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1. Consensus study on factors influencing the academic entrepreneur in a middle-income country’s university enterprise

Author

Farrell, Alfred Austin, Ashton, James, Mapanga, Witness, Joffe, Maureen, Chitha, Nombulelo, Beksinska, Mags, Chitha, Wezile, Coovadia, Ashraf, Cutland, Clare L., Drennan, Robin L., Kahn, Kathleen, Koekemoer, Lizette L., Micklesfield, Lisa K., Miot, Jacqui, Naidoo, Julian, Papathanasopoulos, Maria, Sive, Warrick, Smit, Jenni, Tollman, Stephen M., Veller, Martin G., Ware, Lisa J., Wing, Jeffrey, and Norris, Shane A.

Published
2024
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3. Multimorbidity and overall survival among women with breast cancer: results from the South African Breast Cancer and HIV Outcomes Study

Author

Ayeni, Oluwatosin A., Joffe, Maureen, Mapanga, Witness, Chen, Wenlong Carl, O’Neil, Daniel S., Phakathi, Boitumelo, Nietz, Sarah, Buccimazza, Ines, Čačala, Sharon, Stopforth, Laura W., Jacobson, Judith S., Crew, Katherine D., Neugut, Alfred I., Ramiah, Duvern, Ruff, Paul, Cubasch, Herbert, Chirwa, Tobias, McCormack, Valerie, Micklesfield, Lisa K., and Norris, Shane A.

Published
2023
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4. Geospatial disparities in survival of patients with breast cancer in sub-Saharan Africa from the African Breast Cancer-Disparities in Outcomes cohort (ABC-DO): a prospective cohort study

Author

Kim, Joanne, Macharia, Peter M, McCormack, Valerie, Foerster, Milena, Galukande, Moses, Joffe, Maureen, Cubasch, Herbert, Zietsman, Annelle, Anele, Angelica, Offiah, Shadrach, Parham, Groesbeck, Pinder, Leeya F, Anderson, Benjamin O, Schüz, Joachim, dos Santos-Silva, Isabel, and Togawa, Kayo

Published
2024
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7. The impact of HIV on non-adherence for tamoxifen among women with breast cancer in South Africa

Author

Ayeni, Oluwatosin A., Chiwambutsa, Shingirai, Chen, Wenlong Carl, Kapungu, Nyasha, Kanji, Comfort, Thelingwani, Roslyn, Murugan, Nivashni, Mathiba, Rofhiwa, Phakathi, Boitumelo, Nietz, Sarah, Ramiah, Duvern, O’Neil, Daniel S., Jacobson, Judith S., Ruff, Paul, Cubasch, Herbert, Chirwa, Tobias, Joffe, Maureen, Masimirembwa, Collen, and Neugut, Alfred I.

Published
2023
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8. Discovery and technical validation of high-performance methylated DNA markers for the detection of cervical lesions at risk of malignant progression in low- and middle-income countries

Author

Fackler, Mary Jo, Pleas, Madison, Li, Youran, Soni, Anushri, Xing, Deyin, Cope, Leslie, Ali, Syed, Van Le, Quang, Van Nguyen, Chu, Pham, Han Thi, Duong, Long Minh, Vanden Berg, Eunice, Wadee, Reubina, Michelow, Pamela, Chen, Wenlong Carl, Joffe, Maureen, Fjeldbo, Christina Saetan, Lyng, Heidi, and Sukumar, Saraswati

Published
2024
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10. Health system experiences of breast cancer survivors in urban South Africa

Author

Lambert, Madeleine, Mendenhall, Emily, Kim, Andrew Wooyoung, Cubasch, Herbert, Joffe, Maureen, and Norris, Shane A

Subjects
Health Services and Systems, Nursing, Health Sciences, Clinical Research, Breast Cancer, Prevention, Cancer, Behavioral and Social Science, Management of diseases and conditions, 7.1 Individual care needs, Adaptation, Psychological, Adult, Aged, Black People, Breast Neoplasms, Cancer Survivors, Comorbidity, Delayed Diagnosis, Female, Health Services Accessibility, Humans, Mastectomy, Middle Aged, Social Support, South Africa, Stress, Psychological, breast cancer, chemotherapy, comorbidity, mastectomy, Paediatrics and Reproductive Medicine, Public Health and Health Services, Obstetrics & Reproductive Medicine, Reproductive medicine, Public health
Abstract

