128 results on '"Jimenez MJ"'
Search Results
2. A resilient type of familial hypercholesterolaemia: case-control follow-up of genetically characterized older patients in the SAFEHEART cohort
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Pérez de Isla L, Watts GF, Muñiz-Grijalvo O, Díaz-Díaz JL, Alonso R, Zambón D, Fuentes-Jimenez F, Mauri M, Padró T, Vidal-Pardo JI, Barba MA, Ruiz-Pérez E, Michán A, Mediavilla JD, Hernandez AM, Romero-Jimenez MJ, Badimon L, and Mata P
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Statins ,Older individuals ,Cardiovascular disease ,Familial hypercholesterolaemia ,HDL-cholesterol ,Lipid-lowering treatment - Abstract
AIMS : Knowledge of the features of patients with familial hypercholesterolaemia (FH) who are protected from atherosclerotic cardiovascular disease (ASCVD) is important for the clinical and prognostic care of this apparently high-risk condition. Our aim was to investigate the determinant and characteristics of patients with FH who are protected from ASCVD and have normal life expectancy, so-called 'resilient' FH (R-FH). METHODS AND RESULTS : Spanish Familial Hypercholesterolaemia cohort study (SAFEHEART) is an open, multicentre, nation-wide, long-term prospective cohort study in genetically defined patients with heterozygous FH in Spain. Patients in the registry who at the time of analysis were at least 65 years or those who would have reached that age had they not died from an ASCVD event were analysed as a case-control study. Resilient FH was defined as the presence of a pathogenic mutation causative of FH in a patient aged =65 years without clinical ASCVD. Nine hundred and thirty registrants with FH met the study criteria. A defective low-density lipoprotein (LDL)-receptor mutation, higher plasma level of high-density lipoprotein cholesterol (HDL-C), younger age, female gender, absence of hypertension, and lower plasma lipoprotein (a) [Lp(a)] concentration were independently predictive of R-FH. In a second model, higher levels of HDL-C and lower 10-year score in SAFEHEART-RE were also independently predictive of R-FH. CONCLUSION : Resilient FH may be typified as being female and having a defective LDL-receptor mutation, higher levels of plasma HDL-C, lower levels of Lp(a), and an absence of hypertension. The implications of this type of FH for clinical practice guidelines and the value for service design and optional care of FH remains to be established. TRIAL REGISTRATION: ClinicalTrials.gov number NCT02693548.
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- 2022
3. Prognostic Factors for Early Mortality of Hematological Patients Admitted to the Intensive Care Unit: Preliminary Results of A Prospective Multicenter Study
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Dominguez, FMM, Gaspar, JL, Segura, MR, Porras, RP, Domenech, ED, Moreno-Gonzalez, G, Vincent, MG, Gonzalez-Sierra, PA, Chacon, MJ, Chacon, EM, Toscano, MDM, Romero, MG, Coll, CMF, Jimenez, MJ, Marcos, MP, Jimenez-Ubieto, A, Robles, MC, Alves, SC, Torres, NR, Gonzalez, JFF, Gonzalez-Campos, J, Cuadrado, IM, Ortega, JLR, Rodriguez-Arboli, E, Perez-Simon, JA, Palomo, YC, and Ildefonso, E
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- 2020
4. Defibrotide in hematopoietic transplantation: a GETH / GETMON study
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Gonzalez, VM, Diaz, DC, Molina, B, Regueiro, A, Perez, MA, Palomo, P, Riesco, S, Garcia, E, Fernandez, JM, Perez, A, Jimenez, MJ, Guerreiro, M, Vallejo, C, Gallardo, AI, Lopez, O, Benito, A, Marsal-Ricoma J, Duarte, M, Bento, L, and Diaz, MA
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- 2020
5. Defibrotide in Hematopoietic Stem Cell Transplant: An Study of Grupo Espanol De Trasplante Hematopoyetico (GETH) And Grupo Espanol De Trasplante De Medula En NinOS (GETMON)
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Vicent, MG, de Heredia, CD, de Pablo, JG, Molina, B, Regueiro, A, Perez, A, Palomo, P, Prieto, L, Garcia, E, Fernandez, JM, Jimenez, MJ, Regueiro, M, Vallejo, C, Gallardo, AI, Lopez, O, Benito, A, Marsal, J, Lopez, M, Bento, L, Badell, I, Pedraza, A, Jimenez, A, Gonzalez, P, Kwon, M, Costilla, L, Belendez, C, Esquirol, A, Espigado, I, Lavilla, E, and Diaz, MA
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- 2020
6. The influence of HE history, HE status and neuropsychological test type on learning ability in patients with cirrhosis
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Zarantonello L, Turco M, Formentin C, Izquierdo-Altarejos P, Vuerich A, Barcenas Jimenez MJ, Montoliu C, Felipo V, Angeli P, Amodio P, and Montagnese S
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learning ability ,cirrhosis ,hepatic encephalopathy ,neuropsychological test ,human activities - Abstract
Background & Aims Learning ability may be impaired in patients with a history of overt hepatic encephalopathy (OHE). The aim of this study was to compare performance on the first/second attempt at a series of tests. Methods Two hundred and fourteen patients with cirrhosis were enrolled. On the day of study, 41% were classed as unimpaired, 38% as having minimal HE and 21% as having mild OHE; 58% had a history of OHE. Performance was compared between two versions of the trail-making test A (TMT-A), and between the first/second half of a simple/choice reaction time (sRT and cRT), and a working memory test (ScanRT). Results Both patients with and without OHE history improved in TMT-A, sRT and ScanRT. Only patients with no OHE history improved in cRT. All patients, regardless of their HE status on the day of study, improved in TMT-A and sRT. Only patients with mild OHE on the day of study improved in cRT. Only unimpaired patients improved in ScanRT. When OHE history and HE status on the day of study were tested together, only HE status had an effect. The same held true when age, the Model for End Stage Liver Disease (MELD) and educational attainment were adjusted for. Conclusions HE status on the day of study and the type of neuropsychological test had an effect on learning ability in a well-characterized group of patients with cirrhosis.
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- 2019
7. Donor lymphocyte infusions for B-cell malignancies relapse after T-cell replete allogeneic hematopoietic cell transplantation (vol 54, pg 1133, 2019)
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Orti, G, Garcia-Cadenas, I, Lopez-Corral, L, Perez, A, Jimenez, MJ, Sanchez-Ortega, I, Alonso, L, Sisinni, L, Fox, L, Villacampa, G, Badell, I, de Heredia, CD, Parody, R, Ferra, C, Solano, C, Caballero, D, Martino, R, Querol, S, and Valcarcel, D
- Abstract
In the original version of this article, author 'Lucia López-Corral' was incorrectly listed as 'Lucia López'. This has now been corrected in both the PDF and HTML versions of the article to 'Lucia López-Corral'.
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- 2019
8. Effects of the Therapeutic Armamentarium on Survival and Time to Next Treatment in CMML Subtypes: An International Analysis of 950 Cases Coordinated By the AGMT Study Group
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Pleyer, L, Leisch, M, Kourakli, A, Padron, E, Maciejewski, JP, Xicoy, B, Kaivers, J, Ungerstedt, J, Heibl, S, Patiou, P, Hunter, AM, Mora, E, Geissler, K, Dimou, M, Jimenez, MJ, Kiesl, D, Viniou, NA, Patel, BJ, Sangerman, MA, Valent, P, Roubakis, C, del Castillo, TB, Galanopoulos, A, Calabuig, M, Bonadies, N, de Almeida, AM, Cermak, J, Jerez, A, Montoro, J, Cortes, A, Pita, AA, Andrade, BL, Lindberg, EH, Germing, U, Sekeres, MA, List, AF, Symeonidis, A, Sanz, GF, and Greil, R
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- 2019
9. Analysis of post Allo-HCT relapse in acute leukaemia patients, a comparative on second Allo-HCT and donor lymphocyte infusions
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Orti, G, Sanz, J, Garcia-Cadenas, I, Sanchez-Ortega, I, Jimenez, MJ, Barba, P, Ferra, C, Parody, R, Sierra, J, Sanz, MA, Querol, S, and Valcarcel, D
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- 2017
10. Search for neutron excitations across the N=20 shell gap in Ne25-29
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Belleguic, M, Azaiez, F, Dombradi, Z, Sohler, D, Lopez-Jimenez, MJ, Otsuka, Taka, Saint-Laurent, MG, Sorlin, O, Stanoiu, M, Utsuno, Y, Penionzhkevich, YE, Achouri, NL, Angelique, JC, Borcea, C, Bourgeois, C, Daugas, JM, De Oliveira-Santos, F, Dlouhy, Z, Donzaud, C, Duprat, J, Elekes, Z, Grevy, S, Guillemaud-Mueller, D, Leenhardt, S, Lewitowicz, M, Lukyanov, SM, Mittig, W, Porquet, MG, Pougheon, F, Roussel-Chomaz, P, Savajols, H, Sobolev, Y, Stodel, C, and Timar, J
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Nuclear Theory ,Nuclear Experiment - Abstract
Nuclear structure of the neutron rich 25 − 29 Ne nuclei has been investigated through the in-beam γ -ray spectroscopy technique using fragmentation reactions of both stable and radioactive beams. Level schemes have been deduced for these Ne isotopes. In order to examine the importance of intruder fp configurations, they are compared to shell model calculations performed either in the restricted sd or in the larger sdpf valence space. The 25 , 26 Ne and 27 Ne nuclei were found to be in agreement with the sd shell model calculations, whereas 28 Ne exhibits signatures of the intruder fp shell contribution ispartof: Physical Review C, Nuclear Physics vol:72 issue:5 status: published
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- 2005
11. Solving NP-complete Problems by Spiking Neural P Systems with Budding Rules
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Paun, G, Perez Jimenez, MJ, Riscos Nunez, A, Rozenberg, G, Salomaa, A, Ishdorj, T, Leporati, A, Pan, L, Wang, J, Ishdorj, TO, LEPORATI, ALBERTO OTTAVIO, Wang, J., Paun, G, Perez Jimenez, MJ, Riscos Nunez, A, Rozenberg, G, Salomaa, A, Ishdorj, T, Leporati, A, Pan, L, Wang, J, Ishdorj, TO, LEPORATI, ALBERTO OTTAVIO, and Wang, J.
- Abstract
Inspired by the growth of dendritic trees in biological neurons, we introduce spiking neural P systems with budding rules. By applying these rules in a maximally parallel way, a spiking neural P system can exponentially increase the size of its synapse graph in a polynomial number of computation steps. Such a possibility can be exploited to efficiently solve computationally difficult problems in deterministic polynomial time, as it is shown in this paper for the NP-complete decision problem SAT
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- 2010
12. In-beam gamma-ray spectroscopy of the neutron-rich nitrogen isotopes (19-22)N
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Sohler, D, Stanoiu, M, Dombradi, Z, Azaiez, F, Brown, BA, Saint-Laurent, MG, Sorlin, O, Penionzhkevich, Y-E, Achouri, NL, Angelique, JC, Belleguic, M, Borcea, C, Bourgeois, C, Daugas, JM, De Oliveira-Santos, F, Dlouhy, Z, Donzaud, C, Duprat, J, Elekes, Z, Grevy, S, Guillemaud-Mueller, D, Ibrahim, F, Leenhardt, S, Lewitowicz, M, Lopez-Jimenez, MJ, Lukyanov, SM, Mittig, W, Mrazek, J, Negoita, F, Podolyak, Z, Porquet, MG, Pougheon, F, Roussel-Chomaz, P, Savajols, H, Sletten, G, Sobolev, Y, Stodel, C, Timar, J, Sohler, D, Stanoiu, M, Dombradi, Z, Azaiez, F, Brown, BA, Saint-Laurent, MG, Sorlin, O, Penionzhkevich, Y-E, Achouri, NL, Angelique, JC, Belleguic, M, Borcea, C, Bourgeois, C, Daugas, JM, De Oliveira-Santos, F, Dlouhy, Z, Donzaud, C, Duprat, J, Elekes, Z, Grevy, S, Guillemaud-Mueller, D, Ibrahim, F, Leenhardt, S, Lewitowicz, M, Lopez-Jimenez, MJ, Lukyanov, SM, Mittig, W, Mrazek, J, Negoita, F, Podolyak, Z, Porquet, MG, Pougheon, F, Roussel-Chomaz, P, Savajols, H, Sletten, G, Sobolev, Y, Stodel, C, and Timar, J
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- 2008
13. Precipitating/aggravating factors of porphyria cutanea tarda in Spanish patients
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Cruz-Rojo, J., Fontanellas, A., Moran-Jimenez, Mj, Navarro-Ordonez, S., Maria Garcia-Bravo, Mendez, M., Munoz-Rivero, Mc, and Salamanca, Re
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Adult ,Family Health ,Male ,Porphyria Cutanea Tarda ,Alcohol Drinking ,Histocompatibility Antigens Class I ,Membrane Proteins ,Estrogens ,Middle Aged ,Hepatitis C ,Risk Factors ,Spain ,Mutation ,Humans ,Uroporphyrinogen Decarboxylase ,Female ,Genetic Predisposition to Disease ,Hemochromatosis ,Age of Onset ,Hemochromatosis Protein ,Alleles - Abstract
Erythrocyte uroporphyrinogen decarboxylase (UROD) activity was measured to classify 118 Spanish patients with porphyria cutanea tarda (PCT) into three subtypes: sporadic-, familial- and type III-PCT. Seventy-four patients (63%) had eythrocyte UROD activity within the normal range (74% to 126% of the mean activity of 43 healthy controls) and were classified as sporadic-PCT (47%) or as type III-PCT (16%) whenever a family history of PCT was documented. Forty-four patients (37%) had decreased UROD activity and were classified as familial-PCT. The frequency of both familial-PCT and type III-PCT was higher than reported in other countries. The clinical expression of PCT was associated with the coexistence of two or more risk factors in 80% of the sporadic-PCT patients and in 89% of the familial-PCT patients. Hepatitis C virus and alcohol abuse were risk factors frequently found in these patients, being unrelated to age of onset of skin lesions. A heavy alcohol intake was the main risk factor for type III-PCT. Estrogens appeared as a precipitating factor for women with familial-PCT. The H63D mutation in the hemochromatosis type 1 gene was more frequently found than the C282Y mutation. Both mutations appeared to play a role as precipitating factors in sporadic-PCT when associated with hepatitis C virus infection and alcohol abuse.
14. Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study
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Khatri, C, Ward, AE, Nepogodiev, D, Ahmed, I, Chaudhry, D, Dhaif, F, Bankhad-Kendall, B, Kaafarani, H, Bretherton, C, Mahmood, A, Marais, L, Parsons, N, Bhangu, A, Metcalfe, A, Siaw-Acheampong, K, Dawson, BE, Evans, JP, Glasbey, JC, Gujjuri, RR, Heritage, E, Jones, CS, Kamarajah, SK, Keatley, JM, Lawday, S, Li, E, Mckay, SC, Pellino, G, Tiwari, A, Simoes, JFF, Trout, IM, Venn, ML, Wilkin, RJW, Ademuyiwa, AO, Agarwal, A, Al Ameer, E, Alderson, D, Alser, O, Arnaud, AP, Augestad, KM, Bankhead-Kendall, B, Benson, RA, Chakrabortee, S, Blanco-Colino, R, Brar, A, Bravo, A Minaya, Breen, KA, Buarque, I Lima, Caruana, E, Cunha, MF, Davidson, GH, Desai, A, Di Saverio, S, Edwards, J, Elhadi, M, Farik, S, Fiore, M, Fitzgerald, JE, Ford, S, Gallo, G, Ghosh, D, Gomes, GMA, Griffiths, E, Halkias, C, Harrison, EM, Hutchinson, P, Isik, A, Kolias, A, Lawani, I, Lederhuber, H, Leventoglu, S, Loffler, MW, Martin, J, Mashbari, H, Mazingi, D, Mohan, H, Moore, R, Moszkowicz, D, Ng-Kamstra, JS, Metallidis, S, Moug, S, Niquen, M, Ntirenganya, F, Outani, O, Pata, F, Pinkney, TD, Pockney, P, Radenkovic, D, Ramos-De la Medina, A, Roberts, K, Santos, I, Schache, A, Schnitzbauer, A, Stewart, GD, Shaw, R, Shu, S, Soreide, K, Spinelli, A, Sundar, S, Tabiri, S, Townend, P, Tsoulfas, G, van Ramshorst, G, Vidya, R, Vimalachandran, D, Wright, N, Mak, JKC, Kulkarni, R, Sharma, N, Nankivell, P, Tirotta, F, Parente, A, Breik, O, Kisiel, A, Cato, LD, Saeed, S, Pathanki, AM, Almond, M, Kamal, M, Chebaro, A, Lecolle, K, Truant, S, El Amrani, M, Zerbib, P, Pruvot, FR, Mathieu, D, Surmei, E, Mattei, L, Marin, H, Dudek, J, Singhal, T, El-Hasani, S, Nehra, D, Walters, A, Cuschieri, J, Ho, M, Wade, RG, Johnstone, J, Bourke, G, Brunelli, A, Elkadi, H, Otify, M, Pompili, C, Burke, JR, Bagouri, E, Chowdhury, M, Abual-Rub, Z, Kaufmann, A, Munot, S, Lo, T, Young, A, Kowal, M, Wall, J, Peckham-Cooper, A, Winter, SC, Belcher, E, Stavroulias, D, Di Chiara, F, Wallwork, K, Qureishi, A, Lami, M, Sravanam, S, Mastoridis, S, Shah, K, Chidambaram, S, Smillie, R, Shaw, AV, Bandyopadhyay, S, Cernei, C, Jeyaretna, D, Ganau, M, Piper, RJ, Duck, E, Brown, S, Jelley, C, Tucker, SC, Bond-Smith, G, Griffin, XL, Tebala, GD, Neal, N, Vatish, M, Noton, TM, Ghattaura, H, Maher, M, Fu, H, Risk, OBF, Majd, Soleymani H, Sinha, S, Shankar, S, Aggarwal, A, Kharkar, H, Lakhoo, K, Verberne, C, Senent-Boza, A, Sanchez-Arteaga, A, Benitez-Linero, I, Manresa-Manresa, F, Tallon-Aguilar, L, Melero-Cortes, L, Fernandez-Marin, MR, Duran-Munoz-Cruzado, VM, Ramallo-Solis, I, Beltran-Miranda, P, Pareja-Ciuro, F, Anton-Eguia, BT, Dawson, AC, Drane, A, Oliva Mompean, F, Gomez-Rosado, J, Reguera-Rosal, J, Valdes-Hernandez, J, Capitan-Morales, L, del Toro Lopez, MD, Patel, M, Shabana, A, Alanbuki, A, Usman, O, Tang, A, Beamish, AJ, Price, C, Bosanquet, D, Magowan, D, Solari, F, Williams, G, Nassa, H, Smith, L, Elliott, L, Mccabe, G, Holroyd, D, Jamieson, NB, Mariani, NM, Nicastro, V, Li, Z, Parkins, K, Spencer, N, Harries, R, Egan, RJ, Motter, D, Jenvey, C, Mahoney, R, Fine, N, Minto, T, Henry, A, Gill, C, Dunne, N, Sarma, DR, Godbole, C, Carlos, W, Tewari, N, Jeevan, D, Naredla, P, Khajuria, A, Connolly, H, Robertson, S, Sweeney, C, Di Taranto, G, Shanbhag, S, Dickson, K, McEvoy, K, Skillman, J, Sait, M, Al-omishy, H, Baig, M, Heer, B, Lunevicius, R, Sheel, ARG, Sundhu, M, Santini, AJA, Fathelbab, MSAT, Hussein, KMA, Nunes, QM, Jones, RP, Shahzad, K, Haq, I, Baig, MMAS, Hughes, JL, Kattakayam, A, Rajput, K, Misra, N, Shah, SB, Clynch, AL, Georgopoulou, N, Sharples, HM, Apampa, AA, Nzenwa, IC, Sud, A, Podolsky, D, Coleman, NL, Callahan, MP, Dunstan, M, Beak, P, Gerogiannis, I, Ebrahim, A, Alwadiya, A, Goyal, A, Phillips, A, Bhalla, A, Demetriou, C, Grimley, E, Theophilidou, E, Ogden, E, Malcolm, FL, Davies-Jones, G, Ng, JCK, Mirza, M, Hassan, M, Elmaleh, N, Daliya, P, Williams, S, Bateman, A, Chia, Z, A'Court, J, Konarski, A, Faulkner, G, Talwar, R, Patel, K, Askari, A, Jambulingam, PS, Shaw, S, Maity, A, Hatzantonis, C, Sagar, J, Kudchadkar, S, Cirocchi, N, Chan, CH, Eberbach, H, Bayer, J, Erdle, B, Sandkamp, R, Breen, K, Velmahos, G, Maurer, LR, El Moheb, M, Gaitanidis, A, Naar, L, Christensen, MA, Kapoen, C, Langeveld, K, El Hechi, M, Mokhtari, A, Main, B, Maccabe, T, Newton, C, Blencowe, NS, Fudulu, DP, Bhojwani, D, Baquedano, M, Caputo, M, Rapetto, F, Flannery, O, Hassan, A, Ward, A, Tadross, D, Majkowski, L, Blundell, C, Forlani, S, Nair, R, Guha, S, Brown, SR, Steele, C, Kelty, CJ, Newman, T, Lee, M, Chetty, G, Lye, G, Balasubramanian, SP, Shah, Sureshkumar N, Sherif, M, Al-mukhtar, A, Whitehall, E, Giblin, A, Wells, F, Sharkey, A, Adamec, A, Madan, S, Konsten, J, Van Heinsbergen, M, Sou, A, Simpson, D, Hamilton, E, Blair, J, Jimeno Fraile, J, Morales-Garcia, D, Carrillo-Rivas, M, Toledo Martinez, E, Pascual, A, Landaluce-Olavarria, A, Gonzalez De Miguel, M, Gomez Cruzado, Fernandez L, Begona, E, Lecumberri, D, Calvo Rey, A, Prada Hervella, GM, Dos Santos Carregal, L, Rodriguez, Fernandez MI, Freijeiro, M, El Drubi Vega, S, Van den Eynde, J, Oosterlinck, W, Van den Eynde, R, Sermon, A, Boeckxstaens, A, Cordonnier, A, De Coster, J, Jaekers, J, Politis, C, Miserez, M, Galipienso Eri, M, Garcia Montesino, JD, Dellonder Frigole, J, Noriego Munoz, D, Lizzi, V, Vovola, F, Arminio, A, Cotoia, A, Sarni, AL, Bekheit, M, Kamera, BS, Elhusseini, M, Sharma, P, Ahmeidat, A, Gradinariu, G, Cymes, W, Hannah, A, Mignot, G, Shaikh, S, Agilinko, J, Sgro, A, Rashid, MM, Milne, K, McIntyre, J, Akhtar, MA, Turnbull, A, Brunt, A, Stewart, KE, Wilson, MSJ, Rutherford, D, McGivern, K, Massie, E, Duff, S, Moura, F, Brown, BC, Khan, A, Asaad, P, Wadham, B, Aneke, IA, Collis, J, Warburton, H, Thomas, M, Pearce, L, Fountain, DM, Laurente, R, Sigamoney, KV, Dasa, M, George, K, Naqui, Z, Galhoum, M, Lipede, C, Gabr, A, Radhakrishnan, A, Hasan, MT, Kalenderov, R, Pathmanaban, O, Colombo, F, Chelva, R, Subba, K, Abou-Foul, AK, Khalefa, M, Hossain, F, Moores, T, Pickering, L, Shah, J, Anthoney, J, Emmerson, O, Bevan, K, Makin-Taylor, R, Ong, CS, Callan, R, Bloom, O, Chauhan, G, Kaur, J, Burahee, A, Bleibleh, S, Pigadas, N, Snee, D, Bhasin, S, Crichton, A, Habeebullah, A, Bodla, AS, Yassin, N, Mondragon, M, Dewan, V, Giuffrida, MC, Marano, A, Palagi, S, Grimaldi, Di Maria S, Testa, V, Peluso, C, Borghi, F, Simonato, A, Puppo, A, D'Agruma, M, Chiarpenello, R, Pellegrino, L, Maione, F, Cianflocca, D, Pruiti, Ciarello V, Giraudo, G, Gelarda, E, Dalmasso, E, Abrate, A, Daniele, A, Ciriello, V, Rosato, F, Garnero, A, Leotta, L, Chiozza, M, Anania, G, Urbani, A, Radica, Koleva M, Carcoforo, P, Portinari, M, Sibilla, M, Archer, JE, Odeh, A, Siddaiah, N, Baumber, R, Parry, J, Carmichael, H, Velopulos, CG, Wright, FL, Urban, S, McIntyre, Jr RC, Schroeppel, TJ, Hennessy, EA, Dunn, J, Zier, L, Parmar, C, Mccluney, S, Shah, S, Munoz Vives, JM, Osorio, A, Gomez Diaz, CJ, Guariglia, CA, Soto Montesinos, C, Sanchon, L, Xicola Martinez, M, Guardia, N, Collera, P, Diaz Del Gobbo, R, Sanchez Jimenez, R, Farre Font, R, Flores Clotet, R, Brathwaite, CEM, Liu, H, Petrone, P, Hakmi, H, Sohail, AH, Baltazar, G, Heckburn, R, Aujayeb, A, Townshend, D, McLarty, N, Shenfine, A, Jackson, K, Johnson, C, Madhvani, K, Hampton, M, Hormis, AP, Young, R, Miu, V, Sheridan, K, MacDonald, L, Green, S, Onos, L, Dean, B, Luney, C, Myatt, R, Williams, MA, McVeigh, J, Alqallaf, A, Ben-Sassi, A, Mohamed, I, Mellor, K, Joshi, P, Joshi, Y, Crichton, R, Sonksen, J, Aldridge, K, Layton, GR, Karki, B, Jeong, H, Pankhania, S, Asher, S, Folorunso, A, Mistry, S, Singh, B, Winyard, J, Mangwani, J, Babu, BHB, Liyanage, ASD, Newman, S, Blake, I, Weerasinghe, C, Ballabio, M, Bisagni, P, Longhi, M, Armao, T, Madonini, M, Gagliano, A, Pizzini, P, Alga, A, Nordberg, M, Sandblom, G, Jallad, S, Lord, J, Anderson, C, El Kafsi, J, Logishetty, K, Saadya, A, Midha, R, Ip, M, Ponniah, Subbiah H, Stockdale, T, Bacarese-Hamilton, T, Foster, L, James, A, Anjarwalla, N, Henriques, Marujo D, Hettige, R, Baban, C, Tenovici, A, Salerno, G, Hardie, J, Page, S, Anazor, F, King, SD, Luck, J, Kazzaz, S, HKruijff, S, De Vries, JPPM, Steinkamp, PJ, Jonker, PKC, Van