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19 results on '"Jimura, Tomohiro"'

4. A Clinical Study of 9 Cases of Relapsing Polychondritis

Author

Nagano, Hiromi, primary, Miyamoto, Yumi, additional, Jimura, Tomohiro, additional, Iuchi, Hiroyuki, additional, Umakoshi, Mizuo, additional, Makise, Takao, additional, Kawabata, Masaki, additional, Miyashita, Keiichi, additional, Ohori, Junichirou, additional, Miyanohara, Ikuyo, additional, and Kurono, Yuichi, additional

Published
2019
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8. Transcutaneous immunization with pneumococcal surface protein A in mice

Author

Nagano, Hiromi, primary, Kawabata, Masaki, additional, Sugita, Gen, additional, Tsuruhara, Akitoshi, additional, Ohori, Junichiro, additional, Jimura, Tomohiro, additional, Miyashita, Keiichi, additional, Kurono, Yuichi, additional, Tomonaga, Kazuhiro, additional, Briles, David E., additional, and Fujihashi, Kohtaro, additional

Published
2017
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12. Examination of the Acute Adverse Event in Cetuximab with Radiotherapy for Head and Neck Cancer—Comparison with Radiation Alone and Another Form of Chemoradiotherapy—

Author

Nagano, Hiromi, primary, Miyamoto, Yumi, additional, Iuchi, Hiroyuki, additional, Jimura, Tomohiro, additional, Umakoshi, Mizuo, additional, Makise, Takao, additional, Kawabata, Masaki, additional, Miyashita, Keiichi, additional, Harada, Mizue, additional, Miyanohara, Ikuyo, additional, and Kurono, Yuichi, additional

Published
2016
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13. Transcutaneous immunization with pneumococcal surface protein A in mice.

Author

Nagano, Hiromi, Kawabata, Masaki, Sugita, Gen, Tsuruhara, Akitoshi, Ohori, Junichiro, Jimura, Tomohiro, Miyashita, Keiichi, Kurono, Yuichi, Tomonaga, Kazuhiro, Briles, David E., and Fujihashi, Kohtaro

Abstract

Objective: Pneumococcal infection caused by Streptococcus pneumoniae is a major upper respiratory tract disease that causes severe illness and mortality. Therefore, it is important to develop safe and effective vaccines to prevent pneumococcal infections. The goal of the study was to investigate the effectiveness of transcutaneous immunization (TCI) for induction of pneumococcal surface protein A (PspA) responses in the upper respiratory tract.Methods: C57BL/6 mice were transcutaneously immunized with 1 μg of PspA and 2 μg of cholera toxin (CT) six times at weekly intervals and compared with transcutaneously treated controls (PBS alone/PspA alone/CT alone). Two weeks after the final immunization, nasal washes (NWs), saliva, and plasma samples were collected and subjected to a PspA-specific ELISA. Three weeks after the final immunization, mice were challenged with S. pneumoniae strain EF3030, and the numbers of CFUs in NWs and nasal passages (NPs) were determined.Results: Higher levels of PspA-specific IgM, IgG, and IgA Abs were noted in plasma of TCI with PspA plus CT compared with controls. Transcutaneous immunization mice also had significantly increased PspA-specific S-IgA Ab responses in NWs and saliva and, importantly, showed significantly lower numbers of bacteria CFUs in NWs and NPs compared with controls.Conclusion: These results show that TCI with PspA plus CT induces antigen-specific mucosal and systemic immune responses. This suggests that this method is an effective mucosal immunization strategy for induction of protective pneumococcal-specific Ab responses in blockade of S. pneumoniae colonization of the nasal cavity.Level Of Evidence: NA. Laryngoscope, 128:E91-E96, 2018. [ABSTRACT FROM AUTHOR]

Published
2018
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14. Role of Phosphorylcholine-Specific Immunoglobulin M in Acute Upper Respiratory Tract Infections

Author

Moon, Sung K., Kawauchi, Hideyuki, Oh, Seung-Ha, Ohori, Junichiro, Jimura, Tomohiro, and Kurono, Yuichi

Abstract

Objectives: The aim of this study was to clarify the role of serum phosphorylcholine (PC)–specific immunoglobulin M (IgM) as a natural antibody against infectious diseases.Methods: The relationship between serum PC-specific IgM level and C-reactive protein level or white blood cell counts was examined in patients with severe upper respiratory tract infections (ie, acute epiglottitis and peritonsillar abscess).Results: PC-specific IgM level was significantly negatively correlated with C-reactive protein level and white blood cell count. In addition, C-reactive protein level and white blood cell count was significantly lower in women than in men, whereas PC-specific IgM level was significantly higher in women.Conclusions: PC-specific IgM is suggested to have protective and suppressive effects against the progression of infectious and inflammatory reactions. Higher levels of PC-specific IgM in women might be one of the reasons why the incidence and severity of acute epiglottitis and peritonsillar abscess are lower in women.

Published
2019
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