35 results on '"Joel Yong"'
Search Results
2. The Translation of Nanomedicines in the Contexts of Spinal Cord Injury and Repair
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Wenqian Wang, Joel Yong, Paul Marciano, Ryan O’Hare Doig, Guangzhao Mao, and Jillian Clark
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nanomedicine ,spinal cord injury ,nanomaterial ,nanoparticle physico-chemistry ,nanocarrier drug delivery systems ,tissue engineering ,Cytology ,QH573-671 - Abstract
Purpose of this review: Manipulating or re-engineering the damaged human spinal cord to achieve neuro-recovery is one of the foremost challenges of modern science. Addressing the restricted permission of neural cells and topographically organised neural tissue for self-renewal and spontaneous regeneration, respectively, is not straightforward, as exemplified by rare instances of translational success. This review assembles an understanding of advances in nanomedicine for spinal cord injury (SCI) and related clinical indications of relevance to attempts to design, engineer, and target nanotechnologies to multiple molecular networks. Recent findings: Recent research provides a new understanding of the health benefits and regulatory landscape of nanomedicines based on a background of advances in mRNA-based nanocarrier vaccines and quantum dot-based optical imaging. In relation to spinal cord pathology, the extant literature details promising advances in nanoneuropharmacology and regenerative medicine that inform the present understanding of the nanoparticle (NP) biocompatibility–neurotoxicity relationship. In this review, the conceptual bases of nanotechnology and nanomaterial chemistry covering organic and inorganic particles of sizes generally less than 100 nm in diameter will be addressed. Regarding the centrally active nanotechnologies selected for this review, attention is paid to NP physico-chemistry, functionalisation, delivery, biocompatibility, biodistribution, toxicology, and key molecular targets and biological effects intrinsic to and beyond the spinal cord parenchyma. Summary: The advance of nanotechnologies for the treatment of refractory spinal cord pathologies requires an in-depth understanding of neurobiological and topographical principles and a consideration of additional complexities involving the research’s translational and regulatory landscapes.
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- 2024
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3. Chondroitin Sulfate Proteoglycan 4 as a Marker for Aggressive Squamous Cell Carcinoma
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Kathryn Chen, Joel Yong, Roland Zauner, Verena Wally, John Whitelock, Mila Sajinovic, Zlatko Kopecki, Kang Liang, Kieran Francis Scott, and Albert Sleiman Mellick
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chondroitin sulfate proteoglycan ,cutaneous squamous cell carcinoma ,head and neck squamous cell carcinoma ,cancer biomarker ,gene expression ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Chondroitin sulfate (CS) proteoglycan 4 (CSPG4) is a cell surface proteoglycan that is currently under investigation as a marker of cancer malignancy, and as a potential target of anticancer drug treatment. CSPG4 acts as a driver of tumourigenesis by regulating turnover of the extracellular matrix (ECM) to promote tumour cell invasion, migration as well as inflammation and angiogenesis. While CSPG4 has been widely studied in certain malignancies, such as melanoma, evidence is emerging from global gene expression studies, which suggests a role for CSPG4 in squamous cell carcinoma (SCC). While relatively treatable, lack of widely agreed upon diagnostic markers for SCCs is problematic, especially for clinicians managing certain patients, including those who are aged or infirm, as well as those with underlying conditions such as epidermolysis bullosa (EB), for which a delayed diagnosis is likely lethal. In this review, we have discussed the structure of CSPG4, and quantitatively analysed CSPG4 expression in the tissues and pathologies where it has been identified to determine the usefulness of CSPG4 expression as a diagnostic marker and therapeutic target in management of malignant SCC.
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- 2022
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4. Biomedical Applications of Metal–Organic Frameworks at the Subcellular Level
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Jueyi Xue, Jian Liu, Joel Yong, and Kang Liang
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biomimetics ,biopreservation ,metal–organic frameworks ,organelle-targeting therapy ,subcellular structures ,Biotechnology ,TP248.13-248.65 ,Medical technology ,R855-855.5 - Abstract
Organelles, or subcellular structures, are the fundamental functional units in almost all eukaryotic cells. Consequently, they play a critical role in the development of various biomedical applications, such as targeted drug delivery, biosensing, imaging, and biomimetics. Many efforts are devoted to developing nanosystems that can target specific organelles in a controlled manner. A series of nanomaterials with high porosity, stability, and easy‐to‐tailor properties, named metal–organic frameworks (MOFs), have shown to be a promising new class of nanocarriers and bioprotective exoskeletons for biomedical and biocatalytical platforms at the subcellular level. Herein, the recent state‐of‐the‐art progress of MOF nanomaterials for bioapplications at the subcellular level is highlighted. In the first section, MOF‐derived biomimetics organelles and subcellular structures are highlighted. Then, the strategies of organelle‐targeted MOF therapy and biosensing are illustrated. Next, MOF‐based biopreservation of organelles is introduced. Finally, a personal perspective about the challenges and future innovative designs is discussed.
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- 2021
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5. Current Status of the Use of Salvaged Blood in Metastatic Spine Tumour Surgery
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Naresh Kumar, Nivetha Ravikumar, Joel Yong Hao Tan, Kutbuddin Akbary, Ravish Shammi Patel, and Rajesh Kannan
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Cancer surgery ,Metastatic cancer surgery ,Intraoperative cell salvage ,Autologous salvaged blood ,Circulating neoplastic cells ,Metastatic spine tumour surgery ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
To review the current status of salvaged blood transfusion (SBT) in metastatic spine tumour surgery (MSTS), with regard to its safety and efficacy, contraindications, and adverse effects. We also aimed to establish that the safety and adverse event profile of SBT is comparable and at least equal to that of allogeneic blood transfusion. MEDLINE and Scopus were used to search for relevant articles, based on keywords such as “cancer surgery,” “salvaged blood,” and “circulating tumor cells.” We found 159 articles, of which 55 were relevant; 20 of those were excluded because they used other blood conservation techniques in addition to cell salvage. Five articles were manually selected from reference lists. In total, 40 articles were reviewed. There is sufficient evidence of the clinical safety of using salvaged blood in oncological surgery. SBT decreases the risk of postoperative infections and tumour recurrence. However, there are some limitations regarding its clinical applications, as it cannot be employed in cases of sepsis. In this review, we established that earlier studies supported the use of salvaged blood from a cell saver in conjunction with a leukocyte depletion filter (LDF). Furthermore, we highlight the recent emergence of sufficient evidence supporting the use of intraoperative cell salvage without an LDF in MSTS.
