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我々は，バイオインフォマティクス解析のためのセマンティックウェブサービスの実現を目指して，解析ウェブサービスの充実とともに，学術論文中から解析手順知識(ワークフロー)を半自動抽出する技術を開発し網羅的な収集を試みている．このようなワークフローを利用することで，ユーザの解析目的に対してそれを実現するための解析方法の組合せを提示するためのサービスを提供する．本稿では，網羅的な解析手順知識の収集によって初めて分かる解析技術の経年的変化の分析結果を中心に報告する．

目的: 1被験例の30年間の記録を通して, 咬合小面と各種下顎位の咬合接触の関係について検討する.方法: 1被験者について, 25, 39, 55歳時の咬合小面および咬合接触を記録した. 咬合接触の記録顎位は, 咬頭嵌合位, 最後方咬合位, 前方滑走運動路上の4顎位, 左右側方滑走運動路上の各4顎位の計14顎位である. これらの接触部と重なった咬合小面を咬合接触小面とし, 得られた咬合小面, 咬合接触小面数を記録した.結果: 1. 咬合小面数は経時的に増加し, 特に大臼歯部での増加数はほかの歯種に比べ多く, 咬頭嵌合位における咬合接触小面数も同様に増加していた. 2. 最後方咬合位における咬合接触小面数は, 各年齢を通じて第二大臼歯に最も多く認められ, 経時的に増加していた. 3. 前方運動における咬合接触小面数は, 前歯や小臼歯では減少していたが, 大臼歯では増加した. 4. 側方運動における作業側の咬合接触小面数は, 右側方運動では一定の傾向は認められなかったが, 左側方運動では経時的に増加した, 平衡側は, 左右側方運動とも大臼歯では咬頭嵌合位から1, 2mmの側方位で増加した.結論: 本被験者の咬合小面数は経時的に増加し, なかでも大臼歯における増加数は, ほかの歯種に比べ多かった. この咬合小面の経時的変化には各種下顎位の咬合接触が関係し, 特に咬頭嵌合位における咬合接触の影響が大きいことが示された.

Large-scale genome projects generate an unprecedented number of protein sequences, most of them are experimentally uncharacterized. Predicting the 3D structures of sequences provides important clues as to their functions. We constructed the Genomes TO Protein structures and functions (GTOP) database, containing protein fold predictions of a huge number of sequences. Predictions are mainly carried out with the homology search program PSI-BLAST, currently the most popular among high-sensitivity profile search methods. GTOP also includes the results of other analyses, e.g. homology and motif search, detection of transmembrane helices and repetitive sequences. We have completed analyzing the sequences of 41 organisms, with the number of proteins exceeding 120 000 in total. GTOP uses a graphical viewer to present the analytical results of each ORF in one page in a ‘color-bar’ format. The assigned 3D structures are presented by Chime plug-in or RasMol. The binding sites of ligands are also included, providing functional information. The GTOP server is available at http://spock.genes.nig.ac.jp/~genome/gtop.html.

Purpose: There has been a significant number of malocclusion patients who suffer from the osteoarthritis associated with TMJ, and acquired anterior open bites were reported as a representative example. Treatments for patients with malocclusion often prove difficult, as the condyle position is not stable. It remains unknown as to whether this is due to the disease or the condyle position. This case report documents a clinical application of a Digital Gothic Arch Tracer for occlusal diagnosis and subsequent management and treatment of malocclusion with osteoarthritis.Materials and methods: This case report presents the treatment process of a female patient (51 years, 6 months of age) with an acquired dual-bite malocclusion with severe osteoarthritis in the temporomandibular joint (TMJ). The occlusal condition of the patient was examined by a Digital Gothic Arch Tracer (DGAT, Gothic Display: Shofu Inc.). The GDAT was used as it provides an extra-oral tracing of jaw movements. While it is simple and easy to use, the accuracy remains impressively high, as several jaw motions are included into the final calculation.Results: The ensuing treatment plan was as follows: Upon the first examination, the occlusal position was recorded with DGAT. The DGAT data was then evaluated for correlations between the terminal points of the rapid habitual opening-closing movements (tapping points), apex point and speaking position. The gothic arch figure revealed that when approaching the terminal points of the tapping points and the speaking position, there was a separation at the apex point. From this, we reached a conclusion on the new occlusal position for tapping points and the speaking position. Based on the DGAT results, via the occlusal adjustment method, we set the new occlusal position. On their final visit the patient received Prosthodontics treatment. The DGAT was able to provide an avenue of examination that maintained the original occlusal position without raising the vertical dimension. Therefore, it was rather simple and exact to compare the Tapping points and Apex points.Conclusion: Using a Digital Gothic Arch Tracer, we successfully carried out the occlusal examination and treatment of a patient with osteoarthritis and malocclusion.

Spontaneously broken symmetry is discussed from the viewpoint of Thom’s catastrophe theory. It is just the Maxwell convention in cusp catastrophe and is a special case of the usual symmetry breaking. The relation between usual symmetry breaking and ‘bag theory’ is suggested briefly.

ヒマシ油の熱分解によって得たエナントールを酸化してエナント酸に変え,これを順次塩化チオニル,臭素および無水エタノールと処理して, α-ブロムーエナント酸エチルを合成した。またレブリン酸エチルを合成し, これら二つのエステルをReformatsky反応により縮合させて, α-アミル-β-メチル-β-オキシーアジピン酸エチルのγ-ラクトンに導き, このγ-ラクトンを熱分解してジヒドロジャスモンを得た。また別に上記のγ-ラクトンをDieckmann反応によってジヒドロジャスモンに導き,これを熱分解によって得たものと比較したところ,この両者が全く同一物であることを確認した。