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2,268 results on '"Johnson, James R."'

3. Using source-associated mobile genetic elements to identify zoonotic extraintestinal E. coli infections

Author

Liu, Cindy M., Aziz, Maliha, Park, Daniel E., Wu, Zhenke, Stegger, Marc, Li, Mengbing, Wang, Yashan, Schmidlin, Kara, Johnson, Timothy J., Koch, Benjamin J., Hungate, Bruce A., Nordstrom, Lora, Gauld, Lori, Weaver, Brett, Rolland, Diana, Statham, Sally, Hall, Brantley, Sariya, Sanjeev, Davis, Gregg S., Keim, Paul S., Johnson, James R., and Price, Lance B.

Published
2023
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4. Author Correction: Building a global alliance of biofoundries.

Author

Hillson, Nathan, Caddick, Mark, Cai, Yizhi, Carrasco, Jose A, Chang, Matthew Wook, Curach, Natalie C, Bell, David J, Feuvre, Rosalind Le, Friedman, Douglas C, Fu, Xiongfei, Gold, Nicholas D, Herrgård, Markus J, Holowko, Maciej B, Johnson, James R, Johnson, Richard A, Keasling, Jay D, Kitney, Richard I, Kondo, Akihiko, Liu, Chenli, Martin, Vincent JJ, Menolascina, Filippo, Ogino, Chiaki, Patron, Nicola J, Pavan, Marilene, Poh, Chueh Loo, Pretorius, Isak S, Rosser, Susan J, Scrutton, Nigel S, Storch, Marko, Tekotte, Hille, Travnik, Evelyn, Vickers, Claudia E, Yew, Wen Shan, Yuan, Yingjin, Zhao, Huimin, and Freemont, Paul S

Subjects
MD Multidisciplinary
Abstract

The original version of this Comment contained errors in the legend of Figure 2, in which the locations of the fifteenth and sixteenth GBA members were incorrectly given as '(15) Australian Genome Foundry, Macquarie University; (16) Australian Foundry for Advanced Biomanufacturing, University of Queensland.'. The correct version replaces this with '(15) Australian Foundry for Advanced Biomanufacturing (AusFAB), University of Queensland and (16) Australian Genome Foundry, Macquarie University'. This has been corrected in both the PDF and HTML versions of the Comment.

Published
2019

5. Building a global alliance of biofoundries.

Author

Hillson, Nathan, Caddick, Mark, Cai, Yizhi, Carrasco, Jose A, Chang, Matthew Wook, Curach, Natalie C, Bell, David J, Le Feuvre, Rosalind, Friedman, Douglas C, Fu, Xiongfei, Gold, Nicholas D, Herrgård, Markus J, Holowko, Maciej B, Johnson, James R, Johnson, Richard A, Keasling, Jay D, Kitney, Richard I, Kondo, Akihiko, Liu, Chenli, Martin, Vincent JJ, Menolascina, Filippo, Ogino, Chiaki, Patron, Nicola J, Pavan, Marilene, Poh, Chueh Loo, Pretorius, Isak S, Rosser, Susan J, Scrutton, Nigel S, Storch, Marko, Tekotte, Hille, Travnik, Evelyn, Vickers, Claudia E, Yew, Wen Shan, Yuan, Yingjin, Zhao, Huimin, and Freemont, Paul S

Subjects
Organisms, Genetically Modified, Genetic Engineering, Biotechnology, Biomedical Research, International Cooperation, Organisms, Genetically Modified, MD Multidisciplinary
Abstract

Biofoundries provide an integrated infrastructure to enable the rapid design, construction, and testing of genetically reprogrammed organisms for biotechnology applications and research. Many biofoundries are being built and a Global Biofoundry Alliance has recently been established to coordinate activities worldwide.

