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High-performance eco-friendly all-polymer solar cells were realized by balancing the crystallinity and domain size via hot halogen-free solvent slot-die coating.

The morphology with strong molecular packing order and gradient vertical composition distribution associated with efficient charge transport and collection is critical to achieve high performance in nonfullerene solar cells. However, the rapid solidification process of the active layer upon the fast removal of solvent usually results in a kinetically trapped state with undesired morphology. Herein, we proposed a strategy to extend the crystal growth time of the acceptor via a high-boiling-point additive that selectively dissolved the acceptor. This was enabled by adding dibenzyl ether (DBE) to the poly(3-hexylthiophene) (P3HT):O-IDTBR blend in chlorobenzene (CB) solution. The combination of the kinetic study by time-resolved ultraviolet-visible (UV-vis) absorption spectra and detailed morphological characterization allows us to correlate the crystallization kinetics with the microstructural transition. The results show that the crystal growth time of O-IDTBR increases from 3 to 60 s upon the addition of 0.75% DBE, leading to further evolution of the molecular order of O-IDTBR during the DBE-dominated drying period. Meanwhile, O-IDTBR has more time to migrate toward the substrate owing to the larger surface energy. In addition, the onset of the crystallization process of P3HT is brought forward from 8 to 6 s due to the reduced solvent quality, which favors P3HT to crystallize into a fibril network. As a result, an optimized morphology that features the enhanced molecular packing order of P3HT and O-IDTBR as well as the vertical compositional gradient of O-IDTBR is obtained. Devices based on the optimized blend show more balanced charge transport and suppressed bimolecular recombination, giving rise to an improved power conversion efficiency (PCE) from 4.29 ± 0.04 to 7.30 ± 0.12%.

According to the vehicle dynamics model and the requirements of reliable safety and minimal time, the path planning problem of parking in different types of parking spaces is solved by obstacle avoidance analysis and motion analysis in the case of the optimal solution, and the parking trajectory from the initial position to the designated parking space is obtained. In the static situation, different parking spaces in the parking space are occupied; analyze the parking space type, parking space left and right occupancy situation, and the distance between the vacant parking space and the starting point location of unoccupied cars; and establish the attribute information matrix R0 of the vacant parking space and calculate the KMO value of the matrix R0. This is completed to determine the weak correlation between the attributes of the vacant parking space and use the matrix R0 as the original evaluation matrix of the entropy weight method, using the entropy weight method to calculate the three attributes of parking space type, parking space left and right occupancy situation, and distance between starting point and parking space. These results are weighted in the optimal parking space selection process, the difficulty score of the vacant parking space is determined, and the optimal parking space is determined through the ranking of the scores. In the dynamic case, the number of parking spaces and parking space usage will change over time, with the help of the Bayesian network, the existing parking spaces and number of spaces in the parking lot at the previous moment are learned according to the computer clock, which can be used to reason about the number of parking spaces and parking space availability in the parking lot at the next moment. The weights of the three attributes of parking space type, parking space left and right situation, and distance between the starting point and parking space are updated in the case of a dynamic change of parking space, and then the parking difficulty score of a new vacant parking space using the entropy weight method is used to select the optimal parking space in the dynamic situation. The optimized parking path planning and parking space selection method could contribute to enhancing parking efficiency for the sustainable management of indoor parking lots.

(1) The defects were passivated and the energy levels aligned at the SnO2/perovskite interface by using EOAI. (2) A champion efficiency of 22.61% was realized for the 1.57 eV PSC and a PCE close to 20% was realized for the 1.68 eV PSC with higher stability.

Siloxane with low surface tension can regulate the intermolecular interactions, and optimize the phase separation morphology and molecule stacking, finally contributing to an excellent PCE of 16.4% with small energy loss for ASM-OSCs.

Highly efficient organic solar cells were fabricated by slot-die coating in an open-air environment without additives and any additional treatment by modulating kinetic processes of phase separation and aggregation behaviors.

An efficient organic solar cell with superior deformability with an efficiency of 17.3% and a crack-onset strain of 8.8% is fabricated by diluting the small molecule content through incorporating another polymer donor with suitable miscibility.

