399 results on '"Jiménez-Conde, Jordi"'
Search Results
2. Acute-to-chronic glycemic ratio as an outcome predictor in ischemic stroke in patients with and without diabetes mellitus
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Climent, Elisenda, Rodriguez-Campello, Ana, Jiménez-Balado, Joan, Fernández-Miró, Mercè, Jiménez-Conde, Jordi, Llauradó, Gemma, Ois, Ángel, Flores, Juana A., Cuadrado-Godia, Elisa, Steinhauer, Eva Giralt, and Chillarón, Juan J.
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- 2024
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3. DNA methylation and stroke prognosis: an epigenome-wide association study
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Jiménez-Balado, Joan, Fernández-Pérez, Isabel, Gallego-Fábrega, Cristina, Lazcano, Uxue, Soriano-Tárraga, Carolina, Vallverdú-Prats, Marta, Mola-Caminal, Marina, Rey-Álvarez, Lucía, Macias-Gómez, Adrià, Suárez-Pérez, Antoni, Giralt-Steinhauer, Eva, Rodríguez-Campello, Ana, Cuadrado-Godia, Elisa, Ois, Ángel, Esteller, Manel, Roquer, Jaume, Fernández-Cadenas, Israel, and Jiménez-Conde, Jordi
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- 2024
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4. Role of PATJ in stroke prognosis by modulating endothelial to mesenchymal transition through the Hippo/Notch/PI3K axis
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Medina-Dols, Aina, Cañellas, Guillem, Capó, Toni, Solé, Montse, Mola-Caminal, Marina, Cullell, Natalia, Jaume, Marina, Nadal-Salas, Laura, Llinàs, Jaume, Gómez, Lluis, Tur, Silvia, Jiménez, Carmen, Díaz, Rosa M., Carrera, Caty, Muiño, Elena, Gallego-Fabrega, Cristina, Soriano-Tárraga, Carolina, Ruiz-Guerra, Laura, Pol-Fuster, Josep, Asensio, Víctor, Muncunill, Josep, Fleischer, Aarne, Iglesias, Amanda, Giralt-Steinhauer, Eva, Lazcano, Uxue, Fernández-Pérez, Isabel, Jiménez-Balado, Joan, Gabriel-Salazar, Marina, Garcia-Gabilondo, Miguel, Lei, Ting, Torres-Aguila, Nuria-Paz, Cárcel-Márquez, Jara, Lladó, Jerònia, Olmos, Gabriel, Rosell, Anna, Montaner, Joan, Planas, Anna M., Rabionet, Raquel, Hernández-Guillamon, Mar, Jiménez-Conde, Jordi, Fernández-Cadenas, Israel, and Vives-Bauzá, Cristòfol
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- 2024
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5. Blood DNA Methylation Analysis Reveals a Distinctive Epigenetic Signature of Vasospasm in Aneurysmal Subarachnoid Hemorrhage
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Fernández-Pérez, Isabel, Jiménez-Balado, Joan, Macias-Gómez, Adrià, Suárez‑Pérez, Antoni, Vallverdú-Prats, Marta, Pérez-Giraldo, Alberto, Viles-García, Marc, Peris-Subiza, Julia, Vidal-Notari, Sergio, Giralt-Steinhauer, Eva, Guisado-Alonso, Daniel, Esteller, Manel, Rodriguez-Campello, Ana, Jiménez-Conde, Jordi, Ois, Angel, and Cuadrado-Godia, Elisa
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- 2024
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6. Efficacy and Safety of Mechanical Thrombectomy in Acute Ischemic Stroke Secondary to Infective Endocarditis
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Miró, Jose M., Hernández-Meneses, Marta, Cuervo, Guillermo, Téllez, Adrian, Pericàs, Juan M., Dahl, Anders, García, Delia, Moreno, Asuncion, Ambrosioni, Juan, García de la Mària, Cristina, Cañas, María Alexandra, García-González, Javier, Marco, Francesc, Casals, Climent, Vila, Jordi, Quintana, Eduard, Sandoval, Elena, Falces, Carlos, Pereda, Daniel, Sitges, Marta, Vidal, Barbara, Castella, Manuel, Ortiz, José, Tolosana, José M., Rovira, Irene, Fuster, David, Perissinotti, Andres, Ramírez, Jose, Brunet, Mercè, Soy, Dolors, Castro, Pedro, Llopis, Jaume, Fernández-Hidalgo, Nuria, Escolà-Vergé, Laura, Maisterra, Olga, Fernández, Rubén, Gonzàlez-Alujas, Maria Teresa, Pizzi, María Nazarena, Rello, Pau, Soriano, Toni, Pijuan, Antònia, Sambola, Antonia, Ríos, Remedios, Vigil, Carlota, Roque, Albert, Escrihuela-Vidal, Francesc, Carratalà, Jordi, Grau, Inmaculada, Ardanuy, Carmen, Berbel, Dámaris, Sánchez Salado, Jose Carlos, Alegre, Oriol, Majoral, Alejandro Ruiz, Sbraga, Fabrizio, Blasco, Arnau, Sánchez, Laura Gràcia, Sánchez-Rodríguez, Iván, Pedro-Botet, María Luisa, Sopena, Nieves, Prats-Sánchez, Luis, de Benito, Natividad, Horcajada, Juan Pablo, Roquer, Jaume, Sáez, Carmen, Sanz, Marta, Ramos, Carmen, Ximénez-Carrillo, Álvaro, Vega, Juan, Vilacosta, Isidre, Cardona, Pere, Quesada, Helena, Lara, Blanca, Paipa, Andrés, Nuñez Guillen, Ana, Barranco, Roger, Aja, Lucia, Mora, Paloma, Chirife, Oscar, Aixut, Sonia, Angeles de Miquel, Maria, Martínez-Yelamos, Toni, Molina, Carlos, Rubiera, Marta, Pagola, Jorge, Rodríguez-Luna, David, Boned, Sandra, Muchada, Marian, Tomasello, Alejandro, Ribó, Marc, Piñana, Carlos, Requena, Manuel, Deck, Matías, Garcia-Tornel, Alvaro, Olivé, Marta, Rodriguez, Noelia, Juega, Jesus, Chamorro, Ángel, Amaro, Sergio, Urra, Xabier, Llull, Laura, Renú, Arturo, Rudiloso, Salvatore, Macho, Juan M., Blasco, Jordi, Manzanera, Luis San Roman, López, Antonio, Zarco, Federico, Torné, Ramón, Valero, Ricard, Obach, Víctor, Vera, Víctor, Rodriguez, Alejandro, Vargas, Martha, Laredo, Carlos, Millán, Mònica, Ossa, Natalia Pérez de la, Gomis, Meritxell, Dorado, Laura, Hernández-Pérez, María, Ramos, Anna, Bustamante, Alejandro, Remollo, Sebastià, Castaño, Carlos, Werner, Mariano, Martí-Fàbregas, Joan, Pachón, Anna Ramos, Martínez-Domeño, Alejandro, Camps-Renom, Pol, Lambea, Álvaro, Ezcurra, Garbiñe, Guasch-Jiménez, Marina, Bueno, Rebeca Marín, Pujol, Jordi Branera, Martínez, José Pablo, Dinia, Lavinia, Pellisé, Anna, Ustrell, Xavier, Flores, Alan, Seró, Laia, Serena, Joaquín, Silva, Yolanda, Terceño, Mikel, Bashir, Saima, Murillo, Alan, Krupinski, Jerzy, Huertas, Sonia, Molina, Jessica, Figueras, Georgina, Besora, Sarah, Rodríguez-Campello, Ana, Ois, Ángel, Giralt-Steinhauer, Eva, Cuadrado-Godia, Elisa, Jiménez-Conde, Jordi, Vivas, Elio, Guimaraens, Polo, Cánovas, David, Garcia, Maria del Carmen, Estela, Jordi, Perendreu, Joan, Romero, Nicolas, Correa, Roberto Eduardo, Barrachina, Oriol, Gómez-Choco, Manuel, García, Sonia M., Font Padrós, Maria Àngels, Mengual Chirife, Juan José, Romo, Luis Mena, Palomeras, Ernest, Casado, Virginia, Guanyabens, Nicolau, Álvarez, Marta, Catena, Esther, Camacho Velásquez, José Luis, Purroy, Francisco, Capdevila, Gerard Mauri, Garcia, Cristina, Alhama, Jessica García, Trigo, Irene Bragado, Monedero, Jordi, Perecaula, Mònica, Casanovas, Luis Guillermo, Colom, Carla, Cocho, Dolores, González, Adela Rios, Baiges, Juanjo, Zaragoza, Josep, Escalante, Sonia, Esteve, Patricia, Aragonés, Josep Maria, Saura, Júlia, Soler-Insa, Josep Maria, Mas, Natalia, Diaz, Glòria, Vergés, Margarida, Costa, Xavier, Molina, Liseth, Alemendros, M Cruz, Pérez, Marc, Cabanelas, Ana, Belchi, Olga, Rybyeba, Maria, Barceló, Miquel, Carrión, Dolors, Repullo, Carmen, Sanjurjo, Eduard, Salvat-Plana, Mercè, Roig, Josep, Hidalgo, Verònica, Fagúndez, Olga, Sala, Victòria, Alonso, Anabel, Querol, Marisol, Gorchs, Montse, Jiménez, Xavier, Mora, Maria Àngels, Lapeña, Pau, Olmos, Carmen, Hernández-Fernández, Francisco, Pérez de la Ossa, Natalia, Moreno, Asunción, and Chamorro, Angel
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- 2025
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7. Correction to: Blood DNA Methylation Analysis Reveals a Distinctive Epigenetic Signature of Vasospasm in Aneurysmal Subarachnoid Hemorrhage
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Fernández‑Pérez, Isabel, Jiménez‑Balado, Joan, Macias‑Gómez, Adrià, Suárez‑Pérez, Antoni, Vallverdú‑Prats, Marta, Pérez‑Giraldo, Alberto, Viles‑García, Marc, Peris‑Subiza, Julia, Vidal‑Notari, Sergio, Giralt‑Steinhauer, Eva, Guisado‑Alonso, Daniel, Esteller, Manel, Rodriguez‑Campello, Ana, Jiménez‑Conde, Jordi, Ois, Angel, and Cuadrado‑Godia, Elisa
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- 2024
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8. A multitrait genetic study of hemostatic factors and hemorrhagic transformation after stroke treatment
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Dehghan, Abbas, Heath, Adam S., Morrison, Alanna C., Reiner, Alex P., Johnson, Andrew, Richmond, Anne, Peters, Annette, van Hylckama Vlieg, Astrid, McKnight, Barbara, Psaty, Bruce M., Hayward, Caroline, Ward-Caviness, Cavin, O’Donnell, Christopher, Chasman, Daniel, Strachan, David P., Tregouet, David A., Mook-Kanamori, Dennis, Gill, Dipender, Thibord, Florian, Asselbergs, Folkert W., Leebeek, Frank W.G., Rosendaal, Frits R., Davies, Gail, Homuth, Georg, Temprano, Gerard, Campbell, Harry, Taylor, Herman A., Bressler, Jan, Huffman, Jennifer E., Rotter, Jerome I., Yao, Jie, Wilson, James F., Bis, Joshua C., Hahn, Julie M., Desch, Karl C., Wiggins, Kerri L., Díez-Ahijado, Laia, Raffield, Laura M., Bielak, Lawrence F., Yanek, Lisa R., Kleber, Marcus E., Sabater-Lleal, Maria, Mueller, Martina, Kavousi, Maryam, Mangino, Massimo, Conomos, Matthew P., Liu, Melissa, Brown, Michael R., Jhun, Min-A, Chen, Ming-Huei, de Maat, Moniek P.M., Pankratz, Nathan, Smith, Nicholas L., Peyser, Patricia A., Elliot, Paul, de Vries, Paul S., Wei, Peng, Wild, Philipp S., Morange, Pierre E., van der Harst, Pim, Yang, Qiong, Marioni, Riccardo, Li, Ruifang, Damrauer, Scott M., Cox, Simon R., Trompet, Stella, Felix, Stephan B., Völker, Uwe, Tang, Weihong, Koenig, Wolfgang, Jukema, J. Wouter, Guo, Xiuqing, Gallego-Fabrega, Cristina, Temprano-Sagrera, Gerard, Cárcel-Márquez, Jara, Muiño, Elena, Cullell, Natalia, Lledós, Miquel, Llucià-Carol, Laia, Martin-Campos, Jesús M., Sobrino, Tomás, Castillo, José, Millán, Mònica, Muñoz-Narbona, Lucía, López-Cancio, Elena, Ribó, Marc, Alvarez-Sabin, Jose, Jiménez-Conde, Jordi, Roquer, Jaume, Tur, Silvia, Obach, Victor, Arenillas, Juan F., Segura, Tomas, Serrano-Heras, Gemma, Marti-Fabregas, Joan, Freijo-Guerrero, Marimar, Moniche, Francisco, Castellanos, Maria del Mar, and Fernández-Cadenas, Israel
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- 2024
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9. Factors associated with migraine aura mimicking stroke in code stroke
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Macias-Gómez, Adrià, Suárez-Pérez, Antoni, Rodríguez-Campello, Ana, Giralt-Steinhauer, Eva, Moreira, Antía, Guisado-Alonso, Daniel, Capellades, Jaume, Fernández-Pérez, Isabel, Jiménez-Conde, Jordi, Rey, Lucía, Jiménez-Balado, Joan, Roquer, Jaume, Ois, Ángel, and Cuadrado-Godia, Elisa
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- 2023
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10. Brain volume: An important determinant of functional outcome after acute ischemic stroke
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Schirmer, Markus D., Donahue, Kathleen L., Nardin, Marco J., Dalca, Adrian V., Giese, Anne-Katrin, Etherton, Mark R., Mocking, Steven J. T., McIntosh, Elissa C., Cole, John W., Holmegaard, Lukas, Jood, Katarina, Jimenez-Conde, Jordi, Kittner, Steven J., Lemmens, Robin, Meschia, James F., Rosand, Jonathan, Roquer, Jaume, Rundek, Tatjana, MD, Ralph L. Sacco, Schmidt, Reinhold, Sharma, Pankaj, Slowik, Agnieszka, Stanne, Tara M., Vagal, Achala, Wasselius, Johan, Woo, Daniel, Bevan, Stephen, Heitsch, Laura, Phuah, Chia-Ling, MD, Daniel Strbian, Tatlisumak, Turgut, Levi, Christopher R., Attia, John, McArdle, Patrick F., Worrall, Bradford B., Wu, Ona, Jern, Christina, Lindgren, Arne, Maguire, Jane, Thijs, Vincent, and Rost, Natalia S.
