1. Normalization of Testosterone Levels After Testosterone Replacement Therapy Is Not Associated With Reduced Myocardial Infarction in Smokers
- Author
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Olurinde A. Oni, MBBS, MPH, Rishi Sharma, MD, MHSA, Guoqing Chen, MD, PhD, MPH, Mukut Sharma, PhD, Kamal Gupta, MD, Buddhadeb Dawn, MD, Ram Sharma, PhD, Deepak Parashara, MD, Virginia J. Savin, MD, George Cherian, MD, John A. Ambrose, MD, and Rajat S. Barua, MD, PhD
- Subjects
Medicine (General) ,R5-920 - Abstract
Objective: To examine the effect of cigarette smoking (CS) status and total testosterone (TT) levels after testosterone replacement therapy (TRT) on all-cause mortality, myocardial infarction (MI), and stroke in male smokers and nonsmokers without history of MI and stroke. Participants and Methods: Data from 18,055 males with known CS status and low TT levels who received TRT at the Veterans Health Administration between December 1, 1999, and May 31, 2014, were grouped into (1) current smokers with normalized TT, (2) current smokers with nonnormalized TT, (3) nonsmokers with normalized TT, and (4) nonsmokers with nonnormalized TT. Combined effect of CS status and TT level normalization after TRT on all-cause mortality, MI, and stroke was compared using propensity score–weighted Cox proportional hazard models. Results: Normalization of serum TT levels in nonsmokers was associated with a significant decrease in all-cause mortality (hazard ratio [HR]=0.526; 95% CI, 0.477-0.581; P
- Published
- 2017
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