20 results on '"JingNan Zhu"'
Search Results
2. miR-34a induces neutrophil apoptosis by regulating Cdc42-WASP-Arp2/3 pathway-mediated F-actin remodeling and ROS production
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Meiwan Cao, Baoling Peng, Huan Chen, Min Yang, Peiyu Chen, Liping Ye, Hongli Wang, Lu Ren, Jing Xie, Jingnan Zhu, Xiangye Xu, Wanfu Xu, Lanlan Geng, and Sitang Gong
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MiR-34a ,myelodysplastic syndromes ,neutrophils ,apoptosis ,ROS ,F-actin ,Pathology ,RB1-214 ,Biology (General) ,QH301-705.5 - Abstract
Background The number of neutrophils is significantly reduced in myelodysplastic syndrome (MDS), but the molecular basis remains unclear. We recently found that miR-34a was significantly increased in MDS neutrophils. Therefore, this study aims to clarify the effects of aberrant miR-34a expression on neutrophil counts.Methods miR-34a mimics/inhibitor transfection were performed in neutrophil-like differentiated HL60 (dHL60) cells, and a FACSCalibur flow cytometer was used to measure ROS production and apoptosis. In addition, the Cdc42-WASP-Arp2/3 pathway inhibitor (ML141) and activator (CN02) treated the dHL60 cells, and then ROS production, apoptosis and related proteins expression were detected. And, luciferase reporter assay to verify the relationship of miR-34a and the Cdc42-WASP-Arp2/3 pathway.Results overexpression of miR-34a could induce ROS production and apoptosis, decrease the expression levels of DOCK8, p-WASP, WASP, Arp2, Arp3, and increase F-actin’s expression. Meanwhile, knockdown of miR-34a could decrease ROS production and apoptosis, increase the expression of DOCK8, p-WASP, WASP, Arp2, Arp3, and decrease F-actin’s expression. Immunofluorescence staining showed aberrant miR-34a and Cdc42-WASP-Arp2/3 pathway could induce F-actin membrane transfer. Luciferase reporter assay indicated that DOCK8 was a direct target gene of miR-34a.Conclusion These data indicates miR-34a may induce neutrophil apoptosis by regulating Cdc42-WASP-Arp2/3 pathway-mediated F-actin remodeling and ROS production.
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- 2022
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3. Control research on axial-flux hybrid-excitation generator for offshore vertical axis maglev wind turbine
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Jiming Chen, Qiang Zhang, Jing Liu, Chongwang Xu, and Jingnan Zhu
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Maglev wind turbine ,Levitation force ,Decoupled control ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
Vertical axis wind turbines generally have poor starting performance, but in recent years, they have gradually played a great potential in offshore floating wind power generation system. In order to improve the start-up and low wind speed operation capacity of vertical wind turbine, an asymmetric-primary axial-flux hybrid-excitation generator (APAFHG) which can generate an adjustable levitation force for offshore vertical axis maglev wind turbine is proposed. However, the complexity of levitation force characteristic makes it difficult to control the levitation force of the maglev system and output power of the generator independently. In this paper, the levitation force characteristics of APAFHG are analyzed, and a control strategy is proposed to realize the decoupled control of maglev system and generator power. First of all, the topology of AFAPHG is described and operation principle of AFAPHG is expounded. Secondly, the mathematical model of AFAPHG is deduced, and the levitation force performance of AFAPHG under DC excitation, d-axis and q-axis current is obtained by finite element method. Finally, a compensation strategy based on the levitation force mathematical model is proposed. The results show the compensation strategy can effectively realize the decoupled control of levitation force and generator power.