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- 2018
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6. Intraoperative cell-salvaged autologous blood transfusion is safe in metastatic spine tumour surgery: early outcomes of prospective clinical study
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Kumar, Naresh, Tan, Joel Yong Hao, Chen, Zhaojin, Ravikumar, Nivetha, Milavec, Helena, and Tan, Jiong Hao
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- 2023
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7. Analysis of unplanned hospital readmissions up to 2-years after metastatic spine tumour surgery
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Kumar, Naresh, Thomas, Andrew, Madhu, Sirisha, Ramos, Miguel Rafael David, Shen, Liang, Tan, Joel Yong Hao, Villanueva, Andre, Ravikumar, Nivetha, Liu, Gabriel, and Wong, Hee Kit
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- 2021
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8. Readmission-Free Survival Analysis in Metastatic Spine Tumour Surgical Patients: A Novel Concept
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Kumar, Naresh, Thomas, Andrew Cherian, Ramos, Miguel Rafael David, Tan, Joel Yong Hao, Shen, Liang, Madhu, Sirisha, Lopez, Keith Gerard, Villanueva, Andre, Tan, Jiong Hao, and Vellayappan, Balamurugan A.
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- 2021
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9. Evaluation of the Feasibility of Transfusing Leukocyte Depletion Filter–Processed Intraoperative Cell Salvage Blood in Metastatic Spine Tumor Surgery: Protocol for a Non Randomized Study (Preprint)
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Kumar, Naresh, primary, Hui, Si Jian, additional, Lee, Renick, additional, Athia, Sahil, additional, Tan, Joel Yong Hao, additional, and Tan, Jonathan Jiong Hao, additional
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- 2023
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10. Surgical Management of Missed Pediatric Monteggia Fractures: A Systematic Review and Meta-Analysis
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Tan, Si Heng Sharon, Low, Jia Ying, Chen, Hao, Tan, Joel Yong Hao, Lim, Andrew Kean Seng, and Hui, James Hoipo
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- 2022
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11. Factors influencing extended hospital stay in patients undergoing metastatic spine tumour surgery and its impact on survival
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Kumar, Naresh, Patel, Ravish Shammi, Wang, Samuel Sherng Young, Tan, Joel Yong Hao, Singla, Aditya, Chen, Zhaojin, Ravikumar, Nivetha, Tan, Amanda, Kumar, Nandika, Hey, Dennis Hwee Weng, Prasad, Samuel Vara, and Vellayappan, Balamurugan
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- 2018
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12. Definitive surgery is safe in borderline patients that respond to resuscitation
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Tan, Jiong Hao, Wu, Tien Yi, Hao Tan, Joel Yong, Sharon Tan, Si Heng, Hong, Choon Chiet, Liang, Shen, Mee-Ann Loo, Lynette, Iau, Philip, Murphy., Diarmuid Paul, and O’Neill, Gavin Kane
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- 2020
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13. Epidemiology and estimated economic impact of musculoskeletal injuries in polytrauma patients in a level one trauma centre in Singapore.
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Joel Yong Hao Tan, Jiong Hao Tan, Si Heng Sharon Tan, Liang Shen, Mee-Ann Loo, Lynette, Iau, Philip, Murphy, Diarmuid Paul, and O’Neill, Gavin Kane
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Introduction: Musculoskeletal injuries are the most common reason for surgical intervention in polytrauma patients. Methods: This is a retrospective cohort study of 560 polytrauma patients (injury severity score [ISS] >17) who suffered musculoskeletal injuries (ISS >2) from 2011 to 2015 in National University Hospital, Singapore. Results: 560 patients (444 [79.3%] male and 116 [20.7%] female) were identified. The mean age was 44 (range 3–90) years, with 45.4% aged 21–40 years. 39.3% of the patients were foreign migrant workers. Motorcyclists were involved in 63% of road traffic accidents. The mean length of hospital stay was 18.8 (range 0–273) days and the mean duration of intensive care unit (ICU) stay was 5.7 (range 0–253) days. Patient mortality rate was 19.8%. A Glasgow Coma Scale (GCS) score <12 and need for blood transfusion were predictive of patient mortality (p < 0.05); lower limb injuries, road traffic accidents, GCS score <8 and need for transfusion were predictive of extended hospital stay (p < 0.05); and reduced GCS score, need for blood transfusion and upper limb musculoskeletal injuries were predictive of extended ICU stay. Inpatient costs were significantly higher for foreign workers and greatly exceeded the minimum insurance coverage currently required. Conclusion: Musculoskeletal injuries in polytrauma remain a significant cause of morbidity and mortality, and occur predominantly in economically productive male patients injured in road traffic accidents and falls from height. Increasing insurance coverage for foreign workers in high‑risk jobs should be evaluated. [ABSTRACT FROM AUTHOR]
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- 2023
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14. Definitive Surgery Is Safe in Borderline Patients Who Respond to Resuscitation
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Lynette Mee-Ann Loo, Gavin Kane O'Neill, Joel Yong Hao Tan, Jiong Hao Tan, Tian Yi Wu, Liang Shen, Diarmuid Murphy, Si Heng Sharon Tan, Choon Chiet Hong, and Philip Iau
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Male ,medicine.medical_specialty ,Resuscitation ,medicine.medical_treatment ,Long bone ,Fractures, Bone ,03 medical and health sciences ,External fixation ,0302 clinical medicine ,Fracture Fixation ,medicine ,Humans ,Orthopedics and Sports Medicine ,Femur ,Retrospective Studies ,Fixation (histology) ,030222 orthopedics ,Multiple Trauma ,business.industry ,030208 emergency & critical care medicine ,Retrospective cohort study ,General Medicine ,medicine.disease ,Polytrauma ,Surgery ,Treatment Outcome ,medicine.anatomical_structure ,Breathing ,Female ,business - Abstract