Published
2019

10. Genomic Analysis of Factors Associated with Low Prevalence of Antibiotic Resistance in Extraintestinal Pathogenic Escherichia coli Sequence Type 95 Strains

Author

Stephens, Craig M, Adams-Sapper, Sheila, Sekhon, Manraj, Johnson, James R, and Riley, Lee W

Subjects
Microbiology, Biological Sciences, Biotechnology, Genetics, Infectious Diseases, Biodefense, Antimicrobial Resistance, Prevention, Emerging Infectious Diseases, Digestive Diseases, 2.2 Factors relating to the physical environment, Infection, Good Health and Well Being, Escherichia coli, ExPEC, ST95, antibiotic resistance, genomics, Immunology
Abstract

Extraintestinal pathogenic Escherichia coli (ExPEC) strains belonging to multilocus sequence type 95 (ST95) are globally distributed and a common cause of infections in humans and domestic fowl. ST95 isolates generally show a lower prevalence of acquired antimicrobial resistance than other pandemic ExPEC lineages. We took a genomic approach to identify factors that may underlie reduced resistance. We fully assembled genomes for four ST95 isolates representing the four major fimH-based lineages within ST95 and also analyzed draft-level genomes from another 82 ST95 isolates, largely from the western United States. The fully assembled genomes of antibiotic-resistant isolates carried resistance genes exclusively on large (>90-kb) IncFIB/IncFII plasmids. These replicons were common in the draft genomes as well, particularly in antibiotic-resistant isolates, but we also observed multiple instances of a smaller (8.3-kb) ampicillin resistance plasmid that had been previously identified in Salmonella enterica. Among ST95 isolates, pansusceptibility to antibiotics was significantly associated with the fimH6 lineage and the presence of homologs of the previously identified 114-kb IncFIB/IncFII plasmid pUTI89, both of which were also associated with reduced carriage of other plasmids. Potential mechanistic explanations for lineage- and plasmid-specific effects on the prevalence of antibiotic resistance within the ST95 group are discussed. IMPORTANCE Antibiotic resistance in bacterial pathogens is a major public health concern. This work was motivated by the observation that only a small proportion of ST95 isolates, a major pandemic lineage of extraintestinal pathogenic E. coli, have acquired antibiotic resistance, in contrast to many other pandemic lineages. Understanding bacterial genetic factors that may prevent acquisition of resistance could contribute to the development of new biological, medical, or public health strategies to reduce antibiotic-resistant infections.

Published
2017

12. Longitudinal molecular analysis of clinical and fecal Escherichia coli isolates at a Veterans Affairs Medical Center in Minnesota, USA, 2012-2019.

Author

Clabots, Connie, Thuras, Paul, and Johnson, James R.

Subjects
ESCHERICHIA coli, ESCHERICHIA coli diseases, PULSED-field gel electrophoresis, FECAL analysis, MEDICAL centers, VETERANS' hospitals, CALPROTECTIN, VETERANS' health, IMMUNOMAGNETIC separation
Abstract

Introduction: Extraintestinal Escherichia coli infections represent a growing public health threat, However, current studies often overlook important factors such as temporal patterns of infection, phylogenetic and clonal background, or the host gut E. coli population, despite their likely significance. Methods: In this study, we analyzed >7000 clinical E. coli isolates from patients at the Minneapolis Veterans Affairs Health Care System (2012-2019), and concurrent fecal E. coli from uninfected veterans. We assessed phylogenetic group distribution, membership in selected sequence types (STs), and subsets thereof--including the pandemic, resistance-associated ST131-H30R, and ST1193 lineages--and strain type, as defined by pulsed-field gel electrophoresis. We then analyzed these features alongside the temporal patterns of infection in individual hosts. Results: The H30R lineage emerged as the leading lineage, both overall and among fluoroquinolone-resistant isolates, with ST1193 following among fluoroquinolone-resistant isolates. Recurrences were common, occurring in 31% of subjects and 41% of episodes, and often multiple and delayed/prolonged (up to 23 episodes per subject; up to 2655d post-index). Remarkably, these recurrences typically involved the subject's index strain (63% of recurrences), even when affecting extra-urinary sites. ST131, H30R, ST1193, and fluoroquinoloneresistant strains generally caused significantly more recurrences than did other strains, despite similar recurrence intervals. ST131 strain types shifted significantly over the study period. Infection-causing strains were commonly detectable in host feces at times other than during an infection episode; the likelihood of detection varied with surveillance intensity and proximity to the infection. H30R and ST1193 were prominent causes of fecal-clinical clonal overlap. Discussion: These findings provide novel insights into the temporal and clonal characteristics of E. coli infections in veterans and support efforts to develop anti-colonization interventions. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Leading Virtual Teams: Three Cases

Author

Johnson, James R. and Jeris, Laurel

Abstract

This study investigated virtual team members' and leaders' perceptions of the role of the leader, and hindering and helping forces within virtual teams and their host organizations for developing leaders of such teams. It addresses the expressed need of virtual team leaders for the field of HRD to guide leadership development for this emerging organizational form. In response this study situates leadership requirements, identified by the participants, within an overall developmental context. [For complete proceedings, see ED491481.]