BackgroundBreast cancer is the most common cancer globally and among South African women. Women from socioeconomically disadvantaged South African communities more often present later and receive total mastectomy compared to those from more affluent communities who have more breast conserving surgery (which is less invasive but requires mandatory radiation treatment post-operatively). Standard chemotherapy and total mastectomy treatments are known to cause traumatizing side effects and emotional suffering among South African women; moreover, many women face limited communication with physicians and psychological support.ObjectiveThis article investigates the experiences of women seeking breast cancer treatment at the largest public hospital in South Africa.MethodsWe interviewed 50 Black women enrolled in the South African Breast Cancer Study to learn more about their health system experiences with detection, diagnosis, treatment, and follow-up care for breast cancer. Each interview was between 2-3 hours, addressing perceptions, experiences, and concerns associated with breast cancer and comorbidities such as HIV and hypertension.ResultsWe found most women feared diagnosis, in part, because of the experience of chemotherapy and physical mutilation related to mastectomy. The importance of social support from family, religion, and clinical staff was fundamental for women coping with their condition and adhering to treatment and medication.ConclusionsThese findings exemplify how interventions might promote early detection of breast cancer and better adherence to treatment. Addressing community perceptions of breast cancer, patient needs and desires for treatment, structural barriers to intensive therapies, and the burden of invasive treatments are imperative next steps for delivering better breast cancer care in Soweto and other resource-constrained settings.

Published
2020

11. Testing the generalizability of ancestry-specific polygenic risk scores to predict prostate cancer in sub-Saharan Africa

Author

Kim, Michelle S., Naidoo, Daphne, Hazra, Ujani, Quiver, Melanie H., Chen, Wenlong C., Simonti, Corinne N., Kachambwa, Paidamoyo, Harlemon, Maxine, Agalliu, Ilir, Baichoo, Shakuntala, Fernandez, Pedro, Hsing, Ann W., Jalloh, Mohamed, Gueye, Serigne M., Niang, Lamine, Diop, Halimatou, Ndoye, Medina, Snyper, Nana Yaa, Adusei, Ben, Mensah, James E., Abrahams, Afua O. D., Biritwum, Richard, Adjei, Andrew A., Adebiyi, Akindele O., Shittu, Olayiwola, Ogunbiyi, Olufemi, Adebayo, Sikiru, Aisuodionoe-Shadrach, Oseremen I., Nwegbu, Maxwell M., Ajibola, Hafees O., Oluwole, Olabode P., Jamda, Mustapha A., Singh, Elvira, Pentz, Audrey, Joffe, Maureen, Darst, Burcu F., Conti, David V., Haiman, Christopher A., Spies, Petrus V., van der Merwe, André, Rohan, Thomas E., Jacobson, Judith, Neugut, Alfred I., McBride, Jo, Andrews, Caroline, Petersen, Lindsay N., Rebbeck, Timothy R., and Lachance, Joseph

Published
2022
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13. Treatment guideline concordance, initiation, and abandonment in patients with non-metastatic breast cancer from the African Breast Cancer–Disparities in Outcomes (ABC-DO) cohort in sub-Saharan Africa: a prospective cohort study

Author

Foerster, Milena, McCormack, Valerie, Anderson, Benjamin O, Boucheron, Pauline, Zietsman, Annelle, Cubasch, Herbert, Joffe, Maureen, Anele, Angelica, Offiah, Shadrach, Galukande, Moses, Parham, Groesbeck, Pinder, Leeya F, Ginsburg, Ophira, Schüz, Joachim, dos-Santos-Silva, Isabel, and Kantelhardt, Eva J

Published
2022
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15. Overall and central obesity and prostate cancer risk in African men

Author

Agalliu, Ilir, Lin, Wei-Kaung Jerry, Zhang, Janice S., Jacobson, Judith S., Rohan, Thomas E., Adusei, Ben, Snyper, Nana Yaa F., Andrews, Caroline, Sidahmed, Elkhansa, Mensah, James E., Biritwum, Richard, Adjei, Andrew A., Okyne, Victoria, Ainuson-Quampah, Joana, Fernandez, Pedro, Irusen, Hayley, Odiaka, Emeka, Folasire, Oluyemisi Folake, Ifeoluwa, Makinde Gabriel, Aisuodionoe-Shadrach, Oseremen I., Nwegbu, Maxwell Madueke, Pentz, Audrey, Chen, Wenlong Carl, Joffe, Maureen, Neugut, Alfred I., Diallo, Thierno Amadou, Jalloh, Mohamed, Rebbeck, Timothy R., Adebiyi, Akindele Olupelumi, and Hsing, Ann W.

Published
2022
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16. Uncovering the genetic architecture and evolutionary roots of androgenetic alopecia in African men

Author

Janivara, Rohini, primary, Hazra, Ujani, additional, Pfennig, Aaron, additional, Harlemon, Maxine, additional, Kim, Michelle S., additional, Eaaswarkhanth, Muthukrishnan, additional, Chen, Wenlong C., additional, Ogunbiyi, Adebola, additional, Kachambwa, Paidamoyo, additional, Petersen, Lindsay N., additional, Jalloh, Mohamed, additional, Mensah, James E., additional, Adjei, Andrew A., additional, Adusei, Ben, additional, Joffe, Maureen, additional, Gueye, Serigne M., additional, Aisuodionoe-Shadrach, Oseremen I., additional, Fernandez, Pedro W., additional, Rohan, Thomas E., additional, Andrews, Caroline, additional, Rebbeck, Timothy R., additional, Adebiyi, Akindele O., additional, Agalliu, Ilir, additional, and Lachance, Joseph, additional