Objectives We hypothesize that in adequately resuscitated borderline polytrauma patients with long bone fractures (femur and tibia) or pelvic fractures; early (within 4 days) definitive stabilization (EDS) can be performed without an increase in post-operative ventilation and post-operative complications. Design Retrospective Cohort Study SETTING:: Level 1 Trauma Centre PATIENTS:: In total 103 patients were included in this study of which 18 (17.5%) were female and 85(82.5%) were male. These patients were borderline trauma patients who had the following parameters prior to definitive surgery, normal coagulation profile, lactate Intervention These patients were treated either according to Early Total Care (ETC), definitive surgery on day of admission, or Damage Control Orthopaedics (DCO) principles, temporizing external fixation followed by definitive surgery at a later date. Timing of definitive surgical fixation was recorded as EDS or late definitive surgical fixation (LDS) (>4 days). Main outcome measurements Primary outcome measured was duration of ventilation more than 3 days post definitive surgery and presence of post-operative complications. Results 35 (34.0%) patients received ETC, while 68 (66.0%) patients were treated with DCO. In total 51 (49.5%) of all patients had LDS while 52 (50.5%) patients had EDS. On Logistic Regression the following factors were found to be predictive of higher rates of post -operative ventilation ≥ 3 days, Units of Blood Transfused and time to definitive surgery>4 days. Increased age, Head AIS 3 or more and Time to definitive surgery were found to be associated with an increased risk of post-operative complications. Conclusions Borderline polytrauma patients with no severe soft tissue injuries such as chest or head injuries may be treated with EDS if adequately resuscitated with no increase in need for post-operative ventilation and complications. Level of evidence Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
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- 2021
15. Locking the Ultrasound-Induced Active Conformation of Metalloenzymes in Metal-Organic Frameworks
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Jieying Liang, Muhammad Yazid Bin Zulkifli, Joel Yong, Zeping Du, Zhimin Ao, Aditya Rawal, Jason A. Scott, Jeffrey R. Harmer, Joseph Wang, and Kang Liang
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Colloid and Surface Chemistry ,Metalloproteins ,Solvents ,General Chemistry ,Heme ,Enzymes, Immobilized ,Biochemistry ,Catalysis ,Horseradish Peroxidase ,Metal-Organic Frameworks - Abstract
Enhancing the enzymatic activity inside metal-organic frameworks (MOFs) is a critical challenge in chemical technology and bio-technology, which, if addressed, will broaden their scope in energy, food, environmental, and pharmaceutical industries. Here, we report a simple yet versatile and effective strategy to optimize biocatalytic activity by using MOFs to rapidly "lock" the ultrasound (US)-activated but more fragile conformation of metalloenzymes. The results demonstrate that up to 5.3-fold and 9.3-fold biocatalytic activity enhancement of the free and MOF-immobilized enzymes could be achieved compared to those without US pretreatment, respectively. Using horseradish peroxidase as a model, molecular dynamics simulation demonstrates that the improved activity of the enzyme is driven by an opened gate conformation of the heme active site, which allows more efficient substrate binding to the enzyme. The intact heme active site is confirmed by solid-state UV-vis and electron paramagnetic resonance, while the US-induced enzyme conformation change is confirmed by circular dichroism spectroscopy and Fourier-transform infrared spectroscopy. In addition, the improved activity of the biocomposites does not compromise their stability upon heating or exposure to organic solvent and a digestion cocktail. This rapid locking and immobilization strategy of the US-induced active enzyme conformation in MOFs gives rise to new possibilities for the exploitation of highly efficient biocatalysts for diverse applications.
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- 2022
16. Regulating the Coordination Environment of Mesopore-Confined Single Atoms from Metalloprotein-MOFs for Highly Efficient Biocatalysis
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Jieying Liang, Bernt Johannessen, Zhibin Wu, Richard F. Webster, Joel Yong, Muhammad Yazid Bin Zulkifli, Joshua S. Harbort, You Rou Cheok, Haotian Wen, Zhimin Ao, Biao Kong, Shery L. Y. Chang, Jason Scott, and Kang Liang
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Mechanics of Materials ,Mechanical Engineering ,Iron ,Metalloproteins ,Biocatalysis ,General Materials Science ,Metal-Organic Frameworks ,Catalysis - Abstract
Single-atom catalysts (SACs) exhibit unparalleled atomic utilization and catalytic efficiency, yet it is challenging to modulate SACs with highly dispersed single-atoms, mesopores, and well-regulated coordination environment simultaneously and ultimately maximize their catalytic efficiency. Here, a generalized strategy to construct highly active ferric-centered SACs (Fe-SACs) is developed successfully via a biomineralization strategy that enables the homogeneous encapsulation of metalloproteins within metal-organic frameworks (MOFs) followed by pyrolysis. The results demonstrate that the constructed metalloprotein-MOF-templated Fe-SACs achieve up to 23-fold and 47-fold higher activity compared to those using metal ions as the single-atom source and those with large mesopores induced by Zn evaporation, respectively, as well as up to a 25-fold and 1900-fold higher catalytic efficiency compared to natural enzymes and natural-enzyme-immobilized MOFs. Furthermore, this strategy can be generalized to a variety of metal-containing metalloproteins and enzymes. The enhanced catalytic activity of Fe-SACs benefits from the highly dispersed atoms, mesopores, as well as the regulated coordination environment of single-atom active sites induced by metalloproteins. Furthermore, the developed Fe-SACs act as an excellent and effective therapeutic platform for suppressing tumor cell growth. This work advances the development of highly efficient SACs using metalloproteins-MOFs as a template with diverse biotechnological applications.
