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Your search keyword '"Jiang, Yong'An"' showing total 14 results
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14 results on '"Jiang, Yong'An"'

5. The Application Value of CT Radiomics Combined with Clinical Parameters in Predicting the Duration of Invasive Mechanical Ventilation in Patients with Traumatic Brain Injury

Author

Fan, Xinjiang, primary, Jiang, Yong’An, additional, Fan, Hengyi, additional, Yuan, Raorao, additional, Li, Yuping, additional, Zhang, Yichen, additional, Qin, Qian, additional, Cai, Jianhui, additional, Huang, Jun, additional, Zhang, Yan, additional, and Cheng, Shiqi, additional

Published
2024
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13. Determination and toxicity evaluation of the generated byproducts from sulfamethazine degradation during catalytic oxidation process

Author

Jiang Yong'an, Yanhua Xu, Xiyang Liu, Yongjun Zhang, Fei Huang, Kun Zhao, Yang Yu, and Yide He

Subjects
Environmental Engineering, Health, Toxicology and Mutagenesis, 0208 environmental biotechnology, 02 engineering and technology, 010501 environmental sciences, Ecotoxicology, 01 natural sciences, Catalysis, Gas Chromatography-Mass Spectrometry, Water Purification, chemistry.chemical_compound, Anti-Infective Agents, Nitric acid, Environmental Chemistry, Animals, Humans, Microbial biodegradation, Zebrafish, 0105 earth and related environmental sciences, Sewage, Public Health, Environmental and Occupational Health, Sulfamethazine, General Medicine, General Chemistry, Pollution, 020801 environmental engineering, Anti-Bacterial Agents, Catalytic oxidation, chemistry, Environmental chemistry, Toxicity, Respirometer, Degradation (geology), Ecotoxicity, Oxidation-Reduction
Abstract

Sulfamethazine (SMZ), a kind of sulfonamide antibiotics, can exist for a long periods of time and has been widely detected in the environment, which could pose a potential health threat to human beings. In this study, sludge-derived carbon (SC) catalyst was modified and applied to degrade SMZ during catalytic oxidation process. Degradation products and possible transformation pathways were investigated based on data of GC–MS. The toxicity evolution of SMZ degradation after catalytic oxidation process was tested with zebrafish and microbial degradation respirometer. As a consequence, SC modified with nitric acid (SC HNO3) exhibited highly catalytic efficiency reached 92.2% SMZ conversion and 75.2% total organic carbon (TOC) removal rate after 480 min. Ten kinds of possible products were identified by GC–MS during degradation process of SMZ, indicating two possible pathways. No pronounced malformation was observed in the toxicity experiments with zebrafish until 120 h post fertilization (hpf). However, further analysis showed that zebrafish incubated with SMZ solution had higher mortality, lower hatching rate, slower spontaneous movement and shorter body length, compared with the group used normal nutrient solution, while the water after treatment had lower toxicity effects on zebrafish. The toxicity experiments with microbial degradation respirometer showed that SMZ solution had lower value of oxygen uptake, which indicated that SMZ solution had higher values of toxicity and inhibition of pharmaceutical compounds. This study provides a catalyst with low cost and high catalytic efficiency for degradation process of SMZ and gives a deeper insight into the ecotoxicity of treated water.

Published
2019

14. Association of triglyceride glucose index with stroke: from two large cohort studies and mendelian randomization analysis.

Author

Jiang Y, Shen J, Chen P, Cai J, Zhao Y, Liang J, Cai J, Cheng S, and Zhang Y

Abstract

Introduction: The triglyceride glucose index (TyG) is associated with cardiovascular diseases; however, its association with stroke remains unclear. This study aimed to elucidate this relationship by examining two extensive cohort studies using two-sample Mendelian randomization (MR)., Methods: Using data from the 1999-2018 National Health and Nutrition Examination Survey (NHANES) and the Medical Information Mart for Intensive Care (MIMIC)-IV, the correlation between TyG (continuous and quartile) and stroke was examined using multivariate Cox regression models and sensitivity analyses. Two-sample MR was employed to establish causality between TyG and stroke using the inverse variance weighting method. Genome-wide association study catalog queries were performed for single nucleotide polymorphism-mapped genes, and the STRING platform used to assess protein interactions. Functional annotation and enrichment analyses were also conducted., Results: From the NHANES and MIMIC-IV cohorts, we included 740 and 589 participants with stroke, respectively. After adjusting for covariates, TyG was linearly associated with the risk of stroke death (NHANES: hazard ratio [HR] 0.64, 95% confidence interval [CI]: 0.41-0.99, P=0.047; Q3 vs. Q1, HR 0.62, 95%CI: 0.40-0.96, P=0.033; MIMIC-IV: HR 0.46, 95%CI: 0.27-0.80, P=0.006; Q3 vs. Q1, HR 0.32, 95%CI: 0.12-0.86; Q4 vs. Q1, HR 0.30, 95%CI: 0.10-0.89, P=0.030, P for trend=0.017). Two-sample MR analysis showed genetic prediction supported a causal association between a higher TyG and a reduced risk of stroke (odds ratio 0.711, 95%CI: 0.641-0.788, P=7.64e-11)., Conclusions: TyG was causally associated with a reduced risk of stroke. TyG is a critical factor for stroke risk management., (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.)

Published
2024
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