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4. Online Gambling in Youth

Author

Potenza, Marc N., Mestre-Bach, Gemma, Demetrovics, Zsolt, Derevensky, Jeffrey, Fernandez-Aranda, Fernando, Gainsbury, Sally M., Jiménez-Murcia, Susana, Kraus, Shane W., Christakis, Dimitri A., editor, and Hale, Lauren, editor

Published
2025
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11. GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors.

Author

Docherty, Anna, Mullins, Niamh, Ashley-Koch, Allison, Qin, Xuejun, Coleman, Jonathan, Shabalin, Andrey, Kang, JooEun, Murnyak, Balasz, Wendt, Frank, Adams, Mark, Campos, Adrian, DiBlasi, Emily, Fullerton, Janice, Kranzler, Henry, Bakian, Amanda, Monson, Eric, Rentería, Miguel, Walss-Bass, Consuelo, Andreassen, Ole, Behera, Chittaranjan, Bulik, Cynthia, Edenberg, Howard, Kessler, Ronald, Mann, J, Nurnberger, John, Pistis, Giorgio, Streit, Fabian, Ursano, Robert, Polimanti, Renato, Dennis, Michelle, Garrett, Melanie, Hair, Lauren, Harvey, Philip, Hauser, Elizabeth, Hauser, Michael, Huffman, Jennifer, Jacobson, Daniel, Madduri, Ravi, McMahon, Benjamin, Oslin, David, Trafton, Jodie, Awasthi, Swapnil, Berrettini, Wade, Bohus, Martin, Chang, Xiao, Chen, Hsi-Chung, Chen, Wei, Christensen, Erik, Crow, Scott, Duriez, Philibert, Edwards, Alexis, Fernández-Aranda, Fernando, Galfalvy, Hanga, Gandal, Michael, Gorwood, Philip, Guo, Yiran, Hafferty, Jonathan, Hakonarson, Hakon, Halmi, Katherine, Hishimoto, Akitoyo, Jain, Sonia, Jamain, Stéphane, Jiménez-Murcia, Susana, Johnson, Craig, Kaplan, Allan, Kaye, Walter, Keel, Pamela, Kennedy, James, Kim, Minsoo, Klump, Kelly, Levey, Daniel, Li, Dong, Liao, Shih-Cheng, Lieb, Klaus, Lilenfeld, Lisa, Marshall, Christian, Mitchell, James, Okazaki, Satoshi, Otsuka, Ikuo, Pinto, Dalila, Powers, Abigail, Ramoz, Nicolas, Ripke, Stephan, Roepke, Stefan, Rozanov, Vsevolod, Scherer, Stephen, Schmahl, Christian, Sokolowski, Marcus, Starnawska, Anna, Strober, Michael, Su, Mei-Hsin, Thornton, Laura, Treasure, Janet, Ware, Erin, Watson, Hunna, Witt, Stephanie, Woodside, D, Yilmaz, Zeynep, Zillich, Lea, and Adolfsson, Rolf

Subjects
Biological Markers, Depressive Disorders, Genetics, Schizophrenia Spectrum and Other Psychotic Disorders, Self-Harm, Suicide, Humans, Genome-Wide Association Study, Suicide, Attempted, Depressive Disorder, Major, Risk Factors, Suicidal Ideation, Polymorphism, Single Nucleotide, Genetic Predisposition to Disease, Genetic Loci
Abstract

OBJECTIVE: Suicidal behavior is heritable and is a major cause of death worldwide. Two large-scale genome-wide association studies (GWASs) recently discovered and cross-validated genome-wide significant (GWS) loci for suicide attempt (SA). The present study leveraged the genetic cohorts from both studies to conduct the largest GWAS meta-analysis of SA to date. Multi-ancestry and admixture-specific meta-analyses were conducted within groups of significant African, East Asian, and European ancestry admixtures. METHODS: This study comprised 22 cohorts, including 43,871 SA cases and 915,025 ancestry-matched controls. Analytical methods across multi-ancestry and individual ancestry admixtures included inverse variance-weighted fixed-effects meta-analyses, followed by gene, gene-set, tissue-set, and drug-target enrichment, as well as summary-data-based Mendelian randomization with brain expression quantitative trait loci data, phenome-wide genetic correlation, and genetic causal proportion analyses. RESULTS: Multi-ancestry and European ancestry admixture GWAS meta-analyses identified 12 risk loci at p values

Published
2023

14. Physiological and Brain Activity After a Combined Cognitive Behavioral Treatment Plus Video Game Therapy for Emotional Regulation in Bulimia Nervosa: A Case Report

