11 results on '"Johshita T"'
Search Results
2. Histological variety of localized lymphoid hyperplasia of the large intestine: histopathological, immunohistochemical and genotypic findings of 16 cases.
- Author
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Kojima M, Nakamura N, Itoh H, Motoori T, Hoshi K, Enomoto Y, Johshita T, and Nakamine H
- Subjects
- Aged, Diagnosis, Differential, Female, Follow-Up Studies, Gene Rearrangement, Genotype, Humans, Hyperplasia diagnosis, Hyperplasia genetics, Immunoglobulin Heavy Chains genetics, Immunohistochemistry, Lymphatic Diseases genetics, Lymphocytes pathology, Lymphoma, B-Cell diagnosis, Male, Middle Aged, Young Adult, Hyperplasia pathology, Intestine, Large pathology, Lymphatic Diseases pathology
- Abstract
Previous reports emphasized that localized lymphoid hyperplasia (LLH) of the large intestine is usually histologically characterized by large lymphoid follicles with striking enlarged germinal centers, and a narrow surrounding mantle zone and marginal zone (MZ). To clarify the histological varieties of LLH of the large intestine, 16 such cases have been studied. The present study demonstrated histological diversity of the LLH of the large intestine including (i) reactive follicular hyperplasia (RFH) (n=8), (ii) RFH with progressive transformation of the germinal center (PTGC) (n=3), (iii) RFH with MZ hyperplasia (n=3) and (iv) RFH with PTGC and MZ hyperplasia (n=2). Overall histomorphological findings of the present series appear quite different from previous descriptions of LLH of the large intestine. The present study showed histological variety of the LLH of the large intestine. Moreover, LLH of the large intestine should be differentiated from extranodal marginal zone B-cell lymphoma and nodular lymphocyte predominant Hodgkin lymphoma as well as follicular lymphoma. Immunohistological studies demonstrated the reactive nature of all 16 lesions. However, three cases showing RFH demonstrated immunoglobulin heavy chain gene rearrangement by polymerase chain reaction study in 12 cases examined. It remains unclear whether these three cases showing RFH could be a sign of the prelymphomatous stage (incipient follicular lymphoma) or representing merely an exaggeration of normal B-cell clonal response in the germinal centers. more...
- Published
- 2009
- Full Text
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3. Immunohistological findings of suppurative granulomas of Yersinia enterocolitica appendicitis: a report of two cases.
- Author
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Kojima M, Morita Y, Shimizu K, Yoshida T, Yamada I, Togo T, and Johshita T
- Subjects
- Abdominal Abscess metabolism, Abdominal Abscess microbiology, Adult, Appendicitis metabolism, Appendicitis microbiology, Biomarkers metabolism, Dendritic Cells metabolism, Dendritic Cells pathology, Female, Granuloma metabolism, Granuloma microbiology, Humans, Immunoglobulin M metabolism, Immunohistochemistry, Lymph Nodes metabolism, Lymph Nodes pathology, Middle Aged, Monocytes pathology, Plasma Cells pathology, T-Lymphocytes pathology, Yersinia Infections complications, Yersinia Infections metabolism, Yersinia enterocolitica genetics, Abdominal Abscess pathology, Appendicitis pathology, Granuloma pathology, Yersinia Infections pathology, Yersinia enterocolitica isolation & purification
- Abstract
We report on the histopathologic and immunohistologic findings of two cases of suppurative granulomatous appendicitis of Yersinia enterocolitica (Y. ent.). Using formalin-fixed, paraffin-embedded materials, polymerase chain reaction revealed Y. ent. in both cases. Histologically, the epithelioid cell granulomas (EPGs) were transmural in both cases. The EPGs were predominantly nonsuppurative, and were surrounded by a lymphoid cuff composed of small lymphocytes. A portion of EPGs contained suppuration of the centers of the granulomas (central microabscesses). The EPGs were composed of numerous histiocytes with or without epithelioid cell features, along with scattered small T-lymphocytes and plasmacytoid monocytes. None of the EPGs contained monocytoid B-cells. Immunohistochemical study demonstrated that EPGs were usually surrounded by surface IgM/D+ small mantle zone lymphocytes. Moreover, CNA.42 immunostaining occasionally demonstrated residual follicular dendritic cells in the center of the EPGs. The overall histomorphologic and immunohistochemical findings demonstrated that the EPGs with Y. ent. are of the B-cell negative hypersensitivity type and occur in reactive germinal centers. In one case, regional lymph nodes contained EPGs showing the same histologic and immunohistologic findings as those of the appendix. The present study indicates that among abscesses forming epithelioid granulomatous lesions, EPGs with Y. ent. were B-cell negative granulomas, and it demonstrates histopathologic and immunohistochemical findings different from those of cat scratch disease and lymphogranuloma venerum, which contain numerous monocytoid B-cells. more...
