255 results on '"Johnson, Kirby D."'
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2. RNA-regulatory exosome complex suppresses an apoptotic program to confer erythroid progenitor cell survival in vivo
3. Interferon regulatory factor-8-dependent innate immune alarm senses GATA2 deficiency to alter hematopoietic differentiation and function
4. GATA2 deficiency elevates interferon regulatory factor-8 to subvert a progenitor cell differentiation program
5. Gata2 +9.5 enhancer regulates adult hematopoietic stem cell self-renewal and T-cell development
6. Pathogenic human variant that dislocates GATA2 zinc fingers disrupts hematopoietic gene expression and signaling networks
7. Gata2 −77 enhancer regulates adult hematopoietic stem cell survival
8. Genomic Determinants of Hematopoietic Progenitor Sensitivity to Innate Immune Signaling
9. Human leukemia mutations corrupt but do not abrogate GATA-2 function
10. Single-nucleotide human disease mutation inactivates a blood-regenerative GATA2 enhancer
11. Chromatin Domain Activation via GATA-1 Utilization of a Small Subset of Dispersed GATA Motifs within a Broad Chromosomal Region
12. Coregulator-Dependent Facilitation of Chromatin Occupancy by GATA-1
13. Hematopoietic-Specific Activators Establish an Overlapping Pattern of Histone Acetylation and Methylation within a Mammalian Chromatin Domain
14. Cooperative Activities of Hematopoietic Regulators Recruit RNA Polymerase II to a Tissue-Specific Chromatin Domain
15. p53−/− synergizes with enhanced NrasG12D signaling to transform megakaryocyte-erythroid progenitors in acute myeloid leukemia
16. RNA-Regulatory Exosome Complex Suppresses an Apoptotic Program to Confer Erythroid Progenitor Cell Survival In Vivo
17. Mechanism governing a stem cell-generating cis-regulatory element
18. GATA2 haploinsufficiency caused by mutations in a conserved intronic element leads to MonoMAC syndrome
19. Conditionally pathogenic genetic variants of a hematopoietic disease–suppressing enhancer
20. Differential Sensitivities of Transcription Factor Target Genes Underlie Cell Type-Specific Gene Expression Profiles
21. Conditionally Pathogenic Genetic Variants of a Hematopoietic Disease-Suppressing Enhancer
22. Linking GATA2 Deficiency to Dysregulated Innate Immune Signaling
23. Spacing Constraints of Neighboring Zinc Finger Modules within GATA2
24. MLG: multilayer graph clustering for multi-condition scRNA-seq data
25. Gata2 +9.5 enhancer regulates adult hematopoietic stem cell self-renewal and T cell development
26. Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity
27. GATA2 deficiency during embryogenesis elevates Interferon Regulatory Factor-8 to subvert a progenitor cell differentiation program
28. GATA2 Enhancer Modules Governing Hematopoietic Regeneration
29. Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignancies
30. Constructing and deconstructing GATA2-regulated cell fate programs to establish developmental trajectories
31. Gata2 −77 enhancer regulates adult hematopoietic stem cell survival
32. Dynamic Nucleoprotein Structure of the β-Globin Locus: Establishing a Rational Molecular Basis for Therapeutic Modulation of Hemoglobin Switching
33. Loss-of-Function and Gain-of-Function Consequences of GATA2 Disease Mutations
34. GATA2-Dependent Developmental and Regenerative Networks
35. Establishment and Regulation of Chromatin Domains: Mechanistic Insights from Studies of Hemoglobin Synthesis
36. Requirements for utilization of CREB binding protein by hypersensitive site two of the β-globin locus control region
37. Blood disease–causing and –suppressing transcriptional enhancers: general principles and GATA2 mechanisms
38. Single-Nucleotide Human Disease Mutation Inactivates a Blood-Regenerative Enhancer
39. Gata2−77 enhancer regulates adult hematopoietic stem cell survival
40. Mechanisms of erythrocyte development and regeneration: implications for regenerative medicine and beyond
41. Integrating Enhancer Mechanisms to Establish a Hierarchical Blood Development Program
42. p53 −/− synergizes with enhanced NrasG12D signaling to transform megakaryocyte-erythroid progenitors in acute myeloid leukemia
43. Interconnections between DDX41-Dependent Post-Transcriptional and GATA Factor-Instigated Transcriptional Mechanisms That Govern Hematopoiesis
44. GATA Factor-G-Protein-Coupled Receptor Circuit Suppresses Hematopoiesis
45. A GATA-2-GPR65 Regulatory Module Controls Hematopoietic Stem Cell Generation
46. Mouse Modeling of GATA2 Related MDS/AML
47. Cistrome Control of Hematopoieitic Stem/Progenitor Cell Function
48. Cis-regulatory mechanisms governing stem and progenitor cell transitions
49. Integrating Enhancer Mechanisms to Establish a Hierarchical Blood Development Program.
50. Hematopoietic Signaling Mechanism Revealed from a Stem/Progenitor Cell Cistrome
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