7 results on '"Jonathan Taylormoore"'
Search Results
2. Optical coherence tomography to monitor vigabatrin toxicity in children
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Janet L. Alexander, William McClintock, Mohamad S. Jaafar, Marlet Bazemore, Madison M. Berl, Marijean Miller, Heather de Beaufort, Nancy Elling, Catherine Origlieri, William Madigan, Jonathan Taylormoore, Kelly A. Hutcheson, Brooke Geddie, and Bethany Karwoski
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Male ,Retinal Ganglion Cells ,medicine.medical_specialty ,Adolescent ,genetic structures ,Nerve fiber layer ,Retina ,Vigabatrin ,03 medical and health sciences ,chemistry.chemical_compound ,Nerve Fibers ,0302 clinical medicine ,Retinal Diseases ,Tuberous Sclerosis ,Ophthalmology ,Electroretinography ,Humans ,Medicine ,Prospective Studies ,Child ,Prospective cohort study ,medicine.diagnostic_test ,Cumulative dose ,business.industry ,Fundus photography ,Infant ,Retinal ,eye diseases ,Surgery ,medicine.anatomical_structure ,chemistry ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,030221 ophthalmology & optometry ,Anticonvulsants ,Female ,sense organs ,Visual Fields ,business ,Tomography, Optical Coherence ,030217 neurology & neurosurgery ,medicine.drug - Abstract
The antiepileptic drug vigabatrin is known to cause permanent loss of vision. Both visual field testing and electroretinogram are used to detect retinal damage. Adult data on optical coherence tomography (OCT) shows that retinal nerve fiber layer (RNFL) thinning may be an early indicator of vigabatrin-induced retinal toxicity. The purpose of this study was to investigate whether OCT can detect early vigabatrin-induced retinal toxicity in children.Pediatric patients (≤18 years of age) requiring vigabatrin for seizure control who were followed at our institution were invited to participate. Patients were examined according to manufacturer guidelines, with most examinations taking place under general anesthesia. RNFL thickness was measured by OCT (Stratus Model 3000, Zeiss) and compared to total cumulative dose of vigabatrin. In most cases, indirect ophthalmoscopy, fundus photography, and electroretinography were also performed.OCT and complete dosing data was available for 19 patients. Patients with tuberous sclerosis (TS, n = 12) received higher cumulative doses (mean, 1463 g) than non-TS patients (mean, 351 g, P = 0.044). RNFL thinning was detected in the nasal (P 0.01), superior (P 0.01), and inferior (P 0.05) quadrants in patients with TS, particularly once cumulative dose exceeded 1500 g.In our study population of patients with TS, higher cumulative doses of vigabatrin were associated with RNFL thinning in the nasal, superior, and inferior quadrants. These findings were pronounced once cumulative dose exceeded 1500 g. This pattern of RNFL thinning is similar to what has been shown in adult patients taking vigabatrin.
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- 2016
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3. Superior Versus Inferior Monocanalicular Stent Retention in the Pediatric Population
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William P. Madigan, Monica Manrique, Richard H Birdsong, Brian Sajorda, Heather de Beaufort, Jonathan Taylormoore, Bethany Karwoski, Jana Bregman, and Kelly A. Hutcheson
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medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,medicine ,Stent ,General Medicine ,business ,Surgery ,Pediatric population - Published
- 2020
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4. Periocular facial scald burns in children: is ophthalmology consultation necessary?
