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10. Unveiling the Power of Cloaking Metal–Organic Framework Platforms via Supramolecular Antibody Conjugation

Author

Oh, Jun Yong, primary, Jana, Batakrishna, additional, Seong, Junmo, additional, An, Eun-Koung, additional, Go, Eun Min, additional, Jin, Seongeon, additional, Ok, Hae Won, additional, Seu, Min-Seok, additional, Bae, Jong-hoon, additional, Lee, Chaiheon, additional, Lee, Seonghwan, additional, Kwon, Tae-Hyuk, additional, Seo, Jeong Kon, additional, Choi, Eunshil, additional, Jin, Jun-O, additional, Kwak, Sang Kyu, additional, Lah, Myoung Soo, additional, and Ryu, Ja-Hyoung, additional

Published
2024
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14. Anti-Inflammatory Effect of Fucoidan from Costaria costata Inhibited Lipopolysaccharide-Induced Inflammation in Mice.

Author

Zhang, Wei, Lee, Peter C. W., and Jin, Jun-O

Abstract

Seaweed extracts, especially fucoidan, are well known for their immune-modulating abilities. In this current study, we extracted fucoidan from Costaria costata, a seaweed commonly found in coastal Asia, and examined its anti-inflammatory effect. Fucoidan was extracted from dried C. costata (FCC) using an alcohol extraction method at an extraction rate of 4.5 ± 0.21%. The extracted FCC comprised the highest proportion of carbohydrates, along with sulfate and uronic acid. The immune regulatory effect of FCC was examined using bone marrow-derived dendritic cells (BMDCs). Pretreatment with FCC dose-dependently decreased the lipopolysaccharide (LPS)-induced upregulation of co-stimulatory molecules and major histocompatibility complex. In addition, FCC prevented morphological changes in LPS-induced BMDCs. Moreover, treatment of LPS-induced BMDCs with FCC suppressed the secretion of pro-inflammatory cytokines. In C57BL/6 mice, oral administration of FCC suppressed LPS-induced lung inflammation, reducing the secretion of pro-inflammatory cytokines in the bronchoalveolar lavage fluid. Finally, the administration of FCC suppressed LPS-induced sepsis. Therefore, FCC could be developed as a health supplement based on the observed anti-inflammatory effects. [ABSTRACT FROM AUTHOR]

Published
2024
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32. High‐Performance Near‐Infrared Chlorinated Rylenecarboximide Fluorophores via Consecutive C−N and C−C Bond Formation.

Author

Wu, Ze‐Hua, Skabeev, Artem, Zagranyarski, Yulian, Duan, Ruomeng, Jin, Jun‐O, Kwak, Minseok, Basché, Thomas, Müllen, Klaus, and Li, Chen

Subjects
FLUORESCENCE yield, PERYLENE, FLUOROPHORES, STOKES shift, INTRAMOLECULAR proton transfer reactions
Abstract

A new class of near‐infrared (NIR) fluorophores, PAI, is obtained by consecutive C−N/C−C bond formation between diphenylamines and 9,10‐dibromoperylenecarboximide. Owing to the rigid structure, extended π‐conjugation and pronounced push‐pull substitution, these fluorophores show emission maxima up to 804 nm and large Stokes shifts. The extraordinarily high fluorescence quantum yields from 47 % to 70 % are attributed to chloro substitution in the bay positions of the perylene core. These characteristics, together with high photostability, qualify them as useful NIR emitters for applications as biomarkers and security inks. [ABSTRACT FROM AUTHOR]

Published
2023
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37. Lipid Nanocarrier-Based Drug Delivery Systems: Therapeutic Advances in the Treatment of Lung Cancer

Author

Kim,So-Jung, Puranik,Nidhi, Yadav,Dhananjay, Jin,Jun-O, Lee,Peter CW, Kim,So-Jung, Puranik,Nidhi, Yadav,Dhananjay, Jin,Jun-O, and Lee,Peter CW

