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La llegenda de fra Joan Garí, primer eremita de Montserrat, es documenta entre els segles XIII-XV a través de textos escrits en llatí o en català, però en el segle xvi aquest mateix relat es va transmetre sobretot a través d’obres devotes o historiogràfiques impreses en castellà per autors com Pedro de Burgos, Pedro de Medina o Pere Antoni Beuter. En aquest article s’ofereix un panorama general sobre les reescriptures medievals o cinc-centistes d’aquesta llegenda, i es posa especial èmfasi en dues de les versions castellanes més extenses, ambdues anònimes: la Historia de fray Juan Garín, sense dades tipogràfiques però impresa a Toledo durant els darrers dies de 1527 o poc després; i la Vida de fray Juan Garín (València, 1561), basada en el Libro de los milagros (1536) de Pedro de Burgos. La Vida, gairebé desconeguda, ens ha arribat a través d’un plec solt de la Biblioteca Comunale Augusta de Perugia. A banda d’introduir i comparar la Historia i la Vida amb altres versions de la mateixa llegenda, aquest article ofereix una edició acarada d’ambdós textos. The legend of friar Joan Garí, the first hermit of Montserrat, is documented between the 13th and 15th centuries through texts written in Latin or Catalan, but in the 16th century the same story was transmitted mainly through devotional or historiographical printed works written in Spanish by authors such as Pedro de Burgos, Pedro de Medina or Pere Antoni Beuter. This article provides an overview of the medieval or sixteenth-century rewritings of this legend, with special emphasis on two of the most extensive Spanish versions, both anonymous: the Historia de fray Juan Garín, without typographic data but printed in Toledo during the last days of 1527 or shortly thereafter; and the Vida de fray Juan Garín (Valencia, 1561), based on the Libro de los Milagros (1536) by Pedro de Burgos. The Vida, an almost unknown work, has reached us through a chapbook of the Biblioteca Comunale Augusta in Perugia. In addition to introducing and comparing the Historia and the Vida with other versions of the same legend, this article offers a face-to-face edition of both texts. Aquest article s’emmarca en el projecte de recerca UJI-B2020-04, finançat per la Universitat Jaume I.

Tot partint de la consulta i anàlisi de les dades de BITECA (Bibliografia de textos antics catalans, valencians i balears), es localitzen i s'editen diversos testimonis dels segles XV-XVI, inèdits o poc coneguts, de les següents obres rimades de devoció: «Quan vos venc, Maria, l’àngel Gabriel», «Estant Elisabet», «Ara sus, companya, sus», «Ave, llum i estela clara», «Regina excel·lent», «No sens turment, dolor incomprensible», «Glòria teniu infinida», «Vós qui fés la santa vida», «Beata Caterina, verge fuist e regina» «Si se’n va monsènyer sant Joan», «Jesucrist nasqué la nit de Nadal», «Sang, està fixa», «O gloriosa Verge Maria, neta e pura», «Saviesa de Déu lo Pare», «Ador-te devotament, veritat increada». This paper, based on the analysis of data from BITECA (Bibliografia de textos antics catalans, valencians i balears), presents and edits several unpublished or little-known witnesses of rhymed works and devotional poems dating from the 15th and 16th centuries. Its starting lines are as follows: «Quan vos venc, Maria, l’àngel Gabriel», «Estant Elisabet», «Ara sus, companya, sus», «Ave, llum i estela clara», «Regina excel·lent», «No sens turment, dolor incomprensible», «Glòria teniu infinida», «Vós qui fés la santa vida», «Beata Caterina, verge fuist e regina» «Si se’n va monsènyer sant Joan», «Jesucrist nasqué la nit de Nadal», «Sang, està fixa», «O gloriosa Verge Maria, neta e pura», «Saviesa de Déu lo Pare», «Ador-te devotament, veritat increada».