Published
2004

27. Transdermal Detection of MB-102 and Correlation to Meropenem Pharmacokinetics During Continuous Renal Replacement Therapy: In Vivo Results

Author

Dorshow, Richard B., primary, Johnson, James R., additional, Shieh, Jeng-Jong, additional, Riley, I. Rochelle, additional, Rogers, Thomas E., additional, Pino, Christopher J., additional, Johnston, Kimberly A., additional, Tang, Peter, additional, Nolin, Thomas D., additional, Humes, H. David, additional, and Goldstein, Stuart L., additional

Published
2023
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30. TEMPORARY REMOVAL: Using source-associated mobile genetic elements to identify zoonotic extraintestinal E. coli infections

Author

Liu, Cindy M., primary, Aziz, Maliha, additional, Park, Daniel E., additional, Wu, Zhenke, additional, Stegger, Marc, additional, Li, Mengbing, additional, Wang, Yashan, additional, Schmidlin, Kara, additional, Johnson, Timothy J., additional, Koch, Benjamin J., additional, Hungate, Bruce A., additional, Nordstrom, Lora, additional, Gauld, Lori, additional, Weaver, Brett, additional, Rolland, Diana, additional, Statham, Sally, additional, Hall, Brantley, additional, Sariya, Sanjeev, additional, Davis, Gregg S., additional, Keim, Paul S., additional, Johnson, James R., additional, and Price, Lance B., additional

Published
2023
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38. Oral Therapy for Aerococcus urinae Bacteremia and Thoracic Spondylodiscitis of Presumed Urinary Origin

Author

Butcher, Brandon, Holman, Echko, Johnson, James R., and Boothby, Aaron

Subjects
Features
Abstract

BACKGROUND: Aerococcus urinae (A urinae), considered a rare pathogen, has been identified with increasing frequency in urine cultures. Only 8 cases of spondylodiscitis due to A urinae have been reported. Optimal treatment for invasive A urinae infection is undefined. However, the reported cases were treated successfully with diverse antibiotic regimen combinations, all including a β-lactam and beginning with at least 2 weeks of IV antibiotics. CASE PRESENTATION: A 74-year-old man presented to the emergency department after 2 weeks of midthoracic back pain, lower extremity weakness, gait imbalance, fatigue, anorexia, rigors, and subjective fevers. The patient was presumed to have discitis secondary to a urinary tract infection with possible pyelonephritis and was given empiric vancomycin and ceftriaxone. Spinal magnetic resonance imaging with contrast supported spondylodiscitis. Preliminary results from the admission blood and urine cultures showed gram-positive cocci in clusters. CONCLUSIONS: A urinae urinary tract infection in the absence of obvious predisposing factors should prompt evaluation for urinary outflow obstruction. We suspect a review of a US Department of Veterans Affairs population might uncover a higher incidence of A urinae infection than previously suspected.

Published
2022

47. Sepsis From the Gut: The Enteric Habitat of Bacteria That Cause Late-Onset Neonatal Bloodstream Infections

Author

Carl, Mike A., Ndao, I. Malick, Springman, A. Cody, Manning, Shannon D., Johnson, James R., Johnston, Brian D., Burnham, Carey-Ann D., Weinstock, Erica Sodergren, Weinstock, George M., Wylie, Todd N., Mitreva, Makedonka, Abubucker, Sahar, Zhou, Yanjiao, Stevens, Harold J., Hall-Moore, Carla, Julian, Samuel, Shaikh, Nurmohammad, Warner, Barbara B., and Tarr, Phillip I.

Published
2014
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