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6 results on '"Jiangcheng He"'

1. The chemical composition of Diwu YangGan capsule and its potential inhibitory roles on hepatocellular carcinoma by microarray-based transcriptomics

Author

Qingxin Shi, Jiangcheng He, Guangya Chen, Jinlin Xu, Zhaoxiang Zeng, Xueyan Zhao, Binbin Zhao, Xiang Gao, Zhihua Ye, Mingzhong Xiao, and Hanmin Li

Subjects
Hepatocellular carcinoma, Diwu YangGan, Microarray analysis, LC-MS, Signaling pathways, Medicine
Abstract

The Traditional Chinese Medicine compound preparation known as Diwu Yanggan capsule (DWYG) can effectively hinder the onset and progression of hepatocellular carcinoma (HCC), which is recognized worldwide as a significant contributor to fatalities associated with cancer. Nevertheless, the precise mechanisms implicated have remained ambiguous. In present study, the model of HCC was set up by the 2-acetylaminofluorene (2-AAF)/partial hepatectomy (PH) in rats. To confirm the differentially expressed genes (DEGs) identified in the microarray analysis, real-time quantitative reverse transcription PCR (qRT-PCR) was conducted. In the meantime, the liquid chromatography-quadrupole time of flight mass spectrometry (LC-QTOF-MS/MS) was employed to characterize the component profile of DWYG. Consequently, the DWYG treatment exhibited the ability to reverse 51 variation genes induced by 2-AAF/PH. Additionally, there was an overlap of 54 variation genes between the normal and model groups. Upon conducting RT-qPCR analysis, it was observed that the expression levels of all genes were increased by 2-AAF/PH and subsequently reversed after DWYG treatment. Notably, the fold change of expression levels for all genes was below 0.5, with 3 genes falling below 0.25. Moreover, an investigation was conducted to determine the signaling pathway that was activated/inhibited in the HCC group and subsequently reversed in the DWYG group. Moreover, the component profile of DWYG encompassed a comprehensive compilation of 206 compounds that were identified or characterized. The findings of this study elucidated the potential alleviative mechanisms of DWYG in the context of HCC, thereby holding significant implications for its future clinical utilization and widespread adoption.

Published
2024
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4. In vivo detoxification of lipopolysaccharide by antimicrobial peptides

Author

Wenxu Zhang, Carsten Schmuck, Junchen Wu, and Jiangcheng He

Subjects
0301 basic medicine, Lipopolysaccharides, Lipopolysaccharide, Antimicrobial peptides, Biomedical Engineering, Chemie, Pharmaceutical Science, Bioengineering, medicine.disease_cause, 01 natural sciences, Microbiology, Sepsis, Cell wall, 03 medical and health sciences, chemistry.chemical_compound, Mice, medicine, Animals, Humans, Amino Acid Sequence, Pharmacology, biology, Dose-Response Relationship, Drug, 010405 organic chemistry, Pseudomonas aeruginosa, Septic shock, Organic Chemistry, Pathogenic bacteria, medicine.disease, biology.organism_classification, 0104 chemical sciences, 030104 developmental biology, chemistry, Biochemistry, A549 Cells, Bacteria, Biotechnology, Antimicrobial Cationic Peptides
Abstract

Abundant lipopolysaccharide (LPS) can result in sepsis and septic shock, indicating a serious Gram-negative bacterial contamination. We have developed a novel strategy based on dendritic antimicrobial peptides that can detoxify LPS. The dendritic antimicrobial peptides bind to LPS at the surface of Gram-negative bacteria, killing the bacteria but removing the LPS from the cell wall of dead Gram-negative bacteria, hence detoxifying pathogenic bacteria in its host cells and effectively improving survival of animals infected with Pseudomonas aeruginosa. Our findings provide a way to detoxify bacterial contamination.

Published
2017

6. Uplift of a coral island in the Andaman Sea due to the 2004 Sumatra earthquake measured using remote sensing reflectance of water

Author

Jiangcheng He and Soo Chin Liew

Subjects
geography, geography.geographical_feature_category, Coral, Magnitude (mathematics), Subsidence, Coral reef, Geotechnical Engineering and Engineering Geology, Tectonics, Waves and shallow water, Oceanography, Remote sensing (archaeology), Ocean color, Epicenter, Bathymetry, Electrical and Electronic Engineering, Reef, Seismology, Geology
Abstract

The 2004 Sumatra earthquake, together with the tsunami that followed, caused massive destruction in many coastal areas of the Indian Ocean. Uplift and subsidence of land near the epicenter of the earthquake in the Andaman Sea have been reported. In this letter, we report observations of the uplift in high-resolution SPOT-5 satellite images in a coral island near the Andaman Islands. The depth of the submerged reefs was measured using water reflectance models commonly employed in the ocean color research community. The uplift magnitude was estimated by the difference in water depth measured in the pre- and post-earthquake images, taking into account the difference in tide levels. The uplift was found to be 1.6 m with an uncertainty of about 0.3 m. The methodology could be widely used for efficient estimation of shallow water depth of broad areas, particularly over shallow coral reefs.

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