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3. Identification of 1,2,3-triazolium salt-based inhibitors of Leishmania infantum trypanothione disulfide reductase with enhanced antileishmanial potency in cellulo and increased selectivity

Author

de Lucio, Héctor, Revuelto, Alejandro, Carriles, Alejandra A., de Castro, Sonia, García-González, Sonia, García-Soriano, Juan Carlos, Alcón-Calderón, Mercedes, Sánchez-Murcia, Pedro A., Hermoso, Juan A., Gago, Federico, Camarasa, María-José, Jiménez-Ruiz, Antonio, and Velázquez, Sonsoles

Published
2022
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6. The repertoire of iron superoxide dismutases from Leishmania infantum as targets in the search for therapeutic agents against leishmaniasis.

Author

García-Soriano, Juan Carlos, de Lucio, Héctor, Elvira-Blázquez, Daniel, Alcón-Calderón, Mercedes, Sanz del Olmo, Natalia, Sánchez-Murcia, Pedro A., Ortega, Paula, de la Mata, Francisco Javier, and Jiménez-Ruiz, Antonio

Subjects
LEISHMANIA infantum, PARASITIC diseases, SUPEROXIDE dismutase, LEISHMANIASIS, DRUG target
Abstract

Species of Leishmania and Trypanosoma genera are the causative agents of relevant parasitic diseases. Survival inside their hosts requires the existence of a potent antioxidant enzymatic machinery. Four iron superoxide dismutases have been described in trypanosomatids (FeSODA, FeSODB1, FeSODB2, and FeSODC) that hold a potential as therapeutic targets. Nonetheless, very few studies have been developed that make use of the purified enzymes. Moreover, FeSODC remains uncharacterised in Leishmania. In this work, for the first time, we describe the purification and enzymatic activity of recombinant versions of the four Leishmania FeSOD isoforms and establish an improved strategy for developing inhibitors. We propose a novel parameter [(V*cyt. c − Vcyt. c)/Vcyt. c] which, in contrast to that used in the classical cytochrome c reduction assay, correlates linearly with enzyme concentration. As a proof of concept, we determine the IC50 values of two ruthenium carbosilane metallodendrimers against these isoforms. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Stratification of Older Adults According to Frailty Status and Falls Using Gait Parameters Explored Using an Inertial System.

Author

Neira Álvarez, Marta, Huertas-Hoyas, Elisabet, Novak, Robert, Sipols, Ana Elizabeth, García-Villamil-Neira, Guillermo, Rodríguez-Sánchez, M. Cristina, Del-Ama, Antonio J., Ruiz-Ruiz, Luisa, De Villa, Sara García, and Jiménez-Ruiz, Antonio R.

Subjects
OLDER people, RANDOM forest algorithms, FRAILTY, NURSING care facilities, GAIT in humans
Abstract

Featured Application: The main finding shows that characteristics assessed using the G-STRIDE device can effectively stratify participants according to their state of frailty and occurrence of falls. Background: The World Health Organization recommends health initiatives focused on the early detection of frailty and falls. Objectives: 1—To compare clinical characteristics, functional performance and gait parameters (estimated with the G-STRIDE inertial sensor) between different frailty groups in older adults with and without falls. 2—To identify variables that stratify participants according to frailty status and falls. 3—To verify the sensitivity, specificity and accuracy of the model that stratifies participants according to frailty status and falls. Methods: Observational, multicenter case-control study. Participants, adults over 70 years with and without falls were recruited from two outpatient clinics and three nursing homes from September 2021 to March 2022. Clinical variables and gait parameters were gathered using the G-STRIDE inertial sensor. Random Forest regression was applied to stratify participants. Results: 163 participants with a mean age of 82.6 ± 6.2 years, of which 118 (72%) were women, were included. Significant differences were found in all gait parameters (both conventional assessment and G-STRIDE evaluation). A hierarchy of factors contributed to the risk of frailty and falls. The confusion matrix and the performance metrics demonstrated high accuracy in classifying participants. Conclusions: Gait parameters, particularly those assessed by G-STRIDE, are effective in stratifying individuals by frailty status and falls. These findings underscore the importance of gait analysis in early intervention strategies. [ABSTRACT FROM AUTHOR]

Published
2024
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16. GSTRIDE: A database of frailty and functional assessments with inertial gait data from elderly fallers and non-fallers populations

Author

García-Villamil Neira, Guillermo [0000-0002-3869-4410], Neira Álvarez, Marta [0000-0002-5488-7749], Huertas Hoyas, Elisabet [0000-0002-5840-541X], Ruiz Ruiz, Luisa [0000-0003-0316-7781], García-de-Villa, Sara [0000-0002-7054-5810], Del-Ama, Antonio J.[0000-0001-6215-2593], Rodríguez Sánchez, María Cristina [0000-0001-9243-2166], Jiménez Ruiz, Antonio R [0000-0001-9771-1930], García-Villamil Neira, Guillermo, Neira Álvarez, Marta, Huertas Hoyas, Elisabet, Ruiz Ruiz, Luisa, García-de-Villa, Sara, Del-Ama, Antonio J., Rodríguez Sánchez, María Cristina, Jiménez Ruiz, Antonio R., García-Villamil Neira, Guillermo [0000-0002-3869-4410], Neira Álvarez, Marta [0000-0002-5488-7749], Huertas Hoyas, Elisabet [0000-0002-5840-541X], Ruiz Ruiz, Luisa [0000-0003-0316-7781], García-de-Villa, Sara [0000-0002-7054-5810], Del-Ama, Antonio J.[0000-0001-6215-2593], Rodríguez Sánchez, María Cristina [0000-0001-9243-2166], Jiménez Ruiz, Antonio R [0000-0001-9771-1930], García-Villamil Neira, Guillermo, Neira Álvarez, Marta, Huertas Hoyas, Elisabet, Ruiz Ruiz, Luisa, García-de-Villa, Sara, Del-Ama, Antonio J., Rodríguez Sánchez, María Cristina, and Jiménez Ruiz, Antonio R.

Published
2022

17. GetSensorData: An extensible Android-based application for multi-sensor data registration

Author

Jiménez Ruiz, Antonio R. [0000-0001-9771-1930], Juan D. Gutiérrez, Jiménez Ruiz, Antonio R., Fernando Seco, Fernando J. Álvarez, Teodoro Aguilera, Joaquín Torres-Sospedra, Fran Melchor, Jiménez Ruiz, Antonio R. [0000-0001-9771-1930], Juan D. Gutiérrez, Jiménez Ruiz, Antonio R., Fernando Seco, Fernando J. Álvarez, Teodoro Aguilera, and Joaquín Torres-Sospedra, Fran Melchor

Abstract

Smartphones are powerful tools with extensive sensorization that can provide useful information in research or everyday life applications. This information can be obtained from the device's built-in sensors or through other external sensors connected physically via USB or wirelessly via Bluetooth or WiFi. This paper presents the GetSensorData application that provides an open-source, flexible and extensible framework for registering sensor data from Android devices. The application uses standard formatting and synchronization, easing interoperability with other software. End developers (particularly those involved in research) can save the effort and time of creating their sensor acquisition applications and fully concentrate on the higher-level data processing tasks. The application has been used and successfully evaluated for six years by various research groups in different activities related to their work areas. Some examples are the calibration of positioning systems in competitions held at conferences, modeling wireless signal path loss propagation in indoor environments or data collection for unsupervised learning algorithms.