Published
2024
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17. The Association of HIV Status with Triple-Negative Breast Cancer in South African Breast Cancer Patients

Author

Dubner, Jacob L., primary, Neugut, Alfred I., additional, Joffe, Maureen, additional, O’Neil, Daniel S., additional, Ayeni, Oluwatosin A., additional, Chen, Carl, additional, Buccimazza, Ines, additional, Čačala, Sharon R., additional, Stopforth, Laura W., additional, Farrow, Hayley A., additional, Nietz, Sarah, additional, Murugan, Nivashini, additional, Phakathi, Boitumelo, additional, Jacobson, Judith S., additional, Crew, Katherine, additional, McCormack, Valarie, additional, Ruff, Paul, additional, Cubasch, Herbert, additional, and Pumpalova, Yoanna S., additional

Published
2024
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18. High-performance methylated DNA markers for the detection of cervical lesions at risk of malignant progression in low- and middle-income countries

Author

Fackler, Mary Jo, primary, Pleas, Madison, additional, Li, Youran, additional, Soni, Anushri, additional, Xing, Deyin, additional, Cope, Leslie, additional, Ali, Syed, additional, Le, Quang Van, additional, Nguyen, Chu Van, additional, Pham, Han Thi, additional, Duong, Long Minh, additional, Berg, Eunice Van Den, additional, Wadee, Reubina, additional, Michelow, Pamela, additional, Chen, Wenlong Carl, additional, Joffe, Maureen, additional, Fjeldbo, Christina Santen, additional, Lyng, Hiedi, additional, and Sukumar, Saraswati, additional

Published
2023
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21. Breast cancer survival and survival gap apportionment in sub-Saharan Africa (ABC-DO): a prospective cohort study

Author

McCormack, Valerie, McKenzie, Fiona, Foerster, Milena, Zietsman, Annelle, Galukande, Moses, Adisa, Charles, Anele, Angelica, Parham, Groesbeck, Pinder, Leeya F, Cubasch, Herbert, Joffe, Maureen, Beaney, Thomas, Quaresma, Manuela, Togawa, Kayo, Abedi-Ardekani, Behnoush, Anderson, Benjamin O, Schüz, Joachim, and dos-Santos-Silva, Isabel

Published
2020
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22. A comparison of complete pathologic response rates following neoadjuvant chemotherapy among South African breast cancer patients with and without concurrent HIV infection

Author

Nietz, Sarah, O’Neil, Daniel S, Ayeni, Oluwatosin, Chen, Wenlong Carl, Joffe, Maureen, Jacobson, Judith S, Neugut, Alfred I, Ruff, Paul, Mapanga, Witness, Buccimazza, Ines, Singh, Urishka, Čačala, Sharon, Stopforth, Laura, Phakathi, Boitumelo, Chirwa, Tobias, and Cubasch, Herbert

Published
2020
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24. The South African breast cancer and HIV outcomes study: Profiling the cancer centres and cohort characteristics, diagnostic pathways, and treatment approaches

Author

Mapanga, Witness, primary, Ayeni, Oluwatosin A., additional, Chen, Wenlong Carl, additional, Jacobson, Judith S., additional, Neugut, Alfred I., additional, Ruff, Paul, additional, Cubasch, Herbert, additional, O’Neil, Daniel S., additional, Buccimazza, Ines, additional, Čačala, Sharon, additional, Stopforth, Laura W., additional, Farrow, Hayley A., additional, Nietz, Sarah, additional, Phakathi, Boitumelo, additional, Chirwa, Tobias, additional, McCormack, Valerie A., additional, and Joffe, Maureen, additional

Published
2023
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25. Heterogeneous genetic architectures and evolutionary genomics of prostate cancer in Sub-Saharan Africa

Author

Rebbeck, Timothy, primary, Janivara, Rohini, additional, Chen, Wenlong, additional, Hazra, Ujani, additional, Baichoo, Shakuntala, additional, Agalliu, Ilir, additional, Kachambwa, Paidamoyo, additional, Simonti, Corinne, additional, Brown, Lyda, additional, Tambe, Saanika, additional, Kim, Michelle, additional, Harlemon, Maxine, additional, Jalloh, Mohamed, additional, Muzondiwa, Dillon, additional, Naidoo, Daphne, additional, Ajayi, Olabode, additional, Snyper, Nana, additional, Niang, Lamine, additional, Diop, Halimatou, additional, Ndoye, Medina, additional, Mensah, James, additional, Darkwa-Abrahams, Afua, additional, Biritwum, Richard, additional, Adjei, Andrew, additional, Adebiyi, Akindele, additional, Shittu, Olayiwola, additional, Ogunbiyi, Olufemi, additional, Adebayo, Sikiru, additional, Nwegbu, Maxwell, additional, Ajibola, Hafees, additional, Oluwole, Olabode, additional, Jamda, Mustapha, additional, Pentz, Audrey, additional, Haiman, Christopher, additional, Spies, Petrus, additional, Merwe, Andre Van der, additional, Cook, Michael, additional, Chanock, Stephen J., additional, Berndt, Sonja I., additional, Watya, Stephen, additional, Lubwama, Alex, additional, Muchengeti, Mazvita, additional, Doherty, Sean, additional, Smyth, Natalie, additional, Lounsbury, David, additional, Fortier, Brian, additional, Rohan, Thomas, additional, Jacobson, Judith, additional, Neugut, Alfred, additional, Hsing, Ann, additional, Gusev, Alexander, additional, Aisuodionoe-Shadrach, Oseremen, additional, Joffe, Maureen, additional, Adusei, Ben, additional, Gueye, Serigne, additional, Fernandez, Pedro, additional, McBride, Jo, additional, Andrews, Caroline, additional, Petersen, Lindsay, additional, and Lachance, Joseph, additional

