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278 results on '"Jin, Aizhen"'

4. Composite Score of Healthy Lifestyle Factors and Risk of Hepatocellular Carcinoma: Findings from a Prospective Cohort Study

Author

Luu, Hung N, Behari, Jaideep, Goh, George Boon-Bee, Wang, Renwei, Jin, Aizhen, Thomas, Claire E, Clemente, Jose C, Odegaard, Andrew O, Koh, Woon-Puay, and Yuan, Jian-Min

Subjects
Epidemiology, Biomedical and Clinical Sciences, Health Sciences, Hepatitis - C, Liver Cancer, Hepatitis, Liver Disease, Infectious Diseases, Chronic Liver Disease and Cirrhosis, Rare Diseases, Clinical Research, Cancer, Prevention, Emerging Infectious Diseases, Digestive Diseases, Aetiology, 2.2 Factors relating to the physical environment, Good Health and Well Being, Aged, Carcinoma, Hepatocellular, Female, Follow-Up Studies, Healthy Lifestyle, Humans, Liver Neoplasms, Male, Prospective Studies, Risk Assessment, Risk Factors, Singapore, Medical and Health Sciences, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundWhile the associations between individual lifestyle factors and risk of hepatocellular carcinoma (HCC) have been described previously, their combined impact on HCC risk is unknown.MethodsThe association of a composite score of healthy lifestyle factors, including body mass index, alcohol consumption, cigarette smoking, alternative Mediterranean diet, and sleep duration, and HCC risk was examined in the Singapore Chinese Health Study, an ongoing prospective cohort study of 63,257 Chinese men and women. Cox proportional hazard regression method was used to estimate HR and its 95% confidence interval (CI). Conditional logistic regression method was used to evaluate this composite lifestyle score-HCC risk association among a subset of individuals who tested negative for hepatitis B surface antigen (HBsAg) and anti-hepatitis C antibody.ResultsAfter a mean follow-up of 17.7 years, 561 participants developed HCC. Individuals with higher composite scores representing healthier lifestyles (range 0-8) were at significantly lower risk of HCC. Compared with the lowest composite score category (0-4), the HRs (95% CIs) for the composite scores of 5, 6, 7, and 8 were 0.67 (0.62-0.85), 0.61 (0.48-0.77), 0.49 (0.37-0.65), and 0.13 (0.06-0.30), respectively (P trend < 0.0001). A similar inverse association was observed in participants with negative HBsAg and anti-hepatitis C virus (HCV)-negative serology (HR, 0.38; 95% CI, 0.19-0.79; for the highest vs. the lowest category of the composite scores; P trend = 0.001).ConclusionsHealthy lifestyles protect against HCC development, especially for individuals without hepatitis B virus and HCV infections.ImpactThis study highlights the importance of a comprehensive lifestyle modification strategy for HCC primary prevention.

Published
2021

9. Occupational exposure to endocrine disrupting substances and the risk of breast Cancer: the Singapore Chinese health study

Author

Acheampong, Teofilia, Yuan, Jian-Min, Koh, Woon Puay, Jin, Aizhen, and Odegaard, Andrew

Subjects
Health Services and Systems, Health Sciences, Breast Cancer, Estrogen, Prevention, Cancer, Aged, Breast Neoplasms, Endocrine Disruptors, Female, Humans, Industry, Middle Aged, Occupational Diseases, Occupational Exposure, Occupations, Pregnancy, Proportional Hazards Models, Prospective Studies, Reproductive History, Singapore, Breast cancer risk, Endocrine disruptors, Occupational exposure, Prospective population-based cohort, Public Health and Health Services, Public Health, Epidemiology, Health services and systems, Public health
Abstract

BackgroundEvidence from basic research links exposure to endocrine disrupting chemicals (EDCs) with a higher risk for breast cancer. However, there is less evidence from observational epidemiological research and the results are equivocal. Therefore, we examined the association between occupational exposure to substances where exposure to EDCs is likely and the risk of breast cancer.MethodsA prospective study consisting of a population-based cohort of 33,458 Singaporean Chinese women aged 45-74 years enrolled in the Singapore Chinese Health Study (SCHS) from 1993 to 98 and followed through 2014. Subjects' self-reported occupational exposure and duration to industries, job titles, and substance types were garnered at baseline, and cases of incident breast cancer (N = 988) were determined by linkage with the Singapore Cancer Registry. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated for exposure to substances, job titles, and industries.ResultsThere was no association between cumulative exposure to substances via occupation where EDC exposure is likely and risk of breast cancer. These results were consistent for hypothesized high (HR 0.94, 95% CI: 0.66-1.35), medium (HR 1.03 95% CI: 0.77-1.38) and low (HR 0.74, 95% CI 0.48-1.13) combined substance exposure groups when compared with those who were not exposed via occupation. Similar null associations were observed when examining job titles and industry categories.ConclusionsThere was no association between EDC related occupational exposures and breast cancer risk in working women of the Singaporean Chinese Health Study. Future studies that employ rigorous methods with regard to exposure assessment of EDCs are needed.

Published
2018

14. Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population

Author

Chang, Xuling, Gurung, Resham L., Wang, Ling, Jin, Aizhen, Li, Zheng, Wang, Renwei, Beckman, Kenneth B., Adams-Haduch, Jennifer, Meah, Wee Yang, Sim, Kar Seng, Lim, Weng Khong, Davila, Sonia, Tan, Patrick, Teo, Jing Xian, Yeo, Khung Keong, M., Yiamunaa, Liu, Sylvia, Lim, Su Chi, Liu, Jianjun, van Dam, Rob M., Friedlander, Yechiel, Koh, Woon-Puay, Yuan, Jian-Min, Khor, Chiea Chuen, Heng, Chew-Kiat, and Dorajoo, Rajkumar

Published
2021
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26. Abstract 3015: Soluble CD137 and risk of hepatocellular carcinoma: nested case-control studies in cohorts in Shanghai and Singapore

Author

Thomas, Claire E., primary, Adibi, Jennifer J., additional, Kuipers, Allison L., additional, Diergaarde, Brenda, additional, Luu, Hung N., additional, Jin, Aizhen, additional, Koh, Woon-Puay, additional, Gao, Yu-Tang, additional, Adams-Haduch, Jennifer, additional, Wang, Renwei, additional, Lokshin, Anna, additional, Behari, Jaideep, additional, and Yuan, Jian-Min, additional

Published
2023
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40. Abstract 2260: Non-alcoholic fatty liver disease polygenic risk score and risk of hepatocellular carcinoma in an East Asian population

Author

Thomas, Claire E., primary, Diergaarde, Brenda, additional, Kuipers, Allison L., additional, Adibi, Jennifer J., additional, Luu, Hung N., additional, Chang, Xuling, additional, Dorajoo, Rajkumar, additional, Heng, Chew-Kiat, additional, Khor, Chiea-Chuen, additional, Wang, Renwei, additional, Jin, Aizhen, additional, Koh, Woon-Puay, additional, and Yuan, Jian-Min, additional

Published
2022
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42. NAFLD polygenic risk score and risk of hepatocellular carcinoma in an East Asian population

Author

Thomas, Claire E., primary, Diergaarde, Brenda, additional, Kuipers, Allison L., additional, Adibi, Jennifer J., additional, Luu, Hung N., additional, Chang, Xuling, additional, Dorajoo, Rajkumar, additional, Heng, Chew‐Kiat, additional, Khor, Chiea‐Chuen, additional, Wang, Renwei, additional, Jin, Aizhen, additional, Koh, Woon‐Puay, additional, and Yuan, Jian‐Min, additional

Published
2022
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