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Quantitative Biology - Neurons and Cognition - Abstract
Objective: To determine whether brain volume is associated with functional outcome after acute ischemic stroke (AIS). Methods: We analyzed cross-sectional data of the multi-site, international hospital-based MRI-GENetics Interface Exploration (MRI-GENIE) study (July 1, 2014- March 16, 2019) with clinical brain magnetic resonance imaging (MRI) obtained on admission for index stroke and functional outcome assessment. Post-stroke outcome was determined using the modified Rankin Scale (mRS) score (0-6; 0: asymptomatic; 6 death) recorded between 60-190 days after stroke. Demographics and other clinical variables including acute stroke severity (measured as National Institutes of Health Stroke Scale score), vascular risk factors, and etiologic stroke subtypes (Causative Classification of Stroke) were recorded during index admission. Results: Utilizing the data from 912 acute ischemic stroke (AIS) patients (65+/-15 years of age, 58% male, 57% history of smoking, and 65% hypertensive) in a generalized linear model, brain volume (per 155.1cm^3 ) was associated with age (beta -0.3 (per 14.4 years)), male sex (beta 1.0) and prior stroke (beta -0.2). In the multivariable outcome model, brain volume was an independent predictor of mRS (beta -0.233), with reduced odds of worse long-term functional outcomes (OR: 0.8, 95% CI 0.7-0.9) in those with larger brain volumes. Conclusions: Larger brain volume quantified on clinical MRI of AIS patients at time of stroke purports a protective mechanism. The role of brain volume as a prognostic, protective biomarker has the potential to forge new areas of research and advance current knowledge of mechanisms of post-stroke recovery.
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- 2020
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11. Multi‐phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations
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Temprano‐Sagrera, Gerard, Sitlani, Colleen M., Bone, William P., Martin‐Bornez, Miguel, Voight, Benjamin F., Morrison, Alanna C., Damrauer, Scott M., de Vries, Paul S., Smith, Nicholas L., Sabater‐Lleal, Maria, Dehghan, Abbas, Heath, Adam S, Morrison, Alanna C, Reiner, Alex P, Johnson, Andrew, Richmond, Anne, Peters, Annette, van Hylckama Vlieg, Astrid, McKnight, Barbara, Psaty, Bruce M, Hayward, Caroline, Ward‐Caviness, Cavin, O’Donnell, Christopher, Chasman, Daniel, Strachan, David P, Tregouet, David A, Mook‐Kanamori, Dennis, Gill, Dipender, Thibord, Florian, Asselbergs, Folkert W, Leebeek, Frank W.G., Rosendaal, Frits R, Davies, Gail, Homuth, Georg, Temprano, Gerard, Campbell, Harry, Taylor, Herman A, Bressler, Jan, Huffman, Jennifer E, Rotter, Jerome I, Yao, Jie, Wilson, James F, Bis, Joshua C, Hahn, Julie M, Desch, Karl C, Wiggins, Kerri L, Raffield, Laura M, Bielak, Lawrence F, Yanek, Lisa R, Kleber, Marcus E, Mueller, Martina, Kavousi, Maryam, Mangino, Massimo, Liu, Melissa, Brown, Michael R, Conomos, Matthew P, Jhun, Min‐A, Chen, Ming‐Huei, de Maat, Moniek P.M., Pankratz, Nathan, Smith, Nicholas L, Peyser, Patricia A, Elliot, Paul, de Vries, Paul S, Wei, Peng, Wild, Philipp S, Morange, Pierre E, van der Harst, Pim, Yang, Qiong, Le, Ngoc‐Quynh, Marioni, Riccardo, Li, Ruifang, Damrauer, Scott M, Cox, Simon R, Trompet, Stella, Felix, Stephan B, Völker, Uwe, Tang, Weihong, Koenig, Wolfgang, Jukema, J. Wouter, Guo, Xiuqing, Lindstrom, Sara, Wang, Lu, Smith, Erin N, Gordon, William, de Andrade, Mariza, Brody, Jennifer A, Pattee, Jack W, Haessler, Jeffrey, Brumpton, Ben M, Chasman, Daniel I, Suchon, Pierre, Turman, Constance, Germain, Marine, MacDonald, James, Braekkan, Sigrid K, Armasu, Sebastian M, Jackson, Rabecca D, Nielsen, Jonas B, Giulianini, Franco, Puurunen, Marja K, Ibrahim, Manal, Heckbert, Susan R, Bammler, Theo K, Frazer, Kelly A, McCauley, Bryan M, Taylor, Kent, Pankow, James S, Reiner, Alexander P, Gabrielsen, Maiken E, Deleuze, Jean‐François, O’Donnell, Chris J, Kim, Jihye, Kraft, Peter, Hansen, John‐Bjarne, Heit, John A, Kooperberg, Charles, Hveem, Kristian, Ridker, Paul M, Morange, Pierre‐Emmanuel, Johnson, Andrew D, Kabrhel, Christopher, Trégouët, David‐Alexandre, Malik, Rainer, Chauhan, Ganesh, Traylor, Matthew, Sargurupremraj, Muralidharan, Okada, Yukinori, Mishra, Aniket, Rutten‐Jacobs, Loes, Giese, Anne‐Katrin, van der Laan, Sander W, Gretarsdottir, Solveig, Anderson, Christopher D, Chong, Michael, Adams, Hieab HH, Ago, Tetsuro, Almgren, Peter, Amouyel, Philippe, Ay, Hakan, Bartz, Traci M, Benavente, Oscar R, Bevan, Steve, Boncoraglio, Giorgio B, Brown, Robert D, Butterworth, Adam S, Carrera, Caty, Carty, Cara L, Chen, Wei‐Min, Cole, John W, Correa, Adolfo, Cotlarciuc, Ioana, Cruchaga, Carlos, Danesh, John, de Bakker, Paul IW, DeStefano, Anita L, den Hoed, Marcel, Duan, Qing, Engelter, Stefan T, Falcone, Guido J, Gottesman, Rebecca F, Grewal, Raji P, Gudnason, Vilmundur, Gustafsson, Stefan, Harris, Tamara B, Hassan, Ahamad, Havulinna, Aki S, Holliday, Elizabeth G, Howard, George, Hsu, Fang‐Chi, Hyacinth, Hyacinth I, Arfan Ikram, M, Ingelsson, Erik, Irvin, Marguerite R, Jian, Xueqiu, Jiménez‐Conde, Jordi, Johnson, Julie A, Jukema, J Wouter, Kanai, Masahiro, Keene, Keith L, Kissela, Brett M, Kleindorfer, Dawn O, Kubo, Michiaki, Lange, Leslie A, Langefeld, Carl D, Langenberg, Claudia, Launer, Lenore J, Lee, Jin‐Moo, Lemmens, Robin, Leys, Didier, Lewis, Cathryn M, Lin, Wei‐Yu, Lindgren, Arne G, Lorentzen, Erik, Magnusson, Patrik K, Maguire, Jane, Manichaikul, Ani, McArdle, Patrick F, Meschia, James F, Mitchell, Braxton D, Mosley, Thomas H, Nalls, Michael A, Ninomiya, Toshiharu, O’Donnell, Martin J, Pulit, Sara L, Rannikmäe, Kristiina, Rexrode, Kathryn M, Rice, Kenneth, Rich, Stephen S, Rost, Natalia S, Rothwell, Peter M, Rundek, Tatjana, Sacco, Ralph L, Sakaue, Saori, Sale, Michele M, Salomaa, Veikko, Sapkota, Bishwa R, Schmidt, Reinhold, Schmidt, Carsten O, Schminke, Ulf, Sharma, Pankaj, Slowik, Agnieszka, Sudlow, Cathie LM, Tanislav, Christian, Tatlisumak, Turgut, Taylor, Kent D, Thijs, Vincent NS, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tiedt, Steffen, Tzourio, Christophe, van Duijn, Cornelia M, Walters, Matthew, Wareham, Nicholas J, Wassertheil‐Smoller, Sylvia, Wilson, James G, Yusuf, Salim, Amin, Najaf, Aparicio, Hugo S, Arnett, Donna K, Attia, John, Beiser, Alexa S, Berr, Claudine, Buring, Julie E, Bustamante, Mariana, Caso, Valeria, Cheng, Yu‐Ching, Hoan Choi, Seung, Chowhan, Ayesha, Cullell, Natalia, Dartigues, Jean‐François, Delavaran, Hossein, Delgado, Pilar, Dörr, Marcus, Engström, Gunnar, Ford, Ian, Gurpreet, Wander S, Hamsten, Anders, Heitsch, Laura, Hozawa, Atsushi, Ibanez, Laura, Ilinca, Andreea, Ingelsson, Martin, Iwasaki, Motoki, Jackson, Rebecca D, Jood, Katarina, Jousilahti, Pekka, Kaffashian, Sara, Kalra, Lalit, Kamouchi, Masahiro, Kitazono, Takanari, Kjartansson, Olafur, Kloss, Manja, Koudstaal, Peter J, Krupinski, Jerzy, Labovitz, Daniel L, Laurie, Cathy C, Levi, Christopher R, Li, Linxin, Lind, Lars, Lindgren, Cecilia M, Lioutas, Vasileios, Mei Liu, Yong, Lopez, Oscar L, Makoto, Hirata, Martinez‐Majander, Nicolas, Matsuda, Koichi, Minegishi, Naoko, Montaner, Joan, Morris, Andrew P, Muiño, Elena, Müller‐Nurasyid, Martina, Norrving, Bo, Ogishima, Soichi, Parati, Eugenio A, Reddy Peddareddygari, Leema, Pedersen, Nancy