der Plas, WY, Bierman, W, Janssen, Y, Borgstein, ABJ, Gisbertz, SS, Henegouwen, van Berge MI, Enjuto, D, Perez Gonzalez, M, Diaz Pena, P, Gonzalez, J, Marqueta De Salas, M, Martinez Pascual, P, Rodriguez Gomez, L, Garces Garcia, R, Ramos Bonilla, A, Herrera-Merino, N, Fernandez Bernabe, P, Cagigal Ortega, EP, Hernandez, I, de Castro Rubio, Garcia E, Cervera, I, Kashora, F, Siddique, MH, Singh, A, Barmpagianni, C, Basgaran, A, Basha, A, Okechukwu, V, Bartsch, A, Gallagher, P, Maqsood, A, Sahnan, K, Leo, CA, Lewis, SE, Ubhi, HK, Exley, R, Khan, U, Shah, P, Saxena, S, Zafar, N, Abdul-Jabar, H, Mongelli, F, Bernasconi, M, Di Giuseppe, M, Christoforidis, D, La Regina, D, Arigoni, M, Liew, I, Al-Sukaini, A, Mediratta, S, Saxena, D, Brown, O, Boal, M, Dean, H, Higgs, S, Stanger, S, Abdalaziz, H, Constable, J, Ishii, H, Preece, R, Dovell, G, Reddy, 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Pissanou, T, Gilliland, J, Chowdhury, S, Varcada, M, Hart, C, Mirnezami, R, Knowles, J, Angamuthu, N, Vijay, V, Shakir, T, Hasan, R, Tansey, R, Ross, E, Loubani, M, Wilkins, A, Cao, H, Capitelli-McMahon, H, Hitchman, L, Ikram, H, Andronic, A, Ibrahim, AA, Totty, J, Tayeh, S, Chase, T, Humphreys, L, Ayorinde, J, Ghanbari, A, Cuming, T, Williams, K, Chung, E, Hagger, R, Karim, A, Hainsworth, A, Flatman, M, Trompeter, A, Hing, C, Tsinaslanidis, P, Benjamin, MW, Leyte, A, Tan, C, Smelt, J, Vaughan, P, Santhirakumaran, G, Hunt, I, Raza, M, Labib, A, Luo, X, Sudarsanam, A, Rolls, A, Lyons, O, Onida, S, Shalhoub, J, Sugand, K, Park, C, Sarraf, KM, Erridge, S, Kinross, J, Denning, M, Yalamanchili, S, Abuown, A, Ibrahim, M, Martin, G, Davenport, D, Wheatstone, S, Andreani, S, Bath, MF, Sahni, A, Judkins, N, Springford, LR, Sohrabi, C, Bacarese-Hamilton, J, Taylor, FG, Patki, P, Tanabalan, C, Reynolds, J, Alexander, ME, Smart, CJ, Stylianides, N, Abdalla, M, Newton, K, Bhatia, K, Edmondson, R, Abdeh, L, Jones, D, Zeiton, M, Ismail, O, Naseem, H, Advani, R, Fell, A, Smith, A, Nikolaou, S, English, C, Kristinsson, S, Oni, T, Ilahi, N, Ballantyne, K, Woodward, Z, Merh, R, Robertson-Smith, B, Mahmoud, A, Ameerally, P, Finch, JG, Gnanachandran, C, Pop, I, Rogers, M, Yousef, Y, Woods, R, Zahid, H, Mundy, G, Dass, D, Ford, D, Khan, J, Thiruchandran, G, Toh, SKC, Ahmad, Y, Allana, A, Bellis, C, Babawale, O, Phan, YC, Lokman, U, Ismail, M, Koc, T, Witek, A, Duggleby, L, Shamoon, S, Stefan, S, Clancy, H, Singh, S, Mukherjee, S, Ferguson, D, Mansuri, A, Thakrar, A, Wickramarachchi, L, Cuthbert, R, Sivayoganathan, S, Chui, K, Karam, E, Dott, C, Singh, R, Lane, J, Colvin, HV, Badran, A, Cadersa, A, Cumpstey, A, Hamady, Z, Aftab, R, Wensley, F, Byrne, J, Morrison-Jones, V, Sekhon, GK, Shields, H, Shakoor, Z, Yener, A, Talbot, T, Alzetani, A, Cresner, R, Johnson, D, Hughes, I, Hall, J, Rooney, J, Chatterji, S, Zhang, Y, Owen, R, Rudic, M, Hunt, J, Zakai, D, Aladeojebi, A, Ali, M, Gaunt, A, 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Phillips, AW, Ghosh, K, Rogers, LJ, Labib, PL, Miller, D, Minto, G, Hope, N, Marchbank, A, Emslie, K, Panahi, P, Ho, B, Perkins, C, Clough, E, Roy, H, Enemosah, I, Campbell, R, Natale, J, Gohil, K, Rela, M, Raza, N, Menakaya, C, Webb, JI, Antar, M, Modi, N, Sofat, R, Noel, J, Nunn, R, Adegbola, S, Eriberto, F, Sharma, V, Tanna, R, Lodhia, S, Carvalho, L, Osorio, C, Antunes, J, Lourenco, S, Balau, P, Godinho, M, Pereira, A, Keller, DS, Smart, NJ, Apollo - University of Cambridge Repository, Collaborative, COVIDSurg, and Robotics and image-guided minimally-invasive surgery (ROBOTICS)
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Male ,medicine.medical_specialty ,Multivariate analysis ,MORTALITY-RATES ,hip ,SURGERY ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,MULTICENTER ,COVIDSurg Collaborative ,1117 Public Health and Health Services ,Cohort Studies ,Medicine, General & Internal ,Internal medicine ,General & Internal Medicine ,medicine ,Dementia ,Humans ,Prospective Studies ,Aged, 80 and over ,COMPLICATIONS ,Science & Technology ,HIP-FRACTURES ,business.industry ,Hip Fractures ,SARS-CoV-2 ,COVID-19 ,1103 Clinical Sciences ,General Medicine ,Femoral fracture ,Perioperative ,medicine.disease ,Heart failure ,trauma management ,Medicine ,Surgery ,business ,Life Sciences & Biomedicine ,Femoral Fractures ,Kidney disease ,Cohort study ,1199 Other Medical and Health Sciences - Abstract
ObjectivesStudies have demonstrated high rates of mortality in people with proximal femoral fracture and SARS-CoV-2, but there is limited published data on the factors that influence mortality for clinicians to make informed treatment decisions. This study aims to report the 30-day mortality associated with perioperative infection of patients undergoing surgery for proximal femoral fractures and to examine the factors that influence mortality in a multivariate analysis.SettingProspective, international, multicentre, observational cohort study.ParticipantsPatients undergoing any operation for a proximal femoral fracture from 1 February to 30 April 2020 and with perioperative SARS-CoV-2 infection (either 7 days prior or 30-day postoperative).Primary outcome30-day mortality. Multivariate modelling was performed to identify factors associated with 30-day mortality.ResultsThis study reports included 1063 patients from 174 hospitals in 19 countries. Overall 30-day mortality was 29.4% (313/1063). In an adjusted model, 30-day mortality was associated with male gender (OR 2.29, 95% CI 1.68 to 3.13, p80 years (OR 1.60, 95% CI 1.1 to 2.31, p=0.013), preoperative diagnosis of dementia (OR 1.57, 95% CI 1.15 to 2.16, p=0.005), kidney disease (OR 1.73, 95% CI 1.18 to 2.55, p=0.005) and congestive heart failure (OR 1.62, 95% CI 1.06 to 2.48, p=0.025). Mortality at 30 days was lower in patients with a preoperative diagnosis of SARS-CoV-2 (OR 0.6, 95% CI 0.6 (0.42 to 0.85), p=0.004). There was no difference in mortality in patients with an increase to delay in surgery (p=0.220) or type of anaesthetic given (p=0.787).ConclusionsPatients undergoing surgery for a proximal femoral fracture with a perioperative infection of SARS-CoV-2 have a high rate of mortality. This study would support the need for providing these patients with individualised medical and anaesthetic care, including medical optimisation before theatre. Careful preoperative counselling is needed for those with a proximal femoral fracture and SARS-CoV-2, especially those in the highest risk groups.Trial registration numberNCT04323644
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- 2021
15. Passage Number-Induced Replicative Senescence Modulates the Endothelial Cell Response to Protein-Bound Uremic Toxins
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Pedro Aljama, Fatima Guerrero, Sagrario Soriano, Victoria Pulido, Juan Antonio Moreno, María José Velasco Jiménez, Teresa Obrero, Andrés Carmona, Alejandro Martin-Malo, [Guerrero,F, Carmona,A, Jimenez,MJ, Obrero,T, Pulido,V, Moreno,JA, Soriano,S, Martín-Malo,A, Aljama,P] Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Córdoba, Spain. [Guerrero,F, Aljama,P] Department of Medicine, University of Cordoba, Córdoba, Spain. [Moreno,JA] Department of Cell Biology, Physiology and Immunology, University of Cordoba, Córdoba, Spain. [Soriano,S, Martín-Malo,A] Nephrology Unit, Reina Sofia University Hospital, Córdoba, Spain. [Soriano,S, Martín-Malo,A] Spanish Renal Research Network, Institute of Health Carlos III, Madrid, Spain., and This work was supported by the Plan Nacional de I+D+ I Proyectos de Investigación en Salud of Instituto de Salud Carlos III (ISCIII), Subdirección General de Evaluación, Fondos de Desarrollo Regional (FEDER) (PI15/01785, PI17/01785, PI17/00130 and PI20/00375), Spanish Society of Nephrology (Premio Baxter 2018) and Junta de Andalucía Grants (PI-0268-2018 and PIGE-0052-2020). J.A.M. is a senior researcher supported by the Spanish Ministry of Science and Innovation (RYC-2017-22369). A.C. is supported by Consejería de Transformación Económica, Industria, Conocimiento y Universidades de la Junta de Andalucía, cofinanciado por la Unión Europea a través del Fondo Social Europeo 'FSE invierte en tu futuro' (DOC_01428). The APC was funded by Junta de Andalucía Grants (PI-0268-2018).