Author

Fagundo, Ana Beatriz, Via, Esther, Sánchez, Isabel, Jiménez-Murcia, Susana, Forcano, Laura, Soriano-Mas, Carles, Giner-Bartolomé, Cristina, Santamaría, Juan J, Ben-Moussa, Maher, Konstantas, Dimitri, Lam, Tony, Lucas, Mikkel, Nielsen, Jeppe, Lems, Peter, Cardoner, Narcís, Menchón, Jose M, de la Torre, Rafael, and Fernandez-Aranda, Fernando

Subjects
Computer applications to medicine. Medical informatics, R858-859.7, Public aspects of medicine, RA1-1270
Abstract

BackgroundPlayMancer is a video game designed to increase emotional regulation and reduce general impulsive behaviors, by training to decrease arousal and improve decision-making and planning. We have previously demonstrated the usefulness of PlayMancer in reducing impulsivity and improving emotional regulation in bulimia nervosa (BN) patients. However, whether these improvements are actually translated into brain changes remains unclear. ObjectiveThe aim of this case study was to report on a 28-year-old Spanish woman with BN, and to examine changes in physiological variables and brain activity after a combined treatment of video game therapy (VGT) and cognitive behavioral therapy (CBT). MethodsTen VGT sessions were carried out on a weekly basis. Anxiety, physiological, and impulsivity measurements were recorded. The patient was scanned in a 1.5-T magnetic resonance scanner, prior to and after the 10-week VGT/CBT combined treatment, using two paradigms: (1) an emotional face-matching task, and (2) a multi-source interference task (MSIT). ResultsUpon completing the treatment, a decrease in average heart rate was observed. The functional magnetic resonance imaging (fMRI) results indicated a post-treatment reduction in reaction time along with high accuracy. The patient engaged areas typically active in healthy controls, although the cluster extension of the active areas decreased after the combined treatment. ConclusionsThese results suggest a global improvement in emotional regulation and impulsivity control after the VGT therapy in BN, demonstrated by both physiological and neural changes. These promising results suggest that a combined treatment of CBT and VGT might lead to functional cerebral changes that ultimately translate into better cognitive and emotional performances.

Published
2014
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15. Common Genetic Variation and Age of Onset of Anorexia Nervosa.

Author

Watson, Hunna J, Thornton, Laura M, Yilmaz, Zeynep, Baker, Jessica H, Coleman, Jonathan RI, Adan, Roger AH, Alfredsson, Lars, Andreassen, Ole A, Ask, Helga, Berrettini, Wade H, Boehnke, Michael, Boehm, Ilka, Boni, Claudette, Buehren, Katharina, Bulant, Josef, Burghardt, Roland, Chang, Xiao, Cichon, Sven, Cone, Roger D, Courtet, Philippe, Crow, Scott, Crowley, James J, Danner, Unna N, de Zwaan, Martina, Dedoussis, George, DeSocio, Janiece E, Dick, Danielle M, Dikeos, Dimitris, Dina, Christian, Djurovic, Srdjan, Dmitrzak-Weglarz, Monika, Docampo-Martinez, Elisa, Duriez, Philibert, Egberts, Karin, Ehrlich, Stefan, Eriksson, Johan G, Escaramís, Geòrgia, Esko, Tõnu, Estivill, Xavier, Farmer, Anne, Fernández-Aranda, Fernando, Fichter, Manfred M, Föcker, Manuel, Foretova, Lenka, Forstner, Andreas J, Frei, Oleksandr, Gallinger, Steven, Giegling, Ina, Giuranna, Johanna, Gonidakis, Fragiskos, Gorwood, Philip, Gratacòs, Mònica, Guillaume, Sébastien, Guo, Yiran, Hakonarson, Hakon, Hauser, Joanna, Havdahl, Alexandra, Hebebrand, Johannes, Helder, Sietske G, Herms, Stefan, Herpertz-Dahlmann, Beate, Herzog, Wolfgang, Hinney, Anke, Hübel, Christopher, Hudson, James I, Imgart, Hartmut, Jamain, Stephanie, Janout, Vladimir, Jiménez-Murcia, Susana, Jones, Ian R, Julià, Antonio, Kalsi, Gursharan, Kaminská, Deborah, Kaprio, Jaakko, Karhunen, Leila, Kas, Martien JH, Keel, Pamela K, Kennedy, James L, Keski-Rahkonen, Anna, Kiezebrink, Kirsty, Klareskog, Lars, Klump, Kelly L, Knudsen, Gun Peggy S, La Via, Maria C, Le Hellard, Stephanie, Leboyer, Marion, Li, Dong, Lilenfeld, Lisa, Lin, Bochao, Lissowska, Jolanta, Luykx, Jurjen, Magistretti, Pierre, Maj, Mario, Marsal, Sara, Marshall, Christian R, Mattingsdal, Morten, Meulenbelt, Ingrid, Micali, Nadia, Mitchell, Karen S, and Monteleone, Alessio Maria