L, Pera, Joanna, Perola, Markus, Pezzini, Alessandro, Pileggi, Silvana, Rabionet, Raquel, Riba‐Llena, Iolanda, Ribasés, Marta, Romero, Jose R, Roquer, Jaume, Rudd, Anthony G, Sarin, Antti‐Pekka, Sarju, Ralhan, Sarnowski, Chloe, Sasaki, Makoto, Satizabal, Claudia L, Satoh, Mamoru, Sattar, Naveed, Sawada, Norie, Sibolt, Gerli, Sigurdsson, Ásgeir, Smith, Albert, Sobue, Kenji, Soriano‐Tárraga, Carolina, Stanne, Tara, Colin Stine, O, Stott, David J, Strauch, Konstantin, Takai, Takako, Tanaka, Hideo, Tanno, Kozo, Teumer, Alexander, Tomppo, Liisa, Torres‐Aguila, Nuria P, Touze, Emmanuel, Tsugane, Shoichiro, Uitterlinden, Andre G, Valdimarsson, Einar M, van der Lee, Sven J, Völzke, Henry, Wakai, Kenji, Weir, David, Williams, Stephen R, Wolfe, Charles DA, Wong, Quenna, Xu, Huichun, Yamaji, Taiki, Sanghera, Dharambir K, Melander, Olle, Jern, Christina, Strbian, Daniel, Fernandez‐Cadenas, Israel, Longstreth, W T, Rolfs, Arndt, Hata, Jun, Woo, Daniel, Rosand, Jonathan, Pare, Guillaume, Hopewell, Jemma C, Saleheen, Danish, Stefansson, Kari, Worrall, Bradford B, Kittner, Steven J, Seshadri, Sudha, Fornage, Myriam, Markus, Hugh S, Howson, Joanna MM, Kamatani, Yoichiro, Debette, Stephanie, and Dichgans, Martin
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- 2022
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12. Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
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Malik, Rainer, Chauhan, Ganesh, Traylor, Matthew, Sargurupremraj, Muralidharan, Okada, Yukinori, Mishra, Aniket, Rutten-Jacobs, Loes, Giese, Anne-Katrin, van der Laan, Sander W, Gretarsdottir, Solveig, Anderson, Christopher D, Chong, Michael, Adams, Hieab HH, Ago, Tetsuro, Almgren, Peter, Amouyel, Philippe, Ay, Hakan, Bartz, Traci M, Benavente, Oscar R, Bevan, Steve, Boncoraglio, Giorgio B, Brown, Robert D, Butterworth, Adam S, Carrera, Caty, Carty, Cara L, Chasman, Daniel I, Chen, Wei-Min, Cole, John W, Correa, Adolfo, Cotlarciuc, Ioana, Cruchaga, Carlos, Danesh, John, de Bakker, Paul IW, DeStefano, Anita L, den Hoed, Marcel, Duan, Qing, Engelter, Stefan T, Falcone, Guido J, Gottesman, Rebecca F, Grewal, Raji P, Gudnason, Vilmundur, Gustafsson, Stefan, Haessler, Jeffrey, Harris, Tamara B, Hassan, Ahamad, Havulinna, Aki S, Heckbert, Susan R, Holliday, Elizabeth G, Howard, George, Hsu, Fang-Chi, Hyacinth, Hyacinth I, Ikram, M Arfan, Ingelsson, Erik, Irvin, Marguerite R, Jian, Xueqiu, Jiménez-Conde, Jordi, Johnson, Julie A, Jukema, J Wouter, Kanai, Masahiro, Keene, Keith L, Kissela, Brett M, Kleindorfer, Dawn O, Kooperberg, Charles, Kubo, Michiaki, Lange, Leslie A, Langefeld, Carl D, Langenberg, Claudia, Launer, Lenore J, Lee, Jin-Moo, Lemmens, Robin, Leys, Didier, Lewis, Cathryn M, Lin, Wei-Yu, Lindgren, Arne G, Lorentzen, Erik, Magnusson, Patrik K, Maguire, Jane, Manichaikul, Ani, McArdle, Patrick F, Meschia, James F, Mitchell, Braxton D, Mosley, Thomas H, Nalls, Michael A, Ninomiya, Toshiharu, O’Donnell, Martin J, Psaty, Bruce M, Pulit, Sara L, Rannikmäe, Kristiina, Reiner, Alexander P, Rexrode, Kathryn M, Rice, Kenneth, Rich, Stephen S, Ridker, Paul M, Rost, Natalia S, Rothwell, Peter M, Rotter, Jerome I, Rundek, Tatjana, Sacco, Ralph L, Sakaue, Saori, and Sale, Michele M
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Biological Sciences ,Genetics ,Human Genome ,Prevention ,Brain Disorders ,Stroke ,Cerebrovascular ,2.1 Biological and endogenous factors ,Cardiovascular ,Computational Biology ,Databases ,Genetic ,Epigenesis ,Genetic ,Female ,Gene Regulatory Networks ,Genetic Loci ,Genetic Predisposition to Disease ,Genome-Wide Association Study ,Humans ,INDEL Mutation ,Linkage Disequilibrium ,Male ,Models ,Genetic ,Polymorphism ,Single Nucleotide ,Risk Factors ,AFGen Consortium ,Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium ,International Genomics of Blood Pressure (iGEN-BP) Consortium ,INVENT Consortium ,STARNET ,BioBank Japan Cooperative Hospital Group ,COMPASS Consortium ,EPIC-CVD Consortium ,EPIC-InterAct Consortium ,International Stroke Genetics Consortium ,METASTROKE Consortium ,Neurology Working Group of the CHARGE Consortium ,NINDS Stroke Genetics Network ,UK Young Lacunar DNA Study ,MEGASTROKE Consortium ,Medical and Health Sciences ,Developmental Biology ,Agricultural biotechnology ,Bioinformatics and computational biology - Abstract
Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown. We conducted a multiancestry genome-wide-association meta-analysis in 521,612 individuals (67,162 cases and 454,450 controls) and discovered 22 new stroke risk loci, bringing the total to 32. We further found shared genetic variation with related vascular traits, including blood pressure, cardiac traits, and venous thromboembolism, at individual loci (n = 18), and using genetic risk scores and linkage-disequilibrium-score regression. Several loci exhibited distinct association and pleiotropy patterns for etiological stroke subtypes. Eleven new susceptibility loci indicate mechanisms not previously implicated in stroke pathophysiology, with prioritization of risk variants and genes accomplished through bioinformatics analyses using extensive functional datasets. Stroke risk loci were significantly enriched in drug targets for antithrombotic therapy.
- Published
- 2018
13. Altered methylation pattern in EXOC4 is associated with stroke outcome: an epigenome-wide association study
- Author
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Cullell, Natalia, Soriano-Tárraga, Carolina, Gallego-Fábrega, Cristina, Cárcel-Márquez, Jara, Muiño, Elena, Llucià-Carol, Laia, Lledós, Miquel, Esteller, Manel, de Moura, Manuel Castro, Montaner, Joan, Rosell, Anna, Delgado, Pilar, Martí-Fábregas, Joan, Krupinski, Jerzy, Roquer, Jaume, Jiménez-Conde, Jordi, and Fernández-Cadenas, Israel
- Published
- 2022
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14. Risk factors analysis according to regional distribution of white matter hyperintensities in a stroke cohort
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Medrano-Martorell, Santiago, Capellades, Jaume, Jiménez-Conde, Jordi, González-Ortiz, Sofía, Vilas-González, Marta, Rodríguez-Campello, Ana, Ois, Ángel, Cuadrado-Godia, Elisa, Avellaneda, Carla, Fernández, Isabel, Merino-Peña, Elisa, Roquer, Jaume, Martí-Fàbregas, Joan, and Giralt-Steinhauer, Eva
- Published
- 2022
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15. Genetic basis of lacunar stroke: a pooled analysis of individual patient data and genome-wide association studies
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Traylor, Matthew, Persyn, Elodie, Tomppo, Liisa, Klasson, Sofia, Abedi, Vida, Bakker, Mark K, Torres, Nuria, Li, Linxin, Bell, Steven, Rutten-Jacobs, Loes, Tozer, Daniel J, Griessenauer, Christoph J, Zhang, Yanfei, Pedersen, Annie, Sharma, Pankaj, Jimenez-Conde, Jordi, Rundek, Tatjana, Grewal, Raji P, Lindgren, Arne, Meschia, James F, Salomaa, Veikko, Havulinna, Aki, Kourkoulis, Christina, Crawford, Katherine, Marini, Sandro, Mitchell, Braxton D, Kittner, Steven J, Rosand, Jonathan, Dichgans, Martin, Jern, Christina, Strbian, Daniel, Fernandez-Cadenas, Israel, Zand, Ramin, Ruigrok, Ynte, Rost, Natalia, Lemmens, Robin, Rothwell, Peter M, Anderson, Christopher D, Wardlaw, Joanna, Lewis, Cathryn M, and Markus, Hugh S
- Published
- 2021
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16. Sex-Stratified Genome-Wide Association Study in the Spanish Population Identifies a Novel Locus for Lacunar Stroke.