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Aging ,senescence ,Senescencia ,Health, Toxicology and Mutagenesis ,Endothelial cells ,Cell ,Envejecimiento ,Toxicology ,P-cresol ,Umbilical vein ,endothelial dysfunction ,Anatomy::Cardiovascular System::Blood Vessels::Endothelium, Vascular [Medical Subject Headings] ,Diseases::Female Urogenital Diseases and Pregnancy Complications::Female Urogenital Diseases::Urologic Diseases::Kidney Diseases::Renal Insufficiency::Renal Insufficiency, Chronic [Medical Subject Headings] ,Indoxyl sulfate ,Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Movement [Medical Subject Headings] ,Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] ,Cresols ,Cell Movement ,Hidroxitolueno butilado ,Endothelial dysfunction ,Cellular Senescence ,Anatomy::Cells::Epithelial Cells::Endothelial Cells::Human Umbilical Vein Endothelial Cells [Medical Subject Headings] ,Diseases::Male Urogenital Diseases::Urologic Diseases::Kidney Diseases::Renal Insufficiency::Renal Insufficiency, Chronic [Medical Subject Headings] ,Chemistry ,Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Indoles::Indican [Medical Subject Headings] ,Cell migration ,endothelial cells ,Cell biology ,Endothelial stem cell ,medicine.anatomical_structure ,Medicine ,Senescence ,Premature aging ,Tóxinas urémicas ,Article ,p-cresol ,Chemicals and Drugs::Inorganic Chemicals::Oxygen Compounds::Reactive Oxygen Species [Medical Subject Headings] ,Human Umbilical Vein Endothelial Cells ,medicine ,Humans ,Renal Insufficiency, Chronic ,indoxyl sulfate ,aging ,Células endoteliales ,Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons, Cyclic::Hydrocarbons, Aromatic::Benzene Derivatives::Phenols::Cresols [Medical Subject Headings] ,medicine.disease ,Apoptosis ,Endothelium, Vascular ,Indican ,Indicán - Abstract
Endothelial aging may be induced early in pathological situations. The uremic toxins indoxyl sulfate (IS) and p-cresol (PC) accumulate in the plasma of chronic kidney disease (CKD) patients, causing accelerated endothelial aging, increased cardiovascular events and mortality. However, the mechanisms by which uremic toxins exert their deleterious effects on endothelial aging are not yet fully known. Thus, the aim of the present study is to determine the effects of IS and PC on endothelial damage and early senescence in cultured human umbilical vein endothelial cells (HUVECs). Hence, we establish an in vitro model of endothelial damage mediated by different passages of HUVECs and stimulated with different concentrations of IS and PC to evaluate functional effects on the vascular endothelium. We observe that cell passage-induced senescence is associated with apoptosis, ROS production and decreased endothelial proliferative capacity. Similarly, we observe that IS and PC cause premature aging in a dose-dependent manner, altering HUVECs’ regenerative capacity, and decreasing their cell migration and potential to form vascular structures in vitro. In conclusion, IS and PC cause accelerated aging in HUVECs, thus contributing to endothelial dysfunction associated with CKD progression.
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- 2021
16. Building energy performance assessment based on in-situ measurements : challenges and general framework
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Fitton, R, Bouchie, R, Spiekman, M, Jack, R, Spindler, U, Gorzalka, P, Jimenez, MJ, Erkoreka, A, Marshall, A, Gorse, C, Chirag, D, Alan, D, Farmer, DJ, Masy, G, Gori, V, Pandraud, G, Deltour, J, Van Gelder, L, Roels, S, Metzger, S, and Hughes, T
- Abstract
Subtask 1 investigated the possibilities and limitations of common data bases and monitoring systems. This subtask is strongly related to subtasks 2 and 3 by linking the available input data – as much as possible based on existing (non-intrusive) monitoring systems and data bases – to the accuracy of the predicted outcome. A state of the art survey of existing methods, their costs, timeframe and typical accuracy was made. In a second part the step from monitoring to current on board measuring methods was reviewed. Finally, the application of an on-site measured heat transfer coefficient within the global energy efficiency framework was proposed.
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- 2021
17. Risk factors and outcome of COVID-19 in patients with hematological malignancies
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Carmen Eva Perez, Maria Trabazo, Diana Martínez, Irene Garcia-Garcia, Carola Diaz, Rocío Parody, Rosa Coll, José Luis Piñana, Rebeca Bailén, Ignacio De La Fuente, Marta Valero, María-José Jiménez, Irene García-Cadenas, Teresa Zudaire, I Espigado, Agustin Nieto, Ana Serrano, Angel Cedillo, Noemí Fernández, Guiomar Bautista, Adolfo Saez, María Dolores Morales, Luisa Sisinni, Beatriz Merchán, Lourdes Vázquez, Anna Sureda, Laura Fox, Josep-Maria Ribera, Rodrigo Martino, Alejandro Luna, Ana I. Pimentel, Juan Carlos Vallejo, Gonzalo Benzo, Jose Lopez, Carme Talarn, Raquel Saldaña, María Calbacho, Anabelle Chinea, Dunia de Miguel, Maria Carmen Montoya, Manuel Jurado, Irene Gómez-Catalan, Carlos Solano, Marta González-Vicent, Pascual Fernández, Piñana, José Luis, Piñana, José Luis [0000-0001-8533-2562], Infectious Complications Subcommittee of the Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH), [Piñana,JL] Hematology División, Hospital Universitario y Politécnico La Fe, Instituto de Investigación Sanitaria La Fe, Valencia, Spain. [Piñana,JL] CIBERONC, Instituto Carlos III, Madrid, Spain. [Martino,R, Garcia‑Cadenas,I] Hematology División, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. [García-García,I, Luna,A, Chinea,A, Saez,AJ] Hematology División, Hospital Ramon y Cajal, Madrid, Spain. [Parody,R, Sureda,A] Hematology División, Institut Català Oncologia-Hospital Duran i Reynals, Barcelona, Spain. [Morales,MD, Merchán,B, de Miguel,D] Hematology División, Hospital de Guadalajara, Guadalajara, Spain. [Benzo,G] Hematology División, Hospital La Princesa, Madrid, Spain. [Gómez-Catalan,I, Serrano,A, Montoya,MC] Hematology División, Hospital de Albacete, Albacete, Spain. [Coll,R] Hematology División, Institut Català Oncologia-Hospital Josep Trueta, Girona, Spain. [De La Fuente,I, Pérez,C] Hematology División, Hospital Clínico de Valladolid, Valladolid, Spain. [Diaz,C] Hematology División, Hospital Carlos Haya, Malaga, Spain. [Lopez, JL] Hematology División, Hospital Fundación Jiménez Díaz, Madrid, Spain. [Bailen,R] Hematology División, Hospital Gregorio Marañon, Madrid, Spain. [Zudaire,T] Hematology División, Hospital de Navarra, Navarra, Spain. [Martínez,D] Hematology División, Hospital a Coruña, Coruña, Spain. [Jurado,M] Hematology División, Hospital Virgen de la Nieves, Granada, Spain. [Calbacho,M] Hematology División, Hospital 12 de Octubre, Madrid, Spain. [Vázquez,L] Hematology División, Hospital Universitario de Salamanca, Salamanca, Spain. [Fox,L] Hematology División, Hospital Vall d`Hebron, Barcelona, Spain. [Pimentel,AI] Hematology División, Hospital Clínico Universitario Lozano Blesa, IIS Aragon, Zaragoza, Spain. [Bautista,G] Hematology División, Hospital Puerta de Hierro, Madrid, Spain. [Nieto,A] Hematology División, Hospital de Vigo, Vigo, Spain. [Fernandez,P] Hematology División, Hospital General de Alicante, Alicante, Spain. [Vallejo,JC] Hematology División, Hospital de Donostia, Donostia, Spain. [Solano,C] Hematology División, Hospital Clínico Universitario de Valencia, Valencia, Spain. [Valero,M] Hematology División, Hospital Arnau de Vilanova, Valencia, Spain.[Espigado,I] Department of Hematology, University Hospital Virgen del Rocío/ University of Sevilla, CSIC/ Institute of Biomedicine of Sevilla, Sevilla, Spain. [Saldaña,R] Hematology División, Hospital de Jerez, Jerez, Spain. [Sisinni,L] Pediatric Hematology-Oncology División, Hospital la Paz, Madrid, Spain. [Ribera,JM, Jimenez,MJ] Hematology División, ICO-Hospital Germans Trias i Pujol, Josep Carreras Research Institute, Badalona, Spain. [Trabazo,M] Pediatric División, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. [Gonzalez-Vicent,M] Pediatric División, Hospital niño Jesús, Madrid, Spain. [Fernández,N] Hematology División, Hospital Marqués de Valdecilla, Santander, Spain. [Talarn,C] Hematology División, Hospital Joan XXIII, Tarragona, Spain. [Cedillo,A] Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH), Madrid, Spain. [Piñana,JL] Division of Clinical Hematology, Hospital Universitario la Fe de Valencia, Valencia, Spain., Institut Català de la Salut, [Piñana JL] Hematology División, Hospital Universitario y Politécnico La Fe, Instituto de Investigación Sanitaria La Fe, Valencia, Spain. CIBERONC, Instituto Carlos III, Madrid, Spain. Division of Clinical Hematology, Hospital Universitario la Fe de Valencia, Avda Fernando Abril Martorell, 106 CP 46026 Valencia, Spain. [Martino R] Hematology División, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. [García-García I] Hematology División, Hospital Ramon y Cajal, Madrid, Spain. [Parody R] Hematology División, Institut Català Oncologia-Hospital Duran i Reynals, Barcelona, Spain. [Morales MD] Hematology División, Hospital de Guadalajara, Guadalajara, Spain. [Benzo G] Hematology División, Hospital La Princesa, Madrid, Spain. [Fox L] Servei d’Hematologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus
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0301 basic medicine ,Cancer Research ,Diseases::Neoplasms::Neoplasms by Site::Hematologic Neoplasms [Medical Subject Headings] ,COVID-19 (Malaltia) - Mortalitat ,Coronavirus infections ,Azithromycin ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings] ,Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] ,0302 clinical medicine ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Retrospective Studies [Medical Subject Headings] ,Reacción en cadena de la polimerasa ,virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES] ,Hematologic neoplasms ,Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings] ,Hematology ,Factors de risc en les malalties ,Stem cell transplantation ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Transplantation::Cell Transplantation::Stem Cell Transplantation::Hematopoietic Stem Cell Transplantation [Medical Subject Headings] ,Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES] ,lcsh:Diseases of the blood and blood-forming organs ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Prognosis ,Multicenter study ,Polymerase chain reaction ,Oncology ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Transplantation::Cell Transplantation::Stem Cell Transplantation [Medical Subject Headings] ,030220 oncology & carcinogenesis ,Malalties hematològiques ,Factores de riesgo ,medicine.drug ,medicine.medical_specialty ,Pronòstic mèdic ,Risk factors in diseases ,Infecciones por coronavirus ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Analysis of Variance::Multivariate Analysis [Medical Subject Headings] ,Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::C-Reactive Protein [Medical Subject Headings] ,Neutropenia ,Hematologia oncològica ,lcsh:RC254-282 ,Trasplante de células madre ,03 medical and health sciences ,Other subheadings::Other subheadings::Other subheadings::/mortality [Other subheadings] ,Internal medicine ,medicine ,Persons::Persons::Age Groups::Child [Medical Subject Headings] ,Mortality ,neoplasias::neoplasias por localización::neoplasias hematológicas [ENFERMEDADES] ,Persons::Persons::Age Groups::Adult [Medical Subject Headings] ,Estudio multicéntrico ,Estudio restrospectivo ,Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings] ,Otros calificadores::Otros calificadores::Otros calificadores::/mortalidad [Otros calificadores] ,Performance status ,lcsh:RC633-647.5 ,business.industry ,SARS-CoV-2 ,Research ,Neoplasias hemtaológicas ,Hematologic diseases ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Mortality [Medical Subject Headings] ,COVID-19 ,Retrospective cohort study ,Odds ratio ,Neoplasms::Neoplasms by Site::Hematologic Neoplasms [DISEASES] ,medicine.disease ,Diseases::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [Medical Subject Headings] ,Confidence interval ,Retrospective studies ,Transplantation ,030104 developmental biology ,Sang - Malalties ,Mortalidad ,Risk factor ,business - Abstract
Background Prognostic factors of poor outcome in patients with hematological malignancies and COVID-19 are poorly defined. Patients and methods This was a Spanish transplant group and cell therapy (GETH) multicenter retrospective observational study, which included a large cohort of blood cancer patients with laboratory-confirmed SARS-CoV-2 infection through PCR assays from March 1st 2020 to May 15th 2020. Results We included 367 pediatric and adult patients with hematological malignancies, including recipients of autologous (ASCT) (n = 58) or allogeneic stem cell transplantation (allo-SCT) (n = 65) from 41 hospitals in Spain. Median age of patients was 64 years (range 1–93.8). Recipients of ASCT and allo-SCT showed lower mortality rates (17% and 18%, respectively) compared to non-SCT patients (31%) (p = 0.02). Prognostic factors identified for day 45 overall mortality (OM) by logistic regression multivariate analysis included age > 70 years [odds ratio (OR) 2.1, 95% confidence interval (CI) 1.2–3.8, p = 0.011]; uncontrolled hematological malignancy (OR 2.9, 95% CI 1.6–5.2, p 20 mg/dL (OR 3.3, 95% CI 1.7–6.4, p
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- 2020
18. A novel image thresholding method based on membrane computing and fuzzy entropy
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Hong Peng, Peng Shi, Jun Wang, Mario J. Pérez-Jiménez, Universidad de Sevilla. Departamento de Ciencias de la Computación e Inteligencia Artificial, Universidad de Sevilla. TIC193: Computación Natural, Peng, Hsu, Wang, J, Perez-Jimenez, MJ, and Shi, Peng
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Statistics and Probability ,Tissue P systems ,Image segmentation ,business.industry ,Balanced histogram thresholding ,General Engineering ,Scale-space segmentation ,Pattern recognition ,Membrane Computing ,Thresholding ,Class (biology) ,Thresholding method ,Image (mathematics) ,Fuzzy entropy ,Artificial Intelligence ,Segmentation ,Artificial intelligence ,business ,Membrane computing ,Mathematics - Abstract
Multi-level thresholding methods are a class of most popular image segmentation techniques, however, they are not computationally efficient since they exhaustively search the optimal thresholds to optimize the objective function. In order to eliminate the shortcoming, a novel multi-level thresholding method for image segmentation based on tissue P systems is proposed in this paper. The fuzzy entropy is used as the evaluation criterion to find optimal segmentation thresholds. The presented method can effectively search the optimal thresholds for multi-level thresholding based on fuzzy entropy due to parallel computing ability and particular mechanism of tissue P systems. Experimental results of both qualitative and quantitative comparisons for the proposed method and several existing methods illustrate its applicability and effectiveness.