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- 2022
17. A Biomolecular Toolbox for Precision Nanomotors
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Joel Yong, Albert S. Mellick, John Whitelock, Joseph Wang, and Kang Liang
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Mechanics of Materials ,Mechanical Engineering ,General Materials Science - Abstract
The application of nanomotors for cancer diagnosis and therapy is a new and exciting area of research, which when combined with precision nanomedicine, promises to solve many of the issues encountered by previous development of passive nanoparticles. The goal of this article is to introduce nanomotor and nanomedicine researchers to the deep pool of knowledge available regarding cancer cell biology and biochemistry, as well as provide a greater appreciation of the complexity of cell membrane compositions, extracellular surfaces, and their functional consequences. We first provide a short description of the nanomotor state-of-art for cancer therapy and diagnosis, as well as recommendations for future directions of the field. Then, a biomolecular targeting toolbox has been collated for researchers looking to apply their nanomaterial of choice to a biological setting, as well as providing a glimpse into currently available clinical therapies and technologies. This toolbox contains an overview of different classes of targeting molecules available for high affinity and specific targeting and cell surface targets to aid researchers in the selection of a clinical disease model and targeting methodology. Biological systems are complex, and there is a steep learning curve for material scientists applying their skills to the fields of biochemistry and immunology. It is hoped that this review will provide biological context, inspiration, and direction to future nanomotor and nanomedicine research. This article is protected by copyright. All rights reserved.
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- 2022
18. Analysis of unplanned hospital readmissions up to 2-years after metastatic spine tumour surgery
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Hee-Kit Wong, Joel Yong Hao Tan, Sirisha Madhu, Liang Shen, Andrew Cherian Thomas, Nivetha Ravikumar, Miguel Rafael David Ramos, Naresh Kumar, Gabriel Liu, and Andre Villanueva
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medicine.medical_specialty ,Time Factors ,Multivariate analysis ,Tumour surgery ,Disease ,Logistic regression ,Patient Readmission ,03 medical and health sciences ,0302 clinical medicine ,Neoplasms ,Internal medicine ,medicine ,Humans ,Orthopedics and Sports Medicine ,Lung cancer ,Radiation treatment planning ,Retrospective Studies ,030222 orthopedics ,business.industry ,medicine.disease ,Spine ,Surgery ,sense organs ,Neurosurgery ,Spinal metastases ,business ,030217 neurology & neurosurgery - Abstract
The aim of this study was to investigate rates, causes, and risk factors of unplanned hospital readmissions (UHR) within 30 days, 90 days, 1 year and 2 years after metastatic spine tumour surgery (MSTS) to augment multi-disciplinary treatment planning and improve patient education. We retrospectively reviewed 272-patients who underwent MSTS between 2005 and 2016. Hospital records were utilised to obtain demographics, oncological, procedural details, and postoperative outcomes. All UHR within 2 years were reviewed. Primary outcomes were rates, causes, and risk factors of UHR. Risk factors for UHR were evaluated utilising multivariate logistic regression analysis. Thirty-day, 90 day, 1 year, and 2 year UHR-rates after MSTS were 17.2%, 31.1%, 46.2%, and 52.7%, respectively. Lung cancer primaries had the highest UHR-events (24.7%) whilst renal/thyroid displayed the least (6.6%). Disease-related causes (16.2%) were the most common reason for readmissions across all timeframes, followed by respiratory (13.7%) and progression of metastatic spine disease (12.7%). Urological conditions accounted for majority of readmissions within 30-days; disease-related causes, symptomatic spinal metastases, and respiratory conditions represented the most common causes at 30–90 days, 90 days–1 year, and 1–2 years, respectively. An ECOG >1 (p = 0.057), CCI >7 (p = 0.01), and primary lung tumour (p = 0.02) significantly increased UHR-risk on multivariate analysis. Seventy-four percent of patients had at least one UHR within 2 years of MSTS and majority were secondary to disease-related causes. Majority of first UHR occurred between 30 and 90 days post-surgery. Local disease progression and overall disease progression account for the highest UHR-events at 90 days–1 year and 1–2 year timeframes, respectively. We define UHR in specific timeframes, thus enabling better surveillance and reducing unnecessary morbidity.
