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32 results on '"Jo, C. H."'

8. Menin mediates epigenetic regulation via histone H3 lysine 9 methylation

Author

Yang, Y-J, primary, Song, T-Y, additional, Park, J, additional, Lee, J, additional, Lim, J, additional, Jang, H, additional, Kim, Y-N, additional, Yang, J-H, additional, Song, Y, additional, Choi, A, additional, Lee, H Y, additional, Jo, C H, additional, Han, J W, additional, Kim, S-T, additional, Youn, H-D, additional, and Cho, E-J, additional

Published
2013
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12. Acid-base/Na, K, Cl. Experimental and clinical

Author

Choi, H.-J., primary, Lim, J.-S., additional, Park, E.-J., additional, Jung, H. J., additional, Lee, Y.-J., additional, Kwon, T.-H., additional, Cesar, K. R., additional, Araujo, M., additional, de Braganca, A. C., additional, Magaldi, A. J., additional, Freisinger, W., additional, Ditting, T., additional, Heinlein, S., additional, Schatz, J., additional, Veelken, R., additional, Burki, R., additional, Mohebbi, N., additional, Wang, X., additional, Serra, A., additional, Wagner, C., additional, Rodionova, K., additional, Schmieder, R., additional, Yano, Y., additional, Kudo, L. H., additional, Choi, H.-J., additional, Yoon, Y.-J., additional, Hwang, G.-S., additional, Jo, C. H., additional, Kim, S., additional, Park, J. S., additional, Lee, C. H., additional, Kang, C. M., additional, Kim, G.-H., additional, Kokeny, G., additional, Szoleczky, P., additional, Fang, L., additional, Rosivall, L., additional, Mozes, M. M., additional, Lampert, A., additional, LEE, W.-C., additional, Wang, Y.-C., additional, Chen, J.-B., additional, Santos, C., additional, Gomes, A. M., additional, Ventura, A., additional, Almeida, C., additional, Seabra, J., additional, Daher, E., additional, Leite de Figueiredo, P., additional, Montenegro, R., additional, Martins, M., additional, Bezerra da Silva, G., additional, Liborio, A., additional, Sromicki, J., additional, Matter, S., additional, Sitzmann, K., additional, Hess, B., additional, Lee, J., additional, Lee, J. W., additional, Oh, Y. K., additional, Na, K. Y., additional, Joo, K. W., additional, Earm, J.-H., additional, Han, J. S., additional, Ninchoji, T., additional, Kaito, H., additional, Nozu, K., additional, Hashimura, Y., additional, Nakanishi, K., additional, Yoshikawa, N., additional, Iijima, K., additional, Matsuo, M., additional, Gorini, A., additional, Addesse, R., additional, Comegna, C., additional, Galderisi, C., additional, Cecilia, A., additional, Tomaselli, M., additional, Di Lullo, L., additional, and Polito, P., additional

Published
2011
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25. Surface characterization and chondrogenic differentiation of mesenchymal stromal cells derived from synovium.

Author

Jo, C. H., Ahn, H. J., Kim, H. J., Seong, S. C., and Lee, M. C.

Subjects
*SURFACE analysis, *CHONDROGENESIS, *STEM cell research, *SYNOVIAL membranes, *OSTEOARTHRITIS, *FIBROBLAST growth factors, *DIAGNOSTIC use of flow cytometry, *THERAPEUTICS
Abstract

Background Synovium is the only tissue that can produce hyaline cartilage in benign conditions, such as synovial chondromatosis and osteoarthritis, suggesting potential advantages in chondrogenesis using mesenchymal stromal cells. We performed surface characterization of cells isolated from the synovium of patients with osteoarthritis after different passages and induced chondrogenic differentiation. Methods Using cells obtained from synovium, colony-forming unit fibroblast assay and characterization of cell-surface markers by flow cytometry using 22 different Ab at different passages were performed. Cells were cultured under chondrogenic conditions and evaluated grossly, histologically, immunohistochemically and by [35S]sulfate incorporation and reverse transcription-PCR. Results The positive cell-surface markers of immediately isolated cells were CD10, CD13, CD14, CD34, CD44, CD45, CD49a, CD62e, CD73 and HLA-DR. After the first passage (P), CD14, CD34, CD45, CD62e and HLA-DR disappeared, whereas CD105 and CD166 appeared and CD10, CD13, CD44, CD49a and CD73 showed increased expression levels. The surface marker expression level did not vary much after P1 through to P8. The chondrogenic differentiation potential of cells from the synovium was confirmed using various evaluation methods. Discussion We have demonstrated that cells from synovium contain a mesenchymal stromal cell population capable of chondrogenic differentiation, which seems to increase with passage under our culture conditions. The cell-surface markers were found to change remarkably after the first passage and then remained stable. The results of this study may be helpful for sorting mesenchymal stromal cells from heterogeneous synovial cells for future studies. [ABSTRACT FROM AUTHOR]

