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1. Neuropsychiatric symptoms and lifelong mental activities in cerebral amyloid angiopathy – a cross-sectional study

Author

Dörner, Marc, Tyndall, Anthony, Hainc, Nicolin, von Känel, Roland, Neumann, Katja, Euler, Sebastian, Schreiber, Frank, Arndt, Philipp, Fuchs, Erelle, Garz, Cornelia, Glanz, Wenzel, Butryn, Michaela, Schulze, Jan Ben, Schiebler, Sarah Lavinia Florence, John, Anna-Charlotte, Hildebrand, Annkatrin, Hofmann, Andreas B., Machetanz, Lena, Kirchebner, Johannes, Tacik, Pawel, Grimm, Alexander, Jansen, Robin, Pawlitzki, Marc, Henneicke, Solveig, Bernal, Jose, Perosa, Valentina, Düzel, Emrah, Meuth, Sven G., Vielhaber, Stefan, Mattern, Hendrik, and Schreiber, Stefanie

Published
2024
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3. Neuropsychiatric symptoms and lifelong mental activities in cerebral amyloid angiopathy - a cross-sectional study

Author

Dörner, Marc; https://orcid.org/0000-0003-3229-1677, Tyndall, Anthony, Hainc, Nicolin; https://orcid.org/0000-0003-0916-7387, von Känel, Roland; https://orcid.org/0000-0002-8929-5129, Neumann, Katja, Euler, Sebastian; https://orcid.org/0000-0002-5009-8355, Schreiber, Frank, Arndt, Philipp, Fuchs, Erelle, Garz, Cornelia, Glanz, Wenzel, Butryn, Michaela, Schulze, Jan Ben; https://orcid.org/0000-0002-5252-3976, Schiebler, Sarah Lavinia Florence, John, Anna-Charlotte, Hildebrand, Annkatrin, Hofmann, Andreas B, Machetanz, Lena; https://orcid.org/0000-0001-6838-9380, Kirchebner, Johannes; https://orcid.org/0000-0002-6072-9958, Tacik, Pawel, Grimm, Alexander, Jansen, Robin, Pawlitzki, Marc; https://orcid.org/0000-0003-3080-2277, Henneicke, Solveig, Bernal, Jose, Perosa, Valentina, Düzel, Emrah, Meuth, Sven G, Vielhaber, Stefan, Mattern, Hendrik, et al, Dörner, Marc; https://orcid.org/0000-0003-3229-1677, Tyndall, Anthony, Hainc, Nicolin; https://orcid.org/0000-0003-0916-7387, von Känel, Roland; https://orcid.org/0000-0002-8929-5129, Neumann, Katja, Euler, Sebastian; https://orcid.org/0000-0002-5009-8355, Schreiber, Frank, Arndt, Philipp, Fuchs, Erelle, Garz, Cornelia, Glanz, Wenzel, Butryn, Michaela, Schulze, Jan Ben; https://orcid.org/0000-0002-5252-3976, Schiebler, Sarah Lavinia Florence, John, Anna-Charlotte, Hildebrand, Annkatrin, Hofmann, Andreas B, Machetanz, Lena; https://orcid.org/0000-0001-6838-9380, Kirchebner, Johannes; https://orcid.org/0000-0002-6072-9958, Tacik, Pawel, Grimm, Alexander, Jansen, Robin, Pawlitzki, Marc; https://orcid.org/0000-0003-3080-2277, Henneicke, Solveig, Bernal, Jose, Perosa, Valentina, Düzel, Emrah, Meuth, Sven G, Vielhaber, Stefan, Mattern, Hendrik, and et al