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- 2021
19. Definitive Surgery Is Safe in Borderline Patients Who Respond to Resuscitation
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Tan, Jiong Hao, primary, Wu, Tian Yi, additional, Tan, Joel Yong Hao, additional, Sharon Tan, Si Heng, additional, Hong, Choon Chiet, additional, Shen, Liang, additional, Loo, Lynette Mee-Ann, additional, Iau, Philip, additional, Murphy, Diarmuid P., additional, and O'Neill, Gavin Kane, additional
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- 2021
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20. Factors influencing extended hospital stay in patients undergoing metastatic spine tumour surgery and its impact on survival
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Dennis Hey, Nivetha Ravikumar, Samuel Sherng Young Wang, Joel Yong Hao Tan, Zhaojin Chen, Ravish Shammi Patel, Amanda Tan, Naresh Kumar, Nandika Kumar, Aditya Singla, Balamurugan Vellayappan, and Samuel Vara Prasad
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Male ,medicine.medical_specialty ,Percentile ,Multivariate analysis ,Logistic regression ,Neurosurgical Procedures ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,Physiology (medical) ,Internal medicine ,medicine ,Humans ,In patient ,Spinal Cord Neoplasms ,Aged ,business.industry ,Incidence (epidemiology) ,Univariate ,Retrospective cohort study ,General Medicine ,Length of Stay ,Middle Aged ,Patient Discharge ,Neurology ,030220 oncology & carcinogenesis ,Cohort ,Female ,Surgery ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Metastatic spine tumour surgeries (MSTS) are indicated for preservation or restoration of neurological function, to provide mechanical stability and pain alleviation. The goal of MSTS is to improve the quality of life of the patients with spinal metastases and rarely for oncological control which is usually achieved by adjuvant therapies. Hence outcome measures such as length of stay (LOS) and rate of complications after MSTS are important indicators of quality but there is limited literature evidence for the same. We carried out a retrospective study to determine the incidence and the factors influencing normal (nLOS) and extended length of stay (eLOS) after MSTS. Data of 220 consecutive patients who underwent MSTS between 2005 and 2015 were retrieved from hospital electronic records. The preoperative, intraoperative and postoperative variables, discharge destinations as well as socioeconomic factors were analyzed. eLOS defined as positive when the LOS exceeded the 75th percentile for this cohort, was the key outcome indicator. Univariate and multivariate logistic regression analyses were performed to determine the predictive factors of eLOS. The overall median LOS was 7 days (1-30 days) and 55 patients had eLOS (LOS ≥ 11 days). Multivariate analysis revealed that significant variables independently associated with eLOS were instrumentation9 spinal segmental levels (OR 2.89, 95% CI 1.1-7.5, p = 0.032) and presence of postoperative complications (OR 3.68, 95% CI 1.85-7.30, p 0.001). Metastatic tumours other than breast, prostate and lung have lesser risk of eLOS (OR 0.31, 95% CI 0.14-0.70, p = 0.004). Survival estimates show that patients with eLOS have shorter survival than patients with nLOS (Crude HR 1.81, 95% CI 1.13-2.89, p = 0.003).
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- 2018
21. Managing mental illness in primary care - General Practitioners' perspective
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Wayne Freeman Chong, Harold Lim, and Shing Yew Joel Yong
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general practice ,gp ,mental illness ,primary care ,Medicine (General) ,R5-920 - Published
- 2013
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22. How Solar Hybrid Wind Turbine Brings Continuous Power Supply and Cost Optimization to Offshore Platforms in Malaysia
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Joel Yong Sen Lee and Daniel Khee Meng Liew
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Environmental science ,Submarine pipeline ,Turbine ,Cost optimization ,Power (physics) ,Marine engineering - Abstract
Solar power is one of the consideration for many oil & gas platform operators who are going for renewable energy to provide power. However for solar power, continuous power has been an issue especially during the Northeast monsoon (October – March) where the sun is frequently blocked by rain clouds. By using a hybrid of Photovoltaic (PV) modules and wind turbines to harvest both solar and wind power, power generation will be more stable and reliable. The results of this can be concluded by the results taken from a Malaysia offshore platform which had installed a wind turbine to their solar system in March 2018. The results show more consistent power generation with the hybridization of solar and wind power.
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- 2020
23. Current Status of the Use of Salvaged Blood in Metastatic Spine Tumour Surgery
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Ravish Shammi Patel, Joel Yong Hao Tan, Naresh Kumar, Rajesh Kannan, Nivetha Ravikumar, and Kutbuddin Akbary
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medicine.medical_specialty ,Blood transfusion ,Tumour surgery ,medicine.medical_treatment ,MEDLINE ,Intraoperative cell salvage ,Review Article ,030204 cardiovascular system & hematology ,Cell saver ,lcsh:RC346-429 ,Metastatic cancer surgery ,Sepsis ,03 medical and health sciences ,0302 clinical medicine ,Circulating tumor cell ,Cancer surgery ,Autologous salvaged blood ,medicine ,Adverse effect ,lcsh:Neurology. Diseases of the nervous system ,business.industry ,medicine.disease ,Surgery ,Circulating neoplastic cells ,030220 oncology & carcinogenesis ,Metastatic spine tumour surgery ,Neurology (clinical) ,business - Abstract
To review the current status of salvaged blood transfusion (SBT) in metastatic spine tumour surgery (MSTS), with regard to its safety and efficacy, contraindications, and adverse effects. We also aimed to establish that the safety and adverse event profile of SBT is comparable and at least equal to that of allogeneic blood transfusion. MEDLINE and Scopus were used to search for relevant articles, based on keywords such as “cancer surgery,” “salvaged blood,” and “circulating tumor cells.” We found 159 articles, of which 55 were relevant; 20 of those were excluded because they used other blood conservation techniques in addition to cell salvage. Five articles were manually selected from reference lists. In total, 40 articles were reviewed. There is sufficient evidence of the clinical safety of using salvaged blood in oncological surgery. SBT decreases the risk of postoperative infections and tumour recurrence. However, there are some limitations regarding its clinical applications, as it cannot be employed in cases of sepsis. In this review, we established that earlier studies supported the use of salvaged blood from a cell saver in conjunction with a leukocyte depletion filter (LDF). Furthermore, we highlight the recent emergence of sufficient evidence supporting the use of intraoperative cell salvage without an LDF in MSTS.