Breast cancer (BC) is a serious threat to women’s health and metastasis is the major cause of BC-associated mortality. Various techniques are currently used to preoperatively describe the metastatic status of tumors, based on which a comprehensive treatment protocol was determined. However, accurately staging a tumor before surgery remains a challenge, which may lead to the miss of optimal treatment options. More severely, the failure to detect and remove occult micrometastases often causes tumor recurrences. There is an urgent need to develop a more precise and non-invasive strategy for the detection of the tumor metastasis in lymph nodes and distant organs. Based on the facts that tumor metastasis is closely related to the primary tumor microenvironment (TME) evolutions and that metabolomics profiling of the circulatory system can precisely reflect subtle changes within TME, we suppose whether metabolomic technology can be used to achieve non-invasive and real-time monitoring of BC metastatic status. In this study, the metastasis status of BC mouse models with different tumor-bearing times was firstly depicted to mimic clinical anatomic TNM staging system. Metabolomic profiling together with metastasis-related changes in TME among tumor-bearing mice with different metastatic status was conducted. A range of differential metabolites reflecting tumor metastatic states were screened and in vivo experiments proved that two main metastasis-driving factors in TME, TGF-β and hypoxia, were closely related to the regular changes of these metabolites. The differential metabolites level changes were also preliminarily confirmed in a limited number of clinical BC samples. Metabolite lysoPC (16:0) was found to be useful for clinical N stage diagnosis and the possible cause of its changes was analyzed by bioinformatics techniques.

In contrast to classical bulk heterojunction (BHJ) in organic solar cells (OSCs), the quasi-homojunction (QHJ) with extremely low donor content (≤10 wt.%) is unusual and generally yields much lower device efficiency. Here, representative polymer donors and nonfullerene acceptors are selected to fabricate QHJ OSCs, and a complete picture for the operation mechanisms of high-efficiency QHJ devices is illustrated. PTB7-Th:Y6 QHJ devices at donor:acceptor (D:A) ratios of 1:8 or 1:20 can achieve 95% or 64% of the efficiency obtained from its BHJ counterpart at the optimal D:A ratio of 1:1.2, respectively, whereas QHJ devices with other donors or acceptors suffer from rapid roll-off of efficiency when the donors are diluted. Through device physics and photophysics analyses, it is observed that a large portion of free charges can be intrinsically generated in the neat Y6 domains rather than at the D/A interface. Y6 also serves as an ambipolar transport channel, so that hole transport as also mainly through Y6 phase. The key role of PTB7-Th is primarily to reduce charge recombination, likely assisted by enhancing quadrupolar fields within Y6 itself, rather than the previously thought principal roles of light absorption, exciton splitting, and hole transport.

Efficient exciton diffusion and charge transport play a vital role in advancing the power conversion efficiency (PCE) of organic solar cells (OSCs). Here, a facile strategy is presented to simultaneously enhance exciton/charge transport of the widely studied PM6:Y6-based OSCs by employing highly emissive trans-bis(dimesitylboron)stilbene (BBS) as a solid additive. BBS transforms the emissive sites from a more H-type aggregate into a more J-type aggregate, which benefits the resonance energy transfer for PM6 exciton diffusion and energy transfer from PM6 to Y6. Transient gated photoluminescence spectroscopy measurements indicate that addition of BBS improves the exciton diffusion coefficient of PM6 and the dissociation of PM6 excitons in the PM6:Y6:BBS film. Transient absorption spectroscopy measurements confirm faster charge generation in PM6:Y6:BBS. Moreover, BBS helps improve Y6 crystallization, and current-sensing atomic force microscopy characterization reveals an improved charge-carrier diffusion length in PM6:Y6:BBS. Owing to the enhanced exciton diffusion, exciton dissociation, charge generation, and charge transport, as well as reduced charge recombination and energy loss, a higher PCE of 17.6% with simultaneously improved open-circuit voltage, short-circuit current density, and fill factor is achieved for the PM6:Y6:BBS devices compared to the devices without BBS (16.2%).