Published
2022

19. Obtención y purificación de la cisteína sintasa de L. infantum

Author

Escarpa Merodio, Juan, Lucio Ortega, Héctor Elessar de, and Jiménez Ruiz, Antonio

Subjects
Leishmania, Cisteína, Leishmaniosis, Pharmacy, Leishmania infantum, Cisteína sintasa, Farmacia, Biology, Biología y Biomedicina
Abstract

La leishmaniosis es una enfermedad tropical producida por parásitos del género Leishmania y que se manifiesta de diferentes formas algunas como el kala-azar con una gran mortalidad si no se administra tratamiento. El parasito, una vez ha infectado al huésped tras la picadura del insecto vector del género Phlebotomus o Lutzomia, es fagocitado por los monocitos y macrófagos dentro de los cuales produce la infección. Una línea de investigación para el desarrollo de medicamentos contra la infección parasítica consiste en buscar inhibidores de los mecanismos que permiten al protozoo mantenerse dentro de los macrófagos y que le hacen sobrevivir a las condiciones extremas de pH y estrés oxidativo que aparecen en los fagolisosomas. Uno de los mecanismos empleados por los parásitos para hacer frente al estrés oxidativo consiste en un metabolismo de tioles muy desarrollado que permite contrarrestar la oxidación. Debido a esto, resulta muy interesante estudiar las rutas de síntesis de cisteína, componente fundamental del glutatión y tripanotión, moléculas esenciales para el mantenimiento del correcto estado redox del parásito. Una de las rutas más interesantes es la que involucra a la cisteína sintasa ya que es una ruta que no aparece en humanos, lo que la pondría en una posición envidiable como diana terapéutica para el tratamiento de la infección. Se ha visto además que la sobreexpresión de esta enzima causa un aumento de la supervivencia bajo condiciones de estrés oxidativo. Por ello se busca obtener un protocolo para la obtención de esta enzima en una forma activa, lo que permitiría proseguir con ensayos de inhibición para probar compuestos que podrían resultar útiles para combatir la enfermedad.

Published
2022

20. Datasets and Supporting Materials for the IPIN 2021 Competition Track 3 (Smartphone-based, off-site)

Author

Universidad de Extremadura, European Commission, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Consejo Superior de Investigaciones Científicas (España), Ministerio de Economía y Competitividad (España), Torres-Sospedra, Joaquín [0000-0003-4338-4334], Aranda Polo, Fernando J. [0000-0003-3824-3094], Parralejo, Felipe [0000-0003-1739-829X], Álvarez, Fernando J. [0000-0002-7610-1452], Pérez-Navarro, Antoni [0000-0002-7037-0635], Jiménez Ruiz, Antonio R. [0000-0001-9771-1930], Seco Granja, Fernando [0000-0002-2922-2710], Torres-Sospedra, Joaquín, Aranda Polo, Fernando J., Parralejo, Felipe, Bellavista Parent, Vladimir, Álvarez, Fernando J., Pérez-Navarro, Antoni, Jiménez Ruiz, Antonio R., Seco Granja, Fernando, Universidad de Extremadura, European Commission, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Consejo Superior de Investigaciones Científicas (España), Ministerio de Economía y Competitividad (España), Torres-Sospedra, Joaquín [0000-0003-4338-4334], Aranda Polo, Fernando J. [0000-0003-3824-3094], Parralejo, Felipe [0000-0003-1739-829X], Álvarez, Fernando J. [0000-0002-7610-1452], Pérez-Navarro, Antoni [0000-0002-7037-0635], Jiménez Ruiz, Antonio R. [0000-0001-9771-1930], Seco Granja, Fernando [0000-0002-2922-2710], Torres-Sospedra, Joaquín, Aranda Polo, Fernando J., Parralejo, Felipe, Bellavista Parent, Vladimir, Álvarez, Fernando J., Pérez-Navarro, Antoni, Jiménez Ruiz, Antonio R., and Seco Granja, Fernando

Published
2021

21. Off-Line Evaluation of Indoor Positioning Systems in Different Scenarios: The Experiences From IPIN 2020 Competition

Author

European Commission, Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), Japan Science and Technology Agency, Bavarian Ministry of Economy, Infrastructure, Transport and Technology, Fundação para a Ciência e a Tecnologia (Portugal), Ministry of Science and Technology (Taiwan), Slovak Academy of Sciences, Ministry of Education (Slovak Republic), National Natural Science Foundation of China, Government of Singapore, Japan Society for the Promotion of Science, National Key Research and Development Program (China), Potortì, Francesco, Torres-Sospedra, Joaquín, Quezada Gaibor, Darwin, Jiménez Ruiz, Antonio R., Seco Granja, Fernando, Pérez-Navarro, Antoni, Ortiz, Miguel, Zhu, Ni, Renaudin, Valerie, Ichikari, Ryosuke, Shimomura, Ryo, Plets, David, Opiela, Miroslav, Džama, Jakub, Zhang, Liqiang, Li, Hu, Chen, Boxuan, Liu, Yu, Yean, Seanglidet, Lim, Bo Zhi, Teo, Wei Jie, Lee, Bu Sung, Oh, Hong Lye, Ohta, Nozomu, Nagae, Satsuki, Kurata, Takeshi, Wei, Dongyan, Ji, Xinchun, Zhang, Wenchao, Kram, Sebastian, Stahlke, Maximilian, Mutschler, Christopher, Crivello, Antonino, Barsocchi, Paolo, Girolami, Michele, Palumbo, Filippo, Chen, Ruizhi, Wu, Yuan, Li, Wei, Yu, Yue, Xu, Shihao, Huang, Lixiong, Liu, Tao, Kuang, Jian, Niu, Xiaoji, Yoshida, Takuto, Nagata, Yoshiteru, Fukushima, Yuto, Fukatani, Nobuya, Hayashida, Nozomi, Asai, Yusuke, Urano, Kenta, Ge, Wenfei, Lee, Nien-Ting, Fang, Shih-Hau, Jie, You-Cheng, Young, Shawn-Rong, Chien, Ying-Ren, Yu, Chih-Chieh, Ma, Chengqi, Wu, Bang, Zhang, Wei, Wang, Yankun, Fan, Yonglei, Poslad, Stefan, Selviah, David R., Wang, Weixi, Yuan, Hong, Yonamoto, Yoshitomo, Yamaguchi, Masahiro, Kaichi, Tomoya, Zhou, Baoding, Liu, Xu, Gu, Zhining, Yang, Chengjing, Wu, Zhiqian, Xie, Doudou, Huang, Can, Zheng, Lingxiang, Peng, Ao, Jin, Ge, Wang, Qu, Luo, Haiyong, Xiong, Hao, Bao, Linfeng, Zhang, Pushuo, Zhao, Fang, Yu, Chia-An, Hung, Chun-Hao, Antsfeld, Leonid, Chidlovskii, Boris, Jiang, Haitao, Xia, Ming, Yan, Dayu, Li, Yuhang, Dong, Yitong, Silva, Ivo, Pendão, Cristiano, Meneses, Filipe, Nicolau, Maria João, Costa, António, Moreira, Adriano, De Cock, Cedric, European Commission, Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), Japan Science and Technology Agency, Bavarian Ministry of Economy, Infrastructure, Transport and Technology, Fundação para a Ciência e a Tecnologia (Portugal), Ministry of Science and Technology (Taiwan), Slovak Academy of Sciences, Ministry of Education (Slovak Republic), National Natural Science Foundation of China, Government of Singapore, Japan Society for the Promotion of Science, National Key Research and Development Program (China), Potortì, Francesco, Torres-Sospedra, Joaquín, Quezada Gaibor, Darwin, Jiménez Ruiz, Antonio R., Seco Granja, Fernando, Pérez-Navarro, Antoni, Ortiz, Miguel, Zhu, Ni, Renaudin, Valerie, Ichikari, Ryosuke, Shimomura, Ryo, Plets, David, Opiela, Miroslav, Džama, Jakub, Zhang, Liqiang, Li, Hu, Chen, Boxuan, Liu, Yu, Yean, Seanglidet, Lim, Bo Zhi, Teo, Wei Jie, Lee, Bu Sung, Oh, Hong Lye, Ohta, Nozomu, Nagae, Satsuki, Kurata, Takeshi, Wei, Dongyan, Ji, Xinchun, Zhang, Wenchao, Kram, Sebastian, Stahlke, Maximilian, Mutschler, Christopher, Crivello, Antonino, Barsocchi, Paolo, Girolami, Michele, Palumbo, Filippo, Chen, Ruizhi, Wu, Yuan, Li, Wei, Yu, Yue, Xu, Shihao, Huang, Lixiong, Liu, Tao, Kuang, Jian, Niu, Xiaoji, Yoshida, Takuto, Nagata, Yoshiteru, Fukushima, Yuto, Fukatani, Nobuya, Hayashida, Nozomi, Asai, Yusuke, Urano, Kenta, Ge, Wenfei, Lee, Nien-Ting, Fang, Shih-Hau, Jie, You-Cheng, Young, Shawn-Rong, Chien, Ying-Ren, Yu, Chih-Chieh, Ma, Chengqi, Wu, Bang, Zhang, Wei, Wang, Yankun, Fan, Yonglei, Poslad, Stefan, Selviah, David R., Wang, Weixi, Yuan, Hong, Yonamoto, Yoshitomo, Yamaguchi, Masahiro, Kaichi, Tomoya, Zhou, Baoding, Liu, Xu, Gu, Zhining, Yang, Chengjing, Wu, Zhiqian, Xie, Doudou, Huang, Can, Zheng, Lingxiang, Peng, Ao, Jin, Ge, Wang, Qu, Luo, Haiyong, Xiong, Hao, Bao, Linfeng, Zhang, Pushuo, Zhao, Fang, Yu, Chia-An, Hung, Chun-Hao, Antsfeld, Leonid, Chidlovskii, Boris, Jiang, Haitao, Xia, Ming, Yan, Dayu, Li, Yuhang, Dong, Yitong, Silva, Ivo, Pendão, Cristiano, Meneses, Filipe, Nicolau, Maria João, Costa, António, Moreira, Adriano, and De Cock, Cedric