Published
2007
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26. Soy Protein Isolate Reduces Hepatosteatosis in Yellow Avy/aMice Without Altering Coat Color Phenotype

Author

Badger, T. M., Ronis, M. J. J., Wolff, G., Stanley, S., Ferguson, M., Shankar, K., Simpson, P., and Jo, C.-H.

Abstract

Agouti (Avy/a) mice fed an AIN-93G diet containing the soy isoflavone genistein (GEN) prior to and during pregnancy were reported to shift coat color and body composition phenotypes from obese-yellow towards lean pseudoagouti, suggesting epigenetic programming. Human consumption of purified GEN is rare and soy protein is the primary source of GEN. Virgin a/a female and Avy/a male mice were fed AIN-93G diets made with casein (CAS) or soy protein isolate (SPI) (the same approximate GEN levels as in the above mentioned study) for 2 wks prior to mating. Avy/aoffspring were weaned to the same diets and studied at age 75 d. Coat color distribution did not differ among diets, but SPI-fed, obese Avy/aoffspring had lower hepatosteatosis (P< 0.05) and increased (P< 0.05) expression of CYP4a 14, a PPARα-regulated gene compared to CAS controls. Similarly, weanling male Sprague-Dawley (SD) rats fed SPI had elevated hepatic Acyl Co-A Oxidase (ACO) mRNA levels and increased in vitrobinding of PPARα to the PPRE promoter response element. In another hepatosteatosis model, adult SD rats fed a high fat/cholesterol diet, SPI reduced (P< 0.05) steatosis. Thus, 1) consumption of diets made with SPI partially protected against hepatosteatosis in yellow mice and in SD rats, and this may involve induction of PPARα-regulated genes; and 2) the lifetime (in utero, neonatal and adult) exposure to dietary soy protein did not result in a shift in coat color phenotype of Avy/amice. These findings, when compared with those of previously published studies of Avy/amice, lead us to conclude that: 1) the effects of purified GEN differ from those of SPI when GEN equivalents are closely matched; 2) SPI does not epigenetically regulate the agouti locus to shift the coat color phenotype in the same fashion as GEN alone; and 3) SPI may be beneficial in management of non-alcoholic fatty liver disease

Published
2008
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32. Human CD16 as a lysis receptor mediating direct natural killer cell cytotoxicity.

Author

Mandelboim O, Malik P, Davis DM, Jo CH, Boyson JE, and Strominger JL

Subjects
Antibodies, Monoclonal immunology, Histocompatibility Antigens Class I immunology, Humans, Immunoglobulin Fab Fragments immunology, Immunoglobulin Fc Fragments immunology, Immunoglobulins genetics, Immunoglobulins immunology, Protein Binding, Receptors, IgG genetics, Recombinant Fusion Proteins genetics, Recombinant Fusion Proteins immunology, Tumor Cells, Cultured, Antibody-Dependent Cell Cytotoxicity, Killer Cells, Natural immunology, Receptors, Cell Surface immunology, Receptors, IgG immunology
Abstract

In addition to their role in peptide antigen presentation, class I MHC proteins also play a critical role in inhibiting natural killer (NK) cytotoxicity through interaction with NK inhibitory receptors. Thus, NK cells are cytotoxic to virus-infected and tumor cells that have lost class I MHC protein expression. However, the nature of the receptors involved in the triggering of lysis of target cells is poorly understood. CD16 (Fcgamma receptor III) has been described as a receptor expressed on NK cells that facilitates antibody-dependent cellular cytotoxicity (ADCC) by binding to the Fc portion of various antibodies. However, we show here that CD16 has a broader function and is directly involved in the lysis of some virus-infected cells and tumor cells, independent of antibody binding. The presence of a putative CD16 ligand on appropriate target cells has also been demonstrated by the use of a CD16-Ig fusion protein.

Published
1999
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