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Cárcel-Márquez, Jara, Muiño, Elena, Gallego-Fabrega, Cristina, Cullell, Natalia, Lledós, Miquel, Llucià-Carol, Laia, Martín-Campos, Jesús M., Sobrino, Tomás, Campos, Francisco, Castillo, José, Freijo, Marimar, Francisco Arenillas, Juan, Obach, Victor, Álvarez-Sabín, José, Molina, Carlos A., Ribó, Marc, Jiménez-Conde, Jordi, Roquer, Jaume, Muñoz-Narbona, Lucia, and Lopez-Cancio, Elena
- Published
- 2024
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17. The Role of Epigenetics in Brain Aneurysm and Subarachnoid Hemorrhage: A Comprehensive Review
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Fernández-Pérez, Isabel, primary, Macias-Gómez, Adrià, additional, Suárez-Pérez, Antoni, additional, Vallverdú-Prats, Marta, additional, Giralt-Steinhauer, Eva, additional, Bojtos, Lidia, additional, Susin-Calle, Sílvia, additional, Rodriguez-Campello, Ana, additional, Guisado-Alonso, Daniel, additional, Jimenez-Balado, Joan, additional, Jiménez-Conde, Jordi, additional, and Cuadrado-Godia, Elisa, additional
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- 2024
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18. Biological age is a novel biomarker to predict stroke recurrence
- Author
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Soriano-Tárraga, Carol, Lazcano, Uxue, Jiménez-Conde, Jordi, Ois, Angel, Cuadrado-Godia, Elisa, Giralt-Steinhauer, Eva, Rodríguez-Campello, Ana, Gomez-Gonzalez, Alejandra, Avellaneda-Gómez, Carla, Vivanco-Hidalgo, Rosa M., and Roquer, Jaume
- Published
- 2021
- Full Text
- View/download PDF
19. A multitrait genetic study of hemostatic factors and hemorrhagic transformation after stroke treatment
- Author
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National Heart, Lung, and Blood Institute (US), Generalitat de Catalunya, Instituto de Salud Carlos III, European Commission, Gallego-Fabrega, Cristina, Temprano-Sagrera, Gerard, Cárcel-Márquez, Jara, Muiño, Elena, Cullell, Natalia, Lledós, Miquel, Llucià-Carol, Laia, Martin-Campos, Jesús M, Sobrino, Tomás, Castillo, José, Millán, Mònica, Muñoz-Narbona, Lucía, López-Cancio, Elena, Ribó, Marc, Álvarez-Sabín, José, Jiménez-Conde, Jordi, Roquer, Jaume, Tur, Silvia, Obach, Victor, Arenillas, Juan F., Segura, Tomás, Serrano-Heras, Gemma, Marti-Fabregas, Joan, Freijo-Guerrero, Marimar, Moniche, Francisco, Castellanos, Maria Del Mar, Morrison, Alanna C., Smith, Nicholas L., de Vries, Paul S., Fernández-Cadenas, Israel, Sabater-Lleal, Maria, National Heart, Lung, and Blood Institute (US), Generalitat de Catalunya, Instituto de Salud Carlos III, European Commission, Gallego-Fabrega, Cristina, Temprano-Sagrera, Gerard, Cárcel-Márquez, Jara, Muiño, Elena, Cullell, Natalia, Lledós, Miquel, Llucià-Carol, Laia, Martin-Campos, Jesús M, Sobrino, Tomás, Castillo, José, Millán, Mònica, Muñoz-Narbona, Lucía, López-Cancio, Elena, Ribó, Marc, Álvarez-Sabín, José, Jiménez-Conde, Jordi, Roquer, Jaume, Tur, Silvia, Obach, Victor, Arenillas, Juan F., Segura, Tomás, Serrano-Heras, Gemma, Marti-Fabregas, Joan, Freijo-Guerrero, Marimar, Moniche, Francisco, Castellanos, Maria Del Mar, Morrison, Alanna C., Smith, Nicholas L., de Vries, Paul S., Fernández-Cadenas, Israel, and Sabater-Lleal, Maria
- Abstract
[Background] Thrombolytic recombinant tissue plasminogen activator (r-tPA) treatment is the only pharmacologic intervention available in the ischemic stroke acute phase. This treatment is associated with an increased risk of intracerebral hemorrhages, known as hemorrhagic transformations (HTs), which worsen the patient’s prognosis., [Objectives] To investigate the association between genetically determined natural hemostatic factors’ levels and increased risk of HT after r-tPA treatment., [Methods] Using data from genome-wide association studies on the risk of HT after r-tPA treatment and data on 7 hemostatic factors (factor [F]VII, FVIII, von Willebrand factor [VWF], FXI, fibrinogen, plasminogen activator inhibitor-1, and tissue plasminogen activator), we performed local and global genetic correlation estimation multitrait analyses and colocalization and 2-sample Mendelian randomization analyses between hemostatic factors and HT., [Results] Local correlations identified a genomic region on chromosome 16 with shared covariance: fibrinogen-HT, P = 2.45 × 10−11. Multitrait analysis between fibrinogen-HT revealed 3 loci that simultaneously regulate circulating levels of fibrinogen and risk of HT: rs56026866 (PLXND1), P = 8.80 × 10−10; rs1421067 (CHD9), P = 1.81 × 10−14; and rs34780449, near ROBO1 gene, P = 1.64 × 10−8. Multitrait analysis between VWF-HT showed a novel common association regulating VWF and risk of HT after r-tPA at rs10942300 (ZNF366), P = 1.81 × 10−14. Mendelian randomization analysis did not find significant causal associations, although a nominal association was observed for FXI-HT (inverse-variance weighted estimate [SE], 0.07 [−0.29 to 0.00]; odds ratio, 0.87; 95% CI, 0.75-1.00; raw P = .05)., [Conclusion] We identified 4 shared loci between hemostatic factors and HT after r-tPA treatment, suggesting common regulatory mechanisms between fibrinogen and VWF levels and HT. Further research to determine a possible mediating effect of fibrinogen on HT risk is needed.
- Published
- 2024
20. Epigenetics and Aging
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Soriano-Tárraga, Carolina, Jiménez-Conde, Jordi, Roquer, Jaume, Patel, Vinood B., editor, and Preedy, Victor R., editor
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- 2019
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21. The influence of epigenetic biological age on key complications and outcomes in aneurysmal subarachnoid haemorrhage.
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Macias-Gómez, Adrià, Jiménez-Balado, Joan, Fernández-Pérez, Isabel, Suárez-Pérez, Antoni, Vallverdú-Prats, Marta, Guimaraens, Leopoldo, Vivas, Elio, Saldaña, Jesus, Giralt-Steinhauer, Eva, Guisado-Alonso, Daniel, Villalba, Gloria, Gracia, Maria-Pilar, Esteller, Manel, Rodriguez-Campello, Ana, Jiménez-Conde, Jordi, Ois, Angel, and Cuadrado-Godia, Elisa
- Subjects
CEREBRAL vasospasm ,SUBARACHNOID hemorrhage ,EPIGENETICS ,INTRACRANIAL aneurysm ruptures ,DIGITAL subtraction angiography ,CLINICAL trials ,TRANSCRANIAL Doppler ultrasonography - Published
- 2024
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22. White matter hyperintensity quantification in large-scale clinical acute ischemic stroke cohorts – The MRI-GENIE study
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Schirmer, Markus D., Dalca, Adrian V., Sridharan, Ramesh, Giese, Anne-Katrin, Donahue, Kathleen L., Nardin, Marco J., Mocking, Steven J.T., McIntosh, Elissa C., Frid, Petrea, Wasselius, Johan, Cole, John W., Holmegaard, Lukas, Jern, Christina, Jimenez-Conde, Jordi, Lemmens, Robin, Lindgren, Arne G., Meschia, James F., Roquer, Jaume, Rundek, Tatjana, Sacco, Ralph L., Schmidt, Reinhold, Sharma, Pankaj, Slowik, Agnieszka, Thijs, Vincent, Woo, Daniel, Vagal, Achala, Xu, Huichun, Kittner, Steven J., McArdle, Patrick F., Mitchell, Braxton D., Rosand, Jonathan, Worrall, Bradford B., Wu, Ona, Golland, Polina, and Rost, Natalia S.
- Published
- 2019
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23. Short-term exposure to traffic-related air pollution and ischemic stroke onset in Barcelona, Spain
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Vivanco-Hidalgo, Rosa Maria, Wellenius, Gregory A., Basagaña, Xavier, Cirach, Marta, González, Alejandra Gómez, Ceballos, Pablo de, Zabalza, Ana, Jiménez-Conde, Jordi, Soriano-Tarraga, Carolina, Giralt-Steinhauer, Eva, Alastuey, Andrés, Querol, Xavier, Sunyer, Jordi, and Roquer, Jaume
- Published
- 2018
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24. Short and long-term outcome of aneurysmal subarachnoid hemorrhage patients
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Roquer, Jaume, Cuadrado-Godia, Elisa, Guimaraens, Leopoldo, Conesa, Gerardo, Rodríguez-Campello, Ana, Capellades, Jaume, García-Arnillas, María P., Fernández-Candil, Juan L., Avellaneda-Gómez, Carla, Giralt-Steinhauer, Eva, Jiménez-Conde, Jordi, Soriano-Tárraga, Carolina, Villalba-Martínez, Gloria, Vivanco-Hidalgo, Rosa M., Vivas, Elio, and Ois, Angel
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- 2020
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25. Early Neurological Change After Ischemic Stroke Is Associated With 90-Day Outcome
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Heitsch, Laura, Ibanez, Laura, Carrera, Caty, Binkley, Michael M., Strbian, Daniel, Tatlisumak, Turgut, Bustamante, Alejandro, Ribó, Marc, Molina, Carlos, Dávalos, Antoni, López-Cancio, Elena, Muñoz-Narbona, Lucia, Soriano-Tárraga, Carol, Giralt-Steinhauer, Eva, Obach, Victor, Slowik, Agnieszka, Pera, Joanna, Lapicka-Bodzioch, Katarzyna, Derbisz, Justyna, Sobrino, Tomás, Castillo, José, Campos, Francisco, Rodríguez-Castro, Emilio, Arias-Rivas, Susana, Segura, Tomas, Serrano-Heras, Gemma, Vives-Bauza, Cristófol, Díaz-Navarro, Rosa, Tur, Silva, Jimenez, Carmen, Martí-Fàbregas, Joan, Delgado-Mederos, Raquel, Arenillas, Juan, Krupinski, Jerzy, Cullell, Natalia, Torres-Aguila, Nuria P., Muiño, Elena, Cárcel-Márquez, Jara, Moniche, Francisco, Cabezas, Juan A., Ford, Andria L., Dhar, Rajat, Roquer, Jaume, Khatri, Pooja, Jiménez-Conde, Jordi, Fernandez-Cadenas, Israel, Montaner, Joan, Rosand, Jonathan, Cruchaga, Carlos, and Lee, Jin-Moo