Abstract

Every year, for ten years now, the IPIN competition has aimed at evaluating real-world indoor localisation systems by testing them in a realistic environment, with realistic movement, using the EvAAL framework. The competition provided a unique overview of the state-of-the-art of systems, technologies, and methods for indoor positioning and navigation purposes. Through fair comparison of the performance achieved by each system, the competition was able to identify the most promising approaches and to pinpoint the most critical working conditions. In 2020, the competition included 5 diverse off-site off-site Tracks, each resembling real use cases and challenges for indoor positioning. The results in terms of participation and accuracy of the proposed systems have been encouraging. The best performing competitors obtained a third quartile of error of 1 m for the Smartphone Track and 0.5 m for the Foot-mounted IMU Track. While not running on physical systems, but only as algorithms, these results represent impressive achievements.

Published
2022

22. Identification of 1,2,3-triazolium salt-based inhibitors of Leishmania infantum trypanothione disulfide reductase with enhanced antileishmanial potency in cellulo and increased selectivity

Author

Lucio, Héctor de, Revuelto, Alejandro, Carriles, Alejandra A., Castro, Sonia de, García-González, Sonia, García-Soriano, Juan Carlos, Alcón-Calderón, Mercedes, Sánchez-Murcia, Pedro A., Hermoso, Juan A., Gago, Federico, Camarasa Rius, María José, Jiménez-Ruiz, Antonio, Velázquez, Sonsoles, Lucio, Héctor de, Revuelto, Alejandro, Carriles, Alejandra A., Castro, Sonia de, García-González, Sonia, García-Soriano, Juan Carlos, Alcón-Calderón, Mercedes, Sánchez-Murcia, Pedro A., Hermoso, Juan A., Gago, Federico, Camarasa Rius, María José, Jiménez-Ruiz, Antonio, and Velázquez, Sonsoles

Abstract

N-methylation of the triazole moiety present in our recently described triazole-phenyl-thiazole dimerization disruptors of Leishmania infantum trypanothione disulfide reductase (LiTryR) led to a new class of potent in- hibitors that target different binding sites on this enzyme. Subtle structural changes among representative library members modified their mechanism of action, switching from models of classical competitive inhibition to time- dependent mixed noncompetitive inhibition. X-ray crystallography and molecular modeling results provided a rationale for this distinct behavior. The remarkable potency and selectivity improvements, particularly against intracellular amastigotes, of the LiTryR dimerization disruptors 4c and 4d reveal that they could be exploited as leishmanicidal agents. Of note, L. infantum promastigotes treated with 4c significantly reduced their low- molecular-weight thiol content, thus providing additional evidence that LiTryR is the main target of this novel compound.

Published
2022

23. Mobile device-based Bluetooth Low Energy Database for range estimation in indoor environments

Author

#NODATA#, A.R. Jiménez [0000-0001-9771-1930], Pavel Pascacio, Joaquín Torres-Sospedra, Jiménez Ruiz, Antonio R., Sven Casteleyn, #NODATA#, A.R. Jiménez [0000-0001-9771-1930], Pavel Pascacio, Joaquín Torres-Sospedra, Jiménez Ruiz, Antonio R., and Sven Casteleyn

Abstract

The demand to enhance distance estimation and location accuracy in a variety of Non-Line-of-Sight (NLOS) indoor environments has boosted investigation into infrastructure-less ranging and collaborative positioning approaches. Unfortunately, capturing the required measurements to support such systems is tedious and time-consuming, as it requires simultaneous measurements using multiple mobile devices, and no such database are available in literature. This article presents a Bluetooth Low Energy (BLE) database, including Received-Signal-Strength (RSS) and Ground-Truth (GT) positions, for indoor positioning and ranging applications, using mobile devices as transmitters and receivers. The database is composed of three subsets: one devoted to the calibration in an indoor scenario; one for ranging and collaborative positioning under Non-Line-of-Sight conditions; and one for ranging and collaborative positioning in real office conditions. As a validation of the dataset, a baseline analysis for data visualization, data filtering and collaborative distance estimation applying a path-loss based on the Levenberg-Marquardt Least Squares Trilateration method are included.