- Published
- 2007
- Full Text
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4. Atypical lymphocytosis resembling non-Hodgkin's lymphoma in peritoneal effusion of infectious mononucleosis: a case report.
- Author
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Tsuruta S, Ohyama S, Arai H, Kojima M, Johshita T, and Suzuki Y
- Subjects
- Adult, Antigens, CD metabolism, Ascitic Fluid cytology, Diagnosis, Differential, Epstein-Barr Virus Infections complications, Female, Humans, Immunohistochemistry, In Situ Hybridization, Infectious Mononucleosis pathology, Lymphocytes metabolism, Lymphocytosis pathology, Lymphoma, Non-Hodgkin pathology, Ascitic Fluid pathology, Infectious Mononucleosis complications, Lymphocytosis etiology
- Abstract
Peritoneal effusion appears to be an unusual complication of infectious mononucleosis (IM). The cytological features of peritoneal effusion from a patient affected by IM are presented. The patient was a 21-year-old Japanese woman, with typical and physical findings of IM. Ascites disappeared with resolution of acute IM. The cytospin smears of the ascitic fluid were highly cellular, consisting exclusively of lymphoid cells. Lymphoid cells were composed of large cells with broad basophilic cytoplasm, as well as of small to medium-sized cells having scant cytoplasm and irregularly shaped nuclei. The overall cytomorphological pictures posed serious difficulties in differentiating this condition from those of peripheral T-cell lymphomas manifesting ascites. The majority of atypical lymphocytes, including large cells, expressed CD3 and CD8. The present case indicates that IM should be added to the list of lesions considered for the differential diagnosis of non-Hodgkin's lymphoma of the peritoneal fluid, particularly regarding young adults. more...
- Published
- 2004
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5. Small ileal neurofibroma causing intussusception in a non-neurofibromatosis patient.
- Author
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Watanuki F, Ohwada S, Hosomura Y, Okamura S, Kawashima Y, Tanahashi Y, Nakamura S, Iino Y, Johshita T, and Morishita Y
- Subjects
- Adult, Humans, Ileal Neoplasms pathology, Male, Neurofibroma pathology, Submucous Plexus pathology, Ileal Diseases etiology, Ileal Neoplasms complications, Intussusception etiology, Neurofibroma complications
- Abstract
Neurofibromas in the small intestine are usually accompanied by von Recklinghausen's disease (neurofibromatosis), and usually originate in the intramuscular plexus of Auerbach. We present here a solitary neurofibroma, which caused an ileocolic intussusception, originating in the submucosal plexus of Meissner in a non-neurofibromatosis patient. To our knowledge, there is no previous report of a neurofibroma originating in the plexus of Meissner. This condition was clearly confirmed by macroscopic and microscopic evaluation. more...
- Published
- 1995
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6. Malignant lymphoma of Waldeyer's ring. A histological and immunohistochemical study.