Published
2023
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26. FGFR2 genetic variants in women with breast cancer

Author

Dix‑Peek, Thérèse, primary, Dickens, Caroline, additional, Augustine, Tanya, additional, Phakathi, Boitumelo, additional, Van Den Berg, Eunice, additional, Joffe, Maureen, additional, Ayeni, Oluwatosin, additional, Cubasch, Herbert, additional, Nietz, Sarah, additional, Mathew, Christopher, additional, Hayat, Mahtaab, additional, Neugut, Alfred, additional, Jacobson, Judith, additional, Ruff, Paul, additional, and Duarte, Raquel, additional

Published
2023
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28. P-092 High serum free light chains levels in African ancestry population screened for monoclonal gammopathy: implication for definition of FLC reference range accounting for renal function and race

Author

Bertamini, Luca, primary, Alberge, Jean-Baptiste, additional, El-Khoury, Habib, additional, Lee, David, additional, Fleming, Grace, additional, Murphy, Ciara, additional, Davis, Maya, additional, Perry, Jacqueline, additional, Cea-Curry, Christian, additional, Pentz, Audrey, additional, Hlubi, Thulisile, additional, Smyth, Natalie, additional, Sakrikar, Dhananjay, additional, Perkins, Mark, additional, Harding, Stephen, additional, Troske, Derek, additional, Getz, Gad, additional, Rebbeck, Timothy, additional, Joffe, Maureen, additional, Marinac, Catherine, additional, Leung, Nelson, additional, Chen, Wenlong Carl, additional, and Ghobrial, Irene, additional

Published
2023
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31. Biochemical progression free and overall survival among Black men with stage IV prostate cancer in South Africa: Results from a prospective cohort study.

Author

Pumpalova, Yoanna S., Ramakrishnan, Adarsh, May, Michael, Pentz, Audrey, Minkowitz, Shauli, Doherty, Sean, Singh, Elvira, Chen, Wenlong Carl, Rebbeck, Timothy R., Neugut, Alfred I., and Joffe, Maureen

Subjects
PROSTATE cancer, BLACK South Africans, PROGRESSION-free survival, BLACK men, SOUTH Africans, ANDROGEN deprivation therapy
Abstract

Background: Men of African descent are disproportionately affected by prostate cancer (PCa), and many have metastatic disease at presentation. In South Africa (SA), androgen deprivation therapy (ADT) is the first-line treatment for stage IV PCa. Objective: To identify predictors of overall survival (OS) in Black South African men with stage IV PCa treated with ADT. Design, Setting, and Participants: Men diagnosed with prostate cancer (3/22/2016–10/30/2020) at Chris Hani Baragwanath Academic Hospital in Soweto, Johannesburg, were recruited for the Men of African Descent with Cancer of the Prostate study. We included men with newly diagnosed stage IV PCa treated with ADT who had a prostate-specific antigen (PSA) level drawn prior to initiation of ADT and had ≥1 PSA drawn ≥12weeks after ADT start. Outcomes Measures and Statistical Analysis: We used Kaplan–Meier statistics to estimate OS and Cox regression models to identify predictors of OS. Results and Limitations: Of the 1097 men diagnosed with prostate cancer, we included 153 men with stage IV PCa who received ADT and met PSA requirements. The median age was 68.0 years (interquartile range 64–73 years). Median OS from time of ADT initiation was 3.39 years (95% confidence interval (CI): 3.14%–noncalculable), while biochemical progression-free survival was 2.36 years (95% CI: 2.03%–3.73%). Biochemical progression (HR 3.52, 95% CI: 1.85%–6.70%), PSA nadir level >4ng/mL (HR 3.77, 95% CI: 1.86%–7.62%), alkaline phosphatase level at diagnosis >150 IU/dL (HR 3.09, 95% CI: 1.64%– 5.83%), and hemoglobin at diagnosis <13.5 g/dL (HR 2.90, 95% CI: 1.28%–6.56%) were associated with worse OS. Conclusions: In this study, we identified factors associated with poor OS among Black South African men with stage IV PCa treated with ADT. These factors may be useful in identifying patients for upfront treatment escalation, including the use of docetaxel chemotherapy or escalation of therapy at the time of biochemical progression. Patient Summary: In this study, we found that high alkaline phosphatase level, anemia at diagnosis, and high PSA nadir after initiation of androgen deprivation therapy are associated with worse overall survival among Black South African men treated with androgen deprivation therapy for metastatic prostate cancer. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Consensus study on factors influencing the academic entrepreneur in a middle-income country’s university enterprise