Subjects
Age of onset, Anorexia nervosa, Early-onset, GWAS, Genetic risk score, Genetics, Menarche, Mendelian randomization, Puberty, Mental Health, Human Genome, Eating Disorders, Anorexia, Brain Disorders, Pediatric, Prevention, Aetiology, 2.1 Biological and endogenous factors
Abstract

BackgroundGenetics and biology may influence the age of onset of anorexia nervosa (AN). The aims of this study were to determine whether common genetic variation contributes to age of onset of AN and to investigate the genetic associations between age of onset of AN and age at menarche.MethodsA secondary analysis of the Psychiatric Genomics Consortium genome-wide association study (GWAS) of AN was performed, which included 9335 cases and 31,981 screened controls, all from European ancestries. We conducted GWASs of age of onset, early-onset AN (

Published
2022

19. Exploring the influence of circulating endocannabinoids and nucleus accumbens functional connectivity on anorexia nervosa severity

Author

Miranda-Olivos, Romina, Baenas, Isabel, Steward, Trevor, Granero, Roser, Pastor, Antoni, Sánchez, Isabel, Juaneda-Seguí, Asier, del Pino-Gutiérrez, Amparo, Fernández-Formoso, José A., Vilarrasa, Nuria, Guerrero-Pérez, Fernando, Virgili, Nuria, López-Urdiales, Rafael, Jiménez-Murcia, Susana, de la Torre, Rafael, Soriano-Mas, Carles, and Fernández-Aranda, Fernando

Published
2023
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20. Phenotype of Gambling Disorder Patients with Lotteries as a Preferred Form of Gambling

Author

Granero, Roser, Fernández-Aranda, Fernando, Mena-Moreno, Teresa, del Pino-Gutierrez, Amparo, Codina, Ester, Gómez-Peña, Mónica, Moragas, Laura, Aymamí, Neus, Mestre-Bach, Gemma, Steward, Trevor, Agüera, Zaida, Hakånsson, Anders, Vintró-Alcaraz, Cristina, Lozano-Madrid, María, Casalé-Salayet, Gemma, López-González, Hibai, Valenciano-Mendoza, Eduardo, Mora-Maltas, Bernat, Rivas-Pérez, Sandra, Menchón, José M., and Jiménez-Murcia, Susana

Published
2023
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26. Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors.

Author

Mullins, Niamh, Kang, JooEun, Campos, Adrian I, Coleman, Jonathan RI, Edwards, Alexis C, Galfalvy, Hanga, Levey, Daniel F, Lori, Adriana, Shabalin, Andrey, Starnawska, Anna, Su, Mei-Hsin, Watson, Hunna J, Adams, Mark, Awasthi, Swapnil, Gandal, Michael, Hafferty, Jonathan D, Hishimoto, Akitoyo, Kim, Minsoo, Okazaki, Satoshi, Otsuka, Ikuo, Ripke, Stephan, Ware, Erin B, Bergen, Andrew W, Berrettini, Wade H, Bohus, Martin, Brandt, Harry, Chang, Xiao, Chen, Wei J, Chen, Hsi-Chung, Crawford, Steven, Crow, Scott, DiBlasi, Emily, Duriez, Philibert, Fernández-Aranda, Fernando, Fichter, Manfred M, Gallinger, Steven, Glatt, Stephen J, Gorwood, Philip, Guo, Yiran, Hakonarson, Hakon, Halmi, Katherine A, Hwu, Hai-Gwo, Jain, Sonia, Jamain, Stéphane, Jiménez-Murcia, Susana, Johnson, Craig, Kaplan, Allan S, Kaye, Walter H, Keel, Pamela K, Kennedy, James L, Klump, Kelly L, Li, Dong, Liao, Shih-Cheng, Lieb, Klaus, Lilenfeld, Lisa, Liu, Chih-Min, Magistretti, Pierre J, Marshall, Christian R, Mitchell, James E, Monson, Eric T, Myers, Richard M, Pinto, Dalila, Powers, Abigail, Ramoz, Nicolas, Roepke, Stefan, Rozanov, Vsevolod, Scherer, Stephen W, Schmahl, Christian, Sokolowski, Marcus, Strober, Michael, Thornton, Laura M, Treasure, Janet, Tsuang, Ming T, Witt, Stephanie H, Woodside, D Blake, Yilmaz, Zeynep, Zillich, Lea, Adolfsson, Rolf, Agartz, Ingrid, Air, Tracy M, Alda, Martin, Alfredsson, Lars, Andreassen, Ole A, Anjorin, Adebayo, Appadurai, Vivek, Soler Artigas, María, Van der Auwera, Sandra, Azevedo, M Helena, Bass, Nicholas, Bau, Claiton HD, Baune, Bernhard T, Bellivier, Frank, Berger, Klaus, Biernacka, Joanna M, Bigdeli, Tim B, Binder, Elisabeth B, Boehnke, Michael, Boks, Marco P, Bosch, Rosa, and Braff, David L

