Search

Your search keyword '"Jiang, Yucui"' showing total 32 results
Start Over Author "Jiang, Yucui"
32 results on '"Jiang, Yucui"'

7. Gastrodin alleviates NTG-induced migraine-like pain via inhibiting succinate/HIF-1α/TRPM2 signaling pathway in trigeminal ganglion

Author

Ma, Chao, primary, Zhu, Chunran, additional, Zhang, Yajun, additional, Yu, Mei, additional, Song, Yizhi, additional, Chong, Yulong, additional, Yang, Yan, additional, Zhu, Chan, additional, Jiang, Yucui, additional, Wang, Changming, additional, Cheng, Shuo, additional, Jia, Keke, additional, Yu, Guang, additional, Li, Jia, additional, and Tang, Zongxiang, additional

Published
2023
Full Text
View/download PDF

10. ccTCM: a quantitative component and compound platform for promoting the research of traditional Chinese medicine

Author

Yang, Dongqing, primary, Zhu, Zhu, additional, Yao, Qi, additional, Chen, Cuihua, additional, Chen, Feiyan, additional, Gu, Ling, additional, Jiang, Yucui, additional, Chen, Lin, additional, Zhang, Jingyuan, additional, Wu, Juan, additional, Gao, Xingsu, additional, Wang, Junqin, additional, Li, Guochun, additional, and Zhao, Yunan, additional

Published
2023
Full Text
View/download PDF

11. Data from HDAC11 Regulates Glycolysis through the LKB1/AMPK Signaling Pathway to Maintain Hepatocellular Carcinoma Stemness

Author

Bi, Lei, primary, Ren, Yidan, primary, Feng, Maoxiao, primary, Meng, Peng, primary, Wang, Qin, primary, Chen, Weiping, primary, Jiao, Qinlian, primary, Wang, Yuli, primary, Du, Lutao, primary, Zhou, Fuqiong, primary, Jiang, Yucui, primary, Chen, Feiyan, primary, Wang, Chuanxin, primary, Tang, Bo, primary, and Wang, Yunshan, primary

Published
2023
Full Text
View/download PDF

23. HDAC11 Regulates Glycolysis through the LKB1/AMPK Signaling Pathway to Maintain Hepatocellular Carcinoma Stemness

Author

Bi, Lei, primary, Ren, Yidan, additional, Feng, Maoxiao, additional, Meng, Peng, additional, Wang, Qin, additional, Chen, Weiping, additional, Jiao, Qinlian, additional, Wang, Yuli, additional, Du, Lutao, additional, Zhou, Fuqiong, additional, Jiang, Yucui, additional, Chen, Feiyan, additional, Wang, Chuanxin, additional, Tang, Bo, additional, and Wang, Yunshan, additional

Published
2021
Full Text
View/download PDF

28. Protein target identification of ginsenosides in skeletal muscle tissues: discovery of natural small-molecule activators of muscle-type creatine kinase

Author

Chen, Feiyan, Zhu, Kexuan, Chen, Lin, Ouyang, Liufeng, Chen, Cuihua, Gu, Ling, Jiang, Yucui, Wang, Zhongli, Lin, Zixuan, Zhang, Qiang, Shao, Xiao, Dai, Jianguo, and Zhao, Yunan

Abstract

Ginseng effectively reduces fatigue in both animal models and clinical trials. However, the mechanism of action is not completely understood, and its molecular targets remain largely unknown.

Published
2024
Full Text
View/download PDF

29. Facilitation of MrgprD by TRP‐A1 promotes neuropathic pain

Author

Wang, Changming, primary, Gu, Leying, additional, Ruan, Yonglan, additional, Geng, Xiao, additional, Xu, Miao, additional, Yang, Niuniu, additional, Yu, Lei, additional, Jiang, Yucui, additional, Zhu, Chan, additional, Yang, Yan, additional, Zhou, Yuan, additional, Guan, Xiaowei, additional, Luo, Wenqin, additional, Liu, Qin, additional, Dong, Xinzhong, additional, Yu, Guang, additional, Lan, Lei, additional, and Tang, Zongxiang, additional

Published
2018
Full Text
View/download PDF

31. The effect of targeted delivery of anti-TNF-α oligonucleotide into CD169+ macrophages on disease progression in lupus-prone MRL/lpr mice