Author

Farrell, Alfred Austin, primary, Ashton, James, additional, Mapanga, Witness, additional, Joffe, Maureen, additional, Chitha, Nombulelo, additional, Beksinska, Mags, additional, Chitha, Wezile, additional, Coovadia, Ashraf, additional, Cutland, Clare L., additional, Drennan, Robin L., additional, Kahn, Kathleen, additional, Koekemoer, Lizette L., additional, Micklesfield, Lisa K., additional, Miot, Jacqui, additional, Naidoo, Julian, additional, Papathanasopoulos, Maria, additional, Sive, Warrick, additional, Smit, Jenni, additional, Tollman, Stephen M., additional, Veller, Martin G., additional, Ware, Lisa J., additional, Wing, Jeffrey, additional, and Norris, Shane A., additional

Published
2023
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33. Supplementary Figure 4 from Regional Variation in the Tumor Microenvironment, Immune Escape and Prognostic Factors in Breast Cancer in Sub-Saharan Africa

Author

Bauer, Marcus, primary, Vetter, Martina, primary, Stückrath, Kathrin, primary, Yohannes, Meron, primary, Desalegn, Zelalem, primary, Yalew, Tewodros, primary, Bekuretsion, Yonas, primary, Kenea, Tariku W., primary, Joffe, Maureen, primary, van den Berg, Eunice J., primary, Nikulu, Julien I., primary, Bakarou, Kamate, primary, Manraj, Shyam S., primary, Ogunbiyi, Olufemi J., primary, Ekanem, Ima-Obong, primary, Igbinoba, Festus, primary, Diomande, Mohenou, primary, Adebamowo, Clement, primary, Dzamalala, Charles P., primary, Anele, Angelica A., primary, Zietsman, Annelle, primary, Galukande, Moses, primary, Foerster, Milena, primary, dos-Santos-Silva, Isabel, primary, Liu, Biying, primary, Santos, Pablo, primary, Jemal, Ahmedin, primary, Abebe, Tamrat, primary, Wickenhauser, Claudia, primary, Seliger, Barbara, primary, McCormack, Valerie, primary, and Kantelhardt, Eva J., primary

Published
2023
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37. A qualitative study to explore healthcare providers’ perspectives on barriers and enablers to early detection of breast and cervical cancers among women attending primary healthcare clinics in Johannesburg, South Africa

Author

Tshabalala, Gugulethu, primary, Blanchard, Charmaine, additional, Mmoledi, Keletso, additional, Malope, Desiree, additional, O’Neil, Daniel S., additional, Norris, Shane A., additional, Joffe, Maureen, additional, and Dietrich, Janan Janine, additional

Published
2023
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38. Effects of Genetic Polymorphisms of Drug Metabolizing Enzymes and co‐Medications on Tamoxifen Metabolism in Black South African Women with Breast Cancer

Author

Chiwambutsa, Shingirai M., primary, Ayeni, Oluwatosin, additional, Kapungu, Nyasha, additional, Kanji, Comfort, additional, Thelingwani, Roslyn, additional, Chen, Wenlong Carl, additional, Mokone, Dikeledi H., additional, O'Neil, Daniel S., additional, Neugut, Alfred I., additional, Jacobson, Judith S., additional, Ruff, Paul, additional, Cubasch, Herbert, additional, Joffe, Maureen, additional, and Masimirembwa, Collen, additional

Published
2023
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39. Regional variation in the tumor microenvironment, immune escape and prognostic factors in breast cancer in sub-Saharan Africa

Author

Bauer, Marcus, primary, Vetter, Martina, additional, Stückrath, Kathrin, additional, Yohannes, Meron, additional, Desalegn, Zelalem, additional, Yalew, Tewodros, additional, Bekuretsion, Yonas, additional, Kenea, Tariku W., additional, Joffe, Maureen, additional, Van Den Berg, Eunice J., additional, Nikulu, Julien Ilunga., additional, Bakarou, Kamaté, additional, Manraj, Shyam S., additional, Ogunbiyi, Olufemi J., additional, Ekanem, Ima-Obong, additional, Igbinoba, Festus, additional, Diomande, Mohenou, additional, Adebamowo, Clement, additional, Dzamalala, Charles P., additional, Anele, Angelica A., additional, Zietsman, Annelle, additional, Galukande, Moses, additional, Foerster, Milena, additional, dos-Santos-Silva, Isabel, additional, Liu, Biying, additional, Santos, Pablo, additional, Jemal, Ahmedin, additional, Abebe, Tamrat, additional, Wickenhauser, Claudia, additional, Seliger, Barbara, additional, McCormack, Valerie, additional, and Kantelhardt, Eva J., additional