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- 2013
19. Solving NP-Complete Problems by Spiking Neural P Systems with Budding Rules
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Tseren-Onolt Ishdorj, Alberto Leporati, Linqiang Pan, Jun Wang, Paun, G, Perez Jimenez, MJ, Riscos Nunez, A, Rozenberg, G, Salomaa, A, Ishdorj, T, Leporati, A, Pan, L, and Wang, J
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Synapse ,Quantitative Biology::Neurons and Cognition ,Exponential growth ,Computer science ,Computation ,INF/01 - INFORMATICA ,Graph (abstract data type) ,Membrane Computing, spiking neural P systems, budding rules, NP-complete problems ,NP-complete ,Boolean data type ,Algorithm ,Time complexity - Abstract
Inspired by the growth of dendritic trees in biological neurons, we introduce spiking neural P systems with budding rules. By applying these rules in a maximally parallel way, a spiking neural P system can exponentially increase the size of its synapse graph in a polynomial number of computation steps. Such a possibility can be exploited to efficiently solve computationally difficult problems in deterministic polynomial time, as it is shown in this paper for the NP-complete decision problem sat.
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- 2010
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20. A novel variant of P Systems for the modelling of biochemical systems
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Cazzaniga, P, Milanesi, L, MAURI, GIANCARLO, MOSCA, ETTORE, PESCINI, DARIO, Paun, G, Perez Jimenez, MJ, Riscos Nunez, A, Rozenberg, G, Salomaa, A, Cazzaniga, P, Mauri, G, Milanesi, L, Mosca, E, and Pescini, D
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membrane system ,system modeling - Abstract
In the last decade, different computing paradigms and modelling frameworks for the description and simulation of biochemical systems have been proposed. Here, we consider membrane systems, in particular, tissue P systems and τ-DPP, for the development of a novel variant of membrane systems with sizes associated to the volumes involved in the structure and to the molecular species occurring inside the system. Moreover, this variant allows the communication of objects among non adjacent membranes arranged in a hybrid structure, that is, organised in a tissue-like fashion where nodes can have a complex internal structure. The features presented in the new variant of P systems can be used to describe, among others, reaction-diffusion systems, where molecules are involved both in chemical reactions and diffusive processes, and their movements depend on the free space of the volumes; or systems where exist privileged pathways between membranes, which are inspired by the role of microtubule in protein transport within the intracellular space.
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- 2010
21. Transfusion independence after lenalidomide discontinuation in patients with del(5q) myelodysplastic neoplasm: a HARMONY Alliance study.
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Crisà E, Mora E, Germing U, Bally C, Diez Campelo M, Myllymäki M, Jädersten M, Komrokji R, Platzbecker U, Haase D, Hofmann WK, Al Ali NH, Barraco D, Bargay JJ, Bernal T, López Cadenas F, Calvisi A, Capodanno I, Cerrano M, Ciancia R, Crugnola M, Kündgen A, Finelli C, Fozza C, Frairia C, Freja E, Ganster C, Kubasch AS, Jimenez MJ, Latagliata R, Hernandez Mohedo F, Molero A, Vara Pampliega M, Perez CA, Pietrantuono G, Poloni A, Pomares H, Recasens V, Rüfer A, Signori A, Hellstrom-Lindberg E, Fenaux P, Sanz G, and Santini V
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- Humans, Male, Female, Aged, Middle Aged, Aged, 80 and over, Follow-Up Studies, Erythrocyte Transfusion, Adult, Blood Transfusion, Lenalidomide therapeutic use, Lenalidomide administration & dosage, Myelodysplastic Syndromes drug therapy, Myelodysplastic Syndromes genetics, Myelodysplastic Syndromes therapy, Chromosomes, Human, Pair 5 genetics, Chromosome Deletion, Thalidomide analogs & derivatives, Thalidomide therapeutic use
- Abstract
Lenalidomide (LEN) can induce red blood cell-transfusion independence (RBC-TI) in 60-70% of del(5q) myelodysplastic neoplasm (MDS) patients. Current recommendation is to continue LEN in responding patients until failure or progression, with likelihood of toxicity and a high cost for healthcare systems. This HARMONY Alliance study investigated the outcome of MDS del(5q) patients who discontinued LEN while RBC-transfusion independent. We enrolled 118 patients with IPSS-R low-intermediate risk. Seventy patients (59%) discontinued LEN for intolerance, 38 (32%) per their physician decision, nine (8%) per their own decision and one (1%) for unknown reasons. After a median follow-up of 49 months from discontinuation, 50/118 patients lost RBC-TI and 22/30 who underwent cytogenetic re-evaluation lost complete cytogenetic response. The median RBC-TI duration was 56 months. In multivariate analysis, RBC-TI duration after LEN discontinuation correlated with low transfusion burden before LEN therapy, treatment ≥ 12 LEN cycles, younger age and higher Hb level at LEN withdrawal. Forty-eight patients were re-treated with LEN for loss of response and 28 achieved again RBC-TI. These data show that stopping LEN therapy in MDS del(5q) patients who reached RBC-TI allows prolonged maintenance of TI in a large subset of patients., (© 2024. The Author(s), under exclusive licence to Springer Nature Limited.)
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- 2024
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22. [Translated article] Is informed consent just a signature on a piece of paper?
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Núñez JH, Escudero-Cisneros B, Jimenez-Jimenez MJ, and Bosch-García D
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- 2024
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23. Is informed consent just a signature on a piece of paper?
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Núñez JH, Escudero-Cisneros B, Jimenez-Jimenez MJ, and Bosch-García D
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- 2024
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24. Reconsidering preoperative transfusion testing in primary total hip and knee arthroplasty: Are they truly efficient?
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Núñez JH, Jimenez-Jimenez MJ, and Escudero B
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- 2024
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25. Stability of Cesium-Based Lead Halide Perovskites under UV Radiation.
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Qin Z, Caraveo-Frescas JA, Fernandez-Izquierdo L, Arellano-Jimenez MJ, Aguirre-Tostado FS, Reyes-Banda MG, and Quevedo-Lopez MA
- Abstract
Lead halide perovskites have been extensively studied for their potential applications, including photodetectors, solar cells, and high-energy radiation detection. These applications are possible because of their unique optoelectronic properties, such as tunable band gap, high optical absorption coefficient, and unique defect self-healing properties, which result in high defect tolerance. Despite these advantages, the long-term stability remains a critical issue that could hinder commercial applications of these materials. Reports on the stability of lead halide perovskites for optoelectronic applications have normally focused on methylammonium (MA)/formamidinium (FA), with very limited information for other systems, in particular, Cs-containing perovskites. In this paper, we report the stability of thick CsPbBr
3- x Clx polycrystalline thin films (∼8 μm) with several halide Br-Cl ratios after exposure to deep UV radiation. The chemical, crystal structure, optical, and electrical properties are analyzed, and the results are used to propose a degradation mechanism. The chemical analysis on the surface and bulk of the films indicates the formation of cesium oxide after UV exposure, with no significant change in the crystalline structure. The proposed mechanism explains the formation of cesium oxides during UV exposure. The I - V characteristics of diode structures also showed significant degradation after UV exposure, primarily at lower diode rectification ratios. The mechanism proposed in this paper can contribute to developing strategies to enhance the long-term stability of inorganic lead halide perovskites under UV exposure., Competing Interests: The authors declare no competing financial interest., (© 2024 The Authors. Published by American Chemical Society.)- Published
- 2024
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26. Nonlinear Spiking Neural Systems With Autapses for Predicting Chaotic Time Series.
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Liu Q, Peng H, Long L, Wang J, Yang Q, Perez-Jimenez MJ, and Orellana-Martin D
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Spiking neural P (SNP) systems are a class of distributed and parallel neural-like computing models that are inspired by the mechanism of spiking neurons and are 3rd-generation neural networks. Chaotic time series forecasting is one of the most challenging problems for machine learning models. To address this challenge, we first propose a nonlinear version of SNP systems, called nonlinear SNP systems with autapses (NSNP-AU systems). In addition to the nonlinear consumption and generation of spikes, the NSNP-AU systems have three nonlinear gate functions, which are related to the states and outputs of the neurons. Inspired by the spiking mechanisms of NSNP-AU systems, we develop a recurrent-type prediction model for chaotic time series, called the NSNP-AU model. As a new variant of recurrent neural networks (RNNs), the NSNP-AU model is implemented in a popular deep learning framework. Four datasets of chaotic time series are investigated using the proposed NSNP-AU model, five state-of-the-art models, and 28 baseline prediction models. The experimental results demonstrate the advantage of the proposed NSNP-AU model for chaotic time series forecasting.
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- 2024
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27. A prognostic molecular signature of hepatic steatosis is spatially heterogeneous and dynamic in human liver.
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Perry AS, Hadad N, Chatterjee E, Ramos MJ, Farber-Eger E, Roshani R, Stolze LK, Zhao S, Martens L, Kendall TJ, Thone T, Amancherla K, Bailin S, Gabriel CL, Koethe J, Carr JJ, Terry JG, Freedman J, Tanriverdi K, Alsop E, Keuren-Jensen KV, Sauld JFK, Mahajan G, Khan S, Colangelo L, Nayor M, Fisher-Hoch S, McCormick J, North KE, Below J, Wells Q, Abel D, Kalhan R, Scott C, Guilliams M, Fallowfield JA, Banovich NE, Das S, and Shah R
- Abstract
Metabolic dysfunction-associated steatotic liver disease (MASLD) prevalence is increasing in parallel with an obesity pandemic, calling for novel strategies for prevention and treatment. We defined a circulating proteome of human MASLD across ≈7000 proteins in ≈5000 individuals from diverse, at-risk populations across the metabolic health spectrum, demonstrating reproducible diagnostic performance and specifying both known and novel metabolic pathways relevant to MASLD (central carbon and amino acid metabolism, hepatocyte regeneration, inflammation, fibrosis, insulin sensitivity). A parsimonious proteomic signature of MASLD was associated with a protection from MASLD and its related multi-system metabolic consequences in >26000 free-living individuals, with an additive effect to polygenic risk. The MASLD proteome was encoded by genes that demonstrated transcriptional enrichment in liver, with spatial transcriptional activity in areas of steatosis in human liver biopsy and dynamicity for select targets in human liver across stages of steatosis. We replicated several top relations from proteomics and spatial tissue transcriptomics in a humanized "liver-on-a-chip" model of MASLD, highlighting the power of a full translational approach to discovery in MASLD. Collectively, these results underscore utility of blood-based proteomics as a dynamic "liquid biopsy" of human liver relevant to clinical biomarker and mechanistic applications.
- Published
- 2024
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28. Robotic surgery in the management of synchronous esophageal and gastric perforation after endoscopic dilation.
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Donado Jimenez MJ, Jimenez MC, and Cubas R
- Subjects
- Humans, Dilatation adverse effects, Endoscopy adverse effects, Robotic Surgical Procedures adverse effects, Esophageal Perforation etiology, Esophageal Perforation surgery, Stomach Diseases complications, Abdominal Injuries complications, Thoracic Injuries complications
- Abstract
Upper gastrointestinal perforation is a feared complication of diagnostic and therapeutic endoscopy, with an incidence of perforation between 0.3% and 5%. Even though is rare, the mortality rate can be as high as 40%. Currently, there is no consensus on the best therapeutic strategy and it usually depends on patient stability, the extent of perforation, time to diagnosis, surgeon experience and available resourcesWe present a case of a patient who presented to our institution to undergo an ambulatory oesophageal dilation. After dilation, the patient developed two full-thickness gastric perforations and a full-thickness oesophageal perforation without haemodynamic instability. All perforations were diagnosed and treated with a combination of intraoperative endoscopy and robotic surgery with excellent outcomes.We demonstrate that a robotic approach combined with intraoperative diagnostic endoscopy is a safe and feasible treatment option for esophageal and gastric perforations in a stable patient without large extraluminal contamination., Competing Interests: Competing interests: None declared., (© BMJ Publishing Group Limited 2024. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2024
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29. A Survey of Vectorization Methods in Topological Data Analysis.
