16 results on '"Jonas C. Rose"'
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2. Nano-Scaled Lanthanum Hexaboride (LaB6) – Control of Properties in Dependence on Type of Manufacturing
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Rodrigue Ngoumeni, Jonas C. Rose, Martin Möller, Peter Sindlhauser, Karin Peter, and Volkan Yavuz
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010302 applied physics ,Materials science ,Induction plasma technology ,Nanoparticle ,Nanotechnology ,02 engineering and technology ,Lanthanum hexaboride ,021001 nanoscience & nanotechnology ,01 natural sciences ,Grinding ,chemistry.chemical_compound ,chemistry ,Fabrication methods ,0103 physical sciences ,Nano ,0210 nano-technology ,Ball mill ,Ethylene glycol - Abstract
This paper presents the influence of fabrication methods on the optical and photo-thermal properties of nano-LaB6. The nano particles (NPs) were manufactured via continuously operated ball milling or induction plasma technology. Whereas different grinding processes for LaB6 were also discussed using ethylene glycol (EG) and ZrO2 grinding media in previous works, the scaled-up plasma technology presents a new possibility to gain NPs with high yields and narrow size distribution. In our work, NPs more...
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- 2019
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Catalog
3. Predicting the orientation of magnetic microgel rods for soft anisotropic biomimetic hydrogels
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Lukas Kivilip, Esther E. Jaekel, David B. Gehlen, Jonas C. Rose, Wilko Rohlfs, Jose Gerardo-Nava, Laura De Laporte, and Maaike Fölster
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Materials science ,Polymers and Plastics ,Magnetic moment ,Orientation (computer vision) ,Organic Chemistry ,Bioengineering ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Biochemistry ,Rod ,0104 chemical sciences ,Magnetic field ,Condensed Matter::Soft Condensed Matter ,Dipole ,ddc:540 ,Self-healing hydrogels ,Newtonian fluid ,Composite material ,0210 nano-technology ,Anisotropy - Abstract
Polymer chemistry (2019). doi:10.1039/C9PY01008D, Published by RSC Publ., Cambridge
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- 2020
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4. Solvent-Induced Nanotopographies of Single Microfibers Regulate Cell Mechanotransduction
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Yashoda Chandorkar, Tamás Haraszti, Rahul Rimal, Khosrow Rahimi, Laura De Laporte, David B. Gehlen, Jonas C. Rose, and Abdolrahman Omidinia-Anarkoli
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chemistry.chemical_classification ,Materials science ,business.product_category ,Rotational speed ,02 engineering and technology ,Polymer ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,3. Good health ,0104 chemical sciences ,chemistry ,Microfiber ,General Materials Science ,Fiber ,Composite material ,Mechanotransduction ,0210 nano-technology ,Porosity ,business ,Spinning ,ddc:600 ,Microscale chemistry - Abstract
ACS applied materials & interfaces 11(8), 7671-7685 (2019). doi:10.1021/acsami.8b17955, Published by American Chemical Society, Washington, DC
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- 2019
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5. Synthetic 3D PEG-Anisogel Tailored with Fibronectin Fragments Induce Aligned Nerve Extension
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Matthias P. Lutolf, Laura De Laporte, Jonas C. Rose, Christopher Licht, David B. Gehlen, Marta Roccio, Abdolrahman Omidinia Anarkoli, Delphine Blondel, Tamás Haraszti, and Jeffrey A. Hubbell
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Polymers and Plastics ,medicine.medical_treatment ,Cell ,Biocompatible Materials ,02 engineering and technology ,01 natural sciences ,Polyethylene Glycols ,law.invention ,chemistry.chemical_compound ,stiffness ,law ,Materials Chemistry ,Nerve Tissue ,degradation ,Neurons ,biology ,Dynamic mechanical analysis ,021001 nanoscience & nanotechnology ,3. Good health ,medicine.anatomical_structure ,Recombinant DNA ,cell-migration ,0210 nano-technology ,neurite outgrowth ,Bioengineering ,610 Medicine & health ,Polyethylene glycol ,010402 general chemistry ,orientation ,Biomaterials ,ddc:570 ,PEG ratio ,growth-factors ,Neurites ,medicine ,Humans ,extracellular-matrix ,improvement ,Spinal Cord Injuries ,hydrogels ,Cell Proliferation ,poly(ethylene glycol) ,Cell growth ,Growth factor ,technology, industry, and agriculture ,Fibronectins ,0104 chemical sciences ,Fibronectin ,chemistry ,biology.protein ,Biophysics - Abstract
An enzymatically cross-linked polyethylene glycol (PEG)-based hydrogel was engineered to promote and align nerve cells in a three-dimensional manner. To render the injectable, otherwise bioinert, PEG-based material supportive for cell growth, its mechanical and biochemical properties were optimized. A recombinant fibronectin fragment (FNIII9*-10/12-14) was coupled to the PEG backbone during gelation to provide cell adhesive and growth factor binding domains in close vicinity. Compared to full-length fibronectin, FNIII9*-10/1214 supports nerve growth at similar concentrations. In a 3D environment, only the ultrasoft 1 w/v% PEG hydrogels with a storage modulus of similar to 10 Pa promoted neuronal growth. This gel was used to establish the first fully synthetic, injectable Anisogel by the addition of magnetically aligned microelements, such as rod-shaped microgels or short fibers. The Anisogel led to linear neurite extension and represents a large step in the direction of clinical translation with the opportunity to treat acute spinal cord injuries. more...