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- 2022
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4. Research Progress in the Application of Radio Frequency Technology in Fruit and Vegetable Drying
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Jingnan ZHU, Jian PENG, Qingqing GU, Yuanshan YU, Jijun WU, and Yujuan XU
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fruits and vegetables ,radio frequency heating ,drying ,mechanism ,heating uniformity ,Food processing and manufacture ,TP368-456 - Abstract
Drying is one of the most important technologies for fruit and vegetable processing. The energy consumption during drying and the quality of dried products are highly correlated to the selected drying methods. As a new type of physical heating technology, radio frequency (RF) heating technology has attracted much attention in recent years because of its rapid heating, volume heating effect, long energy penetration depth, even microorganism control, and enzyme deactivation. This paper mainly summarized the mechanism and characteristics of RF heating technology, the factors that affecting RF heating technology application in fruit and vegetable. Moreover, the application status of RF technology in fruit and vegetable drying, microorganism control, and enzyme deactivation are also concluded. Finally, the existing problems, possible solutions and future development trends of RF heating technology in fruit and vegetable drying are also proposed. This review could provide theoretical guidelines for RF industrial application in fruit and vegetable drying in the future.
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- 2022
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5. miR-155-5p PROMOTES CD34+ APOPTOSIS AND INHIBITS BONE MARROW HEMATOPOIESIS IN MYELODYSPLASTIC SYNDROMES BY RAC1/CREB/MIR-15B AXIS
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Meiwan Cao, BaoLing Peng, WanFu Xu, PeiYu Chen, Huan Chen, LiPing Ye, Jing Xie, HongLi Wang, Lu Ren, LiYa Xiong, JingNan Zhu, XiangYe Xu, LanLan Geng, and SiTang Gong
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
Myelodysplastic syndromes (MDS) are a group of heterogeneous myeloid clonal diseases that are characterized by ineffective bone marrow hematopoiesis. Since studies have confirmed the significance of miRNAs in ineffective hematopoiesis in MDS, the current report elucidated the mechanism mediated by miR-155-5p. The bone marrow of MDS patients was collected to detect miR-155-5p and to analyze the correlation between miR-155-5p and clinicopathological variables. Isolated bone marrow CD34+ cells were transfected with lentiviral plasmids that interfere with miR-155-5p, followed by apoptosis analysis. Finally, miR-155-5p-targeted regulation of RAC1 expression was identified, as well as the interaction between RAC1 and CREB, the co-localization of RAC1 and CREB, and the binding of CREB to miR-15b. As measured, miR-155-5p was upregulated in the bone marrow of MDS patients. Further cell experiments validated that miR-155-5p promoted CD34+ cell apoptosis. miR-155-5p could reduce the transcriptional activity of miR-15b by inhibiting RAC1, dissociating the interaction between RAC1 and CREB, and inhibiting the activation of CREB. Upregulating RAC1, CREB, or miR-15b could reduce miR-155-5p-mediated apoptosis promotion on CD34+ cells. Additionally, miR-155-5p could force PD-L1 expression, and this effect was impaired by elevating RAC1, CREB, or miR-15b. In conclusion, miR-155-5p mediates PD-L1-mediated apoptosis of CD34+ cells in MDS by RAC1/CREB/miR-15b axis, thereby inhibiting bone marrow hematopoiesis.
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- 2023
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6. Drosophila model and network pharmacology to explore novel targets and novel active components of chinese traditional medications for treating kidney stones
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Shiyu Zhang, Jingnan Zhu, Yingjie Ju, Mingxia Lv, Rongdian Yang, Ying Li, Yaodong Miao, and Yiwen Wang
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Kidney stone ,Drosophila model ,Luteolin ,Quercetin ,Androgen receptor ,Chinese traditional medicine ,Other systems of medicine ,RZ201-999 ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Background: Kidney stone disease is a common urological and metabolic disease in the world. Many traditional Chinese medications(TCMs) are considered to be effective in treating kidney stones and are widely used in China as alternative and supplementary methods besides surgery. However, the active compounds and molecular mechanisms of most TCM treatments for this disease are still unclear, which limits their application. Study design: Sodium oxalate that is fed to Drosophila can cause calculi in the Malpighian tube. The effects of many traditional Chinese drugs were identified through this Drosophila kidney stone model. In this project, we used a network pharmacological approach to analyze a list of traditional Chinese drugs, which showed strong therapeutic effects on the kidney stones in Drosophila. Results: Four active ingredients were predicted to have effects on treating kidney stones. It is noteworthy that all ingredients were predicted to target the Androgen Receptor (AR). In the end, we used the Drosophila model again to verify the therapeutic effects of luteolin and quercetin and proved that AR was a possible target for the treatment of kidney stones. Conclusion: This approach of combining the Drosophila model in vivo experiments with network pharmacology provides a new paradigm for studying TCM therapeutic mechanisms and discovering active ingredients.