Anti-mitochondrial antibodies (AMA), directed against the E2 subunits of the 2-oxo acid dehydrogenase complexes, are markers of Primary Biliary Cholangitis (PBC), a chronic autoimmune liver disease. However, the clinical significance of subunits-specific AMA type PDC-E2 -E2 subunit of the pyruvate dehydrogenase complex-, BCOADC-E2 -E2 subunit of the branched-chain 2-oxo acid dehydrogenase complex-, OGDC-E2 -E2 subunit of the 2-oxo-glutarate dehydrogenase complex- and nPDC -native pyruvate dehydrogenase complex (M2-AMA) . Is not well known, and not all AMA specificities are associated with PBC. The aim of the study was to show the usefulness of the number and combination of subunits-specific AMA positive for the diagnosis of PBC. We detected AMA by indirect immunofluorescence (IIF-AMA) and M2-AMA by dot-blot. We studied the relationship of AMA with some clinical and laboratory variables in 307 patients (37% PBC) with positive dot-blot for M2-AMA. In PBC patients, we detected different E2 subunits of the 2-oxo acid dehydrogenase complexes antibodies (M2-AMA): 82.9% were specific for nPDC, 64.5% for PDC-E2, 44.4% for BCOADC-E2, and 9.6% for OGDC-E2. IIF and dot-blot tests achieved a Area Under the Receiver Operating Characteristic Curve (ROC AUC) of 0.674 (1: 320 cut-off titer, Sensibility (Se) 64.7%, Specificity (Sp) 63.4%) and 0.663 (three specificities M2-AMA, Se 43%, Sp 81.2%), respectively. The detection of different E2 subunits of the 2-oxo acid dehydrogenase complexes antibodies (M2-AMA) by dot-blot showed different ROC AUC: anti-PDC-E2 showed an AUC of 0.610, a Se of 43.7%, and a Sp of 76.4%. Finally, the combined detection of nPDC/BCOADC-E2/PDC-E2 reached an AUC of 0.6095, a Se of 59.6%, and a Sp of 70.2%.The identification of two M2-AMA specificities through dot-blot increased PBC odds ratio (OR) by 2.05 (p:0.031), as compared to the identification of one specificity. Moreover, the identification of three and four specificities increased OR by 4.63 (p:0.000) and by 21.53 (p:0.006), respectively. nPDC/OGDC-E2/PDC-E2 and nPDC/OGDC-E2/BCOADC-E2/PDC-E2 combinations increased PBC OR by 10.04 (p:0.034), as compared to any other combination. 1:320 and 1:640 IIF-AMA increased PBC OR by 4.93 (p:0.009) and 7.67 (p:0.001), respectively, as compared to IIF-AMA titers equal to or less than 1:160. M2-AMA dot-blot was less sensitive but more specific than IIF-AMA, with similar predictive capacity for PBC. Increased numbers of M2-AMA specificities clearly increased the risk of PBC. Some combinations were strongly related to PBC (nPDC/BCOADC-E2/PDC-E2), but others were not (one single M2-AMA, and nPDC plus PDC-E2). M2-AMA dot-blot was less sensitive but more specific than IIF-AMA, with similar predictive capacity for PBC. Increased numbers of M2-AMA specificities clearly increased the risk of PBC, being some combinations, such as nPDC/BCOADC-E2/PDC-E2, more related to PBC than others. Finally, the determination of the number of M2-AMA specificities was more useful than the particular subunit target for PBC diagnosis. In conclusion, the study of the number of M2-AMA specificities by dot-blot should definitely be considered for PBC diagnosis.

