Search

Your search keyword '"Jiao, Ya-Bing"' showing total 11 results
Start Over Author "Jiao, Ya-Bing"
11 results on '"Jiao, Ya-Bing"'

11. Racemic norneolignans from the resin of Ferula sinkiangensis and their COX-2 inhibitory activity.

Author

Bao, Xing-Hui, Li, Yan-Peng, Li, Qian, Cheng, Yong-Xian, Jiao, Ya-Bing, Zhang, Hao-Xing, and Yan, Yong-Ming

Subjects
*CYCLOOXYGENASE 2, *MEDICINAL plants, *LIGNANS, *HIGH performance liquid chromatography, *PHENOLS, *NONSTEROIDAL anti-inflammatory agents, *GUMS & resins, *BIOINFORMATICS, *MASS spectrometry, *PLANT extracts
Abstract

Five new norneolignans sinkianlignans G-K (1 – 5), one phenolic compound ferulagenol A (6) and seven known compounds (7 – 13) were isolated from Ferula sinkiangensis. All the norneolignans were racemic mixtures, and chiral HPLC was used to further separate them. Their structures were assigned, including absolute configurations, using spectroscopic and computational methods. Biological evaluation showed that compounds 1 – 9 had significant COX-2 inhibitory activity with IC 50 values ranging from 3.00 μ M to 23.19 μ M. Five new norneolignans sinkianlignans G-K (1 – 5), one phenolic compound ferulagenol A (6) and seven known compounds (7 – 13) were isolated from Ferula sinkiangensis. All the norneolignans were racemic mixtures, and chiral HPLC was used to further separate them. Their structures were assigned, including absolute configurations, using spectroscopic and computational methods. Biological evaluation showed that compounds 1 – 9 had significant COX-2 inhibitory activity with IC 50 values ranging from 3.00 μ M to 23.19 μ M. [Display omitted] [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results