Published
2022

25. The IPIN 2019 Indoor Localisation Competition-Description and Results

Author

Potortì, Francesco [0000-0003-3835-3920], Crivello, Antonino [0000-0001-7238-2181], Palumbo, Filippo [0000-0001-9778-7142], Girolami, Michele [0000-0002-3683-7158], Barsocchi, Paolo [0000-0002-6862-7593], Torres-Sospedra, Joaquín [0000-0003-4338-4334], Jiménez Ruiz, Antonio Ramón [0000-0001-9771-1930], Pérez-Navarro, Antoni [0000-0002-7037-0635], Martín Mendoza-Silva, Germán [0000-0003-2744-0236], Seco, Fernando [0000-0002-2922-2710], Renaudin, Valerie [0000-0003-4535-5406], Park, Soyoung [0000-0001-5491-6776], Lee, Jae Hong [0000-0002-8222-5435], Park, Chan Gook [0000-0002-7403-951X], Lee, Keumryeol [0000-0003-0930-9007], Choi, Yang-Seok [0000-0002-0510-8198], Talwar, Shilpa [0000-0002-7932-9815], Cho, Seong Yun [0000-0002-4284-2156], Chidlovskii, Boris [0000-0002-2958-2361], Peng, Ao [0000-0003-3348-4358], Wu, Bang [0000-0002-8097-7852], Ma, Chengqi [0000-0002-9146-4470], Poslad, Stefan [0000-0002-3156-9609], Selviah, David R. [0000-0002-0016-0691], Zhang, Wenchao [0000-0002-6412-3961], Yuan, Hong [0000-0002-3807-8132], Leu, Jenq-Shiou [0000-0001-7197-9912], Uchiyama, Hideaki [0000-0002-6119-1184], Thomas, Diego [0000-0002-8525-7133], Shimada, Atsushi [0000-0002-3635-9336], Lungenstrass Poulsen, Tomás [0000-0003-4832-2730], Ashraf, Imran [0000-0002-8271-6496], Ali, Muhammad Usman [0000-0002-4470-8065], Opiela, Miroslav [0000-0001-8802-4442], Moreira, Adriano [0000-0002-8967-118X], Costa, António [0000-0003-0691-1377], Trogh, Jens [0000-0003-0185-5409], Plets, David [0000-0002-8879-5076], Chien, Ying-Ren [0000-0002-3013-0290], Fang, Shih-Hau [0000-0003-1580-0257], Tsao, Yu [0000-0001-6956-0418], Potortì, Francesco, Park, Sangjoon, Crivello, Antonino, Palumbo, Filippo, Girolami, Michele, Barsocchi, Paolo, Lee, Soyeon, Torres-Sospedra, Joaquín, Jiménez Ruiz, Antonio R., Pérez-Navarro, Antoni, Martín Mendoza-Silva, Germán, Seco Granja, Fernando, Ortiz, Miguel, Perul, Johan, Renaudin, Valerie, Kang, Hyunwoong, Park, Soyoung, Lee, Jae Hong, Park, Chan Gook, Ha, Jisu, Han, Jaeseung, Park, Changjun, Kim, Keunhye, Lee, Yonghyun, Gye, Seunghun, Lee, Keumryeol, Kim, Eunjee, Choi, Jeong-Sik, Choi, Yang-Seok, Talwar, Shilpa, Cho, Seong Yun, Ben-Moshe, Boaz, Scherbakov, Alex, Antsfeld, Leonid, Sansano-Sansano, Emilio, Chidlovskii, Boris, Kronenwett, Nikolai, Prophet, Silvia, Landay, Yael, Marbel, Revital, Zheng, Lingxiang, Peng, Ao, Lin, Zhichao, Wu, Bang, Ma, Chengqi, Poslad, Stefan, Selviah, David R., Wu, Wei, Ma, Zixiang, Zhang, Wenchao, Wei, Dongyan, Yuan, Hong, Jiang, Jun-Bang, Huang, Shao-Yung, Liu, Jing-Wen, Su, Kuan-Wu, Leu, Jenq-Shiou, Nishiguchi, Kazuki, Bousselham, Walid, Uchiyama, Hideaki, Thomas, Diego, Shimada, Atsushi, Taniguchi, Rin-Ichiro, Cortés Puschel, Vicente, Lungenstrass Poulsen, Tomás, Ashraf, Imran, Lee, Chanseok, Ali, Muhammad Usman, Im, Yeongjun, Kim, Gunzung, Eom, Jeongsook, Hur, Soojung, Park, Yongwan, Opiela, Miroslav, Moreira, Adriano, Nicolau, Maria João, Pendão, Cristiano, Silva, Ivo, Meneses, Filipe, Costa, António, Trogh, Jens, Plets, David, Chien, Ying-Ren, Chang, Tzu-Yu, Fang, Shih-Hau, Tsao, Yu, Potortì, Francesco [0000-0003-3835-3920], Crivello, Antonino [0000-0001-7238-2181], Palumbo, Filippo [0000-0001-9778-7142], Girolami, Michele [0000-0002-3683-7158], Barsocchi, Paolo [0000-0002-6862-7593], Torres-Sospedra, Joaquín [0000-0003-4338-4334], Jiménez Ruiz, Antonio Ramón [0000-0001-9771-1930], Pérez-Navarro, Antoni [0000-0002-7037-0635], Martín Mendoza-Silva, Germán [0000-0003-2744-0236], Seco, Fernando [0000-0002-2922-2710], Renaudin, Valerie [0000-0003-4535-5406], Park, Soyoung [0000-0001-5491-6776], Lee, Jae Hong [0000-0002-8222-5435], Park, Chan Gook [0000-0002-7403-951X], Lee, Keumryeol [0000-0003-0930-9007], Choi, Yang-Seok [0000-0002-0510-8198], Talwar, Shilpa [0000-0002-7932-9815], Cho, Seong Yun [0000-0002-4284-2156], Chidlovskii, Boris [0000-0002-2958-2361], Peng, Ao [0000-0003-3348-4358], Wu, Bang [0000-0002-8097-7852], Ma, Chengqi [0000-0002-9146-4470], Poslad, Stefan [0000-0002-3156-9609], Selviah, David R. [0000-0002-0016-0691], Zhang, Wenchao [0000-0002-6412-3961], Yuan, Hong [0000-0002-3807-8132], Leu, Jenq-Shiou [0000-0001-7197-9912], Uchiyama, Hideaki [0000-0002-6119-1184], Thomas, Diego [0000-0002-8525-7133], Shimada, Atsushi [0000-0002-3635-9336], Lungenstrass Poulsen, Tomás [0000-0003-4832-2730], Ashraf, Imran [0000-0002-8271-6496], Ali, Muhammad Usman [0000-0002-4470-8065], Opiela, Miroslav [0000-0001-8802-4442], Moreira, Adriano [0000-0002-8967-118X], Costa, António [0000-0003-0691-1377], Trogh, Jens [0000-0003-0185-5409], Plets, David [0000-0002-8879-5076], Chien, Ying-Ren [0000-0002-3013-0290], Fang, Shih-Hau [0000-0003-1580-0257], Tsao, Yu [0000-0001-6956-0418], Potortì, Francesco, Park, Sangjoon, Crivello, Antonino, Palumbo, Filippo, Girolami, Michele, Barsocchi, Paolo, Lee, Soyeon, Torres-Sospedra, Joaquín, Jiménez Ruiz, Antonio R., Pérez-Navarro, Antoni, Martín Mendoza-Silva, Germán, Seco Granja, Fernando, Ortiz, Miguel, Perul, Johan, Renaudin, Valerie, Kang, Hyunwoong, Park, Soyoung, Lee, Jae Hong, Park, Chan Gook, Ha, Jisu, Han, Jaeseung, Park, Changjun, Kim, Keunhye, Lee, Yonghyun, Gye, Seunghun, Lee, Keumryeol, Kim, Eunjee, Choi, Jeong-Sik, Choi, Yang-Seok, Talwar, Shilpa, Cho, Seong Yun, Ben-Moshe, Boaz, Scherbakov, Alex, Antsfeld, Leonid, Sansano-Sansano, Emilio, Chidlovskii, Boris, Kronenwett, Nikolai, Prophet, Silvia, Landay, Yael, Marbel, Revital, Zheng, Lingxiang, Peng, Ao, Lin, Zhichao, Wu, Bang, Ma, Chengqi, Poslad, Stefan, Selviah, David R., Wu, Wei, Ma, Zixiang, Zhang, Wenchao, Wei, Dongyan, Yuan, Hong, Jiang, Jun-Bang, Huang, Shao-Yung, Liu, Jing-Wen, Su, Kuan-Wu, Leu, Jenq-Shiou, Nishiguchi, Kazuki, Bousselham, Walid, Uchiyama, Hideaki, Thomas, Diego, Shimada, Atsushi, Taniguchi, Rin-Ichiro, Cortés Puschel, Vicente, Lungenstrass Poulsen, Tomás, Ashraf, Imran, Lee, Chanseok, Ali, Muhammad Usman, Im, Yeongjun, Kim, Gunzung, Eom, Jeongsook, Hur, Soojung, Park, Yongwan, Opiela, Miroslav, Moreira, Adriano, Nicolau, Maria João, Pendão, Cristiano, Silva, Ivo, Meneses, Filipe, Costa, António, Trogh, Jens, Plets, David, Chien, Ying-Ren, Chang, Tzu-Yu, Fang, Shih-Hau, and Tsao, Yu