Subjects
Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Eating Disorders Working Group of the Psychiatric Genomics Consortium, German Borderline Genomics Consortium, MVP Suicide Exemplar Workgroup, VA Million Veteran Program, Humans, Risk Factors, Suicide, Attempted, Mental Disorders, Depressive Disorder, Major, Polymorphism, Single Nucleotide, Genome-Wide Association Study, Genetic correlation, Genome-wide association study, Pleiotropy, Polygenicity, Suicide, Suicide attempt, Human Genome, Behavioral and Social Science, Mental Health, Prevention, Genetics, Brain Disorders, Aetiology, 2.1 Biological and endogenous factors, Mental health, Good Health and Well Being, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract

BackgroundSuicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders.MethodsWe conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors.ResultsTwo loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged.ConclusionsOur results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.

Published
2022

27. Impact of COVID-19 Lockdown in Eating Disorders: A Multicentre Collaborative International Study

Author

Baenas, Isabel, Etxandi, Mikel, Munguía, Lucero, Granero, Roser, Mestre-Bach, Gemma, Sánchez, Isabel, Ortega, Emilio, Andreu, Alba, Moize, Violeta L, Fernández-Real, Jose-Manuel, Tinahones, Francisco J, Diéguez, Carlos, Frühbeck, Gema, Le Grange, Daniel, Tchanturia, Kate, Karwautz, Andreas, Zeiler, Michael, Imgart, Hartmut, Zanko, Annika, Favaro, Angela, Claes, Laurence, Shekriladze, Ia, Serrano-Troncoso, Eduardo, Cecilia-Costa, Raquel, Rangil, Teresa, Loran-Meler, Maria Eulalia, Soriano-Pacheco, José, Carceller-Sindreu, Mar, Navarrete, Rosa, Lozano, Meritxell, Linares, Raquel, Gudiol, Carlota, Carratala, Jordi, Plana, Maria T, Graell, Montserrat, González-Parra, David, Barrio, José A Gómez-del, Sepúlveda, Ana R, Sánchez-González, Jéssica, Machado, Paulo PP, Håkansson, Anders, Túry, Ferenc, Pászthy, Bea, Stein, Daniel, Papezová, Hana, Gricova, Jana, Bax, Brigita, Borisenkov, Mikhail F, Popov, Sergey V, Gubin, Denis G, Petrov, Ivan M, Isakova, Dilara, Mustafina, Svetlana V, Kim, Youl-Ri, Nakazato, Michiko, Godart, Nathalie, van Voren, Robert, Ilnytska, Tetiana, Chen, Jue, Rowlands, Katie, Voderholzer, Ulrich, Monteleone, Alessio M, Treasure, Janet, Jiménez-Murcia, Susana, and Fernández-Aranda, Fernando

Subjects
Eating Disorders, Health Services, Behavioral and Social Science, Nutrition, Clinical Research, Mental Health, Prevention, Brain Disorders, Mental health, Good Health and Well Being, Adolescent, Adult, Asia, COVID-19, Child, Europe, Feeding and Eating Disorders, Female, Humans, Internationality, Longitudinal Studies, Male, Quarantine, SARS-CoV-2, Social Isolation, Young Adult, eating disorders, COVID-19 lockdown, COVID-19 Isolation Eating Scale, eating symptoms, psychological impact, Food Sciences, Nutrition and Dietetics
Abstract