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Ali D, Asaad A, Jimenez MJ, Nanda V, Paluzo-Hidalgo E, and Soriano-Trigueros M
- Abstract
Attempts to incorporate topological information in supervised learning tasks have resulted in the creation of several techniques for vectorizing persistent homology barcodes. In this paper, we study thirteen such methods. Besides describing an organizational framework for these methods, we comprehensively benchmark them against three well-known classification tasks. Surprisingly, we discover that the best-performing method is a simple vectorization, which consists only of a few elementary summary statistics. Finally, we provide a convenient web application which has been designed to facilitate exploration and experimentation with various vectorization methods.
- Published
- 2023
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30. Self-Healing E-tongue.
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Riul A Jr, de Barros A, Gaál G, Braunger ML, Martinez Jimenez MJ, Avila-Avendano C, Rodrigues V, de Andrade MJ, Quevedo-Lopez M, Alvarez F, and Baughman RH
- Abstract
Self-healing materials inspire the next generation of multifunctional wearables and Internet of Things appliances. They expand the realm of thin film fabrication, enabling seamless conformational coverage irrespective of the shape complexity and surface geometry for electronic skins, smart textiles, soft robotics, and energy storage devices. Within this context, the layer-by-layer (LbL) technique is versatile for homogeneously dispersing materials onto various matrices. Moreover, it provides molecular level thickness control and coverage on practically any surface, with poly(ethylenimine) (PEI) and poly(acrylic acid) (PAA) being the most used materials primarily employed in self-healing LbL structures operating at room temperature. However, achieving thin film composites displaying controlled conductivity and healing ability is still challenging under ambient conditions. Here, PEI and PAA are mixed with conductive fillers (gold nanorods, poly(3,4-ethylene dioxythiophene): polystyrenesulfonate (PEDOT:PSS), reduced graphene oxides, and multiwalled carbon nanotubes) in distinct LbL film architectures. Electrical (AC and DC), optical (Raman spectroscopy), and mechanical (nanoindentation) measurements are used for characterizing composite structures and properties. A delicate balance among electrical, mechanical, and structural characteristics must be accomplished for a controlled design of conductive self-healing composites. As a proof-of-concept, four LbL composites were chosen as sensing units in the first reported self-healing e-tongue. The sensor can easily distinguish basic tastes at low molar concentrations and differentiate trace levels of glucose in artificial sweat. The formed nanostructures enable smart coverages that have unique features for solving current technological challenges.
- Published
- 2023
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31. Gated Spiking Neural P Systems for Time Series Forecasting.
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Liu Q, Long L, Peng H, Wang J, Yang Q, Song X, Riscos-Nunez A, and Perez-Jimenez MJ
- Abstract
Spiking neural P (SNP) systems are a class of neural-like computing models, abstracted by the mechanism of spiking neurons. This article proposes a new variant of SNP systems, called gated spiking neural P (GSNP) systems, which are composed of gated neurons. Two gated mechanisms are introduced in the nonlinear spiking mechanism of GSNP systems, consisting of a reset gate and a consumption gate. The two gates are used to control the updating of states in neurons. Based on gated neurons, a prediction model for time series is developed, known as the GSNP model. Several benchmark univariate and multivariate time series are used to evaluate the proposed GSNP model and to compare several state-of-the-art prediction models. The comparison results demonstrate the availability and effectiveness of GSNP for time series forecasting.
- Published
- 2023
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32. Autonomy with responsibility ¿Is informed consent just a signature on a paper? Evaluation in patients who underwent spine's surgery.
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Núñez JH, Jimenez-Jimenez MJ, Taberner A, Alonzo-González F, Cisneros BE, and Bosch-García D
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- Humans, Retrospective Studies, Neurosurgical Procedures, Informed Consent, Mental Recall
- Abstract
Purpose: To evaluate the information that patients undergoing spine surgery truly receive and assimilate when they sign their informed consent documents., Methods: This was a retrospective study on patients who underwent spine arthrodesis or spine discectomy. Patients were given a full explanation of the surgical technique to be employed and its potential risks before they were included on the surgical waiting list. Before surgery, they were asked to sign an informed consent form. The studied variables included whether patients read the informed consent form, whether they recalled the surgical technique used or the spinal segment operated, whether they were aware of the surgical risks involved, and if they had looked for information about their procedure elsewhere. Answers were analyzed by age and educational level., Results: Of a total of 458 total patients, only 51.9% answered all the questions. Sixty-three percent of patients said they had read the informed consent document before surgery. Although 91.6% of patients were aware of the spine segment operated, only 73.5% remembered the surgical technique employed. A total of 63.9% of patients could recall the vertebral levels operated. 39.1% were not aware of the surgical risks involved, and only 16.0% of patients admitted having looked for additional information. A statistically significant correlation was found between the search for additional information and young age (p < 0.001) on the one hand, and high educational level on the other (p = 0.023)., Conclusion: Even though obtaining informed consent is an important procedure before spinal surgery, almost 40% of the patients in this study underwent surgery without reading the informed consent document or being aware of the risks posed by the procedure., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
- Published
- 2023
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33. Uremic Toxins Induce THP-1 Monocyte Endothelial Adhesion and Migration through Specific miRNA Expression.
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Carmona A, Guerrero F, Muñoz-Castañeda JR, Jimenez MJ, Rodriguez M, Soriano S, and Martin-Malo A
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- Humans, Uremic Toxins, Endothelial Cells, Monocytes, NF-kappa B, Indican toxicity, Tissue Adhesions, Atherosclerosis genetics, MicroRNAs genetics
- Abstract
Atherosclerosis is initiated by the activation of endothelial cells that allows monocyte adhesion and transmigration through the vascular wall. The accumulation of uremic toxins such as indoxyl sulphate (IS) and p-cresol (PC) has been associated with atherosclerosis. Currently, miRNAs play a crucial role in the regulation of monocyte activation, adhesion, and trans-endothelial migration. The aim of the present study is to evaluate the effect of IS and PC on monocyte adhesion and migration processes in monocytes co-cultured with endothelial cells as well as to determine the underlying mechanisms. The incubation of HUVECs and THP-1 cells with both IS and PC toxins resulted in an increased migratory capacity of THP-1 cells. Furthermore, the exposure of THP-1 cells to both uremic toxins resulted in the upregulation of BMP-2 and miRNAs-126-3p, -146b-5p, and -223-3p, as well as the activation of nuclear factor kappa B (NF-κB) and a decrease in its inhibitor IĸB. Uremic toxins, such as IS and PC, enhance the migratory and adhesion capacity of THP-1 cells to the vascular endothelium. These toxins, particularly PC, contribute significantly to uremia-associated vascular disease by increasing in THP-1 cells the expression of BMP-2, NF-κB, and key miRNAs associated with the development of atherosclerotic vascular diseases.
- Published
- 2023
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34. Correction to "Discovery of a Thiadiazole-Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models".
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Finlay MRV, Anderton M, Bailey A, Boyd S, Brookfield J, Cairnduff C, Charles M, Cheasty A, Critchlow SE, Culshaw J, Debreczeni J, Ekwuru T, Hollingsworth I, Jones N, Leroux F, Littleson M, McCarron H, McKelvie J, Mooney L, Nissink JWM, Patel J, Perkins D, Powell S, Quesada MJ, Raubo P, Sabin V, Smith J, Smith PD, Stark A, Ting A, Wang P, Wilson Z, Winter-Holt JJ, Wood JM, Wrigley GL, Yu G, and Zhang P
- Published
- 2023
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35. Persistent biofluid small molecule alterations induced by Trypanosoma cruzi infection are not restored by antiparasitic treatment.
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Dean DA, Roach J, vonBargen RU, Xiong Y, Kane SS, Klechka L, Wheeler K, Sandoval MJ, Lesani M, Hossain E, Katemauswa M, Schaefer M, Harris M, Barron S, Liu Z, Pan C, and McCall LI
- Abstract
Chagas Disease (CD), caused by Trypanosoma cruzi (T. cruzi) protozoa, is a complicated parasitic illness with inadequate medical measures for diagnosing infection and monitoring treatment success. To address this gap, we analyzed changes in the metabolome of T. cruzi- infected mice via liquid chromatography tandem mass spectrometry analysis of clinically-accessible biofluids: saliva, urine, and plasma. Urine was the most indicative of infection status, across mouse and parasite genotypes. Metabolites perturbed by infection in the urine include kynurenate, acylcarnitines, and threonylcarbamoyladenosine. Based on these results, we sought to implement urine as a tool for assessment of CD treatment success. Strikingly, it was found that mice with parasite clearance following benznidazole antiparasitic treatment had comparable overall urine metabolome to mice that failed to clear parasites. These results match with clinical trial data in which benznidazole treatment did not improve patient outcomes in late-stage disease. Overall, this study provides insights into new small molecule-based CD diagnostic methods and a new approach to assess functional treatment response., Competing Interests: Conflicts of Interest: The authors declare no conflict of interest.
- Published
- 2023
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36. Normal Infrarenal Aortic Diameter in Men and Women in a Mediterranean Area.
- Author
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Gené Mola A, Casasa A, Puig Reixach T, de La Figuera M, Jimenez MJ, Fité Matamoros J, Roman Escudero J, and Bellmunt Montoya S
- Subjects
- Humans, Male, Female, Risk Factors, Cross-Sectional Studies, Treatment Outcome, Ultrasonography, Prevalence, Aorta, Abdominal diagnostic imaging, Aortic Aneurysm, Abdominal diagnostic imaging, Aortic Aneurysm, Abdominal epidemiology
- Abstract
Background: Infrarenal aortic diameter (AD) values currently considered normal are based on measurements from epidemiologic studies performed over 20 years ago. Knowledge of expected normal AD is important for understanding the relevance of abdominal aortic dilatation. The aim of this study was to define contemporary reference values for normal infrarenal AD and build a predictive model based on individual features., Methods: A cross-sectional study of participants in a population-based screening program for abdominal aortic aneurysm (AAA) was performed in a healthcare district with 400,000 inhabitants. Men and women aged 65 years were invited to participate. Cardiovascular (CV) risk factors, family history of AAA, personal history of other aneurysms, CV disease, and anthropometric parameters were evaluated. The largest anteroposterior inner-inner diameter of the infrarenal aorta was measured by ultrasound. Multiple linear regressions were used to determine independent predictors of AD. The best-fit model was obtained by randomly selecting 70% of the sample and validating the results in the remaining 30%., Results: A total of 4,730 people (2,089 men and 2,641 women) were invited. The participation rate was 50.4% for men and 44.0% for women. Mean AD (standard deviation, SD) was 16.51 (3.2) mm in the overall group, 17.91 (3.51) mm in men, and 15.25 (2.32) mm in women (P < 0.001). Male sex (P < 0.001), body surface area (P < 0.001), smoking habit (P = 0.012), and history of arterial aneurysms (P = 0.013) were independently associated with increased AD. Dyslipidemia was associated with decreased AD (P < 0.001). The findings were used to build a model for predicting AD based on individual characteristics., Conclusions: ADs in our study population are smaller than those described in classic epidemiological studies. Men have a significantly larger diameter than women and the strongest predictor of increased AD is body surface area. A greater understanding of factors associated with AD will help predict expected sizes in individual members of the population., (Copyright © 2023 Elsevier Inc. All rights reserved.)
- Published
- 2023
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37. Risk factors for cardiovascular events in patients with heterozygous familial hypercholesterolaemia: protocol for a systematic review.
- Author
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Mansilla-Rodríguez ME, Romero-Jimenez MJ, Rigabert Sánchez-Junco A, Gutierrez-Cortizo EN, Sánchez-Ramos JL, Mata P, Pang J, and Watts GF
- Subjects
- Humans, Cross-Sectional Studies, Risk Factors, Systematic Reviews as Topic, Cardiovascular Diseases genetics, Hyperlipoproteinemia Type II complications, Hyperlipoproteinemia Type II genetics
- Abstract
Introduction: Heterozygous familial hypercholesterolaemia (heFH) is the most common monogenic cause of premature atherosclerotic cardiovascular disease. The precise diagnosis of heFH is established by genetic testing. This systematic review will investigate the risk factors that predict cardiovascular events in patients with a genetic diagnosis of heFH., Methods and Analysis: Our literature search will cover publications from database inception until June 2023. We will undertake a search of CINAHL (trial), clinicalKey, Cochrane Library, DynaMed, Embase, Espacenet, Experiments (trial), Fisterra, ÍnDICEs CSIC, LILACS, LISTA, Medline, Micromedex, NEJM Resident 360, OpenDissertations, PEDro, Trip Database, PubPsych, Scopus, TESEO, UpToDate, Web of Science and the grey literature for eligible studies. We will screen the title, abstract and full-text papers for potential inclusion and assess the risk of bias. We will employ the Cochrane tool for randomised controlled trials and non-randomised clinical studies and the Newcastle-Ottawa Scale for assessing the risk of bias in observational studies. We will include full-text peer-reviewed publications, reports of a cohort/registry, case-control and cross-sectional studies, case report/series and surveys related to adults (≥18 years of age) with a genetic diagnostic heFH. The language of the searched studies will be restricted to English or Spanish. The Grading of Recommendations, Assessment, Development and Evaluation approach will be used to assess the quality of the evidence. Based on the data available, the authors will determine whether the data can be pooled in meta-analyses., Ethics and Dissemination: All data will be extracted from published literature. Hence, ethical approval and patient informed consent are not required. The findings of the systematic review will be submitted for publication in a peer-reviewed journal and presentation at international conferences., Prospero Registration Number: CRD42022304273., Competing Interests: Competing interests: All authors have completed the BMJ Group uniform disclosure form declaration of interests statement. PM collaborates with research grants from Amgen and Sanofi and collaboration for familial hypercholesterolaemia studies. GW declares receiving consulting fees from Amgen, Novartis, Arrowhead and Pfizer; payment or honoraria for lectures, presentations, speaker bureaus, manuscript writing or educational events from Amgen, Novartis and Arrowhead; receiving support for attendance at meetings and/or trips from Amgen and Novartis; and participation in a Data Safety Monitoring Board or Advisory Board for Arrowhead and AstraZeneca. JP is supported by grants from the National Health and Medical Research Council (Australia), the Western Australian Department of Health and the Royal Perth Hospital Research Foundation. The other authors declare no competing interests., (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2023
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38. Improved outcomes over time and higher mortality in CMV seropositive allogeneic stem cell transplantation patients with COVID-19; An infectious disease working party study from the European Society for Blood and Marrow Transplantation registry.
