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Your search keyword '"Jocelyn M. Lutes"' showing total 2 results
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2 results on '"Jocelyn M. Lutes"'

1. List of Contributors

Author

Yael Abreu-Villaça, Jane Adams, Richard Agans, Syed F. Ali, Michael Aschner, William J. Barbaresi, David C. Bellinger, Julie Bickel, Lilly Bogičević, Jolene E. Borchelt, Thomas M. Burbacher, Johanna Calderon, Carl E. Cerniglia, Louis W. Chang, John J. Chelonis, Elvis Cuevas, Nancy L. Day, John M. DeSesso, Alessandra A. Dos Santos, Diana Dow-Edwards, Sherry A. Ferguson, Jeffrey W. Fisher, Jan M. Friedman, Julia M. Gohlke, Mari Golub, Devon L. Graham, Kimberly S. Grant, Robert M. Greene, Qiang Gu, Michelle Guignet, Joseph Hanig, Thomas Hartung, Keli M. Hawthorne, Zhen He, Mary E. Huddleston, Saber Hussain, Syed Z. Imam, Shinya Ito, Patricia A. Janulewicz, Karl F. Jensen, David A. Jett, Thomas B. Knudsen, Andrew D. Kraft, Kannan Krishnan, Prateek Lala, Susan M. Lantz, Stephen M. Lasley, Francis S. Lee, Tom Leibson, Pamela J. Lein, Edward D. Levin, Grace Liejun Guo, John C. Lipscomb, Fang Liu, Feiyuan Liu, Shuliang Liu, Jocelyn M. Lutes, Susan L. Makris, Ashley J. Malin, Alexandra Mendlein, Jerrold S. Meyer, Mellessa M. Miller, Philip G. Morgan, Geeta Negi, Irena Nulman, Jeanene K. Olin, Tucker A. Patterson, Merle G. Paule, Michele M. Pisano, Jimcy Platholi, Gale A. Richardson, Courtney Roper, Hector Rosas-Hernandez, Helen J.K. Sable, Katerine S. Saili, Richard L. Salisbury, Sumit Sarkar, Margaret M. Sedensky, Larry P. Sheets, Talya Shulman, William Slikker, Lena Smirnova, Andrew Snyder, Christina Sobin, Gregg D. Stanwood, Suangsuda Supasai, John C. Talpos, Robert L. Tanguay, Charles Timchalk, Anneloes van Baar, Marjolein Verhoeven, Jennifer L. Walters, Cheng Wang, Amy L. Williams, Robert O. Wright, Xiaoxia Yang, Qi Yin, Xuan Zhang, and Todd J. Zurlinden

Published
2018
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2. Developmental Neurotoxicology of Antiepileptic Drugs

Author

Patricia A. Janulewicz, Jane Adams, Jolene E. Borchelt, and Jocelyn M. Lutes

Subjects
Phenytoin, Valproic Acid, Clinical research, business.industry, Neurogenesis, medicine, Phenobarbital, Carbamazepine, Levetiracetam, Pharmacology, Lamotrigine, business, medicine.drug
Abstract

Of the more than 30 drugs approved for the treatment of seizure disorders, only 6 medications have been evaluated for their safety in regard to the developing human brain and behavior following human gestational exposure. The clinical research findings for these medications (phenobarbital, phenytoin, carbamazepine, valproic acid, lamotrigine, and levetiracetam) when used in the monotherapeutic treatment of pregnant women with seizure disorders are reviewed, and from studies using animal models, information is presented on the nature and origin of the effects on the developing nervous system. This review suggests that valproic acid is the most potent with respect to developmental neurotoxicity and that phenobarbital and carbamazepine are also associated with adverse neurobehavioral teratogenic effects. Limited data on the newest medications, lamotrigine and levetiracetam, suggest relative safety. The neurobehavioral effects appear to be mediated by teratogenic impact upon critical developmental processes of neurogenesis, migration, apoptosis, and synaptogenesis.

Published
2018
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