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- 2023
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7. Role of Hypogammaglobulinemia in Invasive Fungal Infections in Children May Be Overlooked
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Jingnan Zhu, Fuping Shen, Yun Cheng, and Jinlin Liu
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hypogammaglobulinemia ,invasive fungal infections ,leukemia ,Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2022
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8. Caution Regarding the Difference Between Flower-Like Lymphocytes and Flower-Like Plasma Cells
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Jingnan Zhu, Zhang Li, Yong Wang, and Jinlin Liu
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flower-like lymphocyte ,flower-like plasma cell ,difference ,Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2022
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9. Comparison of different pretreatments on drying characteristics, physical properties, nutritional compounds and antioxidant activity of heat pump‐dried longan pulp
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Jingnan Zhu, Jian Peng, Jun Li, Lu Li, Jinfeng Bi, Wanyuan Yang, Jianyong Yi, Shupeng Chen, Yujuan Xu, and Qingqing Gu
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Industrial and Manufacturing Engineering ,Food Science - Published
- 2023
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10. Research on Levitation Force Control of an Axial-flux Hybrid-Excitation Generator with PI-Based Torque Distribution
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Jiming Chen, Chongwang Xu, Jingnan Zhu, and Jing Liu
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History ,Computer Science Applications ,Education - Abstract
An asymmetric-primary axial-flux hybrid-excitation generator (APAFHG) has already been proposed to improve the starting performance of vertical axis wind turbines. However, the double-stator single-rotor structure causes a problem: different torque proportions create different rotor maglev forces, which will cause fluctuation and negatively impact the rotor bearing and even the operation of the wind power generation system. Therefore, a mathematical model considering the double-stator single-rotor structure and a proportional integral-based torque control strategy considering double-stator distribution are proposed in this paper to help APAFHG offer a good starting performance in vertical-axis wind power generation system and to stabilize maglev force generated by double-stator quadrature axis current simultaneously. Finally, the cooperation control of the maglev force and torque distribution is realized in MATLAB/Simulink, and the rotor maglev force will be relatively stable despite mechanical torque changes, which is a basis for the wind turbine to stably operate as the wind constantly fluctuates in vertical axis wind power system.
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- 2023
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11. The Mechanism of miR-155/miR-15b Axis Contributed to Apoptosis of CD34+ Cells by Upregulation of PD-L1 in Myelodysplastic Syndromes.
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MeiWan Cao, BaoLing Peng, WanFu Xu, PeiYu Chen, HuiWen Li, Yang Cheng, Huan Chen, LiPing Ye, Jing Xie, HongLi Wang, Lu Ren, LiYa Xiong, JingNan Zhu, XiangYe Xu, LanLan Geng, and SiTang Gong
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MYELODYSPLASTIC syndromes ,BONE marrow cells ,PROGRAMMED death-ligand 1 ,CD34 antigen ,BONE marrow - Abstract
Myelodysplastic syndromes (MDS) are a group of heterogeneous myeloid clonal diseases that are characterized by ineffective bone marrow hematopoiesis. Since studies have confirmed the significance of miRNAs in ineffective hematopoiesis in MDS, the current report elucidated the mechanism mediated by miR-155-5p. The bone marrow of MDS patients was collected to detect miR-155-5p and to analyze the correlation between miR-155-5p and clinicopathological variables. Isolated bone marrow CD34