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- 2019
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6. A catalyst-free, temperature controlled gelation system for in-mold fabrication of microgels
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Martin Möller, Stefan Cichosz, Jens Köhler, Jonas C. Rose, Andreas J D Krüger, David B. Gehlen, Laura De Laporte, and Tamás Haraszti
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Ethylene ,Fabrication ,Materials science ,Oxide ,macromolecular substances ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Catalysis ,chemistry.chemical_compound ,Materials Chemistry ,chemistry.chemical_classification ,technology, industry, and agriculture ,Metals and Alloys ,General Chemistry ,Epoxy ,Polymer ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,chemistry ,Polymerization ,Chemical engineering ,visual_art ,Self-healing hydrogels ,Ceramics and Composites ,visual_art.visual_art_medium ,0210 nano-technology - Abstract
Anisometric microgels are prepared via thermal crosslinking using an in-mold polymerization technique. Star-shaped poly(ethylene oxide-stat-propylene oxide) polymers, end-modified with amine and epoxy groups, form hydrogels, of which the mechanical properties and gelation rate can be adjusted by the temperature, duration of heating, and polymer concentration. Depending on the microgel stiffness, the rod-shaped microgels self-assemble into ordered or disordered structures. more...
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- 2018
7. Injectable Hydrogels: An Injectable Hybrid Hydrogel with Oriented Short Fibers Induces Unidirectional Growth of Functional Nerve Cells (Small 36/2017)
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Jonas C. Rose, Sarah Boesveld, Abdolrahman Omidinia-Anarkoli, Tamás Haraszti, Laura De Laporte, and Urandelger Tuvshindorj
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Materials science ,0206 medical engineering ,Injectable hydrogels ,02 engineering and technology ,General Chemistry ,021001 nanoscience & nanotechnology ,020601 biomedical engineering ,Biomaterials ,Nerve cells ,General Materials Science ,Composite material ,0210 nano-technology ,Biotechnology ,Biomedical engineering - Published
- 2017
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8. Biofunctionalized aligned microgels provide 3D cell guidance to mimic complex tissue matrices
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Christopher Licht, Tamás Haraszti, David B. Gehlen, Jens Köhler, Jonas C. Rose, and Laura De Laporte
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Cell ,Biophysics ,Metal Nanoparticles ,Bioengineering ,Biocompatible Materials ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Ferric Compounds ,Polyethylene Glycols ,Biomaterials ,Extracellular matrix ,chemistry.chemical_compound ,Biomimetics ,ddc:570 ,medicine ,Cell Adhesion ,Humans ,Dimethylpolysiloxanes ,Fibroblast ,Cells, Cultured ,Cell Proliferation ,PEG Hydrogel ,Fibrin ,biology ,Chemistry ,Cell growth ,Hydrogels ,Fibroblasts ,021001 nanoscience & nanotechnology ,Biocompatible material ,0104 chemical sciences ,3. Good health ,Extracellular Matrix ,Fibronectins ,Fibronectin ,medicine.anatomical_structure ,Cross-Linking Reagents ,Mechanics of Materials ,Ceramics and Composites ,biology.protein ,Anisotropy ,0210 nano-technology ,Peptides ,Ethylene glycol ,Porosity - Abstract
