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The combination of microwave and microfluidic technologies has the potential to enable wireless monitoring and interaction with bioparticles, facilitating in this way the exploration of a still largely uncharted territory at the intersection of biology, communication engineering and microscale physics. Opportunely, the scientific and technical requirements of microfluidics and microwave techniques converge to the need of system miniaturization to achieve the required sensitivity levels. This work, therefore, presents the design and optimization of a measurement system for the detection of bioparticles over the frequency range $0.01$ to $10$ $\mathrm{GHz}$, with different coplanar electrodes configurations on a microfluidic platform. The design of the measurement signal-chain setup is optimized for a novel real-time superheterodyne microwave detection system. In particular, signal integrity is achieved by means of a microwave-shielded chamber, which is protected from external electromagnetic interference that may potentially impact the coplanar electrodes mounted on the microfluidic device. Additionally, analytical expressions and experimental validation of the system-level performance are provided and discussed for the different designs of the coplanar electrodes. This technique is applied to measure the electrical field perturbation produced by $10$ $\mathrm{\mu m}$ polystyrene beads with a concentration of $10^5$ $\mathrm{beads/mL}$, and flowing at a rate of $10$ $\mathrm{\mu L/m}$. The achieved SNR is in the order of $40$ $\mathrm{dB}$ for the three coplanar electrodes considered.

Aerodynamic optimization is ubiquitous in the design of most engineering systems interacting with fluids. A common approach is to optimize a performance function defined by a choice of an aerodynamic model, e.g., turbulence RANS model, and at nominal operating conditions. Practical experience indicates that such a deterministic approach may result in considerably sub-optimal designs when the adopted aerodynamic model does not lead to accurate flow predictions or when the actual operating conditions differ from those considered in the design. One approach to address this shortcoming is to consider an average or robust design, wherein the statistical moments of the performance function, given the uncertainty in the operating conditions and the aerodynamic model, is optimized. However, when the number of uncertain inputs is large or the performance function exhibits significant variability, an accurate evaluation of these moments may require a large number of forward and/or adjoint solves, at each iteration of a gradient-based scheme. This, in turn, renders the design computationally expensive, if not infeasible. To tackle this difficulty, we consider a variant of the stochastic gradient descent method where, in each optimization iteration, a stochastic approximation of the objective, constraints, and their gradients are generated. This is done via a small number of forward/adjoint solves corresponding to random selections of the uncertain parameters and aerodynamic model. The methodology is applied to the robust optimization of the standard NACA-0012 subject to parametric and turbulence model uncertainty. With a cost that is a small factor larger than that of the deterministic approach, the stochastic gradient approach significantly improves the performance (mean and variance) of the aerodynamic design for a wide range of operating conditions and turbulence models.

The future of high-performance computing, specifically on future Exascale computers, will presumably see memory capacity and bandwidth fail to keep pace with data generated, for instance, from massively parallel partial differential equation (PDE) systems. Current strategies proposed to address this bottleneck entail the omission of large fractions of data, as well as the incorporation of $\textit{in situ}$ compression algorithms to avoid overuse of memory. To ensure that post-processing operations are successful, this must be done in a way that a sufficiently accurate representation of the solution is stored. Moreover, in situations where the input/output system becomes a bottleneck in analysis, visualization, etc., or the execution of the PDE solver is expensive, the the number of passes made over the data must be minimized. In the interest of addressing this problem, this work focuses on the utility of pass-efficient, parallelizable, low-rank, matrix decomposition methods in compressing high-dimensional simulation data from turbulent flows. A particular emphasis is placed on using coarse representation of the data -- compatible with the PDE discretization grid -- to accelerate the construction of the low-rank factorization. This includes the presentation of a novel single-pass matrix decomposition algorithm for computing the so-called interpolative decomposition. The methods are described extensively and numerical experiments on two turbulent channel flow data are performed. In the first (unladen) channel flow case, compression factors exceeding $400$ are achieved while maintaining accuracy with respect to first- and second-order flow statistics. In the particle-laden case, compression factors of 100 are achieved and the compressed data is used to recover particle velocities., Comment: 28 pages with references, 12 figures

Efficiently performing predictive studies of irradiated particle-laden turbulent flows has the potential of providing significant contributions towards better understanding and optimizing, for example, concentrated solar power systems. As there are many uncertainties inherent in such flows, uncertainty quantification is fundamental to improve the predictive capabilities of the numerical simulations. For large-scale, multi-physics problems exhibiting high-dimensional uncertainty, characterizing the stochastic solution presents a significant computational challenge as many methods require a large number of high-fidelity solves. This requirement results in the need for a possibly infeasible number of simulations when a typical converged high-fidelity simulation requires intensive computational resources. To reduce the cost of quantifying high-dimensional uncertainties, we investigate the application of a non-intrusive, bi-fidelity approximation to estimate statistics of quantities of interest associated with an irradiated particle-laden turbulent flow. This method relies on exploiting the low-rank structure of the solution to accelerate the stochastic sampling and approximation processes by means of cheaper-to-run, lower fidelity representations. The application of this bi-fidelity approximation results in accurate estimates of the QoI statistics while requiring a small number of high-fidelity model evaluations.

The study of complex systems is often based on computationally intensive, high-fidelity, simulations. To build confidence in the prediction accuracy of such simulations, the impact of uncertainties in model inputs on the quantities of interest must be measured. This, however, requires a computational budget that is a possibly large multiple of the cost of a single simulation, and thus may become infeasible for expensive simulation models featuring a large number of uncertain inputs and highly nonlinear behavior. Therefore, this work explores multi-fidelity strategies to accelerate the estimation of the effect of uncertainties. The main idea behind multi-fidelity models is to utilize cheaper, lower-fidelity models - than the intended high-fidelity, expensive model of the problem - to generate a baseline solution that together, with relatively small number of high-fidelity simulations can lead to accurate predictions. The methods are briefly presented, and their performance assessed on an irradiated particle-laden turbulent flow case related to Stanford's PSAAP II particle-based solar energy receiver.