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Omar Z. Ahmed, Randall S. Burd, Jonathan Taylormoore, Konstantinos Spiliopoulos, Carson E. Clay, and Bethany Karwoski
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Chemosis ,medicine.medical_specialty ,Burn Units ,Erythromycin ,Corneal abrasion ,Ophthalmology ,Humans ,Medicine ,Child ,Referral and Consultation ,Retrospective Studies ,Not evaluated ,business.industry ,Incidence (epidemiology) ,Incidence ,General surgery ,Burn center ,General Medicine ,medicine.disease ,eye diseases ,Pediatrics, Perinatology and Child Health ,Emergency Medicine ,sense organs ,medicine.symptom ,Injury treatment ,business ,Positive Finding ,medicine.drug - Abstract
OBJECTIVES Criteria that predict the need for ocular injury treatment in children who suffer periocular facial scald burns are not known. The purpose of this study was to evaluate the incidence and management of ocular injuries among children sustaining facial scald burns and to determine predictors of injuries requiring additional treatment. METHODS Children treated at a burn center with periocular facial scald burns were analyzed. Patient and injury profiles were compared between those evaluated and not evaluated by an ophthalmologist. Factors associated with an ocular injury requiring treatment were determined, and treatment differences before and after ophthalmology consultation were evaluated. RESULTS Seventy-three children with facial scald burns were identified, none with a full-thickness injury. Thirteen children had ocular findings on examination including corneal abrasion, conjunctivitis, scleral burn, and chemosis of the conjunctiva. Twenty-three patients received erythromycin ointment, only 8 of whom had a documented ocular injury. Children seen by an ophthalmologist (n = 24) more often had a positive finding on examination (37.5% vs 8.2%, P = 0.007) and received treatment (66.7% vs 14.3%, P < 0.001). Only 4 patients had modification in their treatment plan after consultation, 3 of whom were started on treatment despite not having a positive finding on examination. CONCLUSIONS Ocular injury after periocular facial scald burns is an infrequent finding. Among children with partial-thickness periocular facial scald burns, initial evaluation and treatment without ophthalmology consultation are appropriate. Ophthalmic antibiotic ointment is an appropriate initial treatment in most symptomatic patients, with ophthalmologic consultation being limited to children without symptomatic improvement.
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- 2018
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5. Predictors of Surgery in Pediatric Orbital Cellulitis
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Rahul K. Shah, Lina Lander, Jonathan Taylormoore, Diego Preciado, and Aditya Mahalingam-Dhingra
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medicine.medical_specialty ,Otorhinolaryngology ,business.industry ,Medicine ,Surgery ,Orbital cellulitis ,business ,medicine.disease - Published
- 2010
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6. Utility of ocular coherence tomography in monitoring vigabatrin retinal toxicity
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Jonathan Taylormoore, Heather de Beaufort, Brooke Geddie, Janet Leath, Marijean Miller, Catherine Origlieri, Bethany Karwoski, William McClintock, Mohamad S. Jaafar, Nancy Elling, Kelly A. Hutcheson, Marlet Bazmore, and William P. Madigan
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Ophthalmology ,medicine.medical_specialty ,Retinal toxicity ,business.industry ,Pediatrics, Perinatology and Child Health ,Medicine ,Tomography ,business ,Vigabatrin ,Coherence (physics) ,medicine.drug - Published
- 2014
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7. Orbital and Periorbital Infections<subtitle>A National Perspective</subtitle>
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Jonathan Taylormoore, Rahul K. Shah, Diego Preciado, Lina Lander, and Aditya Mahalingam-Dhingra
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Diplopia ,medicine.medical_specialty ,Design analysis ,business.industry ,Outcome measures ,General Medicine ,Emergency department ,medicine.disease ,Logistic regression ,Triage ,Otorhinolaryngology ,Emergency medicine ,Medicine ,Surgery ,Orbital cellulitis ,medicine.symptom ,business ,Intensive care medicine ,Resource utilization - Abstract
Objectives To describe the epidemiologic features of pediatric orbital and periorbital infections from a national perspective and to identify predictors of surgery. Design Analysis of the Kids' Inpatient Database. Setting Administrative data set. Patients Pediatric inpatient admissions with an International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis of orbital cellulitis. Main Outcome Measures Hospital admission, socioeconomic, and clinical variables were examined and predictors of surgical intervention were evaluated using logistic regression. Results A total 5440 hospital admissions was noted for pediatric orbital cellulitis; of these, 672 patients (12.4%) underwent surgical intervention. Mean length of stay for all patients was 3.8 days; 90.4% were routinely discharged. Patients who had surgery were older, with a mean (SE) age of 10.1 (0.29) years compared with 6.1 (0.10) years for nonsurgical patients (P Conclusions This study describes the medical and surgical management of pediatric orbital and periorbital infections from a national perspective. Predictors of surgical intervention include older age, presentation with diplopia, and hospital admission via the emergency department. Knowledge of these variables facilitates analysis of resource utilization for pediatric orbital cellulitis and can be used to optimally triage patients, ultimately reducing costs and lengths of stay while preserving quality of care.
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- 2011
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