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Abstract Endosomal trafficking of cell surface receptors is essential to their function. Integrins are transmembrane receptors that integrate adhesion to the extracellular matrix with engagement of the cytoskeleton. Ligated integrins mediate diverse signals that regulate matrix assembly, cell survival, cell morphology, and cell motility. Endosomal trafficking of integrins modulates these signals and contributes to cell motility and is required for cancer cell invasion. The phosphoprotein PEA-15 modulates integrin activation and ERK MAP Kinase signaling. To elucidate novel PEA-15 functions we utilized an unbiased proteomics approach. We identified several binding partners for PEA-15 in the endosome including clathrin and AP-2 as well as integrin β1 and other focal adhesion complex proteins. We confirmed these interactions using proximity ligation analysis, immunofluorescence imaging, pull-down and co-immunoprecipitation. We further found that PEA-15 is enriched in endosomes and was required for efficient endosomal internalization of α5β1 integrin and cellular migration. Importantly, PEA-15 promotion of migration was dependent on PEA-15 phosphorylation at serines 104 and 116. These data support a novel endosomal role for PEA-15 in control of endosomal trafficking of integrins through an association with the β1 integrin and clathrin complexes, and thereby regulation of cell motility.

Information on malnutrition for school‐age children and adolescents (5–19 years) in South Asia is fragmented and inconsistent, which limits the prioritization of nutrition policies, programmes and research for this age group. This scoping review aimed to synthesize existing evidence on the burden of malnutrition for children and adolescents aged 5–19 years in South Asia, and on interventions to improve their nutritional status. Cochrane Library, EMBASE, Medline and Google Scholar were systematically searched for articles published between January 2016 and November 2022. Eligible studies reported the prevalence of undernutrition, overweight/obesity, micronutrient deficiencies and unhealthy dietary intakes, and interventions that aimed to address these in South Asia. In total, 296 articles met our inclusion criteria. Evidence revealed widespread, yet heterogeneous, prevalence of undernutrition among South Asian children and adolescents: thinness (1.9%–88.8%), wasting (3%–48%), underweight (9.5%–84.4%) and stunting (3.7%–71.7%). A triple burden of malnutrition was evident: the prevalence of overweight and obesity ranged from 0.2% to 73% and 0% to 38% (with rapidly rising trends), respectively, alongside persistent micronutrient deficiencies. Diets often failed to meet nutritional requirements and high levels of fast‐food consumption were reported. Education, fortification, supplementation and school feeding programmes demonstrated beneficial effects on nutritional status. Comprehensive and regular monitoring of all forms of malnutrition among children and adolescents, across all countries in South Asia is required. Further, more large‐scale intervention research is needed to ensure policy and programmes effectively target and address malnutrition among children and adolescents in South Asia. Key messages: A triple burden of malnutrition (undernutrition, overweight/obesity and micronutrient deficiencies) is affecting children and adolescents (5–19 years) in South Asia, with heterogeneity within, and between, countries.In most countries, nationally representative data on the nutritional status of children and adolescents is absent and should be prioritized.Interventions targeting children and adolescents are primarily limited to small‐scale trials and focused predominantly on undernutrition and micronutrient deficiencies despite rapidly rising rates of overweight and obesity.Further research is needed to inform the scalability and sustainability of nutrition interventions across different contexts and to understand the effectiveness of policies and programmes that address overnutrition. [ABSTRACT FROM AUTHOR]

Summary: Background: Childhood obesity (5–9 years) in India is likely to contribute 11% to the global burden by 2030. Methods: Data from India's Comprehensive National Nutrition Survey (CNNS, 2016–2018) was used to assess the prevalence and key associated factors of overweight and obesity. Multivariable logistic regression models were applied to identify potential determinants associated with being overweight and obese. Results: Overweight prevalence (including obesity) varied from 1.6% (0–4 years) to 4.8% (10–19 years). The majority of states reported a higher proportion of adolescents overweight and obese, than younger age group 5–9 years. A significantly higher prevalence of children and adolescents with obesity was reported in higher wealth quintiles and residents of urban areas. The prevalence of overweight and obesity and associated demographic and health factors in India included: the presence of NCD risk factor (adolescents: 1.68, 95% CI [1.31–2.14]), micronutrient deficiency (5–9 years children: 1.72, 95% CI [1.30–2.28]), mother's education (5–9 years children: 4.84, 95% CI [2.92–8.03]; adolescents: 2.17, 95% CI [1.42–3.32]), wealth (adolescents: 1.92, 95% CI [1.16–3.19]), place of residence (5–9 years children: 1.68, 95% CI [1.39–2.03]; adolescents: 1.39, 95% CI [1.16–1.66]), child age (5–9 years children: 1.64, 95% CI [1.40–1.93], and screen‐time (adolescents: 1.63, 95% CI [1.22–2.19]. Conclusion: The findings set out policy and research recommendations to pave the path for curtailing the increasing prevalence of overweight and obesity and achieving the World Health Assembly's Global Nutrition target of 'no increase in childhood overweight (Target 4) by 2025'. [ABSTRACT FROM AUTHOR]

The ILR Review invited this group of scholars who work within the fields of sociology, history, and urban planning to share their perspective on the politics of skills. We called on their expertise to draw attention to the politics that drive the definition and development of skill and its use in shaping the rights and voice of workers. The essays in this forum explore the politics of skill along three lines. First, they interrogate the definition and assessment of skill, with particular attention to the ways that structural markers of social difference—such as race, gender, class, and immigration status—shape the valuation of skill. Second, they analyze the ways that the interpretation of skill is shaped by power dynamics at the worksite and in the broader economy. This line of analysis also considers possibilities for industrial renewal and labor mobilization. And third, the essays explore how skill classifications are used to narrow political and civil rights and to justify forms of exploitation and dehumanization. [ABSTRACT FROM AUTHOR]