating autophagy, and promoting angiogenesis in ischemic tissue. Therefore, the potential therapeutic effect of CUR on promoting survival of ischemic random skin flaps and its underlying mechanism associated with autophagy were investigated. After establishment of dorsal random skin flaps, sixty mice were randomly divided into three groups: Control, CUR or CUR+3-methyladenine (3-MA, an autophagy inhibitor). The results showed that CUR increased the viability area and blood flow as well as relieved the edema of skin flaps through promoting angiogenesis, decreasing oxidative stress, and inhibiting apoptosis of the ischemic area. Further study confirmed that CUR activated autophagy in the random skin flaps, and 3-MA effectively reversed the effect on viability, neovascularization, oxidative stress and apoptosis, suggesting autophagy played a vital role in these CUR’s protective effect on random skin flaps. Moreover, this CUR-induced autophagy should be mediated through downregulating the PI3K/AKT/mTOR signaling pathway. Together with secondary response of increased angiogenesis, reduced oxidative stress and apoptosis, CUR effectively improved survival of random skin flaps in vivo. To sum up, our research showed the great potential of CUR using as a promising flap protective therapy for random skin flap survival and regeneration.

This study aims to investigate the coeffects of predominantly exposed anatase TiO2{001} and {101} and CeO2 loading on the photo-oxidation of Hg0 to relieve the adverse effects caused by higher temperatures of 50–250 °C. The effect of loading CeO2 on the photocatalytic activity of morphology-controlled TiO2 was not only investigated using DFT with U correction but also experimentally analyzed by characterizing the electrochemical properties and the formation of free radicals. The theoretical calculation showed that CeO2 loading on TiO2{101} was more stable than that on TiO2{001}. Accordingly, a larger portion of CeO2 was observed to anchor to the (101) plane than to the (001) plane. CeO2 loading is more beneficial for increasing the distribution of photo-induced electrons and holes on the surface of 7%CeTi than on the surface of TiO2 and increases the energy difference between the conduction band edge of 7%CeTi and the standard redox potential of O2/·O2−. Correspondingly, the photocatalytic removal efficiencies (PREs) of Hg0 by 7%CeTi were significantly enhanced compared with those of pristine TiO2. The effect of CeO2 was highly morphologically dependent on the photocatalytic activity. This study provides valuable insight into surface engineering strategies for morphology-controlled photocatalysts for air pollution control technology.

Pancreatic ductal adenocarcinoma (PDAC) has one of the poorest prognoses of all malignancy types. To improve the survival of patients with PDAC, the development of novel anticancer agents is warranted. Riproximin (Rpx) is a newly identified plant lectin, which was isolated from Ximenia americana. The ribosome inactivating protein of type II exhibits potent anticancer activity as recently demonstrated. The rat PDAC cell line ASML was used for in vitro and in vivo studies. The antiproliferative effect of Rpx was assessed using an MTT assay. The modulation of proteins involved in apoptosis was evaluated using western blotting. Tumor-bearing nude rats were treated with Rpx, gemcitabine (GEM) or dinaline (DIN) as single agents, or a combination of Rpx with GEM, or DIN. Rpx was administered intraperitoneally at doses of 1.7–5.4 µg/kg, three times/week, GEM was administered intravenously (50 mg/kg/week) and DIN perorally (10 mg/kg, 5 times/week). Rpx inhibited ASML cell proliferation at IC50-values of 0.8–172 pM, caused apoptosis and reduced tumor growth significantly by 90% (P