Author

Huang, Zhen, Zhang, Zhengping, Zha, Yinhe, Liu, Jialin, Jiang, Yucui, Yang, Yang, Shao, Juan, Sun, Xulun, Cai, Xin, Yin, Yuan, Chen, Jiangning, Dong, Lei, and Zhang, Junfeng

Subjects
*TUMOR necrosis factors, *MACROPHAGES, *DISEASE progression, *OLIGONUCLEOTIDES, *DRUG delivery systems, *MONOCLONAL antibodies, *DRUG efficacy, *LABORATORY mice
Abstract

Abstract: Systemic blockade of TNF-α via monoclonal antibodies and soluble receptors has shown considerable effects against several typical autoimmune disorders, but remains unconvincing for the treatment of lupus. Based on our previous study, a CD169+ macrophage-specific therapy using TNF-α antisense oligonucleotides (ASO) was tested for its efficacy in MRL/lpr lupus-prone mice. ASO-containing cationic agarose hydrogel were injected into mice subcutaneously. Tissue distribution and cellular localization of ASO were determined. The therapeutic effects and possible mechanism were further studied in MRL/lpr lupus-prone mice. The results showed that specifically accumulation of the anti-TNF-α ASO in CD169+ macrophages could significantly reduce TNF-α expression in CD169+ macrophages and inhibit lymphocytes over-proliferation, finally resulted in the relief of the lupus-like symptoms of the animals. The nucleic acid drug based on CD169+ macrophage-specific TNF-α regulation represents a potential therapeutic approach that may be valuable for lupus therapy. [Copyright &y& Elsevier]

Published
2012
Full Text
View/download PDF

32. Facilitation of MrgprD by TRP-A1 promotes neuropathic pain.

Author

Wang C, Gu L, Ruan Y, Geng X, Xu M, Yang N, Yu L, Jiang Y, Zhu C, Yang Y, Zhou Y, Guan X, Luo W, Liu Q, Dong X, Yu G, Lan L, and Tang Z

Subjects
Animals, Calcium Signaling, Cells, Cultured, Cyclic AMP-Dependent Protein Kinases metabolism, Ganglia, Spinal cytology, Ganglia, Spinal metabolism, HEK293 Cells, Humans, Hyperalgesia metabolism, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Neurons metabolism, Receptors, G-Protein-Coupled metabolism, Signal Transduction drug effects, TRPA1 Cation Channel genetics, Up-Regulation, beta-Alanine pharmacology, Neuralgia physiopathology, Receptors, G-Protein-Coupled physiology, TRPA1 Cation Channel physiology
Abstract

Neuropathic pain remains a therapeutic challenge because of its complicated mechanisms. Mas-related GPCR D (MrgprD) is specifically expressed in small-diameter, nociceptive neurons of dorsal root ganglia (DRGs) and is implicated in pain modulation. However, the underlying mechanism of MrgprD involved in neuropathic pain remains elusive. In this study, we used behavioral experiments and physiologic examination methods to investigate the role of MrgprD in chronic constriction injury (CCI)-induced neuropathic pain. We found that MrgprD is necessary for the initiation of mechanical hypersensitivity and cold allodynia, but not for heat allodynia. Moreover, we demonstrated that transient receptor potential cation channel (TRP)-A1 was the ion channel downstream of MrgprD, and the β-alanine-induced calcium signal was attributed mostly to TRP-A1 function. We further showed that PKA serves as a downstream mediator of β-alanine-activated MrgprD signaling to activate TRP-A1 in DRG neurons and in human embryonic kidney 293 cells, to coexpress MrgprD and TRP-A1 plasmids. Finally, we found that the β-alanine-induced pain behavior was increased, whereas the itching behavior was unchanged in CCI models compared with sham-injured animals. Knockout of TRPA1 also attenuated the β-alanine-induced pain behavior in CCI models. In conclusion, MrgprD is essential in cold allodynia in CCI-induced neuropathic pain through the PKA-TRP-A1 pathway. TRP-A1 facilitates MrgprD to development of neuropathic pain. Our findings reveal a novel mechanism of neuropathic pain formation and highlight MrgprD as a promising drug target for the treatment of neuropathic pain.-Wang, C., Gu, L., Ruan, Y., Geng, X., Xu, M., Yang, N., Yu, L., Jiang, Y., Zhu, C., Yang, Y., Zhou, Y., Guan, X., Luo, W., Liu, Q., Dong, X., Yu, G., Lan, L., Tang, Z. Facilitation of MrgprD by TRP-A1 promotes neuropathic pain.

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results