- Published
- 2018
24. Evaluation of the Feasibility of Transfusing Leucocyte Depletion Filter (LDF) Processed Intra-Operative Cell Salvage (IOCS) Blood in Metastatic Spine Tumour Surgery (MSTS): Protocol for a Non Randomised study (Preprint)
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Aravind Kumar, Jiong Hao Tan, Naresh Kumar, Rajesh Kannan, Rohit Vijay Agrawal, Helena Milavec, Joel Yong Hao Tan, and Nivetha Ravikumar
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medicine.medical_specialty ,Tumour surgery ,Intra operative ,medicine.anatomical_structure ,Leucocyte depletion ,business.industry ,Cell ,medicine ,General Medicine ,business ,Surgery - Abstract
BACKGROUND Metastatic Spine Tumour Surgery (MSTS) is often complex and extensive leading to significant blood loss. Allogeneic blood transfusion (ABT) is mainstay of blood replenishment but with immune-mediated post-operative complications. Alternative blood management techniques (salvaged blood transfusion (SBT)) allow us to overcome such complications. Despite widespread use of intra-operative cell salvage (IOCS) in oncological and non-oncological surgeries, surgeons remain reluctant to employ IOCS in MSTS. OBJECTIVE This study will analyse the safety of IOCS-LDF processed blood transfusion to patients undergoing MSTS by assessing clinical outcomes – disease progression: tumour progression and overall survival (OS). We will also evaluate whether reinfusion of IOCS-LDF processed blood can reduce the ABT rates in patients undergoing MSTS by comparing the proportion of MSTS patients requiring ABT in those patients who consent to receive SBT, and those who do not consent for SBT. METHODS We aim to recruit 90-patients (minimum)-30 SBT, 30 ABT and 30 with no blood transfusion (NBT). SBT and ABT form the two experimental arms, while NBT forms the control cohort. All available patient data will be reviewed to determine tumour burden secondary to metastasis and post-operative survival and/or disease progression, improvement in pain, neurology and ambulatory status. Collected data will be studied at 3, 6, 12 and 24 months post-operatively, or until demise, whichever occurs first. Collected outcomes of the experimental groups will be compared with that of the control group. Statistical Analysis: Outcomes will be analysed using one-way ANOVA and Fisher’s exact test. OS will be studied by Kaplan-Meier curve and log rank test. Multivariate and competing risk analysis will be used to study the association between blood transfusion type and tumour progression. All statistical analyses will be done using STATA/SE14.0 RESULTS This is the first clinical study on the use of IOCS in MSTS from various primary malignancies. It will provide major clinical evidence regarding safety and applicability of IOCS in MSTS. It will help reduce ABT usage; thus improving overall blood management of MSTS patients. However, limitation of this study is that not all patients undergoing MSTS will survive for the total follow-up period (two years), thereby theoretically leading to under-reporting of disease progression. CONCLUSIONS Results will be disseminated via peer-reviewed publications and will pave the way for future studies CLINICALTRIAL This study did not involve a healthcare intervention and hence, did not need to be registered
- Published
- 2019
25. How Solar Hybrid Wind Turbine Brings Continuous Power Supply and Cost Optimization to Offshore Platforms in Malaysia
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Lee, Joel Yong, additional and Liew, Daniel Khee, additional
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- 2020
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26. Biomedical Applications of Metal–Organic Frameworks at the Subcellular Level
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Joel Yong, Kang Liang, Jueyi Xue, and Jian Liu
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Chemistry ,fungi ,Nanotechnology ,metal–organic frameworks ,Medical technology ,General Earth and Planetary Sciences ,Metal-organic framework ,biomimetics ,R855-855.5 ,Biomimetics ,subcellular structures ,TP248.13-248.65 ,biopreservation ,organelle-targeting therapy ,Biotechnology ,General Environmental Science - Abstract
Organelles, or subcellular structures, are the fundamental functional units in almost all eukaryotic cells. Consequently, they play a critical role in the development of various biomedical applications, such as targeted drug delivery, biosensing, imaging, and biomimetics. Many efforts are devoted to developing nanosystems that can target specific organelles in a controlled manner. A series of nanomaterials with high porosity, stability, and easy‐to‐tailor properties, named metal–organic frameworks (MOFs), have shown to be a promising new class of nanocarriers and bioprotective exoskeletons for biomedical and biocatalytical platforms at the subcellular level. Herein, the recent state‐of‐the‐art progress of MOF nanomaterials for bioapplications at the subcellular level is highlighted. In the first section, MOF‐derived biomimetics organelles and subcellular structures are highlighted. Then, the strategies of organelle‐targeted MOF therapy and biosensing are illustrated. Next, MOF‐based biopreservation of organelles is introduced. Finally, a personal perspective about the challenges and future innovative designs is discussed.