- Author
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Ljungman P, Tridello G, Piñana JL, Ciceri F, Sengeloev H, Kulagin A, Mielke S, Yegin ZA, Collin M, Einardottir S, Lepretre SD, Maertens J, Campos A, Metafuni E, Pichler H, Folber F, Solano C, Nicholson E, Yüksel MK, Carlson K, Aguado B, Besley C, Byrne J, Heras I, Dignan F, Kröger N, Robin C, Khan A, Lenhoff S, Grassi A, Dobsinska V, Miranda N, Jimenez MJ, Yonal-Hindilerden I, Wilson K, Averbuch D, Cesaro S, Xhaard A, Knelange N, Styczynski J, Mikulska M, and de la Camara R
- Subjects
- Humans, Middle Aged, Bone Marrow, Transplantation, Homologous, Registries, COVID-19 complications, Hematopoietic Stem Cell Transplantation adverse effects, Communicable Diseases complications, Cytomegalovirus Infections complications
- Abstract
Introduction: COVID-19 has been associated with high morbidity and mortality in allogeneic hematopoietic stem cell transplant (allo-HCT) recipients., Methods: This study reports on 986 patients reported to the EBMT registry during the first 29 months of the pandemic., Results: The median age was 50.3 years (min - max; 1.0 - 80.7). The median time from most recent HCT to diagnosis of COVID-19 was 20 months (min - max; 0.0 - 383.9). The median time was 19.3 (0.0 - 287.6) months during 2020, 21.2 (0.1 - 324.5) months during 2021, and 19.7 (0.1 - 383.9) months during 2022 (p = NS). 145/986 (14.7%) patients died; 124 (12.6%) due to COVID-19 and 21 of other causes. Only 2/204 (1%) fully vaccinated patients died from COVID-19. There was a successive improvement in overall survival over time. In multivariate analysis, increasing age (p<.0001), worse performance status (p<.0001), contracting COVID-19 within the first 30 days (p<.0001) or 30 - 100 days after HCT (p=.003), ongoing immunosuppression (p=.004), pre-existing lung disease (p=.003), and recipient CMV seropositivity (p=.004) had negative impact on overall survival while patients contracting COVID-19 in 2020 (p<.0001) or 2021 (p=.027) had worse overall survival than patients with COVID-19 diagnosed in 2022., Discussion: Although the outcome of COVID-19 has improved, patients having risk factors were still at risk for severe COVID-19 including death., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Ljungman, Tridello, Piñana, Ciceri, Sengeloev, Kulagin, Mielke, Yegin, Collin, Einardottir, Lepretre, Maertens, Campos, Metafuni, Pichler, Folber, Solano, Nicholson, Yüksel, Carlson, Aguado, Besley, Byrne, Heras, Dignan, Kröger, Robin, Khan, Lenhoff, Grassi, Dobsinska, Miranda, Jimenez, Yonal-Hindilerden, Wilson, Averbuch, Cesaro, Xhaard, Knelange, Styczynski, Mikulska and de la Camara.)
- Published
- 2023
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39. Impact of HCV Treatment on Recurrence of Hepatocarcinoma After Liver Transplantation.
- Author
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Burgos MM, Grande RG, Ortega SL, Leiva IS, Lombardo JC, Santoyo JS, and Perez MJ
- Subjects
- Humans, Hepacivirus, Neoplasm Recurrence, Local, Liver Cirrhosis complications, Recurrence, Liver Transplantation adverse effects, Hepatitis C etiology, Carcinoma, Hepatocellular complications, Liver Neoplasms complications
- Abstract
The treatment of hepatitis C virus (HCV) has been a revolution in hepatology. Since the beginning of transplantation, liver cirrhosis and hepatocarcinoma on HCV cirrhosis has been the main etiology of liver transplantation. We set out to analyze the impact that C virus treatment has had on liver transplantation. To do so, we divided our cohort into 2 periods, one before virus treatment (from 2000-2014) and one after the onset of treatment (2014-2020). Taking into account this differentiation, we analyzed the percentage of patients transplanted for hepatocarcinoma over cirrhotic liver by HCV in both groups. Among the patients transplanted for HCV, we analyzed whether there were differences in hepatocarcinoma recurrences according to their serologic status at the time of transplantation., (Published by Elsevier Inc.)
- Published
- 2023
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40. A Photochemoenzymatic Hunsdiecker-Borodin-Type Halodecarboxylation of Ferulic Acid.
- Author
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Zippilli C, Bartolome MJ, Hilberath T, Botta L, Hollmann F, and Saladino R
- Subjects
- Catalysis, Coumaric Acids, Oxygen, Solvents, Vanadates, Chloride Peroxidase
- Abstract
A photochemoenzymatic halodecarboxylation of ferulic acid was achieved using vanadate-dependent chloroperoxidase as (bio)catalyst and oxygen and organic solvent as sole stoichiometric reagents in a biphasic system. Performance and selectivity were improved through a phase transfer catalyst, reaching a turnover number of 660.000 for the enzyme., (© 2022 The Authors. ChemBioChem published by Wiley-VCH GmbH.)
- Published
- 2022
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41. Valence State Tuning of Gold Nanoparticles in the Dewetting Process: An X-ray Photoelectron Spectroscopy Study.
- Author
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Lanza G, Martinez Jimenez MJ, Alvarez F, Perez-Taborda JA, and Avila A
- Abstract
Gold nanoparticles (AuNPs) are commonly synthesized using the citrate reduction method, reducing Au
3+ into Au1+ ions and facilitating the disproportionation of aurous species to Au atoms (Au0 ). This method results on citrate-capped AuNPs with valence single states Au0 . Here, we report a methodology that allows obtaining AuNPs by the dewetting process with three different valence states (Au3+ , Au1+ , and Au0 ), which can be fine-tuned with ion bombardment. The chemical surface changes and binding state of the NPs were investigated using core-level X-ray photoelectron spectroscopy (XPS). This is achieved by recording high-resolution Au 4f XPS spectra as a function of ion dose exposure. The results obtained show a time-dependent tuning effect on the Au valence states using low-energy 200 V acceleration voltage Ar+ ion bombardment, and the valence state conversion kinetics involves the reduction from Au3+ and Au1+ to Au0 . Proper control of the reduction in the valence states is critical in surface engineering for controlling catalytic reactions., Competing Interests: The authors declare no competing financial interest., (© 2022 The Authors. Published by American Chemical Society.)- Published
- 2022
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42. Growth of Nitrogen Incorporated Ultrananocrystalline Diamond Coating on Graphite by Hot Filament Chemical Vapor Deposition.
- Author
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Villarreal D, Sharma J, Arellano-Jimenez MJ, Auciello O, and de Obaldía E
- Abstract
This article shows the results of experiments to grow Nitrogen incorporated ultrananocrystalline diamond (N-UNCD) films on commercial natural graphite (NG)/Cu anodes by hot chemical vapor deposition (HFCVD) using a gas mixture of Ar/CH
4 /N2 /H2 . The experiments focused on studying the effect of the pressure in the HFCVD chamber, filament-substrate distance, and temperature of the substrate. It was found that a substrate distance of 3.0 cm and a substrate temperature of 575 C were optimal to grow N-UNCD film on the graphite surface as determined by Raman spectroscopy, SEM, and TEM imaging. XPS analysis shows N incorporation through the film. Subsequently, the substrate surface temperature was increased using a heater, while keeping the substrate-filament distance constant at 3.0 cm. In this case, Raman spectra and SEM images of the substrate surface showed a major composition of graphite in the film as the substrate-surface temperature increased. Finally, the process pressure was increased to 10 Torr where it was seen that the growth of N-UNCD film occurred at 2.0 cm at a substrate temperature of 675 C. These results suggest that as the process pressure increases a smaller substrate-filament distance and consequently a higher substrate surface temperature can still enable the N-UNCD film growth by HFCVD. This effect is explained by a mean free path analysis of the main precursors H2 and CH3 molecules traveling from the filament to the surface of the substrate The potential impact of the process developed to grow electrically conductive N-UNCD films using the relatively low-cost HFCVD process is that this process can be used to grow N-UNCD films on commercial NG/Cu anodes for Li-ion batteries (LIBs), to enable longer stable capacity energy vs. charge/discharge cycles.- Published
- 2022
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43. Discovery and validation of dominantly inherited Alzheimer's disease mutations in populations from Latin America.
- Author
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Takada LT, Aláez-Verson C, Burgute BD, Nitrini R, Sosa AL, Castilhos RM, Chaves MF, Longoria EM, Carrillo-Sánchez K, Brucki SMD, Flores-Lagunes LL, Molina C, Olivares MJ, Ziegemeier E, Petranek J, Goate AM, Cruchaga C, Renton AE, Fernández MV, Day GS, McDade E, Bateman RJ, Karch CM, and Llibre-Guerra JJ
- Subjects
- Adult, Amyloid beta-Protein Precursor genetics, Humans, Latin America, Middle Aged, Mutation genetics, Presenilin-1 genetics, Alzheimer Disease genetics
- Abstract
Background: In fewer than 1% of patients, AD is caused by autosomal dominant mutations in either the presenilin 1 (PSEN1), presenilin 2 (PSEN2), or amyloid precursor protein (APP) genes. The full extent of familial AD and frequency of these variants remains understudied in Latin American (LatAm) countries. Due to the rare nature of these variants, determining the pathogenicity of a novel variant in these genes can be challenging. Here, we use a systematic approach to assign the likelihood of pathogenicity in variants from densely affected families in Latin American populations., Methods: Clinical data was collected from LatAm families at risk for DIAD. Symptomatic family members were identified and assessed by local clinicians and referred for genetic counseling and testing. To determine the likelihood of pathogenicity among variants of unknown significance from LatAm populations, we report pedigree information, frequency in control populations, in silico predictions, and cell-based models of amyloid-beta ratios., Results: We identified five novel variants in the presenilin1 (PSEN1) gene from Brazilian and Mexican families. The mean age at onset in newly identified families was 43.5 years (range 36-54). PSEN1 p.Val103_Ser104delinsGly, p.Lys395Ile, p.Pro264Se, p.Ala275Thr, and p.Ile414Thr variants have not been reported in PubMed, ClinVar, and have not been reported in dominantly inherited AD (DIAD) families. We found that PSEN1 p.Val103_Ser104delinsGly, p.Lys395Ile, p.Pro264Se, and p.Ala275Thr produce Aβ profiles consistent with known AD pathogenic mutations. PSEN1 p.Ile414Thr did not alter Aβ in a manner consistent with a known pathogenic mutation., Conclusions: Our study provides further insights into the genetics of AD in LatAm. Based on our findings, including clinical presentation, imaging, genetic, segregations studies, and cell-based analysis, we propose that PSEN1 p.Val103_Ser104delinsGly, p.Lys395Ile, p.Pro264Se, and p.Ala275Thr are likely pathogenic variants resulting in DIAD, whereas PSEN1 p.Ile414Thr is likely a risk factor. This report is a step forward to improving the inclusion/engagement of LatAm families in research. Family discovery is of great relevance for the region, as new initiatives are underway to extend clinical trials and observational studies to families living with DIAD., (© 2022. The Author(s).)
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- 2022
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44. LAEO-Net++: Revisiting People Looking at Each Other in Videos.