- Published
- 2021
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26. Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies
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Chauhan, Ganesh, Arnold, Corey R, Chu, Audrey Y, Fornage, Myriam, Reyahi, Azadeh, Bis, Joshua C, Havulinna, Aki S, Sargurupremraj, Muralidharan, Smith, Albert Vernon, Adams, Hieab H H, Choi, Seung Hoan, Pulit, Sara L, Trompet, Stella, Garcia, Melissa E, Manichaikul, Ani, Teumer, Alexander, Gustafsson, Stefan, Bartz, Traci M, Bellenguez, Céline, Vidal, Jean Sebastien, Jian, Xueqiu, Kjartansson, Olafur, Wiggins, Kerri L, Satizabal, Claudia L, Xue, Flora, Ripatti, Samuli, Liu, Yongmei, Deelen, Joris, den Hoed, Marcel, Bevan, Steve, Hopewell, Jemma C, Malik, Rainer, Heckbert, Susan R, Rice, Kenneth, Smith, Nicholas L, Levi, Christopher, Sharma, Pankaj, Sudlow, Cathie LM, Nik, Ali Moussavi, Cole, John W, Schmidt, Reinhold, Meschia, James, Thijs, Vincent, Lindgren, Arne, Melander, Olle, Grewal, Raji P, Sacco, Ralph L, Rundek, Tatjana, Rothwell, Peter M, Arnett, Donna K, Jern, Christina, Johnson, Julie A, Benavente, Oscar R, Wassertheil-Smoller, Sylvia, Lee, Jin-Moo, Wong, Quenna, Aparicio, Hugo J, Engelter, Stefan T, Kloss, Manja, Leys, Didier, Pezzini, Alessandro, Buring, Julie E, Ridker, Paul M, Berr, Claudine, Dartigues, Jean-François, Hamsten, Anders, Magnusson, Patrik K, Traylor, Matthew, Pedersen, Nancy L, Lannfelt, Lars, Lindgren, Lars, Lindgren, Cecilia M, Morris, Andrew P, Jimenez-Conde, Jordi, Montaner, Joan, Radmanesh, Farid, Slowik, Agnieszka, Woo, Daniel, Hofman, Albert, Koudstaal, Peter J, Portegies, Marileen L P, Uitterlinden, André G, de Craen, Anton J M, Ford, Ian, Jukema, J Wouter, Stott, David J, Allen, Norrina B, Sale, Michele M, Johnson, Andrew D, Bennett, David A, De Jager, Philip L, White, Charles C, Grabe, Hans Jörgen, Markus, Marcello Ricardo Paulista, Schminke, Ulf, Boncoraglio, Giorgio B, Clarke, Robert, Kamatani, Yoichiro, Dallongeville, Jean, Lopez, Oscar L, Rotter, Jerome I, Nalls, Michael A, Gottesman, Rebecca F, Griswold, Michael E, Knopman, David S, Windham, B Gwen, Beiser, Alexa, Markus, Hugh S, Vartiainen, Erkki, French, Curtis R, Dichgans, Martin, Pastinen, Tomi, Lathrop, Mark, Gudnason, Vilmundur, Kurth, Tobias, Psaty, Bruce M, Harris, Tamara B, Rich, Stephen S, deStefano, Anita L, Schmidt, Carsten Oliver, Worrall, Bradford B, Rosand, Jonathan, Salomaa, Veikko, Mosley, Thomas H, Ingelsson, Erik, van Duijn, Cornelia M, Tzourio, Christophe, Rexrode, Kathryn M, Lehmann, Ordan J, Launer, Lenore J, Ikram, M Arfan, Carlsson, Peter, Chasman, Daniel I, Childs, Sarah J, Longstreth, William T, Junior, Seshadri, Sudha, and Debette, Stéphanie
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- 2016
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27. Interaction of atrial fibrillation and antithrombotics on outcome in intracerebral hemorrhage
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Roquer, Jaume, Vivanco-Hidalgo, Rosa Maria, Prats-Sánchez, Lluís L., Martínez-Domeño, Alejandro, Guisado-Alonso, Daniel, Cuadrado-Godia, Elisa, Giralt Steinhauer, Eva, Jiménez-Conde, Jordi, Rodríguez-Campello, Ana, Martí-Fàbregas, Joan, and Ois, Angel
- Published
- 2019
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28. Validation of a clinical-genetics score to predict hemorrhagic transformations after rtPA
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Carrera, Caty, Cullell, Natalia, Torres-Águila, Nuria, Muiño, Elena, Bustamante, Alejandro, Dávalos, Antonio, López-Cancio, Elena, Ribó, Marc, Molina, Carlos A., Giralt-Steinhauer, Eva, Soriano-Tárraga, Carolina, Mola-Caminal, Marina, Jiménez-Conde, Jordi, Roquer, Jaume, Vives-Bauza, Cristófol, Navarro, Rosa Díaz, Obach, Victor, Arenillas, Juan Francisco, Segura, Tomás, Serrano-Heras, Gemma, Martí-Fàbregas, Joan, Freijo, Marimar, Cabezas, Juan Antonio, Tatlisumak, Turgut, Heitsch, Laura, Ibañez, Laura, Cruchaga, Carlos, Lee, Jin-Moo, Strbian, Daniel, Montaner, Joan, and Fernández-Cadenas, Israel
- Published
- 2019
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29. Big Data Approaches to Phenotyping Acute Ischemic Stroke Using Automated Lesion Segmentation of Multi-Center Magnetic Resonance Imaging Data
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Wu, Ona, Winzeck, Stefan, Giese, Anne-Katrin, Hancock, Brandon L., Etherton, Mark R., Bouts, Mark J.R.J., Donahue, Kathleen, Schirmer, Markus D., Irie, Robert E., Mocking, Steven J.T., McIntosh, Elissa C., Bezerra, Raquel, Kamnitsas, Konstantinos, Frid, Petrea, Wasselius, Johan, Cole, John W., Xu, Huichun, Holmegaard, Lukas, Jiménez-Conde, Jordi, Lemmens, Robin, Lorentzen, Eric, McArdle, Patrick F., Meschia, James F., Roquer, Jaume, Rundek, Tatjana, Sacco, Ralph L., Schmidt, Reinhold, Sharma, Pankaj, Slowik, Agnieszka, Stanne, Tara M., Thijs, Vincent, Vagal, Achala, Woo, Daniel, Bevan, Stephen, Kittner, Steven J., Mitchell, Braxton D., Rosand, Jonathan, Worrall, Bradford B., Jern, Christina, Lindgren, Arne G., Maguire, Jane, and Rost, Natalia S.
- Published
- 2019
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30. A multitrait genetic study of hemostatic factors and hemorrhagic transformation after stroke treatment
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Gallego-Fábrega, Cristina, Temprano-Sagrera, Gerard, Cárcel-Márquez, Jara, Muiño, Elena, Cullel, Natalia, Lledós, Miquel, Llucià-Carol, Laia, Martín-Campos, Jesús M., Sobrino, Tomás, Castillo, José, Millán, Mónica, Muñoz-Narbona, Lucía, López-Cancio Martínez, Elena, Ribó, Marc, Álvarez-Sabín, José, Jiménez-Conde, Jordi, Roquer, Jaume, Tur, Silvia, Obach, Victor, Arenillas, Juan, Segura, Tomás, Serrano-Heras, Gemma, Martí-Fàbregas, Joan, Freijo Guerrero, María del Mar, Moniche Álvarez, Francisco, Castellanos, María del Mar, Morrison, Alana C., Smith, Nicholas L., de Vries, Paul S., Fernández-Cadenas, Israel, Sabater-Lleal, María, Gallego-Fábrega, Cristina, Temprano-Sagrera, Gerard, Cárcel-Márquez, Jara, Muiño, Elena, Cullel, Natalia, Lledós, Miquel, Llucià-Carol, Laia, Martín-Campos, Jesús M., Sobrino, Tomás, Castillo, José, Millán, Mónica, Muñoz-Narbona, Lucía, López-Cancio Martínez, Elena, Ribó, Marc, Álvarez-Sabín, José, Jiménez-Conde, Jordi, Roquer, Jaume, Tur, Silvia, Obach, Victor, Arenillas, Juan, Segura, Tomás, Serrano-Heras, Gemma, Martí-Fàbregas, Joan, Freijo Guerrero, María del Mar, Moniche Álvarez, Francisco, Castellanos, María del Mar, Morrison, Alana C., Smith, Nicholas L., de Vries, Paul S., Fernández-Cadenas, Israel, and Sabater-Lleal, María
- Abstract
[Abstract] Background: Thrombolytic recombinant tissue plasminogen activator (r-tPA) treatment is the only pharmacologic intervention available in the ischemic stroke acute phase. This treatment is associated with an increased risk of intracerebral hemorrhages, known as hemorrhagic transformations (HTs), which worsen the patient's prognosis. Objectives: To investigate the association between genetically determined natural hemostatic factors' levels and increased risk of HT after r-tPA treatment. Methods: Using data from genome-wide association studies on the risk of HT after r-tPA treatment and data on 7 hemostatic factors (factor [F]VII, FVIII, von Willebrand factor [VWF], FXI, fibrinogen, plasminogen activator inhibitor-1, and tissue plasminogen activator), we performed local and global genetic correlation estimation multitrait analyses and colocalization and 2-sample Mendelian randomization analyses between hemostatic factors and HT. Results: Local correlations identified a genomic region on chromosome 16 with shared covariance: fibrinogen-HT, P = 2.45 × 10-11. Multitrait analysis between fibrinogen-HT revealed 3 loci that simultaneously regulate circulating levels of fibrinogen and risk of HT: rs56026866 (PLXND1), P = 8.80 × 10-10; rs1421067 (CHD9), P = 1.81 × 10-14; and rs34780449, near ROBO1 gene, P = 1.64 × 10-8. Multitrait analysis between VWF-HT showed a novel common association regulating VWF and risk of HT after r-tPA at rs10942300 (ZNF366), P = 1.81 × 10-14. Mendelian randomization analysis did not find significant causal associations, although a nominal association was observed for FXI-HT (inverse-variance weighted estimate [SE], 0.07 [-0.29 to 0.00]; odds ratio, 0.87; 95% CI, 0.75-1.00; raw P = .05). Conclusion: We identified 4 shared loci between hemostatic factors and HT after r-tPA treatment, suggesting common regulatory mechanisms between fibrinogen and VWF levels and HT. Further research to determine a possible mediating effect of fibrinogen on HT
- Published
- 2023
31. Fibrinogen nitrotyrosination after ischemic stroke impairs thrombolysis and promotes neuronal death
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ILL-Raga, Gerard, Palomer, Ernest, Ramos-Fernández, Eva, Guix, Francesc X., Bosch-Morató, Mònica, Guivernau, Biuse, Tajes, Marta, Valls-Comamala, Victòria, Jiménez-Conde, Jordi, Ois, Angel, Pérez-Asensio, Fernando, Reyes-Navarro, Mario, Caballo, Carolina, Gil-Gómez, Gabriel, Lopez-Vilchez, Irene, Galan, Ana M., Alameda, Francesc, Escolar, Gines, Opazo, Carlos, Planas, Anna M., Roquer, Jaume, Valverde, Miguel A., and Muñoz, Francisco J.
