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12 results on '"Joguet, Guillaume"'

3. Zika virus infects human testicular tissue and germ cells

Author

Matusali, Giulia, Houzet, Laurent, Satie, Anne-Pascale, Mahe, Dominique, Aubry, Florence, Couderc, Therese, Frouard, Julie, Bourgeau, Salome, Bensalah, Karim, Lavoue, Sylvain, Joguet, Guillaume, Bujan, Louis, Cabie, Andre, Avelar, Gleide, Lecuit, Marc, Le Tortorec, Anna, and Dejucq-Rainsford, Nathalie

Subjects
Host-virus relationships, Semen -- Properties, Testis -- Physiological aspects, Zika virus -- Health aspects, Health care industry
Abstract

Zika virus (ZIKV) is a teratogenic mosquito-borne flavivirus that can be sexually transmitted from man to woman. The finding of high viral loads and prolonged viral shedding in semen suggests that ZIKV replicates within the human male genital tract, but its target organs are unknown. Using ex vivo infection of organotypic cultures, we demonstrated here that ZIKV replicates in human testicular tissue and infects a broad range of cell types, including germ cells, which we also identified as infected in semen from ZIKV-infected donors. ZIKV had no major deleterious effect on the morphology and hormonal production of the human testis explants. Infection induced a broad antiviral response but no IFN upregulation and minimal proinflammatory response in testis explants, with no cytopathic effect. Finally, we studied ZIKV infection in mouse testis and compared it to human infection. This study provides key insights into how ZIKV may persist in semen and alter semen parameters, as well as a valuable tool for testing antiviral agents., Introduction Zika virus (ZIKV) is a teratogenic arthropod-borne flavivirus that recently emerged in the Pacific Islands (2007), Oceania (2013), and the Americas (2015). While ZIKV's primary mode of transmission is [...]

Published
2018
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9. Zika virus replicates within the human testis and infects the germ line

Author

Matusali, Giulia, Houzet, Laurent, Satie, Anne-Pascale, Aubry, Florence, Mahé, Dominique, Couderc, Thérèse, Bensalah, Karim, Platel, Christian, Joguet, Guillaume, Bujan, Louis, Cabié, André, Avelar, Gleide, Lecuit, Marc, Le Tortorec, Anna, Dejucq-Rainsford, Nathalie, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Biologie des Infections - Biology of Infection, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], CHU Pointe-à-Pitre/Abymes [Guadeloupe], CHU Toulouse [Toulouse], Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles et de la Guyane (UAG), Universidade Federal de Minas Gerais [Belo Horizonte] (UFMG), Université Paris Descartes - Paris 5 (UPD5), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), and Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

12. Zika virus in the female genital tract

Author

Prisant, Nadia, primary, Bujan, Louis, additional, Benichou, Hélène, additional, Hayot, Pierre-Humbert, additional, Pavili, Lynda, additional, Lurel, Sylvia, additional, Herrmann, Cecile, additional, Janky, Eustase, additional, and Joguet, Guillaume, additional

Published
2016
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