Search

Your search keyword '"Jones, Lisa A."' showing total 4,592 results
Start Over Author "Jones, Lisa A."
4,592 results on '"Jones, Lisa A."'

1. Program Directors Survey on the Impact of the COVID-19 Pandemic on Cardiology Fellowship Training

Author

Cullen, Michael W, Damp, Julie B, Soukoulis, Victor, Keating, Friederike K, Abudayyeh, Islam, Yang, Eric H, Kondapaneni, Meera, Polk, Donna M, Rose-Jones, Lisa J, Theriot, Paul, and Weissman, Gaby

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Emerging Infectious Diseases, Coronaviruses Disparities and At-Risk Populations, Coronaviruses, Infectious Diseases, Cardiovascular, Quality Education
Published
2024

8. Development of Spheroid-FPOP: An In-Cell Protein Footprinting Method for 3D Tumor Spheroids.

Author

Shortt, Raquel, Wang, Yijia, Hummon, Amanda, and Jones, Lisa

Subjects
Humans, Protein Footprinting, Proteins, Mass Spectrometry, Oxidation-Reduction, Neoplasms, Antineoplastic Agents, Spheroids, Cellular, Tumor Microenvironment
Abstract

Many cancer drugs fail at treating solid epithelial tumors with hypoxia and insufficient drug penetration thought to be contributing factors to the observed chemoresistance. Owing to this, it is imperative to evaluate potential cancer drugs in conditions as close to in vivo as possible, which is not always done. To address this, we developed a mass spectrometry-based protein footprinting method for exploring the impact of hypoxia on protein in 3D colorectal cancer cells. Our group has previously extended the protein footprinting method fast photochemical oxidation of proteins (FPOP) for live cell analysis (IC-FPOP); however, this is the first application of IC-FPOP in a 3D cancer model. In this study, we perform IC-FPOP on intact spheroids (Spheroid-FPOP) using a modified version of the static platform incubator with an XY movable stage (PIXY) FPOP platform. We detected modification in each of three spheroid layers, even the hypoxic core. Pathway analysis revealed protein modifications in over 10 distinct protein pathways, including some involved in protein ubiquitination; a process modulated in cancer pathologies. These results demonstrate the feasibility of Spheroid-FPOP to be utilized as a tool to interrogate protein interactions within a native tumor microenvironment.

Published
2023

9. Measuring Online Prosocial Behaviors in Primary School Children: Psychometric Properties of the Online Civility Scale

Author

Beseler, Cheryl L., Jones, Lisa M., and Mitchell, Kimberly J.

Abstract

Children are online at increasing frequency, for longer periods of time, and at younger ages than ever before. Schools in the USA are engaged in providing online citizenship education to students; however, there are few evaluations of how well programs work or tools to measure program effectiveness. The current study provides psychometric information on one tool, the eight-item online civility scale (OCS), administered as part of an evaluation of the Be Internet Awesome (BIA), digital citizenship curriculum. The OCS was administered securely online to children in grades 4th, 5th, and 6th, to evaluate whether the BIA program improved their online citizenship skills. Psychometric analysis of the OCS was conducted for 824 youth who responded to both the pretest and posttest measures. Item constructs were validated in structural equation models with self-reported online behaviors. The eight items formed a cohesive construct, explaining 60% of the variance in online civility. The item response theory models showed that the items covered a range of the underlying trait. Differential item functioning (DIF) was observed by gender. The difficulty parameter did not show DIF across time (p = 0.11), but the discrimination parameter did (p = 0.002). The OCS construct was significantly and strongly associated with each of the validating variables in the expected directions. The OCS demonstrated excellent psychometric properties and could be a useful evaluation tool in programs designed to promote prosocial online behaviors in children. The scale behaves differently by gender and may discriminate differently across time points after an intervention.

Published
2023
Full Text
View/download PDF

11. MetaCon: Unified Predictive Segments System with Trillion Concept Meta-Learning

Author

Li, Keqian, Hu, Yifan, Palanisamy, Logan, Jones, Lisa, Gupta, Akshay, Grigsby, Jason, Selinger, Ili, Gillingham, Matt, and Tan, Fei

Subjects
Computer Science - Artificial Intelligence, Computer Science - Machine Learning
Abstract

Accurate understanding of users in terms of predicative segments play an essential role in the day to day operation of modern internet enterprises. Nevertheless, there are significant challenges that limit the quality of data, especially on long tail predictive tasks. In this work, we present MetaCon, our unified predicative segments system with scalable, trillion concepts meta learning that addresses these challenges. It builds on top of a flat concept representation that summarizes entities' heterogeneous digital footprint, jointly considers the entire spectrum of predicative tasks as a single learning task, and leverages principled meta learning approach with efficient first order meta-optimization procedure under a provable performance guarantee in order to solve the learning task. Experiments on both proprietary production datasets and public structured learning tasks demonstrate that MetaCon can lead to substantial improvements over state of the art recommendation and ranking approaches.

Published
2022

15. Reading the score : music novels and the alternative world of words

Author

Owen-Jones, Lisa

Abstract

The aim of this thesis is to write a 'music novel' for children and by doing so examine some of the many ways words and music play a role in storytelling. A music novel can be studied critically and to write one is ultimately a creative act. Academic scholarship on literary representations of music has so far been primarily focused on attending to the presence and representation of Western classical music in adult literary texts. Eminent leaders in the field include Delia da Sousa Correa, Emily Petermann, and Werner Wolf. Research into music in children's fiction has not been undertaken to such an extent. This thesis takes a first step towards readdressing this gap in knowledge, taking as examples children's novels by Aimee Lucido (In the Key of Code, 2019), Philip Reeve (Railhead, 2015), and Lewis Carroll (Alice's Adventures in Wonderland, 1865); and a more recent, contemporary adult novel by Matthew Herbert (The Music - A novel through sound, 2018). My detailed analysis centres on how music contributes to the construction and development of these works, as well as music that has made use of fiction as a compositional device in György Ligeti's Nonsense Madrigals (1988-93). The theoretical framing of my study draws on work by Roland Barthes, John Cage, Jean-Jacques Nattiez, and Patricia Waugh. Underdog, my music novel aimed at readers aged eight years and over, is my creative response to the questions this thesis raises. The two soundscapes that accompany the novel are musical paratexts born from Underdog that help unite the words with the music beyond the printed page. I provide a critical reflection on the inspirations behind Underdog which serves as a bridge into critical case studies that investigate what happens when one