The COVID-19 lockdown has had a significant impact on mental health. Patients with eating disorders (ED) have been particularly vulnerable. (1) To explore changes in eating-related symptoms and general psychopathology during lockdown in patients with an ED from various European and Asian countries; and (2) to assess differences related to diagnostic ED subtypes, age, and geography. The sample comprised 829 participants, diagnosed with an ED according to DSM-5 criteria from specialized ED units in Europe and Asia. Participants were assessed using the COVID-19 Isolation Scale (CIES). Patients with binge eating disorder (BED) experienced the highest impact on weight and ED symptoms in comparison with other ED subtypes during lockdown, whereas individuals with other specified feeding and eating disorders (OFSED) had greater deterioration in general psychological functioning than subjects with other ED subtypes. Finally, Asian and younger individuals appeared to be more resilient. The psychopathological changes in ED patients during the COVID-19 lockdown varied by cultural context and individual variation in age and ED diagnosis. Clinical services may need to target preventive measures and adapt therapeutic approaches for the most vulnerable patients.

Published
2022

33. Eating disorders during lockdown: the transcultural influence on eating and mood disturbances in Ibero-Brazilian population

Author

Baenas, Isabel, Neufeld, Carmem Beatriz, Ramos, Rita, Munguía, Lucero, Pessa, Rosane P., Rodrigues, Tânia, Jiménez-Murcia, Susana, Gonçalves, Sónia, Teodoro, Marília C., Pinto-Bastos, Ana, Almeida, Nazaré O., Granero, Roser, Etxandi, Mikel, Soares, Shauana R. S., Fernández-Aranda, Fernando, and Machado, Paulo P. P.

Published
2023
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35. Shared genetic risk between eating disorder‐ and substance‐use‐related phenotypes: Evidence from genome‐wide association studies

Author

Munn‐Chernoff, Melissa A, Johnson, Emma C, Chou, Yi‐Ling, Coleman, Jonathan RI, Thornton, Laura M, Walters, Raymond K, Yilmaz, Zeynep, Baker, Jessica H, Hübel, Christopher, Gordon, Scott, Medland, Sarah E, Watson, Hunna J, Gaspar, Héléna A, Bryois, Julien, Hinney, Anke, Leppä, Virpi M, Mattheisen, Manuel, Ripke, Stephan, Yao, Shuyang, Giusti‐Rodríguez, Paola, Hanscombe, Ken B, Adan, Roger AH, Alfredsson, Lars, Ando, Tetsuya, Andreassen, Ole A, Berrettini, Wade H, Boehm, Ilka, Boni, Claudette, Perica, Vesna Boraska, Buehren, Katharina, Burghardt, Roland, Cassina, Matteo, Cichon, Sven, Clementi, Maurizio, Cone, Roger D, Courtet, Philippe, Crow, Scott, Crowley, James J, Danner, Unna N, Davis, Oliver SP, de Zwaan, Martina, Dedoussis, George, Degortes, Daniela, DeSocio, Janiece E, Dick, Danielle M, Dikeos, Dimitris, Dina, Christian, Dmitrzak‐Weglarz, Monika, Docampo, Elisa, Duncan, Laramie E, Egberts, Karin, Ehrlich, Stefan, Escaramís, Geòrgia, Esko, Tõnu, Estivill, Xavier, Farmer, Anne, Favaro, Angela, Fernández‐Aranda, Fernando, Fichter, Manfred M, Fischer, Krista, Föcker, Manuel, Foretova, Lenka, Forstner, Andreas J, Forzan, Monica, Franklin, Christopher S, Gallinger, Steven, Giegling, Ina, Giuranna, Johanna, Gonidakis, Fragiskos, Gorwood, Philip, Mayora, Monica Gratacos, Guillaume, Sébastien, Guo, Yiran, Hakonarson, Hakon, Hatzikotoulas, Konstantinos, Hauser, Joanna, Hebebrand, Johannes, Helder, Sietske G, Herms, Stefan, Herpertz‐Dahlmann, Beate, Herzog, Wolfgang, Huckins, Laura M, Hudson, James I, Imgart, Hartmut, Inoko, Hidetoshi, Janout, Vladimir, Jiménez‐Murcia, Susana, Julià, Antonio, Kalsi, Gursharan, Kaminská, Deborah, Karhunen, Leila, Karwautz, Andreas, Kas, Martien JH, Kennedy, James L, Keski‐Rahkonen, Anna, Kiezebrink, Kirsty, Kim, Youl‐Ri, Klump, Kelly L, Knudsen, Gun Peggy S, and La Via, Maria C