Natural healing is based on highly orchestrated processes, in which the extracellular matrix plays a key role. To resemble the native cell environment, we introduce an artificial extracellular matrix (aECM) with the capability to template hierarchical and anisotropic structures in situ, allowing a minimally-invasive application via injection. Synthetic, magnetically responsive, rod-shaped microgels are locally aligned and fixed by a biocompatible surrounding hydrogel, creating a hybrid anisotropic hydrogel (Anisogel), of which the physical, mechanical, and chemical properties can be tailored. The microgels are rendered cell-adhesive with GRGDS and incorporated either inside a cell-adhesive fibrin or bioinert poly(ethylene glycol) hydrogel to strongly interact with fibroblasts. GRGDS-modified microgels inside a fibrin-based Anisogel enhance fibroblast alignment and lead to a reduction in fibronectin production, indicating successful replacement of structural proteins. In addition, YAP-translocation to the nucleus increases with the concentration of microgels, indicating cellular sensing of the overall anisotropic mechanical properties of the Anisogel. For bioinert surrounding PEG hydrogels, GRGDS-microgels are required to support cell proliferation and fibronectin production. In contrast to fibroblasts, primary nerve growth is not significantly affected by the biomodification of the microgels. In conclusion, this approach opens new opportunities towards advanced and complex aECMs for tissue regeneration. more...
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- 2017
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9. Cell Encapsulation in Soft, Anisometric Poly(ethylene) Glycol Microgels Using a Novel Radical‐Free Microfluidic System
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Tamás Haraszti, David B. Gehlen, Alexander J. C. Kuehne, Luis P. B. Guerzoni, Alexander Jans, Jonas C. Rose, Laura De Laporte, and Matthias Wessling
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Poly ethylene glycol ,Microgels ,Cell growth ,Chemistry ,Microfluidics ,Dispersity ,Cell ,Nanotechnology ,Cell Encapsulation ,General Chemistry ,Fibroblasts ,Hydrogen-Ion Concentration ,Cell delivery ,Polyethylene Glycols ,Biomaterials ,medicine.anatomical_structure ,Elastic Modulus ,medicine ,Humans ,General Materials Science ,Cell encapsulation ,Cells, Cultured ,Artificial tissue ,Biotechnology - Abstract
Complex 3D artificial tissue constructs are extensively investigated for tissue regeneration. Frequently, materials and cells are delivered separately without benefitting from the synergistic effect of combined administration. Cell delivery inside a material construct provides the cells with a supportive environment by presenting biochemical, mechanical, and structural signals to direct cell behavior. Conversely, the cell/material interaction is poorly understood at the micron scale and new systems are required to investigate the effect of micron-scale features on cell functionality. Consequently, cells are encapsulated in microgels to avoid diffusion limitations of nutrients and waste and facilitate analysis techniques of single or collective cells. However, up to now, the production of soft cell-loaded microgels by microfluidics is limited to spherical microgels. Here, a novel method is presented to produce monodisperse, anisometric poly(ethylene) glycol microgels to study cells inside an anisometric architecture. These microgels can potentially direct cell growth and can be injected as rod-shaped mini-tissues that further assemble into organized macroscopic and macroporous structures post-injection. Their aspect ratios are adjusted with flow parameters, while mechanical and biochemical properties are altered by modifying the precursors. Encapsulated primary fibroblasts are viable and spread and migrate across the 3D microgel structure. more...
