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1. PREDICTION OF POST-STROKE DEPRESSION WITH COMBINED BLOOD BIOMARKERS IL-6, TNF-α, AND FATTY ACID BINDING PROTEIN: A PROSPECTIVE STUDY.

Author

Linlin Wang, Chunyou Chen, Jingang Zhu, Xianjun Bao, and Xiaoxiao Tao

Subjects
CARRIER proteins, MENTAL depression, HAMILTON Depression Inventory, INTERLEUKIN-6, TUMOR necrosis factors, FATTY acids
Abstract

Background: To investigate the expression levels of blood biomarkers interleukin-6 (IL-6), tumour necrosis factor (TNF-α), and intestinal fatty acid binding protein (iFABP) in patients with post-stroke depression (PSD), and their correlation with PSD occurrence. Methods: Clinical data of stroke patients admitted to the First People's Hospital of Wenling from December 2017 to December 2022 were retrospectively analyzed. Patients were classified into two groups based on their Hamilton Depression Rating Scale (HAMD) scores: PSD and non- PSD groups. The blood levels of IL-6, TNF-α, and iFABP were compared between the two groups, and their association with PSD occurrence was analyzed. Results: The PSD group had significantly higher levels of IL-6, TNF-α, and iFABP. The combined detection of these biomarkers demonstrated a greater predictive value for PSD occurrence compared to the individual detection of each biomarker. Conclusions: The study indicates that the levels of IL-6, TNF-α, and iFABP in the blood are significantly increased in patients with PSD. The combined detection of these biomarkers can effectively predict the occurrence of PSD, indicating high clinical value. Urod: Cilj je bio da se istraži ekspresija biomarkera u krvi interleukina-6 (IL-6), faktora tumorske nekroze (TNF-a) i proteina koji vezuje masne kiseline creva (iFABP) kod pacijenata sa depresijom nakon moždanog udara (PSD) i njihovim korelacija sa pojavom PSD-a. Metode: Retrospektivno su analizirani klinički podaci pacijenata sa moždanim udarom koji su primljeni u Prvu narodnu bolnicu Vbnling od decembra 2017. do decembra 2022. godine. Pacijenti su klasifikovani u dve grupe na osnovu rezultata Hamiltonove skale za procenu depresije (HAMD): PSD i ne-PSD grupe. Nivoi IL-6, TNF-a i iFABP u krvi su upoređeni između dve grupe i analizirana je njihova povezanost sa pojavom PSD. Rezultati: PSD grupa je imala značajno više nivoe IL-6, TNF- a i iFABP Kombinovana detekcija ovih biomarkera pokazala je veću prediktivnu vrednostza pojavu PSD-a u poređenju sa pojedinačnom detekcijom svakog biomarkera. Zaključak: Studija ukazuje da su nivoi IL-6, TNF-a i iFABP u krvi značajno povećani kod pacijenata sa PSD. Kombinovana detekcija ovih biomarkera može efikasno predvideti pojavu PSD-a, što ukazuje na visoku kliničku vrednost. [ABSTRACT FROM AUTHOR]

Published
2023
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2. TIGAR suppresses seizures induced by kainic acid through inhibiting oxidative stress and neuronal apoptosis

Author

Qin Mei, Xiaoxiao Tao, Chunyou Chen, Xuewen Feng, Chenfeng Qiu, Linlin Wang, and Jingang Zhu

Subjects
0301 basic medicine, Male, Kainic acid, Biophysics, Apoptosis, Oxidative phosphorylation, Pentose phosphate pathway, medicine.disease_cause, Biochemistry, Hippocampus, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Seizures, medicine, Animals, Glycolysis, Molecular Biology, Neurons, TUNEL assay, Kainic Acid, Apoptosis Regulator, Cell Biology, Glutathione, Molecular biology, Phosphoric Monoester Hydrolases, Oxidative Stress, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Apoptosis Regulatory Proteins, Oxidative stress
Abstract

TP53-induced glycolysis and apoptosis regulator (TIGAR) activates the pentose phosphate pathway (PPP), which feeds reduced nicotinamide adenine dinucleotide phosphate (NADPH) to the antioxidant glutathione pathway. Oxidative stress-induced neuronal apoptosis is the pathological basis of several neurological disorders, including epilepsy. To determine the potential anti-epileptic action TIGAR in a rodent kainic acid (KA)-induced seizure model. Seizures were induced by the intra-cerebroventricular injection of KA, followed by injection of empty or TIGAR-expressing lentiviral vectors. Immunofluorescence was used to detect the localization of TIGAR in the cortices and hippocampi, and the expression levels of relevant proteins were determined by Western blotting. Oxidative stress-related markers were detected using commercially available kits. Neuronal apoptosis was detected by terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) staining. TIGAR were mainly expressed in the neurons and rarely located in the astrocytes, and increased in the cortices and hippocampi of KA-treated rats in a time-dependent manner. Lentivirus-mediated TIGAR overexpression significantly decreased the oxidative stress and neuronal apoptosis induced by KA, resulting in prolonged seizure latency and lower Racine scores. Our findings indicate that TIGAR has anti-epileptic, anti-oxidant and anti-apoptotic effects, and is therefore a promising therapeutictarget for epilepsy.

Published
2019

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