- Published
- 2021
27. Evaluation of the Feasibility of Transfusing Leucocyte Depletion Filter (LDF) Processed Intra-Operative Cell Salvage (IOCS) Blood in Metastatic Spine Tumour Surgery (MSTS): Protocol for a Non Randomised study (Preprint)
- Author
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Kumar, Naresh, primary, Tan, Jiong Hao, additional, Ravikumar, Nivetha, additional, Tan, Joel Yong Hao, additional, Milavec, Helena, additional, Agrawal, Rohit, additional, Kannan, Rajesh, additional, and Kumar, Aravind, additional
- Published
- 2019
- Full Text
- View/download PDF
28. On the role of interconnected mini-grids in net-zero emissions electricity system: insights from Nigeria
- Author
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Joel Yongoua Nana and Michael O Dioha
- Subjects
Nigeria ,interconnected mini-grids ,power systems ,modern energy minimum ,energy transition ,Environmental technology. Sanitary engineering ,TD1-1066 ,Environmental sciences ,GE1-350 ,Science ,Physics ,QC1-999 - Abstract
As developing countries like Nigeria strive to reduce carbon emissions while expanding energy access, mini-grids’ role has gained recognition. However, limited analysis exists regarding the role of interconnected mini-grids (IMGs) in the transition to net-zero emissions electricity generation systems. Here, we employ a bottom-up energy system optimization modeling framework to explore the techno-economic implications of deploying IMGs in net-zero emissions electricity systems, using Nigeria as a case study. We find that IMGs can contribute to modest system-level cost reductions in net-zero emissions electricity systems. IMGs can help minimize stranded electricity generation assets and decrease the reliance on negative emissions technologies in scenarios aiming for net-zero emissions electricity systems by 2050. In scenarios where the net-zero target is delayed until 2070, the widespread deployment of comparatively affordable cleaner generators and the phaseout of fossil fuel power plants may render negative emission technologies unnecessary. The model results further indicate that IMGs can help reduce the use of captive diesel/gasoline gen-sets quickly, and nuclear power has a role in the electricity generation mix in all net-zero emissions scenarios. Moreover, in order to achieve the median per capita electricity consumption observed in high-income countries by the year 2050, Nigeria must undertake a formidable expansion of its current electricity generation capacity at a rate approximately six times greater than that dictated by a business-as-usual trajectory. The study also provides recommendations to address the policy, regulatory, and financial considerations crucial for implementing IMGs successfully.
- Published
- 2024
- Full Text
- View/download PDF
29. Evaluation of Prognostic Factors and Proposed Changes to the Modified Tokuhashi Score in Patients With Spinal Metastases From Breast Cancer
- Author
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Joel Yong Hao Tan, Jiong Hao Tan, Aye Sandar Zaw, Hwee Weng Dennis Hey, Naresh Kumar, and Kimberly-Anne Tan
- Subjects
Oncology ,Adult ,medicine.medical_specialty ,MEDLINE ,Breast Neoplasms ,Severity of Illness Index ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Internal medicine ,Severity of illness ,medicine ,Humans ,Orthopedics and Sports Medicine ,In patient ,Single institution ,Spinal Neoplasms ,Aged ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Prognosis ,Spine ,030220 oncology & carcinogenesis ,Female ,Neurology (clinical) ,Spinal metastases ,business ,030217 neurology & neurosurgery - Abstract
A retrospective study of all patients with histologically confirmed breast cancer spinal metastases presenting to a single institution between May 2001 and April 2012.The aim of this study was to investigate whether the 2014mT is more accurate than the 2005mT.The commonly used 2005 modified Tokuhashi score (2005mT) has become more inaccurate as oncologists move toward treating tumors according to their molecular and genomic profile, rather than their tissue-of-origin. In attempts to improve the accuracy of the 2005mT, a revised score (2014mT) was published, suggesting that hormone receptor negative and triple-negative breast cancer patients be given a modified Tokuhashi histological score of 3 rather than 5.Demographic characteristics, tumor receptor status, clinical findings in relation to the primary tumor and its metastases, and actual survival time were collated. The 2005mT was compared with the 2014mT. Univariate and multivariate Cox regression analyses were used to evaluate the influence of each parameter on survival, and receiver operating characteristic curves were used to determine predictive values of each score version.Of the 185 patients included, 32 underwent operative treatment, while 153 were managed nonoperatively for their spinal metastases. The overall cohort had a median survival time of 24 months following the diagnosis of spinal metastases, with a 6-month survival rate of 90%. Hormone, HER2 and triple-negative receptor statuses were significant predictors of poorer survival upon multivariate analysis (P = 0.004, P = 0.007, P 0.001, and P 0.001, respectively). Age, the original Tokuhashi score components, previous breast surgery for cancer, previous radiotherapy to the breast, previous radiotherapy to the spine, previous chemotherapy, and previous immunotherapy were not significant. At 6 months, the 2005mT AUROC was 0.62, while that of the 2014mT was 0.64 (P = 0.5394).Tumor histological subtype is crucial when prognosticating the survival of patients with breast cancer spinal metastases. Although the 2014mT was marginally more accurate than the 2005mT, its predictive ability remains poor.3.
- Published
- 2017
30. Current Status of the Use of Salvaged Blood in Metastatic Spine Tumour Surgery
- Author
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Kumar, Naresh, primary, Ravikumar, Nivetha, additional, Tan, Joel Yong Hao, additional, Akbary, Kutbuddin, additional, Patel, Ravish Shammi, additional, and Kannan, Rajesh, additional
- Published
- 2018
- Full Text
- View/download PDF
31. Evaluation of Prognostic Factors and Proposed Changes to the Modified Tokuhashi Score in Patients With Spinal Metastases From Breast Cancer
- Author
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Tan, Kimberly-Anne, primary, Tan, Jiong Hao, additional, Zaw, Aye Sandar, additional, Tan, Joel Yong Hao, additional, Hey, Hwee Weng Dennis, additional, and Kumar, Naresh, additional
- Published
- 2018
- Full Text
- View/download PDF
32. Personal Bias or Government Bias? Testing the Hostile Media Effect in a Regulated Press System
- Author
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Shing Yew Joel Yong, Stella C. Chia, Wei Ling Koh, and Zi Wen Diana Wong
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Government ,Hostile media effect ,Sociology and Political Science ,Political science ,Perception ,media_common.quotation_subject ,Control (management) ,Media coverage ,Media relations ,Relation (history of concept) ,Social psychology ,media_common - Abstract
This study examines the hostile media effect in relation to partisans’ perception of the slant of news coverage in a highly regulated press environment—Singapore. We found that partisans in Singapore perceived unbiased news to be in favor of the other side, while the nonpartisans perceived the same news to be neutral. Our findings show that hostile media effects can persist in a restricted press environment where people are aware of the government's control of media coverage. We also found that partisans’ awareness of the government's control of media information contributed to their perception of the article slant as well.