+ cells were transfected with lentiviral plasmids that interfere with miR-155-5p, followed by apoptosis analysis. Finally, miR-155-5p-targeted regulation of RAC1 expression was identified, as well as the interaction between RAC1 and CREB, the co-localization of RAC1 and CREB, and the binding of CREB to miR-15b. As measured, miR-155-5p was upregulated in the bone marrow of MDS patients. Further cell experiments validated that miR- 155-5p promoted CD34+ cell apoptosis. miR-155-5p could reduce the transcriptional activity of miR-15b by inhibiting RAC1, dissociating the interaction between RAC1 and CREB, and inhibiting the activation of CREB. Upregulating RAC1, CREB, or miR-15b could reduce miR- 155-5p-mediated apoptosis promotion on CD34+ cells. Additionally, miR-155-5p could force PDL1 expression, and this effect was impaired by elevating RAC1, CREB, or miR-15b. In conclusion, miR-155-5p mediates PD-L1-mediated apoptosis of CD34+ cells in MDS by RAC1/CREB/miR-15b axis, thereby inhibiting bone marrow hematopoiesis. [ABSTRACT FROM AUTHOR]- Published
- 2023
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12. Soaking Water Applications
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Hoi Tung Chiu, Luca Serventi, Neha Nair, Mingyu Chen, Jingnan Zhu, Sachin Deshmukh, and Jiaying Lin
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Time delayed ,Chemistry ,Ice cream ,Gluten free ,Food science ,Green lentils ,Haricot beans ,Water content ,Yeast metabolism ,Legume - Abstract
Legume soaking exert emulsifying properties. In addition, they contain soluble fibre, protein and phytochemicals that may deliver other functionalities. Plant-based ice creams and gluten-free bakery products rely on expensive hydrocolloids to achieve acceptable texture. Therefore, these applications were tested. Pea soaking water drastically enhanced the melting properties of plant-based ice cream. The dripping time delayed from 5 to 30 minutes and the overall melted volume reduced from 18 to 23 ml/60 ml. Slow melting relates to higher stability and was attributed to the emulsifying ability. In addition, no significant effects on colour and sensory acceptance were observed. When used to formulate gluten-free crackers, a relevant antistaling effect took place. The soaking water of haricot beans and green lentils softened texture during storage, without affecting pasting properties and moisture content. Soluble fibre (beans) and phytochemicals (lentils) were speculated to enhance protein plasticity. In gluten-free bread, yeast metabolism must be considered. Those ingredients that are high in soluble fibre and low in saponins (chickpeas, peas) significantly reduced bread crumb hardness by means of enhanced pore homogeneity, likely resulting from emulsifying abilities that supported higher gas retention and loaf volume. Soaking water of numerous pulses may replace hydrocolloids in ice cream, crackers and bread.
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- 2020
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13. Cooking water of yellow soybeans as emulsifier in gluten-free crackers
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Luca Serventi, Siyun Wang, Fan Fei, Silu Liu, and Jingnan Zhu
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0301 basic medicine ,030109 nutrition & dietetics ,Chemistry ,Potassium ,chemistry.chemical_element ,04 agricultural and veterinary sciences ,General Chemistry ,040401 food science ,Biochemistry ,Industrial and Manufacturing Engineering ,Gluten-free crackers ,03 medical and health sciences ,0404 agricultural biotechnology ,Water dynamics ,Composition (visual arts) ,Thickening ,Food science ,Water content ,Food Science ,Biotechnology - Abstract
Pulse cooking water has been shown to possess several functionalities but no knowledge has been developed on commonly consumed legumes such as soybeans. This study determined composition, functionality and food applications of the cooking water of yellow soybeans (SCW). The SCW contained relevant amounts of minerals, representing about 10% of the recommended daily intake (in 100 g of SCW) of iron, potassium and phosphorous. On a macromolecular level, carbohydrates (both soluble and insoluble), protein and saponins were determined and associated to several functionalities: foaming, emulsifying and thickening. Incorporation of SCW in gluten-free crackers resulted in significant textural changes, increasing softness and moisture content of the product during a 2-day storage at room temperature, likely in result of enhanced water dynamics.