Abstract

IPIN 2019 Competition, sixth in a series of IPIN competitions, was held at the CNR Research Area of Pisa (IT), integrated into the program of the IPIN 2019 Conference. It included two on-site real-time Tracks and three off-site Tracks. The four Tracks presented in this paper were set in the same environment, made of two buildings close together for a total usable area of 1000 m2 outdoors and and 6000 m2 indoors over three floors, with a total path length exceeding 500 m. IPIN competitions, based on the EvAAL framework, have aimed at comparing the accuracy performance of personal positioning systems in fair and realistic conditions: past editions of the competition were carried in big conference settings, university campuses and a shopping mall. Positioning accuracy is computed while the person carrying the system under test walks at normal walking speed, uses lifts and goes up and down stairs or briefly stops at given points. Results presented here are a showcase of state-of-the-art systems tested side by side in real-world settings as part of the on-site real-time competition Tracks. Results for off-site Tracks allow a detailed and reproducible comparison of the most recent positioning and tracking algorithms in the same environment as the on-site Tracks.

Published
2020

26. The IPIN 2019 indoor localisation competition : description and results

Author

Potortì, Francesco, Park, Sangjoon, Crivello, Antonino, Palumbo, Filippo, Girolami, Michele, Barsocchi, Paolo, Lee, Soyeon, Torres-Sospedra, Joaquín, Jiménez Ruiz, Antonio R., Pérez-Navarro, Antoni, Martín Mendoza-Silva, Germán, Seco Granja, Fernando, Ortiz, Miguel, Perul, Johan, Renaudin, Valerie, Kang, Hyunwoong, Park, Soyoung, Lee, Jae Hong, Park, Chan Gook, Ha, Jisu, Han, Jaeseung, Park, Changjun, Kim, Keunhye, Lee, Yonghyun, Gye, Seunghun, Lee, Keumryeol, Kim, Eunjee, Choi, Jeong-Sik, Choi, Yang-Seok, Talwar, Shilpa, Cho, Seong Yun, Ben-Moshe, Boaz, Scherbakov, Alex, Antsfeld, Leonid, Sansano-Sansano, Emilio, Chidlovskii, Boris, Kronenwett, Nikolai, Prophet, Silvia, Landay, Yael, Marbel, Revital, Zheng, Lingxiang, Peng, Ao, Lin, Zhichao, Wu, Bang, Ma, Chengqi, Poslad, Stefan, Selviah, David R., Wu, Wei, Ma, Zixiang, Zhang, Wenchao, Wei, Dongyan, Yuan, Hong, Jiang, Jun-Bang, Huang, Shao-Yung, Liu, Jing-Wen, Su, Kuan-Wu, Leu, Jenq-Shiou, Nishiguchi, Kazuki, Bousselham, Walid, Uchiyama, Hideaki, Thomas, Diego, Shimada, Atsushi, Taniguchi, Rin-Ichiro, Cortés Puschel, Vicente, Lungenstrass Poulsen, Tomás, Ashraf, Imran, Lee, Chanseok, Ali, Muhammad Usman, Im, Yeongjun, Kim, Gunzung, Eom, Jeongsook, Hur, Soojung, Park, Yongwan, Opiela, Miroslav, Moreira, Adriano, Nicolau, Maria João, Pendão, Cristiano, Silva, Ivo, Meneses, Filipe, Costa, António, Trogh, Jens, Plets, David, Chien, Ying-Ren, Chang, Tzu-Yu, Fang, Shih-Hau, Tsao, Yu, Potortì, Francesco [0000-0003-3835-3920], Crivello, Antonino [0000-0001-7238-2181], Palumbo, Filippo [0000-0001-9778-7142], Girolami, Michele [0000-0002-3683-7158], Barsocchi, Paolo [0000-0002-6862-7593], Torres-Sospedra, Joaquín [0000-0003-4338-4334], Jiménez Ruiz, Antonio Ramón [0000-0001-9771-1930], Pérez-Navarro, Antoni [0000-0002-7037-0635], Martín Mendoza-Silva, Germán [0000-0003-2744-0236], Seco, Fernando [0000-0002-2922-2710], Renaudin, Valerie [0000-0003-4535-5406], Park, Soyoung [0000-0001-5491-6776], Lee, Jae Hong [0000-0002-8222-5435], Park, Chan Gook [0000-0002-7403-951X], Lee, Keumryeol [0000-0003-0930-9007], Choi, Yang-Seok [0000-0002-0510-8198], Talwar, Shilpa [0000-0002-7932-9815], Cho, Seong Yun [0000-0002-4284-2156], Chidlovskii, Boris [0000-0002-2958-2361], Peng, Ao [0000-0003-3348-4358], Wu, Bang [0000-0002-8097-7852], Ma, Chengqi [0000-0002-9146-4470], Poslad, Stefan [0000-0002-3156-9609], Selviah, David R. [0000-0002-0016-0691], Zhang, Wenchao [0000-0002-6412-3961], Yuan, Hong [0000-0002-3807-8132], Leu, Jenq-Shiou [0000-0001-7197-9912], Uchiyama, Hideaki [0000-0002-6119-1184], Thomas, Diego [0000-0002-8525-7133], Shimada, Atsushi [0000-0002-3635-9336], Lungenstrass Poulsen, Tomás [0000-0003-4832-2730], Ashraf, Imran [0000-0002-8271-6496], Ali, Muhammad Usman [0000-0002-4470-8065], Opiela, Miroslav [0000-0001-8802-4442], Moreira, Adriano [0000-0002-8967-118X], Costa, António [0000-0003-0691-1377], Trogh, Jens [0000-0003-0185-5409], Plets, David [0000-0002-8879-5076], Chien, Ying-Ren [0000-0002-3013-0290], Fang, Shih-Hau [0000-0003-1580-0257], Tsao, Yu [0000-0001-6956-0418], Potortì, Francesco, Crivello, Antonino, Palumbo, Filippo, Girolami, Michele, Barsocchi, Paolo, Torres-Sospedra, Joaquín, Jiménez Ruiz, Antonio Ramón, Pérez-Navarro, Antoni, Martín Mendoza-Silva, Germán, Seco, Fernando, Renaudin, Valerie, Park, Soyoung, Lee, Jae Hong, Park, Chan Gook, Lee, Keumryeol, Choi, Yang-Seok, Talwar, Shilpa, Cho, Seong Yun, Chidlovskii, Boris, Peng, Ao, Wu, Bang, Ma, Chengqi, Poslad, Stefan, Selviah, David R., Zhang, Wenchao, Yuan, Hong, Leu, Jenq-Shiou, Uchiyama, Hideaki, Thomas, Diego, Shimada, Atsushi, Lungenstrass Poulsen, Tomás, Ashraf, Imran, Ali, Muhammad Usman, Opiela, Miroslav, Moreira, Adriano, Costa, António, Trogh, Jens, Plets, David, Chien, Ying-Ren, Fang, Shih-Hau, and Tsao, Yu