Estudiamos desde el punto de vista bibliográfico siete pliegos sueltos, uno en prosa más seis en verso, que forman parte de un volumen de la Biblioteca Comunale Augusta de Perugia catalogado bajo la signatura [I L 1402]. En algunos de los ejemplares figuran el lugar y la fecha de impresión, es decir, Cuenca y los años 1557 o 1558. A partir de estos datos y del análisis formal de las siete ediciones, podemos atribuirlas todas ellas a la tipografía de Juan de Cánova. Dos de los siete pliegos transmiten poemas no localizados en ninguna otra fuente impresa o manuscrita, hasta donde hemos podido alcanzar en nuestra investigación. Además, el hecho de que una de estas poesías sea en catalán y de autor valenciano (Onofre Almudéver) nos hace sospechar que dichos pliegos, por lo menos en parte, fueron impresos a instancias de algún librero de Valencia. In this paper, we study from a bibliographic point of view seven chapbooks, one in prose and the rest in verse, which are bound in one volume preserved in the Biblioteca Comunale Augusta, Perugia, catalogued under the shelfmark [I L 1402]. Some of these editions include the place (Cuenca) and the date of printing (1557 or 1558). From this information and from the formal analysis of the seven editions, it is possible to ascribe all of them to the press of Juan de Cánova. Two of the seven chapbooks transmit poems that we have not located in any other handwritten or printed source, as far as it has been achieved in our research. Furthermore, the fact that one of these poems is in Catalan and has a Valencian author (Onofre Almudéver) makes us suspect that those chapbooks, at least in part, were printed at the request of a bookseller established in Valencia.

Although the Cobles de la Mort were printed with the Peregrinacio del Venturos Pelegri from the first complete extant edition (1635) until the twentieth century, several witnesses and data analyzed in this paper suggest the Cobles were published independently of the Peregrinacio in the first half of the sixteenth century. A record in the manuscript catalogues of the library of Hernando Colon confirms that in 1536 this bibliophile had already acquired a chapbook containing the Cobles. In addition, a fragment of the Libre de Senequa, an Occitan work of the thirteenth century, is cited in one of the paratexts included in a mid-sixteenth century manuscript copy of the Cobles. The presence of this Occitan source seems to relate the Cobles with the medieval tradition more than with the early modern literature. By comparing these elements with other sources, we deduce the existence of incunabula or postincunabula editions, currently missing, in which the Cobles were printed independently of the Peregrinacio. The...

Estudiamos las alusiones directas o indirectas al mito de Orfeo en la obra poetica de algunos autores de los siglos XVI–XVII que escribieron en catalan o tambien en castellano. Poetas como Joan Pujol o Francesc Fontanella envuelven la referencia al mito orfico en una atmosfera elegiaca. Orfeo es comparado con el ruisenor que llora los polluelos tomados por el labrador en un pasaje de las Georgicas de Virgilio que sera reelaborado en la Egloga I de Garcilaso de la Vega y en Qui vol oyr la gesta de Pere Serafi. En este ultimo poema, a diferencia de la obra de Garcilaso, el canto del ruisenor es respondido por la golondrina. Aunque estas dos aves parecen aludir al mito de Filomela y Procne, la amorosa lamentacion entre pajarillos de diferente especie es un topico comun en la lirica amorosa medieval. Finalmente, analizamos dos obras de Pere Jacint Morla que comparten una escenografia alegorica similar en la que el infierno es descrito como un inhospito edificio o viceversa. En el Somni de l’infern, co...

Des de 1623, el gremi de llibreters de Barcelona, conegut com la Confraria de San Jeroni, gaudi d’una privativa per a vendre en aquesta ciutat la Peregrinacio del Venturos Pelegri, una de les obres en catala que va tenir major difusio impresa a l’Edat Moderna. Entre els anys 1718–1730, sota el regnat de Felip V, es produi un important canvi legislatiu que atorga a la Universitat de Cervera el privilegi per a publicar a Catalunya no nomes el Venturos Pelegri sino tambe altres manuals i obres d’us pedagogic. Tot considerant dades historiques com les que acabem d’indicar, aquest article estudia des d’un punt de vista bibliografic setze edicions impreses a Barcelona, Cervera o Manresa, les quals presenten parcialment les mateixes series xilografiques. Reproduim els gravats emprats en totes elles i establim algunes relacions oportunes a partir de l’analisi d’aquests elements grafics.