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- 2018
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14. Hydrogen-rich saline ameliorated LPS-induced acute lung injury via autophagy inhibition through the ROS/AMPK/mTOR pathway in mice
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Jinghua Zhang, Xuefen Wang, Yong Wang, Jingnan Zhu, and Jinsong Bo
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Lipopolysaccharides ,Male ,Antioxidant ,Lipopolysaccharide ,medicine.medical_treatment ,Acute Lung Injury ,Blotting, Western ,Pharmacology ,Lung injury ,AMP-Activated Protein Kinases ,General Biochemistry, Genetics and Molecular Biology ,chemistry.chemical_compound ,Mice ,medicine ,Autophagy ,Animals ,Saline ,PI3K/AKT/mTOR pathway ,Original Research ,chemistry.chemical_classification ,Reactive oxygen species ,Hydrogen rich saline ,Chemistry ,TOR Serine-Threonine Kinases ,Mice, Inbred C57BL ,Saline Solution ,Reactive Oxygen Species ,Bronchoalveolar Lavage Fluid ,Hydrogen ,Signal Transduction - Abstract
Over-activation of autophagy due to increased levels of reactive oxygen species is a key mechanism of lipopolysaccharide-induced acute lung injury. Hydrogen-rich saline, an antioxidant, has been proved to be an effective agent for the prevention of acute lung injury, but the underlying mechanism remains unclear. Here, we investigated the mechanism through which hydrogen-rich saline prevents acute lung injury by focusing on autophagy regulation. The acute lung injury model was induced using lipopolysaccharide both in vivo and in vitro. The activation of autophagy was observed by detecting the expression of autophagy-related proteins using Western blotting. Lung histopathological changes, malondialdehyde content, wet/dry ratio, inflammatory cell count, protein content in bronchoalveolar lavage fluid, and cell viability were measured to evaluate the severity of acute lung injury. Intracellular reactive oxygen species levels were detected using dihydroethidium, which is a reactive oxygen species fluorescent probe. The results showed that the expression of Beclin-1 and microtubule-associated protein 1 light chain 3 II/I (LC3II/I ratio) was obviously increased after lipopolysaccharide administration. Pretreatment with hydrogen-rich saline markedly inhibited the expression of Beclin-1 and the LC3II/I ratio; ameliorated lung histopathological changes, malondialdehyde content and wet/dry ratio; and reduced protein content and infiltration of inflammatory cells in bronchoalveolar lavage fluid. These protective effects were also observed by pretreatment with autophagy inhibitor 3-methyladenine. Similar results were found in vitro. The production of reactive oxygen species and the activation of the AMPK/mTOR pathway were notably enhanced in MLE-12 cells after lipopolysaccharide treatment, and ameliorated by the hydrogen-rich medium. The activation of AMPK induced by lipopolysaccharide was also inhibited by pretreatment with N-acetyl-L-cysteine (a reactive oxygen species scavenger). In addition, the over-activation of autophagy was also suppressed by compound C (an AMPK inhibitor). In conclusion, hydrogen-rich saline alleviated lipopolysaccharide-induced acute lung injury by inhibiting excessive autophagy activation via the ROS/AMPK/mTOR pathway in mice. Hydrogen-rich saline may be a new therapeutic strategy for acute lung injury prevention and treatment in the future. Impact statement Acute lung injury (ALI), a common complication of many serious health issues, such as serious infection, burns, and shock, is one of the most common critical illnesses in clinical practice with a high mortality rate of 30–40%. There are still short of effective prevention and treatment measures. Evidence is growing that hydrogen-rich saline (HRS) may be an effective drug for the prevention and treatment of ALI. However, the mechanisms involved in have not been clearly understood. In this study, we investigated the underling mechanisms by focusing on autophagy regulation. The results showed that HRS ameliorated lipopolysaccharide-induced ALI in mice by inhibiting autophagy over-activation through ROS/AMPK/mTOR pathway. HRS may be a new therapeutic strategy for ALI prevention and treatment in the future.