Subjects
Biomedical and Clinical Sciences, Biological Psychology, Epidemiology, Health Sciences, Psychology, Pharmacology and Pharmaceutical Sciences, Nutrition, Brain Disorders, Alcoholism, Alcohol Use and Health, Mental Health, Eating Disorders, Substance Misuse, Genetics, Tobacco Smoke and Health, Tobacco, Human Genome, Drug Abuse (NIDA only), Prevention, Clinical Research, 2.1 Biological and endogenous factors, 2.3 Psychological, social and economic factors, Aetiology, Mental health, Good Health and Well Being, Alcoholism, Depressive Disorder, Major, Feeding and Eating Disorders, Genome-Wide Association Study, Humans, Linkage Disequilibrium, Phenotype, Polymorphism, Single Nucleotide, Risk Factors, Schizophrenia, Substance-Related Disorders, Tobacco Use Disorder, eating disorders, genetic correlation, substance use, Medical and Health Sciences, Psychology and Cognitive Sciences, Substance Abuse, Biomedical and clinical sciences, Health sciences
Abstract

Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [rg ], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from ~2400 to ~537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism-based genetic correlations between eating disorder- and substance-use-related phenotypes. Significant positive genetic associations emerged between AUD and AN (rg = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (rg = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (rg = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (rgs = -0.19 to -0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co-varying for major depressive disorder loci. The patterns of association between eating disorder- and substance-use-related phenotypes highlights the potentially complex and substance-specific relationships among these behaviors.

Published
2021

36. Food Addiction

Author

Camacho-Barcia, Lucía, primary, Munguía, Lucero, additional, and Jiménez-Murcia, Susana, additional

Published
2023
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37. Insulin and disorders of behavioural flexibility

Author

Sullivan, Mairéad, Fernandez-Aranda, Fernando, Camacho-Barcia, Lucía, Harkin, Andrew, Macrì, Simone, Mora-Maltas, Bernat, Jiménez-Murcia, Susana, O'Leary, Aet, Ottomana, Angela Maria, Presta, Martina, Slattery, David, Scholtz, Samantha, and Glennon, Jeffrey C.

Published
2023
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38. COVID Isolation Eating Scale (CIES): Analysis of the impact of confinement in eating disorders and obesity—A collaborative international study

Author

Fernández‐Aranda, Fernando, Munguía, Lucero, Mestre‐Bach, Gemma, Steward, Trevor, Etxandi, Mikel, Baenas, Isabel, Granero, Roser, Sánchez, Isabel, Ortega, Emilio, Andreu, Alba, Moize, Violeta L, Fernández‐Real, Jose M, Tinahones, Francisco J, Diegüez, Carlos, Frühbeck, Gema, Le Grange, Daniel, Tchanturia, Kate, Karwautz, Andreas, Zeiler, Michael, Favaro, Angela, Claes, Laurence, Luyckx, Koen, Shekriladze, Ia, Serrano‐Troncoso, Eduardo, Rangil, Teresa, Meler, Maria Eulalia Loran, Soriano‐Pacheco, Jose, Carceller‐Sindreu, Mar, Bujalance‐Arguijo, Sara, Lozano, Meritxell, Linares, Raquel, Gudiol, Carlota, Carratala, Jordi, Sanchez‐Gonzalez, Jessica, Machado, Paulo PP, Håkansson, Anders, Túry, Ferenc, Pászthy, Bea, Stein, Daniel, Papezová, Hana, Bax, Brigita, Borisenkov, Mikhail F, Popov, Sergey V, Kim, Youl‐Ri, Nakazato, Michiko, Godart, Nathalie, Voren, Robert, Ilnytska, Tetiana, Chen, Jue, Rowlands, Katie, Treasure, Janet, and Jiménez‐Murcia, Susana

Subjects
Clinical Research, Anorexia, Behavioral and Social Science, Eating Disorders, Nutrition, Brain Disorders, Mental Health, Mental health, Good Health and Well Being, Adolescent, Adult, Aged, COVID-19, Factor Analysis, Statistical, Feeding and Eating Disorders, Female, Humans, Male, Middle Aged, Obesity, Psychiatric Status Rating Scales, Psychometrics, Social Isolation, Spain, Young Adult, COVID Isolation Eating Scale, eating disorders, obesity, Clinical Sciences, Psychology, Clinical Psychology
Abstract