Published
2023
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40. Abstract 3508: Association between clonal hematopoiesis and risk of prostate cancer in a large sample of African ancestry men

Author

Wang, Anqi, primary, Xu, Yili, additional, Sheng, Xin, additional, Hughley, Raymond, additional, Adusei, Ben, additional, Jalloh, Mohamed, additional, Gueye, Serigne Magueye, additional, Adjei, Andrew A, additional, Mensah, James, additional, Fernandez, Pedro W., additional, Adebiyi, Akin Olupelumi, additional, Aisuodionoe-Shadrach, Oseremen Inokhoife, additional, Petersen, Lindsay, additional, Joffe, Maureen, additional, Bensen, Jeannette T., additional, Mohler, James L., additional, Taylor, Jack A., additional, Butler, Eboneé N., additional, Ingles, Sue A., additional, Rybicki, Benjamin A., additional, Stanford, Janet L., additional, Zheng, Wei, additional, Berndt, Sonja I., additional, Huff, Chad D., additional, Lachance, Joseph, additional, Multigner, Luc, additional, Andrews, Caroline, additional, Rebbeck, Timothy R., additional, Brureau, Laurent, additional, Chanock, Stephen J., additional, de Smith, Adam, additional, Chen, Fei, additional, Darst, Burcu F., additional, Conti, David V., additional, and Haiman, Christopher A., additional

Published
2023
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41. Abstract 1182: Association of prostate cancer candidate genes with overall and aggressive prostate cancer in men of African ancestry

Author

Chen, Fei, primary, Darst, Burcu F., additional, Sheng, Xin, additional, Wang, Anqi, additional, Xu, Yili, additional, Hughley, Raymond, additional, Adusei, Ben, additional, Jalloh, Mohamed, additional, Gueye, Serigne Magueye, additional, Adjei, Andrew A., additional, Mensah, James, additional, Fernandez, Pedro W., additional, Adebiyi, Akindele O., additional, Aisuodionoe-Shadrach, Oseremen, additional, Petersen, Lindsay, additional, Joffe, Maureen, additional, McBride, Jo, additional, Bensen, Jeannette T., additional, Mohler, James L., additional, Taylor, Jack A., additional, Butler, Eboneé N., additional, Ingles, Sue A., additional, Rybicki, Benjamin A., additional, Stanford, Janet L., additional, Zheng, Wei, additional, Berndt, Sonja I., additional, Huff, Chad D., additional, Lachance, Joseph, additional, Multigner, Luc, additional, Andrews, Caroline, additional, Rebbeck, Timothy R., additional, Brureau, Laurent, additional, Chanock, Stephen J., additional, Conti, David V., additional, and Haiman, Christopher A., additional

Published
2023
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42. Table S4 from A Custom Genotyping Array Reveals Population-Level Heterogeneity for the Genetic Risks of Prostate Cancer and Other Cancers in Africa

Author

Harlemon, Maxine, primary, Ajayi, Olabode, primary, Kachambwa, Paidamoyo, primary, Kim, Michelle S., primary, Simonti, Corinne N., primary, Quiver, Melanie H., primary, Petersen, Desiree C., primary, Mittal, Anuradha, primary, Fernandez, Pedro W., primary, Hsing, Ann W., primary, Baichoo, Shakuntala, primary, Agalliu, Ilir, primary, Jalloh, Mohamed, primary, Gueye, Serigne M., primary, Snyper, Nana Yaa F., primary, Adusei, Ben, primary, Mensah, James E., primary, Abrahams, Afua O.D., primary, Adebiyi, Akindele O., primary, Orunmuyi, Akin T., primary, Aisuodionoe-Shadrach, Oseremen I., primary, Nwegbu, Maxwell M., primary, Joffe, Maureen, primary, Chen, Wenlong C., primary, Irusen, Hayley, primary, Neugut, Alfred I., primary, Quintana, Yuri, primary, Seutloali, Moleboheng, primary, Fadipe, Mayowa B., primary, Warren, Christopher, primary, Woehrmann, Marcos H., primary, Zhang, Peng, primary, Ongaco, Chrissie M., primary, Mawhinney, Michelle, primary, McBride, Jo, primary, Andrews, Caroline V., primary, Adams, Marcia, primary, Pugh, Elizabeth, primary, Rebbeck, Timothy R., primary, Petersen, Lindsay N., primary, and Lachance, Joseph, primary

Published
2023
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43. Data from A Custom Genotyping Array Reveals Population-Level Heterogeneity for the Genetic Risks of Prostate Cancer and Other Cancers in Africa