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- 2019
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10. Microfluidic fabrication of polyethylene glycol microgel capsules with tailored properties for the delivery of biomolecules
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Luis P. B. Guerzoni, Jan Bohl, Alexander J. C. Kuehne, Laura De Laporte, Alexander Jans, Jonas C. Rose, and Jens Koehler
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Materials science ,Fabrication ,Microfluidics ,Dispersity ,Biomedical Engineering ,Oxide ,Capsules ,Nanotechnology ,02 engineering and technology ,Polyethylene glycol ,010402 general chemistry ,01 natural sciences ,Polyethylene Glycols ,chemistry.chemical_compound ,Lab-On-A-Chip Devices ,General Materials Science ,chemistry.chemical_classification ,Drug Carriers ,Biomolecule ,technology, industry, and agriculture ,Aqueous two-phase system ,Polymer ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,chemistry ,0210 nano-technology ,Gels - Abstract
Microfluidic encapsulation platforms have great potential not only in pharmaceutical applications but also in the consumer products industry. Droplet-based microfluidics is increasingly used for the production of monodisperse polymer microcapsules for biomedical applications. In this work, a microfluidic technique is developed for the fabrication of monodisperse double emulsion droplets, where the shell is crosslinked into microgel capsules. A six-armed acrylated star-shaped poly(ethylene oxide-stat-propylene oxide) pre-polymer is used to form the microgel shell after a photo-initiated crosslinking reaction. The synthesized microgel capsules are hollow, enabling direct encapsulation of large amounts of multiple biomolecules with the inner aqueous phase completely engulfed inside the double emulsion droplets. The shell thickness and overall microgel sizes can be controlled via the flow rates. The morphology and size of the shells are characterized by cryo-SEM. The encapsulation and retention of 10 kDa FITC-dextran and its microgel degradation mediated release are monitored by fluorescence microscopy. more...
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- 2017
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11. Nerve Cells Decide to Orient inside an Injectable Hydrogel with Minimal Structural Guidance
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Khosrow Rahimi, Jens Köhler, Martin Möller, Laura De Laporte, María Cámara-Torres, and Jonas C. Rose
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magnetic nanoparticles ,Letter ,Materials science ,Superparamagnetic iron oxide nanoparticles ,Metal Nanoparticles ,injectable hydrogel ,Biocompatible Materials ,Bioengineering ,Nanotechnology ,tissue regeneration ,anisotropy ,02 engineering and technology ,Matrix (biology) ,Polypropylenes ,010402 general chemistry ,Ferric Compounds ,01 natural sciences ,Nerve growth ,Polyethylene Glycols ,microgels ,Mice ,Electromagnetic Fields ,Animals ,Humans ,General Materials Science ,Particle Size ,Magnetite Nanoparticles ,Neurons ,Tissue Scaffolds ,Mechanical Engineering ,Hydrogels ,General Chemistry ,Fibroblasts ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Biocompatible material ,0104 chemical sciences ,Low volume ,ddc:540 ,Self-healing hydrogels ,Nerve cells ,magnetic alignment ,Magnetic nanoparticles ,Polyethylenes ,0210 nano-technology ,Chickens - Abstract
Nano letters 17(6), 3782-3791 (2017). doi:10.1021/acs.nanolett.7b01123, Published by ACS Publ., Washington, DC
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- 2017
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12. An Injectable Hybrid Hydrogel with Oriented Short Fibers Induces Unidirectional Growth of Functional Nerve Cells
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Tamás Haraszti, Sarah Boesveld, Jonas C. Rose, Urandelger Tuvshindorj, Laura De Laporte, and Abdolrahman Omidinia-Anarkoli
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Materials science ,Nanotechnology ,Chick Embryo ,02 engineering and technology ,Matrix (biology) ,010402 general chemistry ,01 natural sciences ,Regenerative medicine ,Injections ,Tissue therapy ,Biomaterials ,injectable hydrogels ,Animals ,short fibers ,General Materials Science ,Anisotropy ,Cell Proliferation ,Neurons ,Hydrogels ,General Chemistry ,Fibroblasts ,021001 nanoscience & nanotechnology ,Biocompatible material ,0104 chemical sciences ,Self-healing hydrogels ,Nerve cells ,ddc:540 ,anisotropic structures ,magnetic alignment ,cell and nerve guidance ,Adhesive ,0210 nano-technology ,Biotechnology ,Biomedical engineering - Abstract
Small : nano micro 13(36), 1702207 (2017). doi:10.1002/smll.201702207, Published by Wiley-VCH, Weinheim
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- 2017
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13. Regenerative Medicine: Hierarchical Design of Tissue Regenerative Constructs (Adv. Healthcare Mater. 6/2018)
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Laura De Laporte and Jonas C. Rose
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Biomaterials ,Engineering management ,Computer science ,Biomedical Engineering ,Pharmaceutical Science ,Regenerative medicine ,Hierarchical design - Published
- 2018
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14. Hierarchical Design of Tissue Regenerative Constructs