- Author
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Kojima M, Tamaki Y, Nakamura S, Hosomura Y, Kurabayashi Y, Itoh H, Yoshida K, Niibe H, Suchi T, and Johshita T
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Immunoenzyme Techniques, Immunoglobulin Fragments analysis, Immunoglobulin M analysis, Immunoglobulin kappa-Chains analysis, Immunohistochemistry, Lymphoma therapy, Male, Middle Aged, Neoplasm Staging, Palatal Neoplasms therapy, Palate, Soft, Prognosis, Tonsillar Neoplasms therapy, Lymphoma pathology, Palatal Neoplasms pathology, Tonsillar Neoplasms pathology
- Abstract
The histopathological and immunohistological features of non-Hodgkin's lymphoma limited to the Waldeyer's ring were studied in 22 Japanese patients using a panel of T- and B-cell markers on paraffin-embedded sections. All cases showed a diffuse growth pattern. Twenty cases were B-cell lymphomas and two were T-cell lymphomas. In contrast to the primary malignant lymphomas of the nasal cavity and paranasal sinuses, in which T-cell neoplasms are more frequently seen, the majority of the primary Waldeyer's ring lymphomas were B-cell neoplasms. Sixteen of the 20 cases of B-cell lymphoma were centroblastic lymphomas, and the monomorphic variant comprised the majority of these; the other three B-cell lymphomas were immunocytomas. Two of the T-cell lymphomas showed morphological features of angiocentric lymphomas. more...
- Published
- 1993
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7. Malignant lymphomas of the nasal cavity and paranasal sinuses. A clinicopathologic and immunohistochemical study.
- Author
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Kojima M, Hosomura Y, Kurabayashi Y, Ohno Y, Itoh H, Yoshida K, Johshita T, Tamaki Y, Niibe H, and Nakamura S
- Subjects
- Adult, Aged, Aged, 80 and over, Female, Humans, Immunoenzyme Techniques, Immunophenotyping, Lymphoma, B-Cell pathology, Lymphoma, Non-Hodgkin immunology, Lymphoma, Non-Hodgkin therapy, Lymphoma, T-Cell pathology, Male, Middle Aged, Nasal Cavity pathology, Nose Neoplasms immunology, Nose Neoplasms therapy, Paranasal Sinus Neoplasms immunology, Paranasal Sinus Neoplasms therapy, Survival Rate, Lymphoma, Non-Hodgkin pathology, Nose Neoplasms pathology, Paranasal Sinus Neoplasms pathology
- Abstract
The clinicopathologic and immunohistological features of 20 Japanese patients with non-Hodgkin's lymphomas (NHLs) limited to the sinonasal area were studied using a broad panel of T- and B-cell markers on paraffin-embedded and fresh frozen tissue. All cases showed a diffuse growth pattern. Nine cases were B-cell lymphomas (immunoblastic n = 4, centroblastic n = 3, immunocytoma n = 1, centrocytic n = 1), and nine were T-cell lymphomas (pleomorphic medium and large cell n = 8, angioimmunoblastic n = 1). In two cases, the cell lineage could not be determined. No morphologic features of angiocentric/angiodestructive lymphoproliferative lesions or lymphoepithelial lesions in ductal or glandular epithelium were seen in our series. Eight (89%) of the nine T-cell tumors and four (44%) of the nine B-cell neoplasms involved both the nasal cavity and paranasal sinuses. Six of the nine T-cell neoplasms showed a clinical presentation of rhinitis, whereas all of the B-cell neoplasms showed tumor masses in the nasal cavity and/or paranasal sinuses. The two-year survival rate for T-cell lymphomas was poorer than that for B-cell lymphomas. The five-year survival of patients with NHLs involving both the nasal cavity and paranasal sinuses was also poorer than that of patients in whom NHLs were limited to the nasal cavity. more...
- Published
- 1992
- Full Text
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8. Monocytoid B lymphocytes and epithelioid cell clusters in abscess-forming granulomatous lymphadenitis. With special reference to cat scratch disease.
