1. Comparison of valganciclovir versus foscarnet for the treatment of cytomegalovirus viremia in adult acute leukemia patients after allogeneic hematopoietic cell transplantation.
- Author
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Zhu, Jinjin, Xu, Mimi, Ru, Yuhua, Gong, Huanle, Ding, Yiyang, Zhu, Ziling, Xu, Yang, Fan, Yi, Zhang, Xiang, Tu, Yuqing, Sun, Aining, Qiu, Huiying, Jin, Zhengming, Tang, Xiaowen, Han, Yue, Fu, Chengcheng, Chen, Suning, Ma, Xiao, Chen, Feng, and Song, Tiemei
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HEMATOPOIETIC stem cell transplantation , *ACUTE leukemia , *VALGANCICLOVIR , *VIREMIA , *CYTOMEGALOVIRUSES - Abstract
Cytomegalovirus (CMV) reactivation increases treatment-related mortality (TRM) after allogeneic hematopoietic cell transplantation (allo-HCT). We analyzed 141 adult acute leukemia (AL) patients suffered allo-HCT between 2017 and 2021, who developed CMV viremia post-HCT and treated with valganciclovir or foscarnet, to evaluate effectiveness and safety of both drugs. Viremia clearance rates (14 and 21 d post treatment) and toxicities were similar in two groups. However, valganciclovir was associated with a lower cumulative incidence of CMV recurrence within 180 days (16.7% vs. 35.7%, p=0.029) post CMV clearance. Finally, 2-year TRM was lower in valganciclovir group (9.7% ± 0.2% vs. 26.2% ± 0.3%, p = 0.026), result a superior 2-year overall survival (OS; 88.1% ± 5.2% vs. 64.4% ± 5.5%, p = 0.005) and leukemia-free survival (LFS; 82.0% ± 5.9% vs. 58.9% ± 5.6%, p = 0.009). Valganciclovir might decrease CMV viremia recurrence and led to better long-term outcome than foscarnet in adult AL patients developed CMV viremia post-HCT. Considering the inherent biases of retrospective study, well-designed trials are warranted to validate our conclusion. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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