1. Height Increment and Laboratory Profile of Boys Treated With Aromatase Inhibitors With or Without Growth Hormone
- Author
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Carlos Alberto Longui, Durval Damiani, Ludmila Fernandes Pedrosa, Paula Roberta Vieira Thomé, Joice Marquez de Oliveira, and Cristiane Kochi
- Subjects
Male ,0301 basic medicine ,medicine.medical_specialty ,Adolescent ,medicine.drug_class ,Endocrinology, Diabetes and Metabolism ,Clinical Biochemistry ,Anastrozole ,030209 endocrinology & metabolism ,Biochemistry ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Age Determination by Skeleton ,Internal medicine ,medicine ,Humans ,Outpatient clinic ,Aromatase ,Child ,Testosterone ,Aromatase inhibitor ,Anthropometry ,biology ,Aromatase Inhibitors ,business.industry ,Letrozole ,Biochemistry (medical) ,Age Factors ,Bone age ,General Medicine ,Body Height ,030104 developmental biology ,Growth Hormone ,biology.protein ,business ,Body mass index ,medicine.drug - Abstract
Aromatase inhibitors (AIs) have been used to recover height loss due to their capacity to delay growth plate closure. Long-term studies describing final heights are needed to determine the efficacy and safety profiles of these drugs for the treatment of impaired growth. This study aims to identify the therapeutic efficiency of AIs in improve growth and to describe potential adverse effects during treatment. Retrospective data analysis of 96 adolescents, among which 22 patients already attained near-final height, were followed at outpatient clinics of two referral centers. Patients were all in puberty and present idiopathic decrease in predicted adult height. Patients were treated with Anastrozole (ANZ: 1 mg/day) or Letrozole (LTZ: 2.5 mg/day) with/without recombinant human growth hormone (0.05 mg/kg/day) for 1.0 to 3.5 years (2.1±1.2 years). Height gain, body mass index, lipid, liver enzyme, gonadotropins and testosterone levels were described before and at the end of treatment. Predicted adult height (PAH) and NF height were compared with the TH. The height SDS (adjusted to bone age) significantly increased (p
- Published
- 2017
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