Author

Harlemon, Maxine, primary, Ajayi, Olabode, primary, Kachambwa, Paidamoyo, primary, Kim, Michelle S., primary, Simonti, Corinne N., primary, Quiver, Melanie H., primary, Petersen, Desiree C., primary, Mittal, Anuradha, primary, Fernandez, Pedro W., primary, Hsing, Ann W., primary, Baichoo, Shakuntala, primary, Agalliu, Ilir, primary, Jalloh, Mohamed, primary, Gueye, Serigne M., primary, Snyper, Nana Yaa F., primary, Adusei, Ben, primary, Mensah, James E., primary, Abrahams, Afua O.D., primary, Adebiyi, Akindele O., primary, Orunmuyi, Akin T., primary, Aisuodionoe-Shadrach, Oseremen I., primary, Nwegbu, Maxwell M., primary, Joffe, Maureen, primary, Chen, Wenlong C., primary, Irusen, Hayley, primary, Neugut, Alfred I., primary, Quintana, Yuri, primary, Seutloali, Moleboheng, primary, Fadipe, Mayowa B., primary, Warren, Christopher, primary, Woehrmann, Marcos H., primary, Zhang, Peng, primary, Ongaco, Chrissie M., primary, Mawhinney, Michelle, primary, McBride, Jo, primary, Andrews, Caroline V., primary, Adams, Marcia, primary, Pugh, Elizabeth, primary, Rebbeck, Timothy R., primary, Petersen, Lindsay N., primary, and Lachance, Joseph, primary

Published
2023
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44. Figure S1 from A Custom Genotyping Array Reveals Population-Level Heterogeneity for the Genetic Risks of Prostate Cancer and Other Cancers in Africa

Author

Harlemon, Maxine, primary, Ajayi, Olabode, primary, Kachambwa, Paidamoyo, primary, Kim, Michelle S., primary, Simonti, Corinne N., primary, Quiver, Melanie H., primary, Petersen, Desiree C., primary, Mittal, Anuradha, primary, Fernandez, Pedro W., primary, Hsing, Ann W., primary, Baichoo, Shakuntala, primary, Agalliu, Ilir, primary, Jalloh, Mohamed, primary, Gueye, Serigne M., primary, Snyper, Nana Yaa F., primary, Adusei, Ben, primary, Mensah, James E., primary, Abrahams, Afua O.D., primary, Adebiyi, Akindele O., primary, Orunmuyi, Akin T., primary, Aisuodionoe-Shadrach, Oseremen I., primary, Nwegbu, Maxwell M., primary, Joffe, Maureen, primary, Chen, Wenlong C., primary, Irusen, Hayley, primary, Neugut, Alfred I., primary, Quintana, Yuri, primary, Seutloali, Moleboheng, primary, Fadipe, Mayowa B., primary, Warren, Christopher, primary, Woehrmann, Marcos H., primary, Zhang, Peng, primary, Ongaco, Chrissie M., primary, Mawhinney, Michelle, primary, McBride, Jo, primary, Andrews, Caroline V., primary, Adams, Marcia, primary, Pugh, Elizabeth, primary, Rebbeck, Timothy R., primary, Petersen, Lindsay N., primary, and Lachance, Joseph, primary

Published
2023
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45. The Impact of HIV Infection on Neoadjuvant and Adjuvant Chemotherapy Relative Dose Intensity in South African Patients with Breast Cancer

Author

O’Neil, Daniel S, primary, Ayeni, Oluwatosin A, additional, Farrow, Hayley A, additional, Chen, Wenlong Carl, additional, Demetriou, Georgia, additional, Buccimazza, Ines, additional, Čačala, Sharon, additional, Stopforth, Laura W, additional, Joffe, Maureen, additional, Antoni, Michael H, additional, Lopes, Gilberto, additional, Pumpalova, Yoanna S, additional, Mapanga, Witness, additional, Jacobson, Judith S, additional, Crew, Katherine D, additional, Neugut, Alfred I, additional, Ruff, Paul, additional, and Cubasch, Herbert, additional

Published
2023
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46. Abstract P1-01-03: The Impact of Comorbid HIV infection on Neoadjuvant and Adjuvant Chemotherapy Relative Dose Intensity in South African Breast Cancer Patients

Author

O’Neil, Daniel S., primary, Ayeni, Oluwatosin A, additional, Woolridge, Hayley A. Farrow, additional, Chen, Wenlong Carl, additional, Demetriou, Georgia, additional, Buccimazza, Ines, additional, Cacala, Sharon, additional, Joffe, Maureen, additional, Antoni, Michael, additional, Lopes, Gilberto, additional, Pumpalova, Yoanna, additional, Mapanga, Witness, additional, Jacobson, Judith S., additional, Crew, Katherine D., additional, Neugut, Alfred I., additional, Ruff, Paul, additional, and Cubasch, Herbert, additional

Published
2023
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47. Abstract P4-07-03: The impact of HIV on non-adherence for tamoxifen among women with breast cancer in South Africa