Subjects
Sensor systems, Technology and Engineering, foot-mounted pedestrian dead reckoning, magnetic field, Indoor localisation, camera-based positioning, Indoor navigation, Atmospheric measurements, inertial-based positioning, Stakeholders, Particle filter, smartphone-based positioning, Inertial-based positioning, Smartphone-based positioning, Wireless fidelity, benchmarking, Real-time systems, sensor fusion, particle filter, Sensor fusion, Competition, Sensors, Particle measurements, indoor navigation, CONSTRAINT, Benchmarking, Magnetic field, Wi-Fi fingerprinting, Foot-mounted pedestrian dead reckoning, Camera-based positioning, Kalman filter, competition
Abstract

IPIN 2019 Competition, sixth in a series of IPIN competitions, was held at the CNR Research Area of Pisa (IT), integrated into the program of the IPIN 2019 Conference. It included two on-site real-time Tracks and three off-site Tracks. The four Tracks presented in this paper were set in the same environment, made of two buildings close together for a total usable area of 1000 m2 outdoors and and 6000 m2 indoors over three floors, with a total path length exceeding 500 m. IPIN competitions, based on the EvAAL framework, have aimed at comparing the accuracy performance of personal positioning systems in fair and realistic conditions: past editions of the competition were carried in big conference settings, university campuses and a shopping mall. Positioning accuracy is computed while the person carrying the system under test walks at normal walking speed, uses lifts and goes up and down stairs or briefly stops at given points. Results presented here are a showcase of state-of-the-art systems tested side by side in real-world settings as part of the on-site real-time competition Tracks. Results for off-site Tracks allow a detailed and reproducible comparison of the most recent positioning and tracking algorithms in the same environment as the on-site Tracks., Fundación para la Ciencia y Tecnología; 10.13039/100007225-Ministry of Science and Technology; Institute for Information and communications Technology Promotion IITP grant funded by the Korea government MSIT; Basic Science Research Program through the National Research Foundation of Korea NRF funded by the Ministry of Science; MSIT Ministry of Science and ICT Korea under the ITRC; Slovak Research and Development Agency; Strategic Priority Research Program; Korea government NFA; ICT R and D Program of MSIPIITP; 10.13039/501100004837-Ministerio de Ciencia e Innovación; JSPS KAKENHI; ICT R and D Program of MSIPIITP.

Published
2020
Full Text
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32. Energy-Efficient Indoor Localization WiFi-Fingerprint System: An Experimental Study

Author

Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Salazar González, Jose L. [0000-0002-4823-3749], Soria Morillo, Luis Miguel [0000-0002-6794-9179], Álvarez-García, Juan A. [0000-0002-4106-6044], Enríquez de Salamanca Ros, Fernando [0000-0002-5427-6331], Jiménez Ruiz, Antonio R. [0000-0001-9771-1930], Salazar González, Jose L., Soria Morillo, Luis Miguel, Álvarez-García, Juan A., Enríquez de Salamanca Ros, Fernando, Jiménez Ruiz, Antonio R., Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Salazar González, Jose L. [0000-0002-4823-3749], Soria Morillo, Luis Miguel [0000-0002-6794-9179], Álvarez-García, Juan A. [0000-0002-4106-6044], Enríquez de Salamanca Ros, Fernando [0000-0002-5427-6331], Jiménez Ruiz, Antonio R. [0000-0001-9771-1930], Salazar González, Jose L., Soria Morillo, Luis Miguel, Álvarez-García, Juan A., Enríquez de Salamanca Ros, Fernando, and Jiménez Ruiz, Antonio R.

Abstract

In order to apply indoor localization systems in real environments it is necessary to provide an accurate location without implying a high impact on the user’s normal behaviour. To achieve this goal, in this paper, a combination of battery saving techniques with a system based on WiFi fingerprinting is proposed. This is done by transferring the location calculation workload to the server, leaving user’s mobile devices the only responsibility of making periodic WiFi network scans at dynamic intervals based on user activity, through an application running on background. There are not many studies analyzing energy consumption of existing localization systems, even though it is an important factor in real applications. In this paper, both energy consumption and accuracy are analyzed, having an energy consumption of only 0.8 Wh (having a 3.7 V battery) during a 24-hour cycle and an average localization error of 4.51 meters. Worth to mention that as computation is done on server side the system can be expanded to multiple buildings and floors. Finally, the dataset used in this paper has been published making possible to test new algorithms in the same environment.

Published
2019

33. Challenge 4: Cyberphysical systems and internet of things

Author

Haber Guerra, Rodolfo E., Cembrano Gennari, Gabriela, Villagrá Serrano, Jorge, Jiménez Ruiz, Antonio Ramón, Margarit Taulé, Josep Mª, Fonseca Chácharo, Luis, Gómez Álvarez-Arenas, Tomás Enrique, Camacho Sosa Dias, Jorge, Aparicio, Sofía, Carmona Galán, Ricardo, Fernández Berni, Jorge, del Río Fernández, Rocío, Jiménez Berni, José Antonio, Capdevila Montes, Carlos, Institut de Robòtica i Informàtica Industrial, and Universitat Politècnica de Catalunya. SAC - Sistemes Avançats de Control

Subjects
IoT sensors and actuators, Internet of things, Automation, Internet de les coses, Control theory, Modeling, Architectures, Informàtica::Intel·ligència artificial [Àrees temàtiques de la UPC], Computational frameworks, Internet of Things [Optimisation. Author keywords], IoT hardware designs and CPS platforms
Abstract

Accés lliure al text del llibre a la web de l'editor Cyber-Physical Systems (CPS) and Internet of Things (IoT) are complementary paradigms in digitalization. Sensors and actuators, hardware designs and development platforms, architectures and computational frameworks, modeling, control and optimization, and potential applications are analyzed and presented from impact and main challenges up to strategic plan.

Published
2021

34. Challenge 4: Intelligent robotics

Author

Alenyà Ribas, Guillem|||0000-0002-6018-154X, Villagrá Serrano, Jorge, Fernández Saavedra, Maria Belén, González de Santos, Pablo, Haber Guerra, Rodolfo E., Jiménez Ruiz, Antonio Ramón, Ribeiro, Angela, Rocón de Lima, Eduardo, Borràs Sol, Júlia, Moreno-Noguer, Francesc, Torras, Carme|||0000-0002-2933-398X, Institut de Robòtica i Informàtica Industrial, and Universitat Politècnica de Catalunya. ROBiri - Grup de Robòtica de l'IRI

Subjects
Artificial intelligence, Robòtica, Social aspects of automation, Robotics, Artificial intelligence--Engineering applications, Intel·ligència artificial--Aplicacions a l'enginyeria, Informàtica::Robòtica [Àrees temàtiques de la UPC], Intelligent robots
Abstract

Accés lliure al text del llibre a la web de l'editor Intelligent robotics are called to be the next revolution by providing AI with the capability of interacting with the physical world. Robots are overpassing their cages in the industry to become intelligent machines that can live among us, helping in the service sector, as tools in rehabilitation and assistive tasks, and also as companions. Robotics poses especial problems and AI research must be reshaped and redefined to meet robotics special needs in areas like perception and scene understanding, decision making and learning, and actuation. Besides these classical robotics areas, modern robots need to take into account the central role of human-robot interaction : unstructured environments, unforeseen situations, user preferences, and safety. The challenges to frame this revolution are multiple. We highlight the seven where we identify CSIC has a strategic advantage and thus can cause a better impact. Modern robotics implies robots in human environments, what we called here robots for everyone : easy reprogramming and continuous learning. Deployment can include big-scale mobile robots and cars for autonomous navigation for cities, or small-scale robots for intelligent manipulation for new applications, possibly making use of effective and adaptive coordination of robot fleets. Robots in human environments require safe and ethical human-robot interaction, that can take advantage of seamless cooperative and everywhere localization solutions and dexterity and efficiency through bio-inspired and parallel mechanisms. Advances on intelligent robotics will have a great impact on science, industry, and society in general. Robots have the potential to change people’s lifestyle and thus, require special attention from rule bodies and policymakers. However, robotics is highly experimental and requires special efforts in physically building the prototypes. To make this possible, we believe a new joint lab or infrastructure must be established to facilitate research and testing, foster collaboration and involve industry and policy-makers.