Abstract

BACKGROUND: While several studies in cerebral amyloid angiopathy (CAA) focus on cognitive function, data on neuropsychiatric symptoms (NPS) and lifelong mental activities in these patients are scarce. Since NPS are associated with functional impairment, faster cognitive decline and faster progression to death, replication studies in more diverse settings and samples are warranted. METHODS: We prospectively recruited n = 69 CAA patients and n = 18 cognitively normal controls (NC). The number and severity of NPS were assessed using the Alzheimer's Disease (AD) Assessment Scale's (ADAS) noncognitive subscale. We applied different regression models exploring associations between NPS number or severity and group status (CAA vs. NC), CAA severity assessed with magnetic resonance imaging (MRI) or cognitive function (Mini-Mental State Examination (MMSE), ADAS cognitive subscale), adjusting for age, sex, years of education, arterial hypertension, AD pathology, and apolipoprotein E status. Mediation analyses were performed to test indirect effects of lifelong mental activities on CAA severity and NPS. RESULTS: Patients with CAA had 4.86 times (95% CI 2.20-10.73) more NPS and 3.56 units (95% CI 1.94-5.19) higher expected NPS severity than NC. Higher total CAA severity on MRI predicted 1.14 times (95% CI 1.01.-1.27) more NPS and 0.57 units (95% CI 0.19-0.95) higher expected NPS severity. More severe white matter hyperintensities were associated with 1.21 times more NPS (95% CI 1.05-1.39) and 0.63 units (95% CI 0.19-1.08) more severe NPS. NPS number (MMSE mean difference - 1.15, 95% CI -1.67 to -0.63; ADAS cognitive mean difference 1.91, 95% CI 1.26-2.56) and severity (MMSE - 0.55, 95% CI -0.80 to -0.30; ADAS cognitive mean difference 0.89, 95% CI 0.57-1.21) predicted lower cognitive function. Greater lifelong mental activities partially mediated the relationship between CAA severity and NPS (indirect effect 0.05, 95% CI 0.0007-0.13), and greater lifelong mental activities led t

Published
2024

4. Inferior Frontal Sulcal Hyperintensities on Brain MRI Are Associated with Amyloid Positivity beyond Age—Results from the Multicentre Observational DELCODE Study.

Author

Dörner, Marc, Seebach, Katharina, Heneka, Michael T., Menze, Inga, von Känel, Roland, Euler, Sebastian, Schreiber, Frank, Arndt, Philipp, Neumann, Katja, Hildebrand, Annkatrin, John, Anna-Charlotte, Tyndall, Anthony, Kirchebner, Johannes, Tacik, Pawel, Jansen, Robin, Grimm, Alexander, Henneicke, Solveig, Perosa, Valentina, Meuth, Sven G., and Peters, Oliver

Subjects
AMYLOID, MAGNETIC resonance imaging, OPTIMISM, ALZHEIMER'S disease, MINI-Mental State Examination
Abstract

Inferior frontal sulcal hyperintensities (IFSHs) on fluid-attenuated inversion recovery (FLAIR) sequences have been proposed to be indicative of glymphatic dysfunction. Replication studies in large and diverse samples are nonetheless needed to confirm them as an imaging biomarker. We investigated whether IFSHs were tied to Alzheimer's disease (AD) pathology and cognitive performance. We used data from 361 participants along the AD continuum, who were enrolled in the multicentre DELCODE study. The IFSHs were rated visually based on FLAIR magnetic resonance imaging. We performed ordinal regression to examine the relationship between the IFSHs and cerebrospinal fluid-derived amyloid positivity and tau positivity (Aβ42/40 ratio ≤ 0.08; pTau181 ≥ 73.65 pg/mL) and linear regression to examine the relationship between cognitive performance (i.e., Mini-Mental State Examination and global cognitive and domain-specific performance) and the IFSHs. We controlled the models for age, sex, years of education, and history of hypertension. The IFSH scores were higher in those participants with amyloid positivity (OR: 1.95, 95% CI: 1.05–3.59) but not tau positivity (OR: 1.12, 95% CI: 0.57–2.18). The IFSH scores were higher in older participants (OR: 1.05, 95% CI: 1.00–1.10) and lower in males compared to females (OR: 0.44, 95% CI: 0.26–0.76). We did not find sufficient evidence linking the IFSH scores with cognitive performance after correcting for demographics and AD biomarker positivity. IFSHs may reflect the aberrant accumulation of amyloid β beyond age. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Associations of inferior frontal sulcal hyperintensities on brain MRI with cerebral small vessel disease, cognitive function, and depression symptoms

Author

Dörner, Marc, Pfister, Malte, Tyndall, Anthony, von Känel, Roland, Neumann, Katja, Schreiber, Frank, Arndt, Philipp, Fuchs, Erelle, Garz, Cornelia, Glanz, Wenzel, Butryn, Michaela, John, Anna-Charlotte, Hildebrand, Annkatrin, Euler, Sebastian, Hofmann, Andreas B., Machetanz, Lena, Kirchebner, Johannes, Tacik, Pawel, Grimm, Alexander, Jansen, Robin, Pawlitzki, Marc, Henneicke, Solveig, Perosa, Valentina, Labeit, Bendix, Düzel, Emrah, Meuth, Sven G., Vielhaber, Stefan, Mattern, Hendrik, Bernal, Jose, and Schreiber, Stefanie

Published
2025
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