Herein, a dual-mode sensing platform using cationic N,N-bis(2-(trimethylammonium iodide)propylene)perylene-3,4,9,10-tetracarboxydiimide (PDA+)-assembled DNA strands as a quencher was suggested for estradiol (E2) detection. The aptamer chain was initially anchored with the Ru(II) novel molecule (Ru complex), which was recombined with carbohydrazide (CON4H6) and tris(4,4'-dicarboxylicacid-2,2'-bipyridyl)ruthenium(II) dichloride [Ru(dcbpy)32+] modified on copper oxide (CuO) nanospheres. Intramolecular electrochemiluminescence (ECL) occurring between CON4H6 and Ru(dcbpy)32+ effectively improved the reaction rate and increased the ECL efficiency. By employing effective van der Waals' force, PDA+ was endowed with an efficient ECL quenching probe on an electrode. The signal on the ECL interface can be converted into quenching because of energy transfer between the intercalator and the emitter. Notably, cationic PDA+ possessing a large planar π-π skeleton improved advantageous activity of redox and DNA aptamer indurative loading capacity and directly generated a well-defined cathodic peak to execute the EC bio-detection. This method not only avoids the difficulty of assembling various signal indicators but also improves the sensitivity greatly using the quenching mechanism. In addition, disparate double-response signals coming from different principles of transduction are in a position to verify each other to improve the accuracy. Hence, examination areas of 0.001-100 nM with E2 for ECL and EC were obtained, supplying a novel sensing strategy with promising ideas and perspectives of detection platform construction.

Organic solar cells (OSCs) are promising candidates for next-generation photovoltaic technologies, with their power conversion efficiencies (PCEs) reaching 19%. However, the typically used spin-coating method, toxic halogenated processing solvents, and the conventional bulk-heterojunction (BHJ), which causes excessive charge recombination, hamper the commercialization and further efficiency promotion of OSCs. Here, a simple but effective dual-slot-die sequential processing (DSDS) strategy is proposed to address the above issues by achieving a continuous solution supply, avoiding the solubility limit of the nonhalogen solvents, and creating a graded-BHJ morphology. As a result, an excellent PCE of 17.07% is obtained with the device processed with o-xylene in an open-air environment with no post-treatment required, while a PCE of over 14% is preserved in a wide range of active-layer thickness. The unique film-formation mechanism is further identified during the DSDS processing, which suggests the formation of the graded-BHJ morphology by the mutual diffusion between the donor and acceptor and the subsequent progressive aggregation. The graded-BHJ structure leads to improved charge transport, inhibited charge recombination, and thus an excellent PCE. Therefore, the newly developed DSDS approach can effectively contribute to the realm of high-efficiency and eco-friendly OSCs, which can also possibly be generalized to other organic photoelectric devices.

Short half-life is one of the main causes of drug attrition in clinical development, which also leads to the failure of many leading compounds and hits to become drug candidates. Nowadays, nanomaterials have been applied to drug development to address this problem. In fact, the clinical application of nanoparticles (NPs) is severely limited due to their rapid elimination by the reticuloendothelial system (RES) in vivo. In this paper, we aim to summarize representative strategies on prolonging the circulation time for bridging the gap between excellent pharmaceutics and proper half-life and encourage clinical translation.

Object detectors using deep learning are currently used in various situations, including robot demonstration experiments, owing to their high accuracy. However, there are some problems in the creation of training data, such as the fact that a lot of labor is required for human annotations, and the method of providing training data needs to be carefully considered because the recognition accuracy decreases due to environmental changes such as lighting. In the Nakanoshima Challenge, an autonomous mobile robot competition, it is challenging to detect three types of garbage with red labels. In this study, we developed a garbage detector by semi-automating the annotation process through detection of labels using colors and by preparing training data by changing the lighting conditions in three ways depending on the brightness. We evaluated the recognition accuracy on the university campus and addressed the challenge of using the discriminator in the competition. In this paper, we report these results.

This work outlines an electrochemiluminescence (ECL) platform with versatile and high-performance, which using the complex luminescent molecules [Ru(Ⅱ) complex] formed by carbohydrazide (...

Oxygen vacancies (OVs) enhanced electrochemiluminescence (ECL) biosensing strategy using luminol thermally encapsulated in apoferritin (Lum@apoFt) as an efficient transducer was investigated for ultrasensitive biomarker detection. By applying the oxygen-defect engineering (ODE) strategy, the OVs enriched cobalt-iron oxide (r-CoFe2O4) was fabricated as the sensing substrate to boost the electron mobility and catalyze the generation of superoxide anion radical (O2•-) for signal amplification. It should be noted that r-CoFe2O4 with higher OVs density dramatically accelerated the ECL reaction between O2•- and luminol anionic radicals, achieving 6.5-fold stronger ECL output than CoFe2O4 with no or low OVs density. Moreover, facile encapsulation of approximate 412 luminol molecules in a single apoFt cavity was first realized by an efficient thermal-induction method. The obtained Lum@apoFt complexes exhibited well-maintained ECL efficiency and excellent biocompatibility for biological modifications. On this basis, a biosensor was developed for early diagnostics of squamous cell carcinomas by detecting its representative biomarker named cytokeratin 19 fragment 21-1 (CYFRA 21-1), from which excellent linearity was achieved in 0.5 pg/mL to 50 ng/mL with a detection limit of 0.14 pg/mL. This work not only put forward a novel idea of creating OVs enriched sensing interface with excellent signal-amplification function but also proposes a facile and robust methodology to design apoFt-based transducers for developing more practical nanoscale biosensors in early diagnostics of diseases.