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- 2019
15. Composition of legume soaking water and emulsifying properties in gluten-free bread
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Luca Serventi, Weihan Zhang, Yuling Liu, Kylie J. Dale, Jingnan Zhu, San Huang, and Silu Liu
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Dietary Fiber ,General Chemical Engineering ,Industrial Waste ,Saccharomyces cerevisiae ,Industrial and Manufacturing Engineering ,Diet, Gluten-Free ,0404 agricultural biotechnology ,Nutrient ,Phenols ,Species Specificity ,Dietary Carbohydrates ,Food Quality ,Humans ,Dry matter ,Food science ,Gluten-free bread ,Cooking ,Food-Processing Industry ,Haricot beans ,Legume ,Chemistry ,Water ,Fabaceae ,04 agricultural and veterinary sciences ,Bread ,Pigments, Biological ,Saponins ,040401 food science ,Homogeneous ,Emulsifying Agents ,Fermentation ,Seeds ,Composition (visual arts) ,Dietary Proteins ,High ratio ,Nutritive Value ,Food Science ,New Zealand - Abstract
Soaking of legumes results in the loss of macronutrients, micronutrients and phytochemicals. Fibre, protein and phytochemicals found in legumes exert emulsifying activity that may improve the structure and texture of gluten-free bread. The legume soaking water of haricot beans, garbanzo chickpeas, whole green lentils, split yellow peas and yellow soybeans were tested in this study for functional properties and use as food ingredients. Composition, physicochemical properties and effect on the quality of gluten-free bread were determined for each legume soaking water. Haricot beans and split yellow peas released the highest amount of solids in the legume soaking water: 1.89 and 2.38 g/100 g, respectively. Insoluble fibre was the main constituent of haricot beans legume soaking water, while water-soluble carbohydrates and protein were the major fraction of split yellow peas. High quantities of phenolics (∼400 µg/g) and saponins (∼3 mg/g) were found in the legume soaking water of haricot beans, whole green lentils and split yellow peas. High emulsifying activity (46 and 50%) was found for the legume soaking water of garbanzo chickpeas and split yellow peas, probably due to their protein content and high ratio of water-soluble carbohydrates to dry matter. Such activity resulted in softer texture of the gluten-free bread. A homogeneous structure of crumb pores was found for split yellow peas, opposing that of whole green lentils. A balance between the contents of yeast nutrients and antinutrients was the likely basis of the different appearances.
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- 2017
16. What Drives Product Return Behavior in E-Commerce? The Moderating Effect of Cultural Values
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Anna-Christina Fredershausen, Jingnan Zhu, and Malte Hans
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Social psychology (sociology) ,business.industry ,Order (business) ,Cultural values ,Theory of planned behavior ,General Medicine ,Business ,E-commerce ,Research opportunities ,Product (category theory) ,Marketing ,Cross-cultural studies - Abstract
As e-commerce still experiences phenomenal growth rates, online retailers struggle with high product return rates as an unwanted, but indispensable side-effect of their business. Interestingly, European online retailers experience substantial discrepancies between return rates in different countries. While this observation raises more questions upon antecedents of customer return behavior, it also offers promising research opportunities. What are underlying drivers of return behavior? What might be the influence of cultural values on return behavior? In order to address these questions, we combine concepts from cross-cultural research and social psychology, as we assess the moderating effect of cultural values in a model based on Ajzen's theory of planned behavior. Despite common difficulties of acquiring data from actual customers, we gathered a unique cross-country and cross- cultural dataset by surveying real customers in cooperation with a large European online retailer. Our results suggest customers'...
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- 2016
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17. Cup-like blasts from different lineage: two clinical cases.
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Jingnan Zhu, Fuping Shen, Sujie Zheng, Jiwei Zhao, and Jinlin Liu
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- 2022
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18. The Moderating Effect of Cultural Values on Product Returns in E-Commerce.