- Published
- 2007
33. Singaporeans' perceptions of and attitudes toward long-term care services
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Angelique Chan, Shiou Liang Wee, Wayne Freeman Chong, Joel Yong, Athel J. Hu, and Prassanna Raman
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Gerontology ,Male ,media_common.quotation_subject ,Population ,Older population ,Care recipient ,Interviews as Topic ,Nursing ,Asian People ,Perception ,Medicine ,Humans ,Perceived control ,Service usage ,education ,Qualitative Research ,media_common ,education.field_of_study ,Health Services Needs and Demand ,Singapore ,Caregivers caregiving ,business.industry ,Public Health, Environmental and Occupational Health ,Long-Term Care ,Long-term care ,Attitude ,Female ,business - Abstract
Use of long-term care (LTC) services among older adults in Asia has emerged as an important issue in light of rapidly aging countries and changing family structures. Simply building more LTC facilities will not result in higher usage rates, and more insight is needed on the usage of existing services. Few studies have been conducted among Asian populations outside Western settings on this topic. The multi-ethnic population in Singapore is useful for understanding the factors influencing the use of long-term care services in Asia. We present our qualitative findings on long-term care service usage in the older population (50+ years) over time. We highlight caregivers’ needs as an important determinant of LTC use. Although preferences of the care recipients were considered, caregiver needs, the availability of formal and informal care support, attitudes, perceived control, and social norms surrounding family caregiving governed the use of formal LTC services in Singapore.
- Published
- 2014
34. Managing mental illness in primary care - General Practitioners' perspective
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Harold Lim, Wayne Freeman Chong, and Shing Yew Joel Yong
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medicine.medical_specialty ,Health (social science) ,Sociology and Political Science ,education ,primary care ,Nursing ,medicine ,Dementia ,general practice ,gp ,mental illness ,Geriatrics ,Response rate (survey) ,lcsh:R5-920 ,business.industry ,Health Policy ,medicine.disease ,Mental illness ,Mental health ,Integrated care ,Respondent ,Anxiety ,medicine.symptom ,business ,lcsh:Medicine (General) - Abstract
Background: The Agency for Integrated Care (AIC) conducted a survey to determine the specific areas in which the agency could work with General Practitioners (GPs) to enhance mental illness management in Singapore. This survey was conducted as part of AIC’s engagement strategy and because the Primary Care Surveys 2010 and 2005 noted that a sizeable number of mental health cases are seen by GPs. Methodology: An interviewer-administered questionnaire was conducted among a random sample of 849 group and non-group GPs practicing in four geographical districts of Singapore. The response rate was 64%. Findings: About 70% of the respondent GPs indicated that they were seeing patients with mental illness. Anxiety and depression were the most commonly seen mental conditions. The lack of available drugs and facilities in the clinic, and unfamiliarity with mental health patient management were the main reasons that GPs do not see patients with mental illness. About 39% of the GPs referred patients to a psychologist. About 36% of the GPs referred patients to a counsellor. Availability of additional allied health services in the neighbourhood was crucial in encouraging GPs to see more patients with mental illness. General geriatrics, dementia, general mental health and major depression were the top four areas of interest for further training. Conclusions: The role of GPs in managing mental illnesses remains crucial. There is more pressing need to address their perceived difficulties in managing such patients. The results of the GP Landscape Survey provided evidential bases to enhance the National Mental Health Blueprint in three areas: (i) extension of GP consultation subsidies to middle-income patients, (ii) expansion of allied mental health services to support GPs, and (iii) development of training programmes for GPs in mental illnesses that are commonly encountered by and of interest to GPs.
- Published
- 2013
35. Epidemiology and estimated economic impact of musculoskeletal injuries in polytrauma patients in a level one trauma centre in Singapore.
- Author
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Tan JYH, Tan JH, Tan SHS, Shen L, Loo LM, Iau P, Murphy DP, and O'Neill GK
- Subjects
- Humans, Male, Female, Child, Preschool, Child, Adolescent, Young Adult, Adult, Middle Aged, Aged, Aged, 80 and over, Retrospective Studies, Singapore epidemiology, Length of Stay, Trauma Centers, Multiple Trauma epidemiology
- Abstract
Introduction: Musculoskeletal injuries are the most common reason for surgical intervention in polytrauma patients., Methods: This is a retrospective cohort study of 560 polytrauma patients (injury severity score [ISS] >17) who suffered musculoskeletal injuries (ISS >2) from 2011 to 2015 in National University Hospital, Singapore., Results: 560 patients (444 [79.3%] male and 116 [20.7%] female) were identified. The mean age was 44 (range 3-90) years, with 45.4% aged 21-40 years. 39.3% of the patients were foreign migrant workers. Motorcyclists were involved in 63% of road traffic accidents. The mean length of hospital stay was 18.8 (range 0-273) days and the mean duration of intensive care unit (ICU) stay was 5.7 (range 0-253) days. Patient mortality rate was 19.8%. A Glasgow Coma Scale (GCS) score <12 and need for blood transfusion were predictive of patient mortality (p < 0.05); lower limb injuries, road traffic accidents, GCS score <8 and need for transfusion were predictive of extended hospital stay (p < 0.05); and reduced GCS score, need for blood transfusion and upper limb musculoskeletal injuries were predictive of extended ICU stay. Inpatient costs were significantly higher for foreign workers and greatly exceeded the minimum insurance coverage currently required., Conclusion: Musculoskeletal injuries in polytrauma remain a significant cause of morbidity and mortality, and occur predominantly in economically productive male patients injured in road traffic accidents and falls from height. Increasing insurance coverage for foreign workers in high-risk jobs should be evaluated., Competing Interests: None
- Published
- 2023
- Full Text
- View/download PDF
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