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Background: Local application site reactions are common with sublingual allergy immunotherapy (AIT)‐tablets for the treatment of allergic rhinitis/conjunctivitis (AR/C) and occasionally lead to treatment discontinuation. Because of the lower mast cell density in the vestibular mucosa than the sublingual area, vestibular AIT‐tablet administration may result in fewer adverse events (AEs). This pilot study evaluated the tolerability of the vestibular administration route of AIT‐tablets compared with the sublingual route in adult subjects with AR/C. Methods: Adults (n = 164) aged 18–65 years with AR/C treated with daily birch pollen, grass pollen, ragweed pollen or house dust mite AIT in tablet form were randomized 1:1 to vestibular or sublingual administration for 28 days, followed by 28 days of sublingual administration only. The primary endpoint was the severity (mild, moderate, severe) of local treatment‐related adverse events (TRAEs) during the first 28 days of treatment. Results: During the first 28 days, the percentage of subjects in the vestibular and sublingual groups reporting mild TRAEs were 55.6% versus 50.6%, respectively; moderate TRAEs were 27.2% versus 30.1%; and severe TRAEs were 12.3% versus 6.0% (p =.16). In the vestibular group, 95.1% of the subjects experienced at least one TRAE during the first period versus 81.9% in the sublingual group (p =.01) and discontinuation rates due to AEs were higher (12.3% vs. 3.6%). Conclusion: The frequencies of subjects experiencing severe TRAEs, at least one TRAE, and discontinuations due to AEs at the initiation of AIT‐tablets were numerically higher with vestibular administration than sublingual administration. Sublingual administration should remain the standard of care for subjects treated with AIT‐tablets for AR/C. [ABSTRACT FROM AUTHOR]

This case study explores how Montreal became the first city in the world to adhere to the National Geographic Geotourism Charter and to develop an urban geotourism Mapguide. These initiatives are linked to ecotourism, sustainable tourism and urban tourism, and are now opening the door to a new way of managing tourism in the city. [ABSTRACT FROM AUTHOR]