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- 2015
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32. Machine Learning Approximations to Predict Epigenetic Age Acceleration in Stroke Patients
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Fernández-Pérez, Isabel, primary, Jiménez-Balado, Joan, additional, Lazcano, Uxue, additional, Giralt-Steinhauer, Eva, additional, Rey Álvarez, Lucía, additional, Cuadrado-Godia, Elisa, additional, Rodríguez-Campello, Ana, additional, Macias-Gómez, Adrià, additional, Suárez-Pérez, Antoni, additional, Revert-Barberá, Anna, additional, Estragués-Gázquez, Isabel, additional, Soriano-Tarraga, Carolina, additional, Roquer, Jaume, additional, Ois, Angel, additional, and Jiménez-Conde, Jordi, additional
- Published
- 2023
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33. Perfil clínico y abuso de metanfetamina no recreativa (shabú) entre los pacientes con ictus en la población filipina
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Rodríguez Campello, Ana, primary, Figueras Aguirre, Georgina, additional, Puchades, Victoria, additional, Ois Santiago, Ángel Javier, additional, Cuadrado Godia, Elisa, additional, Giralt Steinhauer, Eva, additional, Jiménez Conde, Jordi, additional, Bertran Recasens, Bernat, additional, Fernández Pérez, Isabel, additional, Soriano Tárraga, Carolina, additional, Mateus, Julián A., additional, and Roquer González, Jaume, additional
- Published
- 2023
- Full Text
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34. Epigenetic Clock Explains White Matter Hyperintensity Burden Irrespective of Chronological Age
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Jiménez-Balado, Joan, primary, Giralt-Steinhauer, Eva, additional, Fernández-Pérez, Isabel, additional, Rey, Lucía, additional, Cuadrado-Godia, Elisa, additional, Ois, Ángel, additional, Rodríguez-Campello, Ana, additional, Soriano-Tárraga, Carolina, additional, Lazcano, Uxue, additional, Macias-Gómez, Adrià, additional, Suárez-Pérez, Antoni, additional, Revert, Anna, additional, Estragués, Isabel, additional, Beltrán-Mármol, Brigitte, additional, Medrano-Martorell, Santiago, additional, Capellades, Jaume, additional, Roquer, Jaume, additional, and Jiménez-Conde, Jordi, additional
- Published
- 2022
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35. Meta-analysis of Genome-wide Association Studies Identifies 1q22 as a Susceptibility Locus for Intracerebral Hemorrhage
- Author
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Woo, Daniel, Falcone, Guido J., Devan, William J., Brown, W. Mark, Biffi, Alessandro, Howard, Timothy D., Anderson, Christopher D., Brouwers, H. Bart, Valant, Valerie, Battey, Thomas W.K., Radmanesh, Farid, Raffeld, Miriam R., Baedorf-Kassis, Sylvia, Deka, Ranjan, Woo, Jessica G., Martin, Lisa J., Haverbusch, Mary, Moomaw, Charles J., Sun, Guangyun, Broderick, Joseph P., Flaherty, Matthew L., Martini, Sharyl R., Kleindorfer, Dawn O., Kissela, Brett, Comeau, Mary E., Jagiella, Jeremiasz M., Schmidt, Helena, Freudenberger, Paul, Pichler, Alexander, Enzinger, Christian, Hansen, Björn M., Norrving, Bo, Jimenez-Conde, Jordi, Giralt-Steinhauer, Eva, Elosua, Roberto, Cuadrado-Godia, Elisa, Soriano, Carolina, Roquer, Jaume, Kraft, Peter, Ayres, Alison M., Schwab, Kristin, McCauley, Jacob L., Pera, Joanna, Urbanik, Andrzej, Rost, Natalia S., Goldstein, Joshua N., Viswanathan, Anand, Stögerer, Eva-Maria, Tirschwell, David L., Selim, Magdy, Brown, Devin L., Silliman, Scott L., Worrall, Bradford B., Meschia, James F., Kidwell, Chelsea S., Montaner, Joan, Fernandez-Cadenas, Israel, Delgado, Pilar, Malik, Rainer, Dichgans, Martin, Greenberg, Steven M., Rothwell, Peter M., Lindgren, Arne, Slowik, Agnieszka, Schmidt, Reinhold, Langefeld, Carl D., and Rosand, Jonathan
- Published
- 2014
- Full Text
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36. Serum magnesium and calcium levels in relation to ischemic stroke: Mendelian randomization study
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Larsson, Susanna C., Traylor, Matthew, Burgess, Stephen, Boncoraglio, Giorgio B., Jern, Christina, Michaëlsson, Karl, Markus, Hugh S., Malik, Rainer, Chauhan, Ganesh, Traylor, Matthew, Sargurupremraj, Muralidharan, Okada, Yukinori, Mishra, Aniket, Rutten-Jacobs, Loes, Giese, Anne-Katrin, van der Laan, Sander W, Gretarsdottir, Solveig, Anderson, Christopher D, Chong, Michael, Adams, Hieab HH, Ago, Tetsuro, Almgren, Peter, Amouyel, Philippe, Ay, Hakan, Bartz, raci M, Benavente, Oscar R, Bevan, Steve, Boncoraglio, Giorgio B, Brown, Robert D, Jr., Butterworth, Adam S, Carrera, Caty, Carty, Cara L, Chasman, Daniel I, Chen, Wei-Min, Cole, John W, Correa, Adolfo, Cotlarciuc, Ioana, Cruchaga, Carlos, Danesh, John, de Bakker, Paul IW, DeStefano, Anita L, Hoed, Marcel den, Duan, Qing, Engelter, Stefan T, Falcone, Guido J, Gottesman, Rebecca F, Grewal, Raji P, Gudnason, Vilmundur, Gustafsson, Stefan, Haessler, Jeffrey, Harris, Tamara B, Hassan, Ahamad, Havulinna, Aki S, Heckbert, Susan R, Holliday, Elizabeth G, Howard, George, Hsu, Fang-Chi, Hyacinth, Hyacinth I, Ikram, M Arfan, Ingelsson, Erik, Irvin, Marguerite R, Jian, Xueqiu, Jiménez-Conde, Jordi, Johnson, Julie A, Jukema, J Wouter, Kanai, Masahiro, Keene, Keith L, Kissela, Brett M, Kleindorfer, Dawn O, Kooperberg, Charles, Kubo, Michiaki, Lange, Leslie A, Langefeld, Carl D, Langenberg, Claudia, Launer, Lenore J, Lee, Jin-Moo, Lemmens, Robin, Leys, Didier, Lewis, Cathryn M, Lin, Wei-Yu, Lindgren, Arne G, Lorentzen, Erik, Magnusson, Patrik K, Maguire, Jane, Manichaikul, Ani, McArdle, Patrick F, Meschia, James F, Mitchell, Braxton D, Mosley, Thomas H, Nalls, Michael A, Ninomiya, Toshiharu, OʼDonnell, Martin J, Psaty, Bruce M, Pulit, Sara L, Rannikmäe, Kristiina, Reiner, Alexander P, Rexrode, Kathryn M, Rice, Kenneth, Rich, Stephen S, Ridker, Paul M, Rost, Natalia S, Rothwell, Peter M, Rotter, Jerome I, Rundek, Tatjana, Sacco, Ralph L, Sakaue, Saori, Sale, Michele M, Salomaa, Veikko, Sapkota, Bishwa R, Schmidt, Reinhold, Schmidt, Carsten O, Schminke, Ulf, Sharma, Pankaj, Slowik, Agnieszka, Sudlow, Cathie LM, Tanislav, Christian, Tatlisumak, Turgut, Taylor, Kent D, Thijs, Vincent NS, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tiedt, Steffen, Trompet, Stella, Tzourio, Christophe, van Duijn, Cornelia M, Walters, Matthew, Wareham, Nicholas J, Wassertheil-Smoller, Sylvia, Wilson, James G, Wiggins, Kerri L, Yang, Qiong, Yusuf, Salim, Amin, Najaf, Aparicio, Hugo S, Arnett, Donna K, Attia, John, Beiser, Alexa S, Berr, Claudine, Buring, Julie E, Bustamante, Mariana, Caso, Valeria, Cheng, Yu-Ching, Choi, Seung Hoan, Chowhan, Ayesha, Cullell, Natalia, Dartigues, Jean-François, Delavaran, Hossein, Delgado, Pilar, Dörr, Marcus, Engström, Gunnar, Ford, Ian, Gurpreet, Wander S, Hamsten, Anders, Heitsch, Laura, Hozawa, Atsushi, Ibanez, Laura, Ilinca, Andreea, Ingelsson, Martin, Iwasaki, Motoki, Jackson, Rebecca D, Jood, Katarina, Jousilahti, Pekka, Kaffashian, Sara, Kalra, Lalit, Kamouchi, Masahiro, Kitazono, Takanari, Kjartansson, Olafur, Kloss, Manja, Koudstaal, Peter J, Krupinski, Jerzy, Labovitz, Daniel L, Laurie, Cathy C, Levi, Christopher R, Li, Linxin, Lind, Lars, Lindgren, Cecilia M, Lioutas, Vasileios, Liu, Yong Mei, Lopez, Oscar L, Makoto, Hirata, Martinez-Majander, Nicolas, Matsuda, Koichi, Minegishi, Naoko, Montaner, Joan, Morris, Andrew P, Muiño, Elena, Müller-Nurasyid, Martina, Norrving, Bo, Ogishima, Soichi, Parati, Eugenio A, Peddareddygari, Leema Reddy, Pedersen, Nancy L, Pera, Joanna, Perola, Markus, Pezzini, Alessandro, Pileggi, Silvana, Rabionet, Raquel, Riba-Llena, Iolanda, Ribasés, Marta, Romero, Jose R, Roquer, Jaume, Rudd, Anthony G, Sarin, Antti-Pekka, Sarju, Ralhan, Sarnowski, Chloe, Sasaki, Makoto, Satizabal, Claudia L, Satoh, Mamoru, Sattar, Naveed, Sawada, Norie, Sibolt, Gerli, Sigurdsson, Ásgeir, Smith, Albert, Sobue, Kenji, Soriano-Tárraga, Carolina, Stanne, Tara, Stine, O Colin, Stott, David J, Strauch, Konstantin, Takai, Takako, Tanaka, Hideo, Tanno, Kozo, Teumer, Alexander, Tomppo, Liisa, Torres-Aguila, Nuria P, Touze, Emmanuel, Tsugane, Shoichiro, Uitterlinden, Andre G, Valdimarsson, Einar M, van der Lee, Sven J, Völzke, Henry, Wakai, Kenji, Weir, David, Williams, Stephen R, Wolfe, Charles DA, Wong, Quenna, Xu, Huichun, Yamaji, Taiki, Sanghera, Dharambir K, Melander, Olle, Jern, Christina, Strbian, Daniel, Fernandez-Cadenas, Israel, Longstreth, W T, Jr, Rolfs, Arndt, Hata, Jun, Woo, Daniel, Rosand, Jonathan, Pare, Guillaume, Hopewell, Jemma C, Saleheen, Danish, Stefansson, Kari, Worrall, Bradford B, Kittner, Steven J, Seshadri, Sudha, Fornage, Myriam, Markus, Hugh S, Howson, Joanna MM, Kamatani, Yoichiro, Debette, Stephanie, and Dichgans, Martin