- Author
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Kojima M, Hosomura Y, Itoh H, Johshita T, Ohno Y, Yoshida K, Asano S, Wakasa H, Nakamura S, and Suchi T
- Subjects
- Abscess pathology, Adolescent, Adult, Aged, Child, Female, Granuloma pathology, Histocytochemistry, Humans, Male, Middle Aged, Silver, Staining and Labeling, B-Lymphocytes pathology, Cat-Scratch Disease pathology, Epithelioid Cells pathology, Lymphadenitis pathology
- Abstract
In order to clarify the appearance of monocytoid B lymphocytes (MBLs) in abscess-forming granulomatous lymphadenitis (AGL) and the relation between AGL and cat-scratch disease (CSD), 48 cases of AGL were studied histologically. MBLs were present in about 50% of AGL cases. Warthin-Starry (WS) silver stain-positive bacteria, which are the causative agent of CSD, were present in 52.4% of AGL cases with MBLs and 59.2% of AGL cases without MBLs. The appearance of MBLs in AGL was not related to various clinical features, including disease interval from initial lymphadenopathy to lymph node biopsy. Histologically, epithelioid cell clusters appeared in about 70% of MBL-positive AGL cases, but were not observed in MBL-negative AGL. Therefore, a close interaction between MBLs and epithelioid cells in AGL is suggested, and we emphasize that the histological features of some AGL cases resemble those of toxoplasmic lymphadenitis. more...
- Published
- 1991
- Full Text
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9. Reactive proliferative lesions in lymph nodes from rheumatoid arthritis patients. A clinicopathological and immunohistological study.
- Author
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Kojima M, Hosomura Y, Itoh H, Johshita T, Yoshida K, Nakamura S, and Suchi T
- Subjects
- Adult, Aged, Antigens, Differentiation immunology, Arthritis, Rheumatoid immunology, Arthritis, Rheumatoid pathology, Biopsy, CD57 Antigens, Cell Division physiology, Female, Humans, Immunoglobulin Heavy Chains immunology, Immunohistochemistry, Lymph Nodes immunology, Lymph Nodes pathology, Lymphatic Diseases immunology, Lymphatic Diseases pathology, Male, Middle Aged, T-Lymphocytes, Helper-Inducer immunology, T-Lymphocytes, Helper-Inducer pathology, T-Lymphocytes, Helper-Inducer physiology, T-Lymphocytes, Regulatory immunology, T-Lymphocytes, Regulatory pathology, T-Lymphocytes, Regulatory physiology, Arthritis, Rheumatoid complications, Lymphatic Diseases etiology
- Abstract
In 22 cases of rheumatoid arthritis (RA), including 4 cases of malignant RA (MRA), reactive proliferative lymph node lesions were studied clinicopathologically and immunohistochemically. This series included 5 males and 17 females. The period between disease onset and lymph node biopsy ranged from 3 months to 41 years. Generalized lymphadenopathy was noted in 13 cases and constitutional symptoms in 8. The histological findings characteristic of RA were 1) follicular hyperplasia with active germinal centers and 2) polyclonal plasma cell infiltration in the interfollicular area. Studies of intracytoplasmic immunoglobulin showed that gamma-heavy chain-expressing plasma cells were a major component in the interfollicular area in 17 RA cases. However, in 4 MRA cases, a prominent increase of mu chain-expressing plasma cells was recognized in the same area. In the 3 cases for which fresh tissue sections were stained with monoclonal antibodies against lymphocytes, we found that the majority of T cells in the interfollicular area had helper/inducer markers. The identical locations of the T cell population and plasma cells indicated that both played a role in the proliferation and/or differentiation of B cells in lymph nodes in RA. more...
- Published
- 1990
- Full Text
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10. [Initiation of arteriosclerosis].
- Author
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Sakata N, Johshita T, and Yoshida Y
- Subjects
- Aged, Animals, Arteries pathology, Cerebral Arteries cytology, Endothelium pathology, Hemodynamics, Humans, Hyperlipidemias complications, Male, Middle Aged, Muscle, Smooth, Vascular pathology, Rabbits, Rats, Arteriosclerosis etiology
- Published
- 1984
11. [INFLUENCE OF ALLOXAN ADMINSITRATION AND HYPOPHYSECTOMY ON THE PANCREATIC ISLETS OF THE RAT].
- Author
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KOBAYASHI K, TAKAHASHI Y, and JOHSHITA T
- Subjects
- Animals, Islands, Rats, Alloxan, Biochemical Phenomena, Biochemistry, Cell Biology, Cytoplasmic Granules, Diabetes Mellitus, Experimental, Hypophysectomy, Islets of Langerhans, Pathology, Research, Toxicology
- Published
- 1964
- Full Text
- View/download PDF
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