1. Increased Interleukin-8 in Epithelial Lining Fluid of Collapsed Lungs During One-Lung Ventilation for Thoracotomy
- Author
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Yoshitaka Yamazaki, Kazuo Yoshida, Tomonobu Koizumi, Joh Hasegawa, Hiroshi Yamamoto, Keishi Kubo, Shino Furuya, Masanori Yasuo, Ryuichi Kondo, Yoshimichi Komatsu, Kenji Tsushima, Sumiko Yoshikawa, and Takashi Eguchi
- Subjects
Male ,Pulmonary Atelectasis ,medicine.medical_specialty ,ARDS ,Lung Neoplasms ,medicine.medical_treatment ,Interleukin-1beta ,Immunology ,Pulmonary Edema ,Respiratory Mucosa ,permeability pulmonary edema ,re-expansion pulmonary edema ,Lung injury ,Collapsed Lung ,Albumins ,Humans ,Immunology and Allergy ,Medicine ,Thoracotomy ,Lung ,Aged ,Inflammation ,bronchoscopic microsampling ,Interleukin-6 ,Tumor Necrosis Factor-alpha ,business.industry ,Interleukin-8 ,Interleukin ,Middle Aged ,respiratory system ,medicine.disease ,thoracic surgery ,One-Lung Ventilation ,respiratory tract diseases ,medicine.anatomical_structure ,Cardiothoracic surgery ,Anesthesia ,Breathing ,Female ,business - Abstract
The present study was designed to evaluate inflammatory changes in collapsed lungs during one-lung ventilation using the assistance of a bronchoscopic microsampling probe. Serial albumin and interleukin (IL)-8 concentrations in epithelial lining fluid (ELF) were measured in seven patients undergoing resection of lung tumors. The samples were taken after induction of anesthesia (baseline), 30 min after one-lung ventilation was started (point 2), just before resuming two-lung ventilation (point 3), and 30 min after two-lung ventilation was restarted (point 4). The albumin and IL-8 concentrations in ELF were significantly increased at point 2 and point 3, respectively, and remained to be high, compared to the baseline. The increase in IL-8 at point 3 was correlated with the interval of one-lung ventilation; however, none developed specific acute lung injury. These findings suggest that inflammatory changes can occur on the epithelium of a collapsed lung even in patients who underwent successful and standard thoracic surgery., Article, INFLAMMATION. 35(6):1844-1850 (2012)
- Published
- 2012
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