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Marin-Jimenez MJ, Kalogeiton V, Medina-Suarez P, and Zisserman A
- Subjects
- Humans, Algorithms
- Abstract
Capturing the 'mutual gaze' of people is essential for understanding and interpreting the social interactions between them. To this end, this paper addresses the problem of detecting people Looking At Each Other (LAEO) in video sequences. For this purpose, we propose LAEO-Net++, a new deep CNN for determining LAEO in videos. In contrast to previous works, LAEO-Net++ takes spatio-temporal tracks as input and reasons about the whole track. It consists of three branches, one for each character's tracked head and one for their relative position. Moreover, we introduce two new LAEO datasets: UCO-LAEO and AVA-LAEO. A thorough experimental evaluation demonstrates the ability of LAEO-Net++ to successfully determine if two people are LAEO and the temporal window where it happens. Our model achieves state-of-the-art results on the existing TVHID-LAEO video dataset, significantly outperforming previous approaches. Finally, we apply LAEO-Net++ to a social network, where we automatically infer the social relationship between pairs of people based on the frequency and duration that they LAEO, and show that LAEO can be a useful tool for guided search of human interactions in videos.
- Published
- 2022
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45. [Drivers and scorecards to improve hypertension control in primary care practice: Recommendations from the HEARTS in the Americas Innovation GroupFactores impulsores y métodos de puntuación para mejorar el control de la hipertensión en la práctica clínica de la atención primaria: recomendaciones del grupo de innovación de HEARTS en las Américas].
- Author
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Brettler JW, Giraldo Arcila GP, Aumala T, Best A, Campbell NR, Cyr S, Gamarra A, Jaffe MG, De la Rosa MJ, Maldonado J, Neira Ojeda C, Haughton M, Malcolm T, Perez V, Rodriguez G, Rosende A, Valdes Gonzalez Y, Wood PW, Zuniga E, and Ordunez P
- Abstract
Background: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the Americas, and hypertension is the most significant modifiable risk factor. However, hypertension control rates remain low, and CVD mortality is stagnant or rising after decades of continuing reduction. In 2016, the World Health Organization (WHO) launched the HEARTS technical package to improve hypertension control. The Pan American Health Organization (PAHO) designed the HEARTS in the Americas Initiative to improve CVD risk management, emphasizing hypertension control, to date implemented in 21 countries., Methods: To advance implementation, an interdisciplinary group of practitioners was engaged to select the key evidence-based drivers of hypertension control and to design a comprehensive scorecard to monitor their implementation at primary care health facilities (PHC). The group studied high-performing health systems that achieve high hypertension control through quality improvement programs focusing on specific process measures, with regular feedback to providers at health facilities., Findings: The final selected eight drivers were categorized into five main domains: (1) diagnosis (blood pressure measurement accuracy and CVD risk evaluation); (2) treatment (standardized treatment protocol and treatment intensification); (3) continuity of care and follow-up; (4) delivery system (team-based care, medication refill), and (5) system for performance evaluation. The drivers and recommendations were then translated into process measures, resulting in two interconnected scorecards integrated into the HEARTS in the Americas monitoring and evaluation system., Interpretation: Focus on these key hypertension drivers and resulting scorecards, will guide the quality improvement process to achieve population control goals at the participating health centers in HEARTS implementing countries.
- Published
- 2022
- Full Text
- View/download PDF
46. [Drivers and scorecards to improve hypertension control in primary care practice: Recommendations from the HEARTS in the Americas Innovation GroupFatores impulsionadores e scorecards para melhorar o controle da hipertensão arterial na atenção primária: recomendações do Grupo de Inovação da Iniciativa HEARTS nas Américas].
- Author
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Brettler JW, Giraldo Arcila GP, Aumala T, Best A, Campbell NR, Cyr S, Gamarra A, Jaffe MG, De la Rosa MJ, Maldonado J, Neira Ojeda C, Haughton M, Malcolm T, Perez V, Rodriguez G, Rosende A, Valdes Gonzalez Y, Wood PW, Zuñiga E, and Ordunez P
- Abstract
Background: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the Americas, and hypertension is the most significant modifiable risk factor. However, hypertension control rates remain low, and CVD mortality is stagnant or rising after decades of continuing reduction. In 2016, the World Health Organization (WHO) launched the HEARTS technical package to improve hypertension control. The Pan American Health Organization (PAHO) designed the HEARTS in the Americas Initiative to improve CVD risk management, emphasizing hypertension control, to date implemented in 21 countries., Methods: To advance implementation, an interdisciplinary group of practitioners was engaged to select the key evidence-based drivers of hypertension control and to design a comprehensive scorecard to monitor their implementation at primary care health facilities (PHC). The group studied high-performing health systems that achieve high hypertension control through quality improvement programs focusing on specific process measures, with regular feedback to providers at health facilities., Findings: The final selected eight drivers were categorized into five main domains: (1) diagnosis (blood pressure measurement accuracy and CVD risk evaluation); (2) treatment (standardized treatment protocol and treatment intensification); (3) continuity of care and follow-up; (4) delivery system (team-based care, medication refill), and (5) system for performance evaluation. The drivers and recommendations were then translated into process measures, resulting in two interconnected scorecards integrated into the HEARTS in the Americas monitoring and evaluation system., Interpretation: Focus on these key hypertension drivers and resulting scorecards, will guide the quality improvement process to achieve population control goals at the participating health centers in HEARTS implementing countries.
- Published
- 2022
- Full Text
- View/download PDF
47. In vitro models for non-alcoholic fatty liver disease: Emerging platforms and their applications.
- Author
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Ramos MJ, Bandiera L, Menolascina F, and Fallowfield JA
- Abstract
Non-alcoholic fatty liver disease (NAFLD) represents a global healthcare challenge, affecting 1 in 4 adults, and death rates are predicted to rise inexorably. The progressive form of NAFLD, non-alcoholic steatohepatitis (NASH), can lead to fibrosis, cirrhosis, and hepatocellular carcinoma. However, no medical treatments are licensed for NAFLD-NASH. Identifying efficacious therapies has been hindered by the complexity of disease pathogenesis, a paucity of predictive preclinical models and inadequate validation of pharmacological targets in humans. The development of clinically relevant in vitro models of the disease will pave the way to overcome these challenges. Currently, the combined application of emerging technologies (e.g., organ-on-a-chip/microphysiological systems) and control engineering approaches promises to unravel NAFLD biology and deliver tractable treatment candidates. In this review, we will describe advances in preclinical models for NAFLD-NASH, the recent introduction of novel technologies in this space, and their importance for drug discovery endeavors in the future., Competing Interests: JA Fallowfield has served as a consultant or advisory board member for Redx Pharma, Novartis, Ferring Pharmaceuticals, Macrophage Pharma, Galecto Biotech, Caldan Therapeutics, Cypralis Ltd, Rallybio, Tectonic Therapeutic, River 2 Renal Corp.,Gilde Healthcare, Guidepoint, Techspert.io and has received research grant funding from Novartis and Intercept Pharmaceuticals. M Jimenez-Ramos MRC iCASE PhD studentship is partially funded by Galecto Biotech., (© 2021 The Author(s).)
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- 2021
- Full Text
- View/download PDF
48. Thoracic Anesthesia during the COVID-19 Pandemic: 2021 Updated Recommendations by the European Association of Cardiothoracic Anaesthesiology and Intensive Care (EACTAIC) Thoracic Subspecialty Committee.
- Author
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Şentürk M, El Tahan MR, Shelley B, Szegedi LL, Piccioni F, Licker MJ, Karzai W, Gil MG, Neskovic V, Vanpeteghem C, Pelosi P, Cohen E, Sorbello M, MBChB JB, Stoica R, Mourisse J, Brunelli A, Jimenez MJ, Drnovsek Globokar M, Yapici D, Morsy AS, Kawagoe I, Végh T, Navarro-Ripoll R, Marczin N, Paloczi B, Unzueta C, Gregorio GD, Wouters P, Rex S, Mukherjee C, Paternoster G, and Guarracino F
- Subjects
- Critical Care, Humans, Pandemics, SARS-CoV-2, Anesthesia, Anesthesiology, COVID-19
- Abstract
The novel coronavirus pandemic has radically changed the landscape of normal surgical practice. Lifesaving cancer surgery, however, remains a clinical priority, and there is an increasing need to fully define the optimal oncologic management of patients with varying stages of lung cancer, allowing prioritization of which thoracic procedures should be performed in the current era. Healthcare providers and managers should not ignore the risk of a bimodal peak of mortality in patients with lung cancer; an imminent spike due to mortality from acute coronavirus disease 2019 (COVID-19) infection, and a secondary peak reflecting an excess of cancer-related mortality among patients whose treatments were deemed less urgent, delayed, or cancelled. The European Association of Cardiothoracic Anaesthesiology and Intensive Care Thoracic Anesthesia Subspecialty group has considered these challenges and developed an updated set of expert recommendations concerning the infectious period, timing of surgery, vaccination, preoperative screening and evaluation, airway management, and ventilation of thoracic surgical patients during the COVID-19 pandemic., (Copyright © 2021 Elsevier Inc. All rights reserved.)
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- 2021
- Full Text
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49. Passage Number-Induced Replicative Senescence Modulates the Endothelial Cell Response to Protein-Bound Uremic Toxins.
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Guerrero F, Carmona A, Jimenez MJ, Obrero T, Pulido V, Moreno JA, Soriano S, Martín-Malo A, and Aljama P
- Subjects
- Aging, Cell Movement drug effects, Endothelium, Vascular drug effects, Human Umbilical Vein Endothelial Cells, Humans, Renal Insufficiency, Chronic, Cellular Senescence drug effects, Cresols toxicity, Indican toxicity
- Abstract
Endothelial aging may be induced early in pathological situations. The uremic toxins indoxyl sulfate (IS) and p-cresol (PC) accumulate in the plasma of chronic kidney disease (CKD) patients, causing accelerated endothelial aging, increased cardiovascular events and mortality. However, the mechanisms by which uremic toxins exert their deleterious effects on endothelial aging are not yet fully known. Thus, the aim of the present study is to determine the effects of IS and PC on endothelial damage and early senescence in cultured human umbilical vein endothelial cells (HUVECs). Hence, we establish an in vitro model of endothelial damage mediated by different passages of HUVECs and stimulated with different concentrations of IS and PC to evaluate functional effects on the vascular endothelium. We observe that cell passage-induced senescence is associated with apoptosis, ROS production and decreased endothelial proliferative capacity. Similarly, we observe that IS and PC cause premature aging in a dose-dependent manner, altering HUVECs' regenerative capacity, and decreasing their cell migration and potential to form vascular structures in vitro. In conclusion, IS and PC cause accelerated aging in HUVECs, thus contributing to endothelial dysfunction associated with CKD progression.
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- 2021
- Full Text
- View/download PDF
50. COVID-19 and stem cell transplantation; results from an EBMT and GETH multicenter prospective survey.
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Ljungman P, de la Camara R, Mikulska M, Tridello G, Aguado B, Zahrani MA, Apperley J, Berceanu A, Bofarull RM, Calbacho M, Ciceri F, Lopez-Corral L, Crippa C, Fox ML, Grassi A, Jimenez MJ, Demir SK, Kwon M, Llamas CV, Lorenzo JLL, Mielke S, Orchard K, Porras RP, Vallisa D, Xhaard A, Knelange NS, Cedillo A, Kröger N, Piñana JL, and Styczynski J
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, COVID-19 virology, Child, Child, Preschool, Female, Follow-Up Studies, Hematologic Neoplasms epidemiology, Hematologic Neoplasms virology, Humans, Infant, Male, Middle Aged, Prognosis, Prospective Studies, Survival Rate, Transplantation, Homologous, Young Adult, COVID-19 complications, Hematologic Neoplasms therapy, Hematopoietic Stem Cell Transplantation methods, SARS-CoV-2 isolation & purification
- Abstract
This study reports on 382 COVID-19 patients having undergone allogeneic (n = 236) or autologous (n = 146) hematopoietic cell transplantation (HCT) reported to the European Society for Blood and Marrow Transplantation (EBMT) or to the Spanish Group of Hematopoietic Stem Cell Transplantation (GETH). The median age was 54.1 years (1.0-80.3) for allogeneic, and 60.6 years (7.7-81.6) for autologous HCT patients. The median time from HCT to COVID-19 was 15.8 months (0.2-292.7) in allogeneic and 24.6 months (-0.9 to 350.3) in autologous recipients. 83.5% developed lower respiratory tract disease and 22.5% were admitted to an ICU. Overall survival at 6 weeks from diagnosis was 77.9% and 72.1% in allogeneic and autologous recipients, respectively. Children had a survival of 93.4%. In multivariate analysis, older age (p = 0.02), need for ICU (p < 0.0001) and moderate/high immunodeficiency index (p = 0.04) increased the risk while better performance status (p = 0.001) decreased the risk for mortality. Other factors such as underlying diagnosis, time from HCT, GVHD, or ongoing immunosuppression did not significantly impact overall survival. We conclude that HCT patients are at high risk of developing LRTD, require admission to ICU, and have increased mortality in COVID-19., (© 2021. The Author(s).)
- Published
- 2021
- Full Text
- View/download PDF
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