The "rods and rings" (RR) antinuclear antibody (ANA) pattern is believed to be restricted to hepatitis C virus (HCV) infection and related to the treatment. This is a 4-year retrospective study of all patients with RR pattern from the 20,000 serum samples received at the Hospital Universitari de Bellvitge for ANA testing. Two control groups with HCV patients without RR pattern: ANA-positive (n = 74) and ANA negative (n = 75) were included. Eighty-seven patients had samples with the RR pattern. Seventy-three were infected with HCV (prevalence of 15% in the HCV population). The RR pattern could not be related to ribavirin treatment, clinical status, biochemistry data, hepatic fibrosis, IL28B genotype, HCV genotype or the presence of autoantibodies related with autoimmune hepatitis. As 14 cases presented other diseases, mainly of autoimmune origin, the presence of RR antibodies may also be explained by alterations in immune regulation caused by autoimmunity or HCV in a particular genetic background.

En este articulo describimos veinticuatro ediciones de pliegos sueltos que podrian asignarse a la tipografia valenciana de Joan Navarro hacia los anos 1560-1563. Todos ellos forman parte de un volumen de la Biblioteca Comunale Augusta de Perugia, clasificado bajo la signatura [I L 1402]. Entre las veinticuatro ediciones, estudiamos de manera mas especifica siete pliegos poeticos que transmiten treinta y cuatro romances. Finalmente, establecemos un panorama general sobre la difusion de estas composiciones desde 1547 hasta 1573, subrayando algunas de las relaciones entre las versiones del volumen de Perugia y otros pliegos poeticos, cancioneros o romanceros impresos en el siglo XVI. Algunos de los precedentes mas destacados de estos siete pliegos son los romanceros publicados en Amberes, las silvas zaragozanas estampadas por Esteban G. de Najera y el Cancionero llamado flor de enamorados de Joan Timoneda, cuya primera edicion, desaparecida en la actualidad, se supone en Valencia hacia los anos 1556-1557. Lo...

A partir des temoignages qui vont du jour de sa mort le 23 Septembre 1461 jusqu’a la fin du XVIIe siecle sont analysees les rumeurs d’empoisonnement du prince Charles de Viane a l’instigation de sa marâtre et la relation de ce motif avec les apparitions de son âme criant vengeance.

La producción poética de Onofre Almudéver se contextualiza en Valencia hacia 1550-1570. En este artículo establecemos un elenco de los manuscritos e impresos antiguos conocidos que transmiten sus poesías, tanto en castellano como en catalán, y las editamos de manera conjunta por primera vez. Este análisis nos permite entender cabalmente lo que ya fue apuntado en algunos estudios referentes a la labor de Almudéver como autor de varios textos proemiales estampados por Joan de Arcos (Valencia, 1561) en tres libros diferentes pero unitarios, donde se incluían el Espill de Jaume Roig y otras piezas de autores valencianos. Esta compilación constituye el núcleo originario y la inspiración de lo que Ramon Miquel i Planas llamó el Cançoner satíric valencià, reincidiendo de este modo en la etiqueta historiográfica «Escuela Valenciana», que por primera vez acuñó Manuel Milà i Fontanals. Miquel i Planas daba una gran relevancia cultural al carácter unitario de los tres impresos de Joan de Arcos, pero también desarrolló una particular interpretación del pasado literario que podría haberse inspirado en algunas de las ideas que Almudéver esbozó en su Epístola proemial. Pero esta epístola, más que un intento de sistematizar un período cultural, debe entenderse como una manera de justificar una determinada estrategia editorial, ya que Almudéver fue un hombre ligado al mercado del libro más que un historiador de la literatura; y su espíritu creador se encauzó sobre todo en la devoción y la pedagogía, así como la escritura de poemas proemiales en alabanza de algunos autores y obras publicados en su tiempo. The poetical works of Onofre Almudéver find their context in Valencia about 1550-1570. In this paper I establish a list of old manuscripts and printed books transmitting his poems, both in Spanish and Catalan; in this paper I also and publish the poems together for the first time. This analysis allows us to understand what was already pointed out in some studies concerning Almudéver’s involvement as author of several introductory texts printed by Joan de Arcos (Valencia, 1561) in three different but unitary books which included Jaume Roig’s Espill and texts by other authors from Valencia. This compilation constitutes the origin and inspiration for what Ramon Miquel i Planas called Cançoner satíric valencià, a name which reinforced the historiographical label «Escola Valenciana», coined for the first time by Manuel Milà i Fontanals. Miquel i Planas saw great cultural relevance in the formal unity of the three books printed by Joan de Arcos, but he also developed a particular interpretation of the literary past which might have been inspired by some of the ideas outlined by Almudéver in his Epístola proemial. However, this epistle must be understood not so much as an effort to systematize a cultural period, but rather as a way to justify a specific editorial strategy, since Almudéver was involved in the book market but not in literary history. His creative spirit was mainly focused on devotion and pedagogy, as well as on the writing of proemial poems in praise of some authors and works published in his time.

