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Notch has been implicated in human cancers and is a putative therapeutic target. However, the regulation of Notch activation in the nucleus remains largely uncharacterized. Therefore, characterizing the detailed mechanisms governing Notch degradation will identify attractive strategies for treating Notch-activated cancers. Here, we report that the long noncoding RNA (lncRNA) BREA2 drives breast cancer metastasis by stabilizing the Notch1 intracellular domain (NICD1). Moreover, we reveal WW domain containing E3 ubiquitin protein ligase 2 (WWP2) as an E3 ligase for NICD1 at K1821 and a suppressor of breast cancer metastasis. Mechanistically, BREA2 impairs WWP2–NICD1 complex formation and in turn stabilizes NICD1, leading to Notch signaling activation and lung metastasis. BREA2 loss sensitizes breast cancer cells to inhibition of Notch signaling and suppresses the growth of breast cancer patient-derived xenograft tumors, highlighting its therapeutic potential in breast cancer. Taken together, these results reveal the lncRNA BREA2 as a putative regulator of Notch signaling and an oncogenic player driving breast cancer metastasis.

Research to realize full electrical spin manipulation and spin–photon coupling on silicon using micromagnets has been prevalent. To realize spin–photon coupling, micromagnets should be placed parallel to the double quantum dot connection direction. However, the parallelly placed micromagnet will also generate detrimental magnetic field gradients, which results in substantial dephasing of the qubit [Yoneda et al., Nat. Nanotechnol. 13, 102–106 (2018); Struck et al., npj Quantum Inf. 6(1), 40 (2020); Takeda et al., Nat. Nanotechnol. 16, 965–969 (2021)]. Here, we develop a scheme of an iterative polygonal micromagnet, which maximizes the qubit Rabi oscillation quality factor [Takeda et al., Sci. Adv. 2, e1600694 (2016)] Q, while allowing strong spin–photon coupling. To find the optimal structure of the micromagnet in the iterative process, the appropriate objective function R (proportional to 1/Q) is selected as the evaluation standard of micromagnet performance. The simulation results by the RADIA package show that the Q value of the polygonal micromagnet is 15% better than that of the rectangular micromagnet at most and up to approximately 30% in subsequent simulation using the OOMMF tool.

Visible Light Communication (VLC) uses the flicker signal from the LED to achieve the transmission of information. In this paper, the amplifier circuit with automatic gain control (AGC) is used to design the receiving end of the visible light communication system. The received signal can be kept stable without distance or other external factors. In this paper, infrared and visible light are used for uplink and downlink data transmission respectively. Compared with the traditional visible light transmission system without AGC, the system proposed in this paper has a significant improvement in transmission distance and speed.