- Published
- 2019
- Full Text
- View/download PDF
37. Genetic Imbalance Is Associated With Functional Outcome After Ischemic Stroke
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Pfeiffer, Dorothea, Chen, Bowang, Schlicht, Kristina, Ginsbach, Philip, Abboud, Sherine, Bersano, Anna, Bevan, Steve, Brandt, Tobias, Caso, Valeria, Debette, Stéphanie, Erhart, Philipp, Freitag-Wolf, Sandra, Giacalone, Giacomo, Grau, Armin J., Hayani, Eyad, Jern, Christina, Jiménez-Conde, Jordi, Kloss, Manja, Krawczak, Michael, Lee, Jin-Moo, Lemmens, Robin, Leys, Didier, Lichy, Christoph, Maguire, Jane M., Martin, Juan J., Metso, Antti J., Metso, Tiina M., Mitchell, Braxton D., Pezzini, Alessandro, Rosand, Jonathan, Rost, Natalia S., Stenman, Martin, Tatlisumak, Turgut, Thijs, Vincent, Touzé, Emmanuel, Traenka, Christopher, Werner, Inge, Woo, Daniel, Del Zotto, Elisabetta, Engelter, Stefan T., Kittner, Steven J., Cole, John W., Grond-Ginsbach, Caspar, Lyrer, Philippe A., and Lindgren, Arne
- Published
- 2019
- Full Text
- View/download PDF
38. PATJ Low Frequency Variants Are Associated With Worse Ischemic Stroke Functional Outcome: A Genome-Wide Meta-Analysis
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Mola-Caminal, Marina, Carrera, Caty, Soriano-Tárraga, Carolina, Giralt-Steinhauer, Eva, Díaz-Navarro, Rosa M., Tur, Sílvia, Jiménez, Carmen, Medina-Dols, Aina, Cullell, Natàlia, Torres-Aguila, Nuria P., Muiño, Elena, Rodríguez-Campello, Ana, Ois, Angel, Cuadrado-Godia, Elisa, Vivanco-Hidalgo, Rosa M., Hernandez-Guillamon, Mar, Solé, Montse, Delgado, Pilar, Bustamante, Alejandro, García-Berrocoso, Teresa, Mendióroz, Maite, Castellanos, Mar, Serena, Joaquín, Martí-Fàbregas, Joan, Segura, Tomás, Serrano-Heras, Gemma, Obach, Victor, Ribó, Marc, Molina, Carlos A., Alvarez-Sabín, José, Palomeras, Ernest, Freijo, Mar, Font, Maria A., Rosand, Jonathan, Rost, Natalia S., Gallego-Fabrega, Cristina, Lee, Jin-Moo, Heitsch, Laura, Ibanez, Laura, Cruchaga, Carlos, Phuah, Chia-Ling, Lemmens, Robin, Thijs, Vincent, Lindgren, Arne, Maguire, Jane, Rannikmae, Kristiina, Sudlow, Catherine L., Jern, Christina, Stanne, Tara M., Lorentzen, Erik, Muñoz-Narbona, Lucía, Dávalos, Antonio, López-Cancio, Elena, Worrall, Bradford B., Woo, Daniel, Kittner, Steven J., Mitchell, Braxton D., Montaner, Joan, Roquer, Jaume, Krupinski, Jurek, Estivill, Xavier, Rabionet, Raquel, Vives-Bauzá, Cristòfol, Fernández-Cadenas, Israel, and Jiménez-Conde, Jordi
- Published
- 2019
- Full Text
- View/download PDF
39. Epigenetics and Aging
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Soriano-Tárraga, Carolina, primary, Jiménez-Conde, Jordi, additional, and Roquer, Jaume, additional
- Published
- 2018
- Full Text
- View/download PDF
40. Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
- Author
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Malik, Rainer, Chauhan, Ganesh, Traylor, Matthew, Sargurupremraj, Muralidharan, Okada, Yukinori, Mishra, Aniket, Rutten-Jacobs, Loes, Giese, Anne-Katrin, van der Laan, Sander W., Gretarsdottir, Solveig, Anderson, Christopher D., Chong, Michael, Adams, Hieab H. H., Ago, Tetsuro, Almgren, Peter, Amouyel, Philippe, Ay, Hakan, Bartz, Traci M., Benavente, Oscar R., Bevan, Steve, Boncoraglio, Giorgio B., Brown, Jr, Robert D., Butterworth, Adam S., Carrera, Caty, Carty, Cara L., Chasman, Daniel I., Chen, Wei-Min, Cole, John W., Correa, Adolfo, Cotlarciuc, Ioana, Cruchaga, Carlos, Danesh, John, de Bakker, Paul I. W., DeStefano, Anita L., den Hoed, Marcel, Duan, Qing, Engelter, Stefan T., Falcone, Guido J., Gottesman, Rebecca F., Grewal, Raji P., Gudnason, Vilmundur, Gustafsson, Stefan, Haessler, Jeffrey, Harris, Tamara B., Hassan, Ahamad, Havulinna, Aki S., Heckbert, Susan R., Holliday, Elizabeth G., Howard, George, Hsu, Fang-Chi, Hyacinth, Hyacinth I., Ikram, M. Arfan, Ingelsson, Erik, Irvin, Marguerite R., Jian, Xueqiu, Jiménez-Conde, Jordi, Johnson, Julie A., Jukema, J. Wouter, Kanai, Masahiro, Keene, Keith L., Kissela, Brett M., Kleindorfer, Dawn O., Kooperberg, Charles, Kubo, Michiaki, Lange, Leslie A., Langefeld, Carl D., Langenberg, Claudia, Launer, Lenore J., Lee, Jin-Moo, Lemmens, Robin, Leys, Didier, Lewis, Cathryn M., Lin, Wei-Yu, Lindgren, Arne G., Lorentzen, Erik, Magnusson, Patrik K., Maguire, Jane, Manichaikul, Ani, McArdle, Patrick F., Meschia, James F., Mitchell, Braxton D., Mosley, Thomas H., Nalls, Michael A., Ninomiya, Toshiharu, O’Donnell, Martin J., Psaty, Bruce M., Pulit, Sara L., Rannikmäe, Kristiina, Reiner, Alexander P., Rexrode, Kathryn M., Rice, Kenneth, Rich, Stephen S., Ridker, Paul M., Rost, Natalia S., Rothwell, Peter M., Rotter, Jerome I., Rundek, Tatjana, Sacco, Ralph L., Sakaue, Saori, Sale, Michele M., Salomaa, Veikko, Sapkota, Bishwa R., Schmidt, Reinhold, Schmidt, Carsten O., Schminke, Ulf, Sharma, Pankaj, Slowik, Agnieszka, Sudlow, Cathie L. M., Tanislav, Christian, Tatlisumak, Turgut, Taylor, Kent D., Thijs, Vincent N. S., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tiedt, Steffen, Trompet, Stella, Tzourio, Christophe, van Duijn, Cornelia M., Walters, Matthew, Wareham, Nicholas J., Wassertheil-Smoller, Sylvia, Wilson, James G., Wiggins, Kerri L., Yang, Qiong, Yusuf, Salim, AFGen Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, International Genomics of Blood Pressure (iGEN-BP) Consortium, INVENT Consortium, STARNET, Bis, Joshua C., Pastinen, Tomi, Ruusalepp, Arno, Schadt, Eric E., Koplev, Simon, Björkegren, Johan L. M., Codoni, Veronica, Civelek, Mete, Smith, Nicholas L., Trégouët, David A., Christophersen, Ingrid E., Roselli, Carolina, Lubitz, Steven A., Ellinor, Patrick T., Tai, E. Shyong, Kooner, Jaspal S., Kato, Norihiro, He, Jiang, van der Harst, Pim, Elliott, Paul, Chambers, John C., Takeuchi, Fumihiko, Johnson, Andrew D., BioBank Japan Cooperative Hospital Group, COMPASS Consortium, EPIC-CVD Consortium, EPIC-InterAct Consortium, International Stroke Genetics Consortium (ISGC), METASTROKE Consortium, Neurology Working Group of the CHARGE Consortium, NINDS Stroke Genetics Network (SiGN), UK Young Lacunar DNA Study, MEGASTROKE Consortium, Sanghera, Dharambir K., Melander, Olle, Jern, Christina, Strbian, Daniel, Fernandez-Cadenas, Israel, Longstreth, Jr, W. T., Rolfs, Arndt, Hata, Jun, Woo, Daniel, Rosand, Jonathan, Pare, Guillaume, Hopewell, Jemma C., Saleheen, Danish, Stefansson, Kari, Worrall, Bradford B., Kittner, Steven J., Seshadri, Sudha, Fornage, Myriam, Markus, Hugh S., Howson, Joanna M. M., Kamatani, Yoichiro, Debette, Stephanie, and Dichgans, Martin
- Published
- 2019
- Full Text
- View/download PDF
41. Sleep modulation of epileptic activity in mesial and neocortical temporal lobe epilepsy: A study with depth and subdural electrodes
- Author
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Rocamora, Rodrigo, Andrzejak, Ralph G., Jiménez-Conde, Jordi, and Elger, Christian E.
- Published
- 2013
- Full Text
- View/download PDF
42. GRECOS Project (Genotyping Recurrence Risk of Stroke): The Use of Genetics to Predict the Vascular Recurrence After Stroke
- Author
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Fernández-Cadenas, Israel, Mendióroz, Maite, Giralt, Dolors, Nafria, Cristina, Garcia, Elena, Carrera, Caty, Gallego-Fabrega, Cristina, Domingues-Montanari, Sophie, Delgado, Pilar, Ribó, Marc, Castellanos, Mar, Martínez, Sergi, Freijo, Marimar, Jiménez-Conde, Jordi, Rubiera, Marta, Alvarez-Sabín, José, Molina, Carlos A., Font, Maria Angels, Grau Olivares, Marta, Palomeras, Ernest, Perez de la Ossa, Natalia, Martinez-Zabaleta, Maite, Masjuan, Jaime, Moniche, Francisco, Canovas, David, Piñana, Carlos, Purroy, Francisco, Cocho, Dolores, Navas, Inma, Tejero, Carlos, Aymerich, Nuria, Cullell, Natalia, Muiño, Elena, Serena, Joaquín, Rubio, Francisco, Davalos, Antoni, Roquer, Jaume, Arenillas, Juan Francisco, Martí-Fábregas, Joan, Keene, Keith, Chen, Wei-Min, Worrall, Bradford, Sale, Michele, Arboix, Adrià, Krupinski, Jerzy, and Montaner, Joan
- Published
- 2017
- Full Text
- View/download PDF
43. Epigenome-wide association study identifies TXNIP gene associated with type 2 diabetes mellitus and sustained hyperglycemia
- Author
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Soriano-Tárraga, Carolina, Jiménez-Conde, Jordi, Giralt-Steinhauer, Eva, Mola-Caminal, Marina, Vivanco-Hidalgo, Rosa M., Ois, Angel, Rodríguez-Campello, Ana, Cuadrado-Godia, Elisa, Sayols-Baixeras, Sergi, Elosua, Roberto, Roquer, Jaume, Jiménez-Conde, Jordi, Soriano-Tárraga, Carolina, Giralt-Steinhauer, Eva, Mola, Marina, Ois, Ángel, Rodríguez-Campello, Ana, Cuadrado-Godia, Elisa, Roquer, Jaume, Krupinski, Jurek, Fernández-Cadenas, Israel, Rabionet, Kelly, Obach, Victor, Vivas, Tófol, Maria, Rosa, Navarro, Díaz, and Lilly, Elaine M.