Author

Ayeni, Oluwatosin A, primary, Chiwambutsa, Shingirai, additional, Chen, Wenlong Carl, additional, Kapungu, Nyasha N., additional, Kanji, Comfort, additional, Thelingwani, Roslyn, additional, Murugan, Nivashni, additional, Mathiba, Rophiwa, additional, Phakathi, Boitumelo, additional, Nietz, Sarah, additional, Ramiah, Duvern, additional, O’Neil, Daniel S., additional, Jacobson, Judith S., additional, Ruff, Paul, additional, Cubasch, Herbert, additional, Chirwa, Tobias, additional, Joffe, Maureen, additional, Masimirembwa, Collen, additional, and Neugut, Alfred I., additional

Published
2023
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48. The Impact of HIV Infection on Neoadjuvant and Adjuvant Chemotherapy Relative Dose Intensity in South African Patients with Breast Cancer.

Author

O'Neil, Daniel S, Ayeni, Oluwatosin A, Farrow, Hayley A, Chen, Wenlong Carl, Demetriou, Georgia, Buccimazza, Ines, Čačala, Sharon, Stopforth, Laura W, Joffe, Maureen, Antoni, Michael H, Lopes, Gilberto, Pumpalova, Yoanna S, Mapanga, Witness, Jacobson, Judith S, Crew, Katherine D, Neugut, Alfred I, Ruff, Paul, and Cubasch, Herbert

Subjects
ADJUVANT chemotherapy, HIV infections, GRANULOCYTE-colony stimulating factor, REGRESSION analysis, CANCER patients, DESCRIPTIVE statistics, RESEARCH funding, COMBINED modality therapy, BREAST tumors, DOSE-response relationship in biochemistry, COMORBIDITY
Abstract

Introduction In the South African Breast Cancer and HIV Outcomes (SABCHO) study, we previously found that breast cancer patients living with HIV and treated with neoadjuvant chemotherapy achieve lower rates of complete pathologic response than patients without HIV. We now assess the impact of comorbid HIV on receipt of timely and complete neoadjuvant and adjuvant chemotherapy. Materials and Methods Since June 2015, the SABCHO study has collected data on women diagnosed with breast cancer at 6 South African hospitals. We selected a sample of participants with stages I-III cancer who received ≥2 doses of neoadjuvant or adjuvant chemotherapy. Data on chemotherapies prescribed and received, filgrastim receipt, and laboratory values measured during treatment were captured from patients' medical records. We calculated the mean relative dose intensity (RDI) for all prescribed chemotherapies. We tested for association between full regimen RDI and HIV status, using linear regression to control for demographic and clinical covariates, and for association of HIV with laboratory abnormalities. Results The 166 participants living with HIV and 159 without HIV did not differ in median chemotherapy RDI: 0.89 (interquartile range (IQR) 0.77-0.95) among those living with HIV and 0.87 (IQR 0.77-0.94) among women without HIV. Patients living with HIV experienced more grade 3+ anemia and leukopenia than those without HIV (anemia: 10.8% vs. 1.9%, P =.001; leukopenia: 8.4% vs. 1.9%, P =.008) and were more likely to receive filgrastim (24.7% vs. 10.7%, P =.001). Conclusions HIV status did not impact neoadjuvant or adjuvant chemotherapy RDI, although patients with breast cancer living with HIV experienced more myelotoxicity during treatment. [ABSTRACT FROM AUTHOR]

Published
2023
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49. Drivers of disparities in stage at diagnosis among women with breast cancer: South African breast cancers and HIV outcomes cohort

Author

Mapanga, Witness, primary, Norris, Shane A., additional, Craig, Ashleigh, additional, Ayeni, Oluwatosin A., additional, Chen, Wenlong C., additional, Jacobson, Judith S., additional, Neugut, Alfred I., additional, Ruff, Paul, additional, Cubasch, Herbert, additional, O’Neil, Daniel S., additional, Buccimazza, Ines, additional, Čačala, Sharon, additional, Stopforth, Laura W., additional, Farrow, Hayley A., additional, Nietz, Sarah, additional, Phakathi, Boitumelo, additional, Chirwa, Tobias, additional, McCormack, Valerie A., additional, and Joffe, Maureen, additional

Published
2023
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50. The impact of HIV on non-adherence for tamoxifen among women with breast cancer in South Africa

Author

Ayeni, Oluwatosin A., primary, Chiwambutsa, Shingirai, additional, Chen, Wenlong Carl, additional, Kapungu, Nyasha, additional, Kanji, Comfort, additional, Thelingwani, Roslyn, additional, Murugan, Nivashni, additional, Mathiba, Rofhiwa, additional, Phakathi, Boitumelo, additional, Nietz, Sarah, additional, Ramiah, Duvern, additional, O’Neil, Daniel S., additional, Jacobson, Judith S., additional, Ruff, Paul, additional, Cubasch, Herbert, additional, Chirwa, Tobias, additional, Joffe, Maureen, additional, Masimirembwa, Collen, additional, and Neugut, Alfred I., additional

Published
2022
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