Published
2021

35. Small Molecule–Peptide Conjugates as Dimerization Inhibitors of Leishmania infantum Trypanothione Disulfide Reductase

Author

Revuelto, Alejandro, primary, López-Martín, Isabel, additional, de Lucio, Héctor, additional, García-Soriano, Juan Carlos, additional, Zanda, Nicola, additional, de Castro, Sonia, additional, Gago, Federico, additional, Jiménez-Ruiz, Antonio, additional, Velázquez, Sonsoles, additional, and Camarasa, María-José, additional

Published
2021
Full Text
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36. Challenge 4: Intelligent robotics

Author

Institut de Robòtica i Informàtica Industrial, Universitat Politècnica de Catalunya. ROBiri - Grup de Robòtica de l'IRI, Alenyà Ribas, Guillem, Villagrá Serrano, Jorge, Fernández Saavedra, Maria Belén, González de Santos, Pablo, Haber Guerra, Rodolfo E., Jiménez Ruiz, Antonio Ramón, Ribeiro, Angela, Rocón de Lima, Eduardo, Borràs Sol, Júlia, Moreno-Noguer, Francesc, Torras, Carme, Institut de Robòtica i Informàtica Industrial, Universitat Politècnica de Catalunya. ROBiri - Grup de Robòtica de l'IRI, Alenyà Ribas, Guillem, Villagrá Serrano, Jorge, Fernández Saavedra, Maria Belén, González de Santos, Pablo, Haber Guerra, Rodolfo E., Jiménez Ruiz, Antonio Ramón, Ribeiro, Angela, Rocón de Lima, Eduardo, Borràs Sol, Júlia, Moreno-Noguer, Francesc, and Torras, Carme

Abstract

Accés lliure al text del llibre a la web de l'editor, Intelligent robotics are called to be the next revolution by providing AI with the capability of interacting with the physical world. Robots are overpassing their cages in the industry to become intelligent machines that can live among us, helping in the service sector, as tools in rehabilitation and assistive tasks, and also as companions. Robotics poses especial problems and AI research must be reshaped and redefined to meet robotics special needs in areas like perception and scene understanding, decision making and learning, and actuation. Besides these classical robotics areas, modern robots need to take into account the central role of human-robot interaction : unstructured environments, unforeseen situations, user preferences, and safety. The challenges to frame this revolution are multiple. We highlight the seven where we identify CSIC has a strategic advantage and thus can cause a better impact. Modern robotics implies robots in human environments, what we called here robots for everyone : easy reprogramming and continuous learning. Deployment can include big-scale mobile robots and cars for autonomous navigation for cities, or small-scale robots for intelligent manipulation for new applications, possibly making use of effective and adaptive coordination of robot fleets. Robots in human environments require safe and ethical human-robot interaction, that can take advantage of seamless cooperative and everywhere localization solutions and dexterity and efficiency through bio-inspired and parallel mechanisms. Advances on intelligent robotics will have a great impact on science, industry, and society in general. Robots have the potential to change people’s lifestyle and thus, require special attention from rule bodies and policymakers. However, robotics is highly experimental and requires special efforts in physically building the prototypes. To make this possible, we believe a new joint lab or infrastructure must be established to facilitate research and testin, Postprint (published version)

Published
2021

37. Challenge 4: Cyberphysical systems and internet of things

Author

Institut de Robòtica i Informàtica Industrial, Universitat Politècnica de Catalunya. SAC - Sistemes Avançats de Control, Haber Guerra, Rodolfo E., Cembrano Gennari, Gabriela, Villagrá Serrano, Jorge, Jiménez Ruiz, Antonio Ramón, Margarit Taulé, Josep Mª, Fonseca Chácharo, Luis, Gómez Álvarez-Arenas, Tomás Enrique, Camacho Sosa Dias, Jorge, Aparicio, Sofía, Carmona Galán, Ricardo, Fernández Berni, Jorge, del Río Fernández, Rocío, Jiménez Berni, José Antonio, Capdevila Montes, Carlos, Institut de Robòtica i Informàtica Industrial, Universitat Politècnica de Catalunya. SAC - Sistemes Avançats de Control, Haber Guerra, Rodolfo E., Cembrano Gennari, Gabriela, Villagrá Serrano, Jorge, Jiménez Ruiz, Antonio Ramón, Margarit Taulé, Josep Mª, Fonseca Chácharo, Luis, Gómez Álvarez-Arenas, Tomás Enrique, Camacho Sosa Dias, Jorge, Aparicio, Sofía, Carmona Galán, Ricardo, Fernández Berni, Jorge, del Río Fernández, Rocío, Jiménez Berni, José Antonio, and Capdevila Montes, Carlos

Abstract

Accés lliure al text del llibre a la web de l'editor, Cyber-Physical Systems (CPS) and Internet of Things (IoT) are complementary paradigms in digitalization. Sensors and actuators, hardware designs and development platforms, architectures and computational frameworks, modeling, control and optimization, and potential applications are analyzed and presented from impact and main challenges up to strategic plan., Postprint (published version)

Published
2021

38. Detecting Fall Risk and Frailty in Elders with Inertial Motion Sensors: A Survey of Significant Gait Parameters

Author

European Commission, Ministerio de Ciencia e Innovación (España), Ruiz-Ruiz, Luisa [0000-0003-0316-7781], Jiménez, Antonio R. [0000-0001-9771-1930], García-Villamil, Guillermo [0000-0002-3869-4410], Seco, Fernando [0000-0002-2922-2710], Ruiz-Ruiz, Luisa, Jiménez Ruiz, Antonio R., García-Villamil, Guillermo, Seco Granja, Fernando, European Commission, Ministerio de Ciencia e Innovación (España), Ruiz-Ruiz, Luisa [0000-0003-0316-7781], Jiménez, Antonio R. [0000-0001-9771-1930], García-Villamil, Guillermo [0000-0002-3869-4410], Seco, Fernando [0000-0002-2922-2710], Ruiz-Ruiz, Luisa, Jiménez Ruiz, Antonio R., García-Villamil, Guillermo, and Seco Granja, Fernando

Abstract

In the elderly, geriatric problems such as the risk of fall or frailty are a challenge for society. Patients with frailty present difficulties in walking and higher fall risk. The use of sensors for gait analysis allows the detection of objective parameters related to these pathologies and to make an early diagnosis. Inertial Measurement Units (IMUs) are wearables that, due to their accuracy, portability, and low price, are an excellent option to analyze human gait parameters in health-monitoring applications. Many relevant gait parameters (e.g., step time, walking speed) are used to assess motor, or even cognitive, health problems in the elderly, but we perceived that there is not a full consensus on which parameters are the most significant to estimate the risk of fall and the frailty state. In this work, we analyzed the different IMU-based gait parameters proposed in the literature to assess frailty state (robust, prefrail, or frail) or fall risk. The aim was to collect the most significant gait parameters, measured from inertial sensors, able to discriminate between patient groups and to highlight those parameters that are not relevant or for which there is controversy among the examined works. For this purpose, a literature review of the studies published in recent years was carried out; apart from 10 previous relevant reviews using inertial and other sensing technologies, a total of 22 specific studies giving statistical significance values were analyzed. The results showed that the most significant parameters are double-support time, gait speed, stride time, step time, and the number of steps/day or walking percentage/day, for frailty diagnosis. In the case of fall risk detection, parameters related to trunk stability or movements are the most relevant. Although these results are important, the total number of works found was limited and most of them performed the significance statistics on subsets of all possible gait parameters; this fact highlights the nee