Confinement during the COVID-19 pandemic is expected to have a serious and complex impact on the mental health of patients with an eating disorder (ED) and of patients with obesity. The present manuscript has the following aims: (1) to analyse the psychometric properties of the COVID Isolation Eating Scale (CIES), (2) to explore changes that occurred due to confinement in eating symptomatology; and (3) to explore the general acceptation of the use of telemedicine during confinement. The sample comprised 121 participants (87 ED patients and 34 patients with obesity) recruited from six different centres. Confirmatory Factor Analyses (CFA) tested the rational-theoretical structure of the CIES. Adequate goodness-of-fit was obtained for the confirmatory factor analysis, and Cronbach alpha values ranged from good to excellent. Regarding the effects of confinement, positive and negative impacts of the confinement depends of the eating disorder subtype. Patients with anorexia nervosa (AN) and with obesity endorsed a positive response to treatment during confinement, no significant changes were found in bulimia nervosa (BN) patients, whereas Other Specified Feeding or Eating Disorder (OSFED) patients endorsed an increase in eating symptomatology and in psychopathology. Furthermore, AN patients expressed the greatest dissatisfaction and accommodation difficulty with remote therapy when compared with the previously provided face-to-face therapy. The present study provides empirical evidence on the psychometric robustness of the CIES tool and shows that a negative confinement impact was associated with ED subtype, whereas OSFED patients showed the highest impairment in eating symptomatology and in psychopathology.

Published
2020

39. Right Prefrontal Cortical Thickness Is Associated With Response to Cognitive-Behavioral Therapy in Children With Obsessive-Compulsive Disorder

Author

Real, Eva, Segalas, Cinto, Morer, Astrid, Brem, Silvia, Ferreira, Sonia, Moreira, Pedro Silva, Hagen, Kristen, Hamatani, Sayo, Takahashi, Jumpei, Yoshida, Tokiko, de Mathis, Maria Alice, Miguel, Euripedes C., Pariente, Jose C., Tang, Jinsong, Bertolín, Sara, Alonso, Pino, Martínez-Zalacaín, Ignacio, Menchón, Jose M., Jimenez-Murcia, Susana, Baker, Justin T., Bargalló, Nuria, Batistuzzo, Marcelo Camargo, Boedhoe, Premika S.W., Brennan, Brian P., Feusner, Jamie D., Fitzgerald, Kate D., Fontaine, Martine, Hansen, Bjarne, Hirano, Yoshiyuki, Hoexter, Marcelo Q., Huyser, Chaim, Jahanshad, Neda, Jaspers-Fayer, Fern, Kuno, Masaru, Kvale, Gerd, Lazaro, Luisa, Machado-Sousa, Mafalda, Marsh, Rachel, Morgado, Pedro, Nakagawa, Akiko, Norman, Luke, Nurmi, Erika L., O’Neill, Joseph, Ortiz, Ana E., Perriello, Chris, Piacentini, John, Picó-Pérez, Maria, Shavitt, Roseli G., Shimizu, Eiji, Simpson, Helen Blair, Stewart, S. Evelyn, Thomopoulos, Sophia I., Thorsen, Anders Lillevik, Walitza, Susanne, Wolters, Lidewij H., Thompson, Paul M., van den Heuvel, Odile A., Stein, Dan J., and Soriano-Mas, Carles

Published
2023
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42. Clustering Treatment Outcomes in Women with Gambling Disorder

Author

Lara-Huallipe, Milagros Lizbeth, Granero, Roser, Fernández-Aranda, Fernando, Gómez-Peña, Mónica, Moragas, Laura, del Pino-Gutierrez, Amparo, Valenciano-Mendoza, Eduardo, Mora-Maltas, Bernat, Baenas, Isabel, Etxandi, Mikel, Menchón, José M., and Jiménez-Murcia, Susana

Published
2022
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43. Identifying Associated Factors for Illegal Acts among Patients with Gambling Disorder and ADHD

Author

Vintró-Alcaraz, Cristina, Mestre-Bach, Gemma, Granero, Roser, Cuquerella, Àngel, Talón-Navarro, María-Teresa, Valenciano-Mendoza, Eduardo, Mora-Maltas, Bernat, del Pino-Gutiérrez, Amparo, Gómez-Peña, Mónica, Moragas, Laura, Fernández-Aranda, Fernando, Codina, Ester, Valero-Solís, Susana, Guillén-Guzmán, Elías, Lara-Huallipe, Milagros Lizbeth, Solé-Morata, Neus, and Jiménez-Murcia, Susana

Published
2022
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47. Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