To suppress the subsynchronous oscillation in the doubly-fed induction generator (DFIG) system with Static VAR Generator (SVG), a feedback linearization control (FLC) method for rotor-side converter (RSC) is proposed, and its oscillation effect under small disturbances is analyzed and verified. Firstly, a 22-order time-domain model of a DFIG system with SVG is established. Secondly, combined with the principle of feedback linearization, the corresponding control method is designed for RSC inner loop control. Thirdly, the effects of PI control and feedback linearization control FLC on the system stability are compared when different parameters change under small disturbance. The results show the effectiveness of the proposed controller.

Expression of the E3 ligase TRIM21 is increased in a broad spectrum of cancers; however, the functionally relevant molecular pathway targeted by TRIM21 overexpression remains largely unknown. Here, we show that TRIM21 directly interacts with and ubiquitinates CLASPIN, a mediator for ATR-dependent CHK1 activation. TRIM21-mediated K63-linked ubiquitination of CLASPIN counteracts the K6-linked ubiquitination of CLASPIN which is essential for its interaction with TIPIN and subsequent chromatin loading. We further show that overexpression of TRIM21, but not a TRIM21 catalytically inactive mutant, compromises CHK1 activation, leading to replication fork instability and tumorigenesis. Our findings demonstrate that TRIM21 suppresses CHK1 activation by preferentially targeting CLASPIN for K63-linked ubiquitination, providing a potential target for cancer therapy.

Improving charge extraction and suppressing charge recombination are critically important to minimize the loss of absorbed photons and improve the device performance of polymer solar cells (PSCs). In this work, highly efficient PSCs are demonstrated by progressively improving the charge extraction and suppressing the charge recombination through the combination of side-chain engineering of new nonfullerene acceptors (NFAs), adopting ternary blends, and introducing volatilizable solid additives. The 2D side chains on BTP-Th induce a certain steric hindrance for molecular packing and phase separation, which is mitigated by fluorination of side chains on BTP-FTh. Moreover, by introducing two highly crystalline molecules as the second acceptor and volatilizable solid additive, respectively, into the BTP-FTh-based host blend, the molecular crystallinity is significantly improved and the blend morphology is finely optimized. As expected, enhanced charge extraction and suppressed charge recombination are progressively realized, contributing to the largely improved fill factor (FF) of the resultant devices. Accompanied by the enhanced open-circuit voltage (V

Power conversion efficiency (PCE) of organic solar cells (OSCs) have crossed 18% mark largely fabricated by spin coating, and optimal photoactive thickness is limited to 100 nm. To increase reproducibility of results with industrial roll-to-roll (R2R) processing, we used slot-die coating coupled with ternary strategy for optimal performance of large are thick OSCs. Based on miscibility differences, we incorporated a highly crystalline molecule BTR-Cl and regulated the phase separation kinetics of D18:Y6 film. BTR-Cl provides an early liquid-liquid phase separation and early aggregation of Y6, which slightly improves the molecular crystallinity and vertical phase separation of ternary blends, resulting in high PCEs of 17.2% and 15.5% for respective thicknesses of 110 and 300 nm photoactive films. Our ternary design strategy for large area and thick films was further utilized to fabricate high-efficiency flexible devices, which promises reproducibility of our lab results from slot-die coating to industrial R2R manufacturing. This article is protected by copyright. All rights reserved.

