376 results on '"Johnson, Douglas S."'
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2. Discovery of Clinical Candidate PF-06648671: A Potent γ-Secretase Modulator for the Treatment of Alzheimer’s Disease
3. Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis
4. Utility of chemical probes for mass spectrometry based chemical proteomics
5. Contributors
6. COVID-19 Among US Dialysis Patients: Risk Factors and Outcomes From a National Dialysis Provider
7. Photoaffinity Labeling and Quantitative Chemical Proteomics Identify LXRβ as the Functional Target of Enhancers of Astrocytic apoE
8. The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease
9. Studies on the stability and stabilization of trans-cyclooctenes through radical inhibition and silver (I) metal complexation
10. Molecular medicine and neurodegenerative diseases.
11. Photobiomodulation therapy combined with static magnetic field is better than placebo in patients with fibromyalgia: a randomized placebo-controlled trial
12. γ-Secretase Modulators as Aβ42-Lowering Pharmacological Agents to Treat Alzheimer’s Disease
13. Leading Integrated Kidney Care Entities of the Future
14. Integrated Care for People with Kidney Disease: The Perspective of a Nonprofit Dialysis Provider
15. Oral Intradialytic Nutritional Supplement Use and Mortality in Hemodialysis Patients
16. γ-Secretase Modulator (GSM) Photoaffinity Probes Reveal Distinct Allosteric Binding Sites on Presenilin
17. The synthesis and in vivo evaluation of [18F]PF-9811: a novel PET ligand for imaging brain fatty acid amide hydrolase (FAAH)
18. Low-intensity LASER and LED (photobiomodulation therapy) for pain control of the most common musculoskeletal conditions
19. Structure-Guided Inhibitor Design for Human FAAH by Interspecies Active Site Conversion
20. Going Upstream: Coordination to Improve CKD Care
21. Blocking of Fatty Acid Amide Hydrolase Activity with PF-04457845 in Human Brain: A Positron Emission Tomography Study with the Novel Radioligand [11C]CURB
22. Chapter 5 - Utility of chemical probes for mass spectrometry based chemical proteomics
23. Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain
24. CC-1065 and the Duocarmycins: Unraveling the Keys to a New Class of Naturally Derived DNA Alkylating Agents
25. Chemoproteomic Profiling of Covalent XPO1 Inhibitors to Assess Target Engagement and Selectivity
26. Chemical Proteomic Technologies for Drug Target Identification
27. Target of γ‐secretase modulators, presenilin marks the spot
28. Challenges with Providing Hospice Care for Patients Undergoing Long-Term Dialysis
29. Fluorophosphonate‐Based Degrader Identifies Degradable Serine Hydrolases by Quantitative Proteomics
30. Photoaffinity Labeling and Quantitative Chemical Proteomics Identify Liver X Receptor β as the Functional Target of Enhancers of Astrocytic Apolipoprotein E
31. Strategies for discovering and derisking covalent, irreversible enzyme inhibitors
32. Contemporary Drug Synthesis
33. Reversed and sandwiched analogs of duocarmycin SA: establishment of the origin of the sequence-selective alkylation of DNA and new insights into the source of catalysis
34. Duocarmycin SA shortened, simplified, and extended agents: a systematic examination of the role of the DNA binding subunit
35. (+)- and ent-(-)-duocarmycin SA and (+)- and ent-(-)-N-BOC-DSA DNA alkylation properties: alkylation site models that accommodate the offset AT-rich adenine N3 alkylation selectivity of the enantiomeric agents
36. PF-06651600, a Dual JAK3/TEC Family Kinase Inhibitor
37. Global Portrait of Protein Targets of Metabolites of the Neurotoxic Compound BIA 10–2474
38. Delaying and Averting Dialysis Treatment: Patient Protection or Moral Hazard?
39. Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation
40. Photochemical syntheses, transformations, and bioorthogonal chemistry oftrans-cycloheptene and silatrans-cycloheptene Ag(i) complexes
41. Discovery of indole-derived pyridopyrazine-1,6-dione γ-secretase modulators that target presenilin
42. Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity
43. Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase
44. Bond with Me If You Can! Natural Product, Covalent Ligand, and Reactivity-Based Probe Compete for Cysteine in PP2A Complex
45. Structural and Chemical Biology of Presenilin Complexes
46. Discovery of cyclopropyl chromane-derived pyridopyrazine-1,6-dione γ-secretase modulators with robust central efficacy
47. Mapping the Binding Site of BMS-708163 on γ-Secretase with Cleavable Photoprobes
48. Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase
49. Photobiomodulation Therapy Improves Performance and Accelerates Recovery of High-Level Rugby Players in Field Test: A Randomized, Crossover, Double-Blind, Placebo-Controlled Clinical Study
50. Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitors
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