The comparison of satirical and burlesque representations of hell allows us to point out some analogies between different works and authors documented in Valencia from 1627 to 1656. Some works of Quevedo printed in this city, as the Sueños and the ballad Los que quisieren saber, seem to have inspired El infierno of Jacinto Alonso Maluenda and the Somni de l’infern of Pere Jacint Morlà. This last author has also written the Pintura de la Torre de Serranos, which identifies allegorically Valencia’s prison as the place of eternal damnation. We examine the literary context of all these testimonies and their relationship with Maluenda’s El infierno, the edition of which is added at the end of this paper.

Resum : El ms. 4504 de Bibliotheque Mazarine de Paris aplega, per una banda, cinc exemplars impresos de la “Peregrinacio del Venturos Pelegri” ab les “Cobles de la Mort” i, per altra banda, una copia manuscrita parcial del Venturos Pelegri amb una traduccio francesa incompleta a cura de Josep Tastu (1787-1849), que s’encarrega de compilar tots els materials del volum. A banda de presentar el contingut general del ms. 4504, descrivim amb detall cada una de les cinc edicions, posant especial emfasi en la mes antiga, probablement datada de mitjan segle XVI o poc despres. Pel fet d’esser el testimoni mes antic que coneixem del Venturos Pelegri , aquest exemplar acefal i apode, estampat a linia seguida amb tres gravats encara visibles, aporta dades rellevants per al coneixement de les vies de difusio d’aquesta obra als segles XVI-XVII. Paraules clau : Edad Moderna, Poesia catalana, Impremta, Xilografia, Josep Tastu. Abstract : The Ms. 4504 of the Bibliotheque Mazarine in Paris contains, on the one hand, five printed copies of the “Peregrinacio del Venturos Pelegri” ab les “Cobles de la Mort” and, on the other hand, a partial hand-written copy of the Venturos Pelegri with an incomplete French translation by Josep Tastu (1787-1849), who compiled all the materials of this volume. Apart from presenting the general content of the ms. 4504, we describe in detail the five editions with particular emphasis on the oldest one, probably dating from the mid-sixteenth century or shortly thereafter. This printed book, now acephalous and apodous, in which the lines go all the way across the page, still preserves three woodcuts. As the earliest witness we know of the Venturos Pelegri , this printed copy provides some evidences to understand the dissemination of this work during the sixteenth and seventeenth centuries. Keywords : Modern Age, Catalan poetry, Printing, Woodcut, Josep Tastu.

Starting from a state of affairs of different bibliographical contributions on medieval Catalan poetry, this article presents the Repertori d’Obres en Vers (ROV) and includes the edition of five unpublished poems of the fifteenth and sixteenth centuries, whose opening lines are: "Per sospirar trobe aleujament", "Dir-vos-ho he –sia secret–", "Ara·n lo punt de ma partida", "En tal cas astich posat" y "En totes parts on gentilesa·s nota". All these poems are anonymous and have been preserved in a single manuscript.