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4 results on '"Jin-Xia Wen"'

2. Photoredox Catalysis Enables Decarboxylative Cyclization with Hypervalent Iodine(III) Reagents: Access to 2,5-Disubstituted 1,3,4-Oxadiazoles

Author

Jian Li, Xue-Chen Lu, Yue Xu, Jin-Xia Wen, Guo-Quan Hou, and Li Liu

Subjects
010405 organic chemistry, Organic Chemistry, Hypervalent molecule, chemistry.chemical_element, Photoredox catalysis, 010402 general chemistry, Iodine, 01 natural sciences, Biochemistry, Combinatorial chemistry, Coupling reaction, 0104 chemical sciences, chemistry, Reagent, Physical and Theoretical Chemistry
Abstract

A novel approach to 2,5-disubstituted 1,3,4-oxadiazoles derivatives via a decarboxylative cyclization reaction by photoredox catalysis between commercially available α-oxocarboxylic acids and hypervalent iodine(III) reagent is described. This powerful transformation involves the coupling reaction between two different kinds of radical species and the formation of C-N and C-O bonds.

Published
2020

3. Catalyst-Free Visible-Light-Promoted Cyclization of Aldehydes: Access to 2,5-Disubstituted 1,3,4-Oxadiazole Derivatives

Author

Yang Li, Jin-Xia Wen, Li Liu, Xue-Chen Lu, Guo-Quan Hou, Jian Li, and Xu Gao

Subjects
Chemistry, General Chemical Engineering, Reagent, Hypervalent molecule, Photoredox catalysis, 1 3 4 oxadiazole derivatives, General Chemistry, QD1-999, Combinatorial chemistry, Article, Catalysis, Visible spectrum
Abstract

An efficient synthesis of a variety of 2,5-disubstituted 1,3,4-oxadiazole derivatives via a cyclization reaction by photoredox catalysis between aldehydes and hypervalent iodine(III) reagents is described. The reaction proceeds under mild conditions and affords various target compounds in excellent yields. The commercially available aldehydes without preactivation and a simple visible-light-promoted procedure without any catalysts make this strategy an alternative to the conventional methods.

Published
2021

4. Prognostic value of a nomogram based on peripheral blood immune parameters in unresectable hepatocellular carcinoma after intensity-modulated radiotherapy

Author

Jian-Xu Li, Mei-Ling He, Mo-Qin Qiu, Liu-Ying Yan, Mei-Ying Long, Jian-Hong Zhong, Rui-Jun Zhang, Chun-Feng Liang, Ya-Dan Pang, Jun-Kun He, Qian-Qian Chen, Jin-Xia Weng, Shi-Xiong Liang, and Bang-De Xiang

Subjects
Hepatocellular carcinoma, Immune parameters, Nomogram, Intensity-modulated radiotherapy, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Abstract Background For patients with unresectable hepatocellular carcinoma (uHCC), intensity-modulated radiotherapy (IMRT) has become one of the options for clinical local treatment. Immune parameters, including platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR) and systemic immune inflammatory (SII), predict survival in various cancers. This study aimed to determine whether peripheral immune parameters can predict survival in patients with uHCC undergoing IMRT and establish a clinically useful prognostic nomogram for survival prediction. Methods The clinical data of 309 HCC patients were retrospectively analyzed and randomly divided into training (n = 216) and validation (n = 93) cohorts. PLR, NLR and SII were collected before and after IMRT. Univariate and multivariate Cox analyses were performed to identify independent prognostic factors affecting survival, which were used to generate a nomogram. Results The median survival was 16.3 months, and significant increases in PLR, NLR, and SII were observed after IMRT (P

Published
2022
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