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Jonas C. Rose and Laura De Laporte
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0301 basic medicine ,Computer science ,Biomedical Engineering ,Pharmaceutical Science ,Computational biology ,law.invention ,Biomaterials ,03 medical and health sciences ,Tissue engineering ,In vivo ,law ,medicine ,Humans ,Regeneration ,3D bioprinting ,Tissue Engineering ,Tissue Scaffolds ,Regeneration (biology) ,Cartilage ,Bioprinting ,Biomaterial ,Extracellular Matrix ,030104 developmental biology ,medicine.anatomical_structure ,Ex vivo ,Hierarchical design - Abstract
The worldwide shortage of organs fosters significant advancements in regenerative therapies. Tissue engineering and regeneration aim to supply or repair organs or tissues by combining material scaffolds, biochemical signals, and cells. The greatest challenge entails the creation of a suitable implantable or injectable 3D macroenvironment and microenvironment to allow for ex vivo or in vivo cell-induced tissue formation. This review gives an overview of the essential components of tissue regenerating scaffolds, ranging from the molecular to the macroscopic scale in a hierarchical manner. Further, this review elaborates about recent pivotal technologies, such as photopatterning, electrospinning, 3D bioprinting, or the assembly of micrometer-scale building blocks, which enable the incorporation of local heterogeneities, similar to most native extracellular matrices. These methods are applied to mimic a vast number of different tissues, including cartilage, bone, nerves, muscle, heart, and blood vessels. Despite the tremendous progress that has been made in the last decade, it remains a hurdle to build biomaterial constructs in vitro or in vivo with a native-like structure and architecture, including spatiotemporal control of biofunctional domains and mechanical properties. New chemistries and assembly methods in water will be crucial to develop therapies that are clinically translatable and can evolve into organized and functional tissues. more...
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- 2018
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15. Strong Photoacoustic Signal Enhancement by Coating Gold Nanoparticles with Melanin for Biomedical Imaging
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Andreas Fery, Dmitry N. Chigrin, Roberto Cao-Milán, Wiltrud Lederle, Alexander J. C. Kuehne, Jonas C. Rose, Rostislav Vinokur, Alina Hermann, Sheila Moli, Laura De Laporte, Tatjana Repenko, Alexander Nedilko, Anne Rix, Martin Mayer, and Gero von Plessen more...
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Materials science ,Photoacoustic imaging in biomedicine ,Nanotechnology ,02 engineering and technology ,Photothermal therapy ,engineering.material ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,0104 chemical sciences ,Electronic, Optical and Magnetic Materials ,Biomaterials ,Melanin ,Signal enhancement ,Coating ,Colloidal gold ,Electrochemistry ,Medical imaging ,engineering ,0210 nano-technology - Published
- 2017
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16. How Much Physical Guidance is Needed to Orient Growing Axons in 3D Hydrogels?
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Esther E. Jaekel, David B. Gehlen, Abdolrahman Omidinia-Anarkoli, Maaike Fölster, Tamás Haraszti, Laura De Laporte, and Jonas C. Rose
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Neurons ,Materials science ,Neurite ,Neuronal Outgrowth ,Biomedical Engineering ,Pharmaceutical Science ,Nanotechnology ,Hydrogels ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Axons ,0104 chemical sciences ,3. Good health ,Biomaterials ,Self-healing hydrogels ,Nerve cells ,Anisotropy ,0210 nano-technology ,Magnetic orientation - Abstract
Directing cells is essential to organize multi-cellular organisms that are built up from subunits executing specific tasks. This guidance requires a precisely controlled symphony of biochemical, mechanical, and structural signals. While many guiding mechanisms focus on 2D structural patterns or 3D biochemical gradients, injectable material platforms that elucidate how cellular processes are triggered by defined 3D physical guiding cues are still lacking but crucial for the repair of soft tissues. Herein, a recently developed anisotropic injectable hybrid hydrogel (Anisogel) contains rod-shaped microgels that orient in situ by a magnetic field and has propelled studying 3D cell guidance. Here, the Anisogel is used to investigate the dependence of axonal guidance on microgel dimensions, aspect ratio, and distance. While large microgels result in high material anisotropy, they significantly reduce neurite outgrowth and thus the guidance efficiency. Narrow and long microgels enable strong axonal guidance with maximal outgrowth including cell sensing over distances of tens of micrometers in 3D. Moreover, nerve cells decide to orient inside the Anisogel within the first three days, followed by strengthening of the alignment, which goes along with oriented fibronectin deposition. These findings demonstrate the potential of the Anisogel to tune structural and mechanical parameters for specific applications. more...
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