Published
2021

39. Efficient Dimerization Disruption of Leishmania infantum Trypanothione Reductase by Triazole-phenyl-thiazoles

Author

Ministerio de Ciencia, Innovación y Universidades (España), Consejo Superior de Investigaciones Científicas (España), Comunidad de Madrid, Revuelto, Alejandro, Lucio, Héctor de, García-Soriano, Juan Carlos, Sánchez-Murcia, Pedro A., Gago, Federico, Jiménez-Ruiz, Antonio, Camarasa Rius, María José, Velázquez, Sonsoles, Ministerio de Ciencia, Innovación y Universidades (España), Consejo Superior de Investigaciones Científicas (España), Comunidad de Madrid, Revuelto, Alejandro, Lucio, Héctor de, García-Soriano, Juan Carlos, Sánchez-Murcia, Pedro A., Gago, Federico, Jiménez-Ruiz, Antonio, Camarasa Rius, María José, and Velázquez, Sonsoles

Abstract

Inhibition of Leishmania infantum trypanothione disulfide reductase (LiTryR) by disruption of its homodimeric interface has proved to be an alternative and unexploited strategy in the search for novel antileishmanial agents. Proof of concept was first obtained by peptides and peptidomimetics. Building on previously reported dimerization disruptors containing an imidazole-phenyl-thiazole scaffold, we now report a new 1,2,3-triazole-based chemotype that yields noncompetitive, slow-binding inhibitors of LiTryR. Several compounds bearing (poly)aromatic substituents dramatically improve the ability to disrupt LiTryR dimerization relative to reference imidazoles. Molecular modeling studies identified an almost unexplored hydrophobic region at the interfacial domain as the putative binding site for these compounds. A subsequent structure-based design led to a symmetrical triazole analogue that displayed even more potent inhibitory activity over LiTryR and enhanced leishmanicidal activity. Remarkably, several of these novel triazole-bearing compounds were able to kill both extracellular and intracellular parasites in cell cultures.

Published
2021

40. Small Molecule–Peptide Conjugates as Dimerization Inhibitors of Leishmania infantum Trypanothione Disulfide Reductase

Author

Ministerio de Ciencia, Innovación y Universidades (España), Consejo Superior de Investigaciones Científicas (España), Comunidad de Madrid, Revuelto, Alejandro [0000-0002-0226-040X], López-Martín, Isabel, Zanda, Nicola, Castro, Sonia de [0000-0002-3838-6856], Velázquez, Sonsoles [0000-0003-2209-1751], Camarasa, María-José [0000-0002-4978-6468], Revuelto, Alejandro, Lucio, Héctor de, García-Soriano, Juan Carlos, Castro, Sonia de, Gago, Federico, Jiménez-Ruiz, Antonio, Velázquez, Sonsoles, Camarasa Rius, María José, Ministerio de Ciencia, Innovación y Universidades (España), Consejo Superior de Investigaciones Científicas (España), Comunidad de Madrid, Revuelto, Alejandro [0000-0002-0226-040X], López-Martín, Isabel, Zanda, Nicola, Castro, Sonia de [0000-0002-3838-6856], Velázquez, Sonsoles [0000-0003-2209-1751], Camarasa, María-José [0000-0002-4978-6468], Revuelto, Alejandro, Lucio, Héctor de, García-Soriano, Juan Carlos, Castro, Sonia de, Gago, Federico, Jiménez-Ruiz, Antonio, Velázquez, Sonsoles, and Camarasa Rius, María José

Abstract

Trypanothione disulfide reductase (TryR) is an essential homodimeric enzyme of trypanosomatid parasites that has been validated as a drug target to fight human infections. Using peptides and peptidomimetics, we previously obtained proof of concept that disrupting protein–protein interactions at the dimer interface of Leishmania infantum TryR (LiTryR) offered an innovative and so far unexploited opportunity for the development of novel antileishmanial agents. Now, we show that linking our previous peptide prototype TRL38 to selected hydrophobic moieties provides a novel series of small-molecule–peptide conjugates that behave as good inhibitors of both LiTryR activity and dimerization.

Published
2021

48. Identificación de dianas terapéuticas contra la infección por SARS-CoV-2

Author

Alcón Calderón, María de las Mercedes and Jiménez Ruiz, Antonio

Subjects
Escisión proteolítica, Furina, SARS-CoV-2, Pharmacy, Dominio de unión al receptor (RBD), Farmacia, Biology, Biología y Biomedicina, Proteína de espiga (S)
Abstract

La aparición del nuevo coronavirus SARS-CoV-2 a finales de 2019 ha resultado en una pandemia internacional debido a la multitud de contagios y muertes documentadas. Los coronavirus provocan enfermedades respiratorias de gravedad gradual, llegando a producir lesiones pulmonares graves e incluso fallo multiorgánico. A pesar de que diferentes tipos de coronavirus han infectado a humanos con anterioridad, es necesaria una investigación en profundidad del SARS-CoV-2 para poder abordar diferentes estrategias terapéuticas frente a la infección que produce. En este artículo, se presentan las características fundamentales del SARS-CoV-2 que favorecen la elevada infectividad y transmisibilidad del virus, así como sus diferencias principales con los coronavirus que le preceden. En este sentido, este virus utiliza el receptor ECA-2 para su entrada en las células y, en el proceso infectivo, es fundamental la participación de una glucoproteína de espiga (S) que se encuentra anclada a la envoltura de SARS-CoV-2. Gracias a varios estudios independientes, se ha podido determinar el mecanismo por el que se produce el reconocimiento entre el virus y su receptor celular, en el que interviene fundamentalmente la proteína S. Asimismo, se ha encontrado que esta proteína alberga un sitio de escisión de furina, una proteasa encargada del procesamiento proteolítico de las subunidades de la proteína S y cuyo papel es primordial para que se produzca la fusión de membranas vírica y celular. Finalmente, en base al estudio realizado, se proponen diversos inhibidores basados en el bloqueo de la interacción virus-receptor y de la fusión de membranas, que se fundamentan en la implicación del dominio de unión con el receptor (RBD) de la proteína S y en la proteasa furina como principal desencadenante del proceso de fusión a través de la escisión proteolítica.

Published
2020

49. Datasets and Supporting Materials for the IPIN 2020 Competition Track 3 (Smartphone-based, off-site)

Author

European Commission, Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), Ministerio de Economía y Competitividad (España), Consejo Superior de Investigaciones Científicas (España), Torres-Sospedra, Joaquín, Quezada Gaibor, Darwin, Jiménez Ruiz, Antonio R., Pérez-Navarro, Antoni, Seco Granja, Fernando, European Commission, Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), Ministerio de Economía y Competitividad (España), Consejo Superior de Investigaciones Científicas (España), Torres-Sospedra, Joaquín, Quezada Gaibor, Darwin, Jiménez Ruiz, Antonio R., Pérez-Navarro, Antoni, and Seco Granja, Fernando

Published
2020

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