Author

Watson, Hunna J, Yilmaz, Zeynep, Thornton, Laura M, Hübel, Christopher, Coleman, Jonathan RI, Gaspar, Héléna A, Bryois, Julien, Hinney, Anke, Leppä, Virpi M, Mattheisen, Manuel, Medland, Sarah E, Ripke, Stephan, Yao, Shuyang, Giusti-Rodríguez, Paola, Hanscombe, Ken B, Purves, Kirstin L, Adan, Roger AH, Alfredsson, Lars, Ando, Tetsuya, Andreassen, Ole A, Baker, Jessica H, Berrettini, Wade H, Boehm, Ilka, Boni, Claudette, Perica, Vesna Boraska, Buehren, Katharina, Burghardt, Roland, Cassina, Matteo, Cichon, Sven, Clementi, Maurizio, Cone, Roger D, Courtet, Philippe, Crow, Scott, Crowley, James J, Danner, Unna N, Davis, Oliver SP, de Zwaan, Martina, Dedoussis, George, Degortes, Daniela, DeSocio, Janiece E, Dick, Danielle M, Dikeos, Dimitris, Dina, Christian, Dmitrzak-Weglarz, Monika, Docampo, Elisa, Duncan, Laramie E, Egberts, Karin, Ehrlich, Stefan, Escaramís, Geòrgia, Esko, Tõnu, Estivill, Xavier, Farmer, Anne, Favaro, Angela, Fernández-Aranda, Fernando, Fichter, Manfred M, Fischer, Krista, Föcker, Manuel, Foretova, Lenka, Forstner, Andreas J, Forzan, Monica, Franklin, Christopher S, Gallinger, Steven, Giegling, Ina, Giuranna, Johanna, Gonidakis, Fragiskos, Gorwood, Philip, Mayora, Monica Gratacos, Guillaume, Sébastien, Guo, Yiran, Hakonarson, Hakon, Hatzikotoulas, Konstantinos, Hauser, Joanna, Hebebrand, Johannes, Helder, Sietske G, Herms, Stefan, Herpertz-Dahlmann, Beate, Herzog, Wolfgang, Huckins, Laura M, Hudson, James I, Imgart, Hartmut, Inoko, Hidetoshi, Janout, Vladimir, Jiménez-Murcia, Susana, Julià, Antonio, Kalsi, Gursharan, Kaminská, Deborah, Kaprio, Jaakko, Karhunen, Leila, Karwautz, Andreas, Kas, Martien JH, Kennedy, James L, Keski-Rahkonen, Anna, Kiezebrink, Kirsty, Kim, Youl-Ri, Klareskog, Lars, Klump, Kelly L, Knudsen, Gun Peggy S, La Via, Maria C, Le Hellard, Stephanie, and Levitan, Robert D

Subjects
Biological Sciences, Genetics, Anorexia, Serious Mental Illness, Nutrition, Prevention, Mental Health, Clinical Research, Human Genome, Brain Disorders, Pediatric, Eating Disorders, Mental health, Adult, Anorexia Nervosa, Body Mass Index, Case-Control Studies, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Genomics, Humans, Male, Mental Disorders, Metabolic Diseases, Phenotype, Prognosis, Quantitative Trait Loci, Anorexia Nervosa Genetics Initiative, Eating Disorders Working Group of the Psychiatric Genomics Consortium, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

Characterized primarily by a low body-mass index, anorexia nervosa is a complex and serious illness1, affecting 0.9-4% of women and 0.3% of men2-4, with twin-based heritability estimates of 50-60%5. Mortality rates are higher than those in other psychiatric disorders6, and outcomes are unacceptably poor7. Here we combine data from the Anorexia Nervosa Genetics Initiative (ANGI)8,9 and the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED) and conduct a genome-wide association study of 16,992 cases of anorexia nervosa and 55,525 controls, identifying eight significant loci. The genetic architecture of anorexia nervosa mirrors its clinical presentation, showing significant genetic correlations with psychiatric disorders, physical activity, and metabolic (including glycemic), lipid and anthropometric traits, independent of the effects of common variants associated with body-mass index. These results further encourage a reconceptualization of anorexia nervosa as a metabo-psychiatric disorder. Elucidating the metabolic component is a critical direction for future research, and paying attention to both psychiatric and metabolic components may be key to improving outcomes.

Published
2019

48. The link between cognition and somatic conditions related to insulin resistance in the UK Biobank study cohort: a systematic review

Author

Fanelli, Giuseppe, Mota, Nina Roth, Salas-Salvadó, Jordi, Bulló, Mònica, Fernandez-Aranda, Fernando, Camacho-Barcia, Lucía, Testa, Giulia, Jiménez-Murcia, Susana, Bertaina-Anglade, Valérie, Franke, Barbara, Poelmans, Geert, van Gils, Veerle, Jansen, Willemijn J., Vos, Stephanie J.B., Wimberley, Theresa, Dalsgaard, Søren, Barta, Csaba, Serretti, Alessandro, Fabbri, Chiara, and Bralten, Janita

Published
2022
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