The high density of defects in MAPbI

Nowadays, the electrochemiluminescence (ECL) immunosensor with the unique superiority of tunable luminescence and ultrahigh sensitivity has become one of the most promising immunoassay techniques, especially for low-abundance biomarkers analysis. However, the use of signal probes with high excited potential and applied emitters which owned good intensity but biotoxicity limited its application. Herein, an ECL resonance energy transfer strategy was developed based on protein bioactivity protection utilizing europium-doped phosphoric acid gadolinium (GdPO4:Eu) as novel low-potential luminophor (donor) and Pd@Cu2O as the quenching probe (acceptor). Specifically, GdPO4:Eu was first prepared by using the hydrothermal synthesis method to apply in ECL, and when it coexisted with K2S2O8, cathode, a strong ECL signal would be generated at a low potential of -1.15 V (vs Ag/AgCl), where the immunocompetence of antigens and antibodies can be maintained well. Electrical pair Eu3+/Eu2+, as the coreactant promoter, produced by potential excitation could produce more SO4•- to accelerate the oxidation process of GdPO4:Eu. Meanwhile, Cu2O coated onto Pd (Pd@Cu2O), as a dual-quencher, enhanced the quenching effect of Pd alone and controlled the ECL intensity of the "signal on" state within a reasonable range. As a result, the proposed biosensor for detection of trace procalcitonin, a biomarker of systemic inflammatory response syndrome, exhibited a far low detection limit, 0.402 fg/mL (S/N = 3). Importantly, this work not only utilized a promising ECL emitter for biosensing platform construction but also had momentous potential in biomarker detection of disease diagnosis and clinical analysis.

The expansion of electrochemiluminescence (ECL) technology to immunoassay at the core of care emphasizes all immune molecules will not be inactivated in the analysis process. That poses a major challenge to ECL-based biosensors due to the deoxynucleotide sequences of an antigen or antibody could be oxidized through a route of excessive cyclic potential. Herein, an ultrasensitive ECL biosensor was developed based on a novel bioactivity-protected sensing strategy utilizing Au nanoclusters (Au NCs) as low-potential luminophor for detection of procalcitonin (PCT). Bovine serum albumin (BSA)-templated Au NCs exhibited a low-potential anodic ECL signal in triethylamine (TEA) solution at 0.87 V, where it is suitable for the survival of immune molecules. Taking advantage of good conductivity and high surface area, a Cu2S snowflake not only functions as a satisfying substrate for connecting immune molecules but also acts as co-reaction accelerator to produce more cationic radicals TEA•+, which could improve the ECL intensity needed to meet the requirements of trace analysis. Otherwise, HWRGWVC (HC-7) heptapeptide as specific antibody immobilizer for site-oriented fixation was introduced to further maintain the bioactivity of an antibody. In view of the preceding discussion, the obtained biosensor exhibited ultrahigh immune recognition to targets so that the detection limit was as low as an unprecedented value of 2.36 fg/mL, which will be of great significance to the application and development of a biosensor in the future.

A highly efficient quench-type electrochemiluminescence (ECL) immunosensor was proposed for the trace detection of amyloid β-protein (Aβ1–42). In this work, tin disulfide nanoflowers (SnS2 NFs) with large specific surface area, favorable catalytic property and chemical stability were prepared and used as substrate material. Taking advantage of the excellent catalytic ability and biocompatibility, palladium nanoparticles (Pd NPs) were in situ reduced on SnS2 NFs to obtain SnS2-Pd. Moreover it could combine with large amounts of luminol and achieve a strong ECL signal output. In addition, copper doped mesoporous tungsten trioxide (Cu:WO3) nanoparticles were selected to quench ECL emission of luminol@SnS2-Pd via resonance energy transfer, where luminol@SnS2-Pd was the donor and Cu:WO3 was the acceptor. On this basis, a quench-type ECL immunosensor was constructed for detection of Aβ1–42. Under optimum conditions, the fabricated ECL immunosensor showed sensitive response to Aβ1–42 concentration from 0.1 pg/mL to 50 ng/mL with a low detection limit of 5.4 fg/mL (S/N = 3). It is expected to be a promising analytical tool for the sensitive detection of Aβ1–42 and other biomarkers with high specificity, good reproducibility and long-term stability.

With the rapid development of wind power, the voltage control strategy of power system is paid more concern. The reactive power provided or absorbed by the wind turbine (WT) can help regulate the voltage fluctuations of power systems. However, the traditional fixed droop control strategy is not applicable to provide reasonable reactive power for WTs. In this work, taking into account the time-varying nature of wind speed and the uncertainty characteristics of wind power, the different distribution ranges of reactive power capacity from WT in a wind power plant (WPP) is investigated based on different wind speed sections, and the voltage control strategy for wind farms based on the probability model of voltage droop gain is proposed. The proposed method can make the WPP exert reactive power compensation ability of WTs in each wind speed section fully and reasonably.