Abstract

So-Jung Kim,1,* Nidhi Puranik,2,* Dhananjay Yadav,3,* Jun-O Jin,1 Peter CW Lee4 1Department of Microbiology, University of Ulsan College of Medicine, Seoul, 05505, South Korea; 2Department of Biochemistry & Genetics, Barkatullah University, Bhopal, Madhya Pradesh, 462026, India; 3Department of Life Science, Yeungnam University, Gyeongsan, 38541, Korea; 4Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, ASAN Medical Center, Seoul, 05505, South Korea*These authors contributed equally to this workCorrespondence: Peter CW Lee, Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, ASAN Medical Center, Seoul, 05505, Korea, Email pclee@amc.seoul.kr Jun-O Jin, Department of Microbiology, University of Ulsan College of Medicine, Seoul, 05505, Korea, Email junojin@amc.seoul.krAbstract: Although various treatments are currently being developed, lung cancer still has a very high mortality rate. Moreover, while various strategies for the diagnosis and treatment of lung cancer are being used in clinical settings, in many cases, lung cancer does not respond to treatment and presents reducing survival rates. Cancer nanotechnology, also known as nanotechnology in cancer, is a relatively new topic of study that brings together scientists from a variety of fields, including chemistry, biology, engineering, and medicine. The use of lipid-based nanocarriers to aid drug distribution has already had a significant impact in several scientific fields. Lipid-based nanocarriers have been demonstrated to help stabilize therapeutic compounds, overcome barriers to cellular and tissue absorption, and improve in vivo drug delivery to specific target areas. For this reason, lipid-based nanocarriers are being actively researched and used for lung cancer treatment and vaccine development. This review discusses the improvements in drug delivery achieved with lipid-based nanocarriers, the o

Published
2023

38. How Advanced are Cancer Immuno-Nanotherapeutics? A Comprehensive Review of the Literature

Author

Yadav,Dhananjay, Puranik,Nidhi, Meshram,Anju, Chavda,Vishal, Lee,Peter Chang-Whan, Jin,Jun-O, Yadav,Dhananjay, Puranik,Nidhi, Meshram,Anju, Chavda,Vishal, Lee,Peter Chang-Whan, and Jin,Jun-O

Abstract

Dhananjay Yadav,1,* Nidhi Puranik,2,* Anju Meshram,3,* Vishal Chavda,4 Peter Chang-Whan Lee,5 Jun-O Jin6 1Department of Life Science, Yeungnam University, Gyeongsan, 38541, South Korea; 2Biological Sciences Department, Bharathiar University, Coimbatore, Tamil Nadu, 641046, India; 3Department of Biotechnology, Kalinga University, Naya Raipur, Chhattisgarh, India; 4Department of Pathology, Stanford School of Medicine, Stanford University Medical Center, Stanford, CA, 94305, USA; 5Department of Biomedical Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul, 05505, South Korea; 6Department of Microbiology, University of Ulsan College of Medicine, Seoul, 05505, South Korea*These authors contributed equally to this workCorrespondence: Peter Chang-Whan Lee, Department of Biomedical Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul, 05505, South Korea, Email pclee@amc.seoul.kr Jun-O Jin, Department of Microbiology, University of Ulsan College of Medicine, Seoul, 05505, South Korea, Email junojin@amc.seoul.krAbstract: Cancer is a broad term for a group of diseases involving uncontrolled cell growth and proliferation. There is no cure for cancer despite recent significant improvements in screening, treatment, and prevention approaches. Among the available treatments, immunotherapy has been successful in targeting and killing cancer cells by stimulating or enhancing the body’s immune system. Antibody-based immunotherapeutic agents that block immune checkpoint proteins expressed by cancer cells have shown promising results. The rapid development of nanotechnology has contributed to improving the effectiveness and reducing the adverse effects of these anti-cancer immunotherapeutic agents. Recently, engineered nanomaterials have been the focus of many state-of-The-art approaches toward effective cancer treatment. In this review, the contribution of various nanomaterials such as polymeric nanoparticles, dendrimers, mi

Published
2023

44. IgLON4 Regulates Myogenesis via Promoting Cell Adhesion and Maintaining Myotube Orientation

Author

Lim, Jeong Ho, primary, Ahmad, Khurshid, additional, Chun, Hee Jin, additional, Hwang, Ye Chan, additional, Qadri, Afsha Fatima, additional, Ali, Shahid, additional, Ahmad, Syed Sayeed, additional, Shaikh, Sibhghatulla, additional, Choi, Jungseok, additional, Kim, Jihoe, additional, Jin, Jun-O, additional, Kim, Myunghee, additional, Han, Sung Soo, additional, Choi, Inho, additional, and Lee, Eun Ju, additional

Published
2022
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