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INTRODUCTION: Historically, prioritizing abundant food production often resulted in overlooking nutrient quality and bioavailability, however, environmental concerns have now propelled sustainable nutrition and health efficacy to the forefront of global attention. In fact, increasing demand for protein is the major challenge facing the food system in the 21st century with an estimation that 70% more food is needed by 2050. This shift has spurred interest in plant-based proteins for their sustainability and health benefits, but most alternative sources of protein are poorly digestible. There are two approaches to solve digestibility: improve the digestibility of food proteins or improve the digestive capacity of consumers. Enhancing nutrient digestibility and bioavailability across diverse protein sources is crucial, with proteases presenting a promising avenue. Research, inspired by the proteases of human breast milk, has demonstrated that exogenous microbial proteases can activate within the human digestive tract and substantially increase the digestion of targeted proteins that are otherwise difficult to fully digest. METHODS: Here, we introduce the use of an acid-active family of bacterial proteases (S53) to improve the digestibility and nutritional quality of a variety of protein sources, evaluated using the INFOGEST 2.0 protocol. RESULTS: Results from in vitro digestibility indicate that the most effective protease in the S53 family substantially improves the digestibility of an array of animal and plant-derived proteins-soy, pea, chickpea, rice, casein, and whey. On average, this protease elevated protein digestibility by 115% during the gastric phase and by 15% in the intestinal phase, based on the degree of hydrolysis. DISCUSSION: The widespread adoption of these proteases has the potential to enhance nutritional value and contribute to food security and sustainability. This approach would complement ongoing efforts to improve proteins in the food supply, increase the quality of more sustainable protein sources and aid in the nourishment of patients with clinically compromised, fragile intestines and individuals like older adults and high-performance athletes who have elevated protein needs.

Introduction: Dementia is a common co-morbidity in older people who require urgent or emergency ambulance attendance and influences clinical decisions and care pathways. Following an initial audit of dementia data and consultation with staff, a specific section (tab) to record dementia was introduced on an ambulance service electronic patient record (ePR). This includes a dementia diagnosis button and a free-text section. We aimed to assess whether and how this improved recording. Methods: To re-audit the proportion of ambulance ePRs where dementia is recorded for patients aged ≥65 years, and to describe the frequency of recording in patients aged <65; to analyse discrepancies in the place of recording dementia on the ePR by comparing data from the new dementia tab and other sections of the ePR. Results: We included 112,193 ePRs of patients aged ≥65 with ambulance attendance from a six-month period. The proportion with dementia recorded in patients aged ≥65 was 16.5%, increasing to 19.9% in patients aged ≥75, as compared to 13.5% (≥65) and 16.5% (≥75) in our previous audit. In this audit, of the 16.5% (n = 18,515) of records with dementia recorded, 69.9% (n = 12,939) used the dementia button and 25.4% (n = 4704) recorded text in the dementia tab. Dementia was recorded in ePR free-text fields (but not the dementia tab) in 29.7% of records. Eighteen other free-text fields were used in addition to, or instead of, the dementia tab, including the patient's social history, previous medical history and mental health. Dementia was present on the ePR of 0.4% (n = 461) of patients aged <65. Conclusions: An ePR dementia tab enabled ambulance clinicians to standardise the location of recording dementia and may have facilitated increased recording. We would recommend other ambulance trusts capture this information in a specific section to improve information sharing and to inform care planning for this patient group. [ABSTRACT FROM AUTHOR]

African American (AA) women have disproportionately high physical inactivity and obesity prevalence rates in comparison to their gender and racial counterparts. AA women experience unique barriers to leisure-time physical activity (LTPA); however, methods to overcome these barriers are less developed. Therefore, this study used semistructured interviews to explore strategies of young, active AA women that support LTPA maintenance and to identify their psychosocial and behavioral characteristics. The International Physical Activity Questionnaire-long was also administered to provide descriptors of participants' LTPA. Ten women (age: M = 26.1, SD = 1.7 years) who met national guidelines for aerobic or muscle-strengthening LTPA at least 6 months (aerobic LTPA: M = 2,578.0, SD = 1,228.5 metabolic equivalent-minutes [MET-min]/week; muscle-strengthening physical activity: M = 4.0, SD = 1.9 days/week) completed the study. Four categories emerged from the interviews: (a) early-life contributors to LTPA participation, (b) characteristics of current LTPA, (c) initiating LTPA participation, and (d) maintaining LTPA participation. Findings revealed participants identified weightlifting as a preferred type of LTPA, identified various planning/preparation methods to overcome LTPA challenges, and relied on social media to initiate and maintain LTPA. This study identified several strategies used by young AA women to maintain regular LTPA and program preferences. These data are important in this understudied group as similar strategies may help inactive young AA women overcome LTPA challenges and promote long-term adherence. This could help prevent health and physical activity disparities in this population. [ABSTRACT FROM AUTHOR]