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Your search keyword '"Johnston, Colette M."' showing total 15 results
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15 results on '"Johnston, Colette M."'

1. Supplemental Methods 1 from CB307: A Dual Targeting Costimulatory Humabody VH Therapeutic for Treating PSMA-Positive Tumors

Author

Archer, Sophie, primary, Brailey, Phillip M., primary, Song, Minjung, primary, Bartlett, Phillip D., primary, Figueiredo, Ines, primary, Gurel, Bora, primary, Guo, Christina, primary, Brucklacher-Waldert, Verena, primary, Thompson, H. Lorraine, primary, Akinwale, Jude, primary, Boyle, Samantha E., primary, Rossant, Christine, primary, Birkett, Neil R., primary, Pizzey, Julia, primary, Maginn, Mark, primary, Legg, James, primary, Williams, Richard, primary, Johnston, Colette M., primary, Bland-Ward, Philip, primary, de Bono, Johann S., primary, and Pierce, Andrew J., primary

Published
2024
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2. Data from CB307: A Dual Targeting Costimulatory Humabody VH Therapeutic for Treating PSMA-Positive Tumors

Author

Archer, Sophie, primary, Brailey, Phillip M., primary, Song, Minjung, primary, Bartlett, Phillip D., primary, Figueiredo, Ines, primary, Gurel, Bora, primary, Guo, Christina, primary, Brucklacher-Waldert, Verena, primary, Thompson, H. Lorraine, primary, Akinwale, Jude, primary, Boyle, Samantha E., primary, Rossant, Christine, primary, Birkett, Neil R., primary, Pizzey, Julia, primary, Maginn, Mark, primary, Legg, James, primary, Williams, Richard, primary, Johnston, Colette M., primary, Bland-Ward, Philip, primary, de Bono, Johann S., primary, and Pierce, Andrew J., primary

Published
2024
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3. Supplementary Figure 1 from CB307: A Dual Targeting Costimulatory Humabody VH Therapeutic for Treating PSMA-Positive Tumors

Author

Archer, Sophie, primary, Brailey, Phillip M., primary, Song, Minjung, primary, Bartlett, Phillip D., primary, Figueiredo, Ines, primary, Gurel, Bora, primary, Guo, Christina, primary, Brucklacher-Waldert, Verena, primary, Thompson, H. Lorraine, primary, Akinwale, Jude, primary, Boyle, Samantha E., primary, Rossant, Christine, primary, Birkett, Neil R., primary, Pizzey, Julia, primary, Maginn, Mark, primary, Legg, James, primary, Williams, Richard, primary, Johnston, Colette M., primary, Bland-Ward, Philip, primary, de Bono, Johann S., primary, and Pierce, Andrew J., primary

Published
2024
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4. CB307: A Dual Targeting Costimulatory Humabody VH Therapeutic for Treating PSMA-Positive Tumors

Author

Archer, Sophie, primary, Brailey, Phillip M., additional, Song, Minjung, additional, Bartlett, Phillip D., additional, Figueiredo, Ines, additional, Gurel, Bora, additional, Guo, Christina, additional, Brucklacher-Waldert, Verena, additional, Thompson, H. Lorraine, additional, Akinwale, Jude, additional, Boyle, Samantha E., additional, Rossant, Christine, additional, Birkett, Neil R., additional, Pizzey, Julia, additional, Maginn, Mark, additional, Legg, James, additional, Williams, Richard, additional, Johnston, Colette M., additional, Bland-Ward, Philip, additional, de Bono, Johann S., additional, and Pierce, Andrew J., additional

Published
2024
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6. Developmentally regulated Xist promoter switch mediates initiation of X inactivation

Author

Johnston, Colette M., Nesterova, Tatyana B., Formstone, Emma J., Newall, Alistair E.T., Duthie, Sarah M., Sheardown, Steven A., and Brockdorff, Neil

Subjects
Genetic regulation -- Research, Biological sciences
Abstract

Developmentally regulated changes in stability of Xist RNA can be attributed to a promoter switch prompting stable and unstable RNA isoforms. Stable Xist RNA comes from the previously identified promoter or from a unique promoter situated 1.5 kb further downstream, while unstable Xist RNA comes from a second novel promoter situated 6.5 kb upstream. It has been shown that promoter switching controls Xist RNA stability at the onset of random and imprinted X inactivation. It has also been shown that imprinted Xist expression takes place as a result of activation of P1/P2 on the Xp allele.

Published
1998

7. Stabilization of Xist RNA mediates initiation of X chromosome inactivation

Author

Sheardown, Steven A., Duthie, Sarah M., Johnston, Colette M., Newall, Alistair E.T., Formstone, Emma J., Arkell, Ruth M., Nesterova, Tatyana B., Alghisi, Gian-Carlo, Rastan, Sohaila, and Brockdorff, Neil

Subjects
X chromosome -- Research, Biological sciences
Abstract

Modulation of Xist RNA was studied to identify its effects on the developmental up-regulation of the X transcript. Results show that up-regulation of Xist RNA marks the beginning of X inactivation due to the increased stability of the transcript it has caused. However, an unstable transcript is caused by the inhibition of the Xist allele such as in the XX ES cells and in XX embryos which also occurs at the onset of X inactivation.

Published
1997

9. Skewing X chromosome choice by modulating sense transcription across the Xist locus

Author

Nesterova, Tatyana B., Johnston, Colette M., Appanah, Ruth, Newall, Alistair E. T., Godwin, Jonathan, Alexiou, Maria, and Brockdorff, Neil

Subjects
Gene mutations -- Physiological aspects, Allelomorphism -- Genetic aspects, Genetic regulation -- Physiological aspects, Genetic transcription -- Physiological aspects, X chromosome -- Genetic aspects, Genetic research -- Analysis, Biological sciences
Abstract

Research has been conducted on Xist locus. The authors have investigated the target mutations at the end of this locus, and have discovered that these mutations cause preferential inactivation of the X chromosome containing targeted allele in XX heterozygotes.

Published
2003

14. The role of Xist in the regulation of X chromosome inactivation

Author

JOHNSTON, COLETTE M., primary, DUTHIE, SARAH M., additional, SHEARDOWN, STEVEN A., additional, NEWALL, ALISTAIR E. T., additional, FORMSTONE, EMMA J., additional, ARKELL, RUTH M., additional, NESTEROVA, TATYANA B., additional, ALGHISI, GIANCARLO, additional, RASTAN, SOHAILA, additional, and BROCKDORFF, NEIL, additional

Published
1998
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