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Along with the anti-cavitation performance, the high speed and the high power density, are the main trends in the development of centrifugal pumps. At present, the most effective method is to install an inducer in front of the impeller. However, the tip leakage of the inducer results in the vortex cavitation at the blade leading edge of the inducer, and the cavitating flow inside the inducer seriously interferes with the hydraulic behavior of the inducer as well as the impeller with the development of the cavitation, thus to badly affect the operational reliability of the high-speed centrifugal pump. In the present paper, the cavitating flow in a high-speed centrifugal pump with an inducer is investigated by numerical simulations and visual experiments for different cavitation numbers. A typical evolution process of the cavitation is shown, including the inception, the development and the deterioration. A general description of the pump head-drop phenomenon is made through the study of the local and global flow fields, and the relationship between the vapor distribution and the static pressure distribution along the inducer is determined to describe the evolution of the cavitation. This paper intends to provide the foundation for studying the overall cavitation state of a high-speed centrifugal pump, and designing the inducer with a better cavitation resistance.

Wogonin, a natural flavonoid, is one of the bioactive compounds of the medicinal herb Eucommia ulmoides OLIV. widely used in southeastern Asia for treating hypertension. However, the molecular mechanisms for the therapeutic benefits remain largely unclear. The present study investigated the vasodilatory effect of wogonin and its possible mechanisms. The flavonoid (0.1-100 µM) caused concentration-dependent relaxations in endothelium-intact aortic rings precontracted with norepinephrine (NE, 1 µM) or potassium chloride (KCl, 60 mM). Preincubation with wogonin (10, 100 µM) for 20 min significantly inhibited the contractile responses to NE (0.1, 1, 10 µM) or KCl (7.5, 15, 30, 60 mM). Relaxant responses to wogonin were not inhibited by N(G)-nitro-L-arginine methylester (100 µM) or endothelial denudation. In a Ca(2+)-free Krebs' solution, wogonin not only blocked Ca(2+) influx-dependent vasoconstriction by either NE (1 µM) or KCl (100 mM), but also inhibited NE (1 µM)-induced tonic contraction, which is dependent on intracellular Ca(2+) release. Wogonin also suppressed the elevation of [Ca(2+)]i induced by KCl (60 mM) after exhausting the calcium store in sarcoplasmic and endoplasmic reticula with thapsigargin (1 µM) or by ATP (100 µM) in primary vascular smooth muscle cells. These findings suggest that wogonin-induced responses are mainly due to the inhibition of both intracellular Ca(2+) release and extracellular Ca(2+) influx.

OBJECTIVE To investigate the vasodilator effect and the endothelium-dependent mechanism of oroxylin A in thoracic aorta isolated from rats. METHODS Thoracic aorta was isolated from Wistar rats. After pretreatment with norepinephrine or KCl, the effects of oroxylin A at different concentrations were detected on isolated vascular rings prepared from rats' thoracic aorta. The response of thoracic aortic ring was evaluated in the presence and absence of endothelium, and NG-nitro-L-arginine methyl ester (L-NAME), a specific inhibitor of nitric oxide synthase. RESULTS Oroxylin A (10 and 100 μmol/L) caused vasodilation on endothelium-intact aortic rings pretreated with norepinephrine (1 μmol/L) and KCl (60 mmol/L) compared with the control (P