- Published
- 2016
- Full Text
- View/download PDF
44. A Polygenic Risk Score Based on a Cardioembolic Stroke Multitrait Analysis Improves a Clinical Prediction Model for This Stroke Subtype
- Author
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Cárcel-Márquez, Jara, primary, Muiño, Elena, additional, Gallego-Fabrega, Cristina, additional, Cullell, Natalia, additional, Lledós, Miquel, additional, Llucià-Carol, Laia, additional, Sobrino, Tomás, additional, Campos, Francisco, additional, Castillo, José, additional, Freijo, Marimar, additional, Arenillas, Juan Francisco, additional, Obach, Victor, additional, Álvarez-Sabín, José, additional, Molina, Carlos A., additional, Ribó, Marc, additional, Jiménez-Conde, Jordi, additional, Roquer, Jaume, additional, Muñoz-Narbona, Lucia, additional, Lopez-Cancio, Elena, additional, Millán, Mònica, additional, Diaz-Navarro, Rosa, additional, Vives-Bauza, Cristòfol, additional, Serrano-Heras, Gemma, additional, Segura, Tomás, additional, Ibañez, Laura, additional, Heitsch, Laura, additional, Delgado, Pilar, additional, Dhar, Rajat, additional, Krupinski, Jerzy, additional, Delgado-Mederos, Raquel, additional, Prats-Sánchez, Luis, additional, Camps-Renom, Pol, additional, Blay, Natalia, additional, Sumoy, Lauro, additional, de Cid, Rafael, additional, Montaner, Joan, additional, Cruchaga, Carlos, additional, Lee, Jin-Moo, additional, Martí-Fàbregas, Joan, additional, and Férnandez-Cadenas, Israel, additional
- Published
- 2022
- Full Text
- View/download PDF
45. DNA Methylation and Ischemic Stroke Risk: An Epigenome-Wide Association Study
- Author
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Cullell, Natalia, additional, Soriano-Tárraga, Carolina, additional, Gallego-Fábrega, Cristina, additional, Cárcel-Márquez, Jara, additional, Torres-Águila, Nuria P., additional, Muiño, Elena, additional, Lledós, Miquel, additional, Llucià-Carol, Laia, additional, Esteller, Manel, additional, Castro de Moura, Manuel, additional, Montaner, Joan, additional, Fernández-Sanlés, Alba, additional, Elosua, Roberto, additional, Delgado, Pilar, additional, Martí-Fábregas, Joan, additional, Krupinski, Jerzy, additional, Roquer, Jaume, additional, Jiménez-Conde, Jordi, additional, and Fernández-Cadenas, Israel, additional
- Published
- 2022
- Full Text
- View/download PDF
46. Genetics and Epigenetics of Spontaneous Intracerebral Hemorrhage
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Giralt-Steinhauer, Eva, primary, Jiménez-Balado, Joan, additional, Fernández-Pérez, Isabel, additional, Rey Álvarez, Lucía, additional, Rodríguez-Campello, Ana, additional, Ois, Ángel, additional, Cuadrado-Godia, Elisa, additional, Jiménez-Conde, Jordi, additional, and Roquer, Jaume, additional
- Published
- 2022
- Full Text
- View/download PDF
47. Intracranial aneurysm classifier using phenotypic factors : an international pooled analysis
- Author
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Morel, Sandrine, Hostettler, Isabel C., Spinner, Georg R., Bourcier, Romain, Pera, Joanna, Meling, Torstein, Alg, Varinder, Houlden, Henry, Bakker, Mark, van’t Hof, Femke, Rinkel, Gabriel, Foroud, Tatiana, Lai, Dongbing, Moomaw, Charles, Worrall, Bradford, Caroff, Jildaz, Constant-dits-Beaufils, Pacôme, Karakachoff, Matilde, Rimbert, Antoine, Rouchaud, Aymeric, Gaal-Paavola, Emilia, Kaukovalta, Hanna, Kivisaari, Riku, Laakso, Aki, Jahromi, Behnam, Tulamo, Riikka, Friedrich, Christoph, Dauvillier, Jerome, Hirsch, Sven, Isidor, Nathalie, Kulcsàr, Zolt, Lövblad, Karl, Martin, Olivier, Machi, Paolo, Mendes Pereira, Vitor, Rüfenacht, Daniel, Schaller, Karl, Schilling, Sabine, Slowik, Agnieszka, Jaaskelainen, Juha, von und zu Fraunberg, Mikael, Jiménez-Conde, Jordi, Cuadrado-Godia, Elisa, Soriano-Tárraga, Carolina, Millwood, Iona, Walters, Robin, The @neurIST project, The ICAN Study Group, Genetics and Observational Subarachnoid Haemorrhage (GOSH) Study Investigators, International Stroke Genetics Consortium (ISGC), Kim, Helen, Redon, Richard, Ko, Nerissa, Rouleau, Guy, Lindgren, Antti, Niemelä, Mika, Desal, Hubert, Woo, Daniel, Broderick, Joseph, Werring, David, Ruigrok, Ynte, Bijlenga, Philippe, Morel, Sandrine, Hostettler, Isabel C., Spinner, Georg R., Bourcier, Romain, Pera, Joanna, Meling, Torstein, Alg, Varinder, Houlden, Henry, Bakker, Mark, van’t Hof, Femke, Rinkel, Gabriel, Foroud, Tatiana, Lai, Dongbing, Moomaw, Charles, Worrall, Bradford, Caroff, Jildaz, Constant-dits-Beaufils, Pacôme, Karakachoff, Matilde, Rimbert, Antoine, Rouchaud, Aymeric, Gaal-Paavola, Emilia, Kaukovalta, Hanna, Kivisaari, Riku, Laakso, Aki, Jahromi, Behnam, Tulamo, Riikka, Friedrich, Christoph, Dauvillier, Jerome, Hirsch, Sven, Isidor, Nathalie, Kulcsàr, Zolt, Lövblad, Karl, Martin, Olivier, Machi, Paolo, Mendes Pereira, Vitor, Rüfenacht, Daniel, Schaller, Karl, Schilling, Sabine, Slowik, Agnieszka, Jaaskelainen, Juha, von und zu Fraunberg, Mikael, Jiménez-Conde, Jordi, Cuadrado-Godia, Elisa, Soriano-Tárraga, Carolina, Millwood, Iona, Walters, Robin, The @neurIST project, The ICAN Study Group, Genetics and Observational Subarachnoid Haemorrhage (GOSH) Study Investigators, International Stroke Genetics Consortium (ISGC), Kim, Helen, Redon, Richard, Ko, Nerissa, Rouleau, Guy, Lindgren, Antti, Niemelä, Mika, Desal, Hubert, Woo, Daniel, Broderick, Joseph, Werring, David, Ruigrok, Ynte, and Bijlenga, Philippe
- Abstract
Intracranial aneurysms (IAs) are usually asymptomatic with a low risk of rupture, but consequences of aneurysmal subarachnoid hemorrhage (aSAH) are severe. Identifying IAs at risk of rupture has important clinical and socio-economic consequences. The goal of this study was to assess the effect of patient and IA characteristics on the likelihood of IA being diagnosed incidentally versus ruptured. Patients were recruited at 21 international centers. Seven phenotypic patient characteristics and three IA characteristics were recorded. The analyzed cohort included 7992 patients. Multivariate analysis demonstrated that: (1) IA location is the strongest factor associated with IA rupture status at diagnosis; (2) Risk factor awareness (hypertension, smoking) increases the likelihood of being diagnosed with unruptured IA; (3) Patients with ruptured IAs in high-risk locations tend to be older, and their IAs are smaller; (4) Smokers with ruptured IAs tend to be younger, and their IAs are larger; (5) Female patients with ruptured IAs tend to be older, and their IAs are smaller; (6) IA size and age at rupture correlate. The assessment of associations regarding patient and IA characteristics with IA rupture allows us to refine IA disease models and provide data to develop risk instruments for clinicians to support personalized decision-making.
- Published
- 2022
48. Table_2_A Polygenic Risk Score Based on a Cardioembolic Stroke Multitrait Analysis Improves a Clinical Prediction Model for This Stroke Subtype.XLSX
- Author
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Cárcel-Márquez, Jara, Muiño, Elena, Gallego-Fabrega, Cristina, Cullell, Nàtalia, Lledós, Miquel, Llucià-Carol, Laia, Sobrino, Tomás, Campos, Francisco, Castillo, José, Freijo-Guerrero, Maria del Mar, Arenillas, Juan F., Obach, Víctor, Álvarez-Sabín, José, Molina, Carlos A., Ribó, Marc, Jiménez-Conde, Jordi, Roquer, Jaume, Muñoz-Narbona, Lucía, López-Cancio, Elena, Millán, Mónica, Díaz-Navarro, Rosa M., Vives-Bauzá, Cristòfol, Serrano-Heras, Gemma, Segura, Tomás, Ibáñez, Laura, Heitsch, Laura, Delgado, Pilar, Dhar, Rajat, Krupinski, Jerzy, Delgado-Mederos, Raquel, Prats-Sánchez, Luis, Camps-Renom, Pol, Blay, Natalia, Sumoy, Lauro, Cid, Rafael de, Montaner, Joan, Cruchaga, Carlos, Lee, Jin-Moo, Marti-Fabregas, Joan, Fernández-Cadenas, Israel, Cárcel-Márquez, Jara, Muiño, Elena, Gallego-Fabrega, Cristina, Cullell, Nàtalia, Lledós, Miquel, Llucià-Carol, Laia, Sobrino, Tomás, Campos, Francisco, Castillo, José, Freijo-Guerrero, Maria del Mar, Arenillas, Juan F., Obach, Víctor, Álvarez-Sabín, José, Molina, Carlos A., Ribó, Marc, Jiménez-Conde, Jordi, Roquer, Jaume, Muñoz-Narbona, Lucía, López-Cancio, Elena, Millán, Mónica, Díaz-Navarro, Rosa M., Vives-Bauzá, Cristòfol, Serrano-Heras, Gemma, Segura, Tomás, Ibáñez, Laura, Heitsch, Laura, Delgado, Pilar, Dhar, Rajat, Krupinski, Jerzy, Delgado-Mederos, Raquel, Prats-Sánchez, Luis, Camps-Renom, Pol, Blay, Natalia, Sumoy, Lauro, Cid, Rafael de, Montaner, Joan, Cruchaga, Carlos, Lee, Jin-Moo, Marti-Fabregas, Joan, and Fernández-Cadenas, Israel
- Abstract
[Background] Occult atrial fibrillation (AF) is one of the major causes of embolic stroke of undetermined source (ESUS). Knowing the underlying etiology of an ESUS will reduce stroke recurrence and/or unnecessary use of anticoagulants. Understanding cardioembolic strokes (CES), whose main cause is AF, will provide tools to select patients who would benefit from anticoagulants among those with ESUS or AF. We aimed to discover novel loci associated with CES and create a polygenetic risk score (PRS) for a more efficient CES risk stratification., [Methods] Multitrait analysis of GWAS (MTAG) was performed with MEGASTROKE-CES cohort (n = 362,661) and AF cohort (n = 1,030,836). We considered significant variants and replicated those variants with MTAG p-value < 5 × 10−8 influencing both traits (GWAS-pairwise) with a p-value < 0.05 in the original GWAS and in an independent cohort (n = 9,105). The PRS was created with PRSice-2 and evaluated in the independent cohort., [Results] We found and replicated eleven loci associated with CES. Eight were novel loci. Seven of them had been previously associated with AF, namely, CAV1, ESR2, GORAB, IGF1R, NEURL1, WIPF1, and ZEB2. KIAA1755 locus had never been associated with CES/AF, leading its index variant to a missense change (R1045W). The PRS generated has been significantly associated with CES improving discrimination and patient reclassification of a model with age, sex, and hypertension., [Conclusion] The loci found significantly associated with CES in the MTAG, together with the creation of a PRS that improves the predictive clinical models of CES, might help guide future clinical trials of anticoagulant therapy in patients with ESUS or AF.
- Published
- 2022
49. Additional file 1 of Altered methylation pattern in EXOC4 is associated with stroke outcome: an epigenome-wide association study
- Author
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Boehringer Ingelheim Fonds, Instituto de Salud Carlos III, Agència de Gestió d'Ajuts Universitaris i de Recerca, Bristol-Myers Squibb, Fundació La Marató de TV3, Fundació Docència i Recerca MútuaTerrassa, Cullell, Nàtalia, Soriano-Tárraga, Carolina, Gallego-Fabrega, Cristina, Cárcel-Márquez, Jara, Muiño, Elena, Llucià-Carol, Laia, Lledós, Miquel, Esteller, Manel, Moura, Manuel Castro de, Montaner, Joan, Rosell, Anna, Delgado, Pilar, Marti-Fabregas, Joan, Krupinski, Jerzy, Roquer, Jaume, Jiménez-Conde, Jordi, Fernández-Cadenas, Israel, Boehringer Ingelheim Fonds, Instituto de Salud Carlos III, Agència de Gestió d'Ajuts Universitaris i de Recerca, Bristol-Myers Squibb, Fundació La Marató de TV3, Fundació Docència i Recerca MútuaTerrassa, Cullell, Nàtalia, Soriano-Tárraga, Carolina, Gallego-Fabrega, Cristina, Cárcel-Márquez, Jara, Muiño, Elena, Llucià-Carol, Laia, Lledós, Miquel, Esteller, Manel, Moura, Manuel Castro de, Montaner, Joan, Rosell, Anna, Delgado, Pilar, Marti-Fabregas, Joan, Krupinski, Jerzy, Roquer, Jaume, Jiménez-Conde, Jordi, and Fernández-Cadenas, Israel
- Published
- 2022
50. Supplementary Material DNA methylation is associated with ischemic stroke risk: An Epigenome-Wide association study
- Author
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Cullell, Nàtalia, Soriano-Tárraga, Carolina, Gallego-Fabrega, Cristina, Cárcel-Márquez, Jara, Torres-Águila, Nuria P., Muiño, Elena, Lledós, Miquel, Llucià-Carol, Laia, Esteller, Manel, Castro de Moura, Manuel, Montaner, Joan, Fernández-Sanlés, Alba, Elosua, Roberto, Delgado, Pilar, Marti-Fabregas, Joan, Krupinski, Jerzy, Roquer, Jaume, Jiménez-Conde, Jordi, Fernández-Cadenas, Israel, Cullell, Nàtalia, Soriano-Tárraga, Carolina, Gallego-Fabrega, Cristina, Cárcel-Márquez, Jara, Torres-Águila, Nuria P., Muiño, Elena, Lledós, Miquel, Llucià-Carol, Laia, Esteller, Manel, Castro de Moura, Manuel, Montaner, Joan, Fernández-Sanlés, Alba, Elosua, Roberto, Delgado, Pilar, Marti-Fabregas, Joan, Krupinski, Jerzy, Roquer, Jaume, Jiménez-Conde, Jordi, and Fernández-Cadenas, Israel
- Abstract
1-Supplementary Methods 1.1-Cohorts included in the study 2-e-Table legends 3-e-Figure legends 4-e-Tables 5-e-Figures 6-e-References
- Published
- 2022
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