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Jingnan Zhu and Brettel, Malte
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PRODUCT returns ,ELECTRONIC commerce ,CONSUMER goods sales & prices ,ONLINE shopping ,CONSUMER preferences - Abstract
Research Question The online-channel has gained fundamental importance for retailers. However, especially selling experience goods such as apparel is accompanied by high rates of product returns (PR), as those often need physical inspections prior to a keep-or-return decision. Since PRs still implicate immediate bottom-line impact due to costs and decreases in net sales, optimization of PR-rates is a key topic for online retailers. In this context, a comprehensive understanding of customer PR-behavior is imperative to managers as it allows for better PR-related decisions (e.g. with regard to marketing measures, PR-policies and processes). Interestingly, European online fashion retailers observe remarkable discrepancies in PR-rates between countries. This raises questions upon drivers of PR-behavior and--at the same time--offers interesting opportunities to further examine antecedents of return behavior, including the potential impact of cultural values. We address these topics by assessing the moderating effect of individual cultural values in an adapted model based on Ajzen's theory of planned behavior. Our research questions are thus as follows: 1. How do customers' attitudes, subjective norms and perceived behavioral control affect their intentions to return products after online shopping? 2. What is the moderating effect of cultural values in this context? Method and Data We obtained a unique survey-dataset on real customers from four different countries in cooperation with a large European online fashion retailer. Our measurement instrument is based on established and validated scales, and was pre-tested in a separate sample of 58 participants for refinement and validation purposes. The main study was conducted in September 2015 by distributing an online survey to a random selection of customers, who had been active during the last 3 months before. The survey yielded 338 responses by customers from Italy (180), Germany (83), Sweden (44) and France (31). According to our partner firm, the mean participant age of 37.3 years and the female share of 76% in our sample is representative for their customer base. Translations and back-translations into French, Italian, German and Swedish were conducted by different native bilingual persons or persons with professional translation experience. We use commonly accepted approaches to test for potential common-method, non-response and informant bias. For our analyses, we use AMOS and SPSS to run confirmatory factor analyses to refine our measurement models, and to run hierarchical regressions with interaction terms to analyze the hypothesized moderator effects. Summary of Findings Customers' intentions to return products after online shopping are influenced by their attitudes and subjective norms (the opinions of important others) towards PRs. In other words: The more favorable the views, opinions or evaluations of customers and their important others are towards PR, the larger is the a priori acceptance of PR while shopping online. With regard to the moderator effects of individual espoused cultural values, according to our hypotheses, the direct effect of customers' attitudes on their intentions to return is positively moderated by masculine cultural values, while the direct effect of subjective norms on intentions to return is positively moderated by feminine cultural values. Key Contributions Our contribution is threefold, as we (1) successfully adapt Ajzen's Theory of Planned Behavior and thus extend its field of application, (2) apply the concept of individual espoused cultural values in a new context and (3) enable managers to take more adequate PR-related decisions, by expanding the research on antecedents of PR behavior. As customers' attitudes and subjective norms affect customer return intentions, online retailers may consider to mildly influence the attitudes of their customers and of the public with regard to the consequences associated with PR via a wide range of communication channels, ranging from private (e.g. via emails) to public channels (e.g. TV commercials). However, content and communication channel should be selected very carefully, as a mere demonization of PR is likely to affect the firm-customer relationship and thus also repurchase-intentions negatively. Moreover, as the effects of attitudes and subjective norms vary depending on the individual cultural values espoused by the customers, online retail managers can--bearing our findings in mind--tailor practical measures more adequately by e.g. adapting the content and intensity of communication to respective customer groups. [ABSTRACT FROM AUTHOR]
- Published
- 2016
19. What Drives Product Return Behavior in E-Commerce? An Application of the Theory of Planned Behavior.
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Jingnan Zhu, Strese, Steffen, and Brettel, Malte
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PRODUCT returns ,ELECTRONIC commerce ,PLANNED behavior theory - Abstract
Research Question While product returns (PR) are regarded as an unwanted, but integral element in the firm-customer exchange process in ecommerce, they are associated with a series of implications and consequences. First, PR diminish net sales and are costly. Second, they potentially harm the environment. Third, PR imply a series of process steps and thus effort and hassle for the customers. Albeit these diverse consequences, existing studies have-to our knowledge-so far neglected the influence of customers' evaluations on PR on their PR-behavior. In this study, we put customers' views and evaluations about PR into the center of our attention. We furthermore explore the underlying beliefs based on which these views and evaluations are formed. We therefore draw on Ajzen's theory of planned behavior and attempt to answer the following research questions: 1. How do customers' intentions to return products after online shopping affect actual rates of product return in ecommerce? 2. How do customers' attitudes, subjective norms and perceived behavioral control affect their intention to return products after online shopping? 3. What are the underlying beliefs which lead to the formation of customers' attitudes, subjective norms and perceived behavioral control towards product returns? Method and Data In order to test and refine the measurement instruments of our main study and to freely elicit salient customer beliefs, we conducted a pilot study with 58 participants. We therefore used open questions for the belief elicitation part and analyzed the qualitative inputs with regard to content and frequency, thus identifying the most frequent beliefs. We then included two items for each belief in our main study to assess the validity of the beliefs elicited. Our main study was conducted in cooperation with a large European online fashion retailer by surveying customers in France, Germany, Sweden and Italy who had been active within a 3-months timeframe before. Since a unique customer- ID was used for each of the 338 participants, we are able to match the questionnaire data with actual transaction-data. We use established scales for our survey and apply commonly accepted approaches to test for potential common-method, non-response and informant bias. In order to assess model fit and to test for hypothesized effects, we conducted a confirmatory factor analysis and used structural equation modelling in AMOS Graphics 23. We furthermore use a MIMIC-model to assess the influence of the beliefs elicited before. Summary of Findings Our initial results suggest customers' intention to return to influence their actual PR-behavior. Furthermore, customers' intentions to return are influenced by their attitudes and subjective norms (attitudes of important others). With regard to the underlying beliefs that lead to the formation of attitudes, subjective norms and perceived behavioral control, we find different sets of beliefs to be dominant. First, instrumental or hedonic behavioral beliefs associated with the facilitating role of PR ("reduced risk of online shopping" and "enabler to forgo shopping trips to local stores") are found to significantly influence the formation of attitudes towards PR. Surprisingly, other salient-but rather negative-beliefs such as "potential environmental damage," "reduced consumer awareness" or "economic losses for local retailers" are not found to be significant in this context. Furthermore, customers regard their online retailer and their parents as important, when forming subjective norms. Third, "return stickers" and "reusable packaging material" delivered with the package as well as an easy PR-process are regarded as important, when forming PBC. Key Contributions With the present study, we expand of the research field on drivers of customer product return behavior, helping future research to build more adequate research models and hypotheses. We adapt Ajzen's Theory of Planned Behavior to a new field of application and give further confirmation to it, as we find significant relationships using real data on actual behavior, while many other studies (on other types of behavior) only have access to self-reported data. Based on the results of our study, practitioners might consider to mildly influence the image of PR (e.g. by mildly educating customers regarding the negative side-effects of PR), thus influencing customers' attitudes and subjective norms. They can design communication measures to influence the views and evaluations of customers towards PR in a more targeted way, as our study provides evidence for the underlying beliefs that lead to the formation of their views and evaluations. [ABSTRACT FROM AUTHOR]
- Published
- 2016
20. What Drives Product Return Behavior in E-Commerce? The Moderating Effect of Cultural Values.
- Author
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Jingnan Zhu, Hans, Malte, and Fredershausen, Anna-Christina
- Abstract
As e-commerce still experiences phenomenal growth rates, online retailers struggle with high product return rates as an unwanted, but indispensable side-effect of their business. Interestingly, European online retailers experience substantial discrepancies between return rates in different countries. While this observation raises more questions upon antecedents of customer return behavior, it also offers promising research opportunities. What are underlying drivers of return behavior? What might be the influence of cultural values on return behavior? In order to address these questions, we combine concepts from cross-cultural research and social psychology, as we assess the moderating effect of cultural values in a model based on Ajzen's theory of planned behavior. Despite common difficulties of acquiring data from actual customers, we gathered a unique cross-country and cross- cultural dataset by surveying real customers in cooperation with a large European online retailer. Our results suggest customers' attitudes towards product returns and their social environment to influence return intentions. Furthermore, we find these relationships to be moderated by cultural values, being weaker or stronger depending on individual espoused masculine/feminine cultural values. We thus contribute to a better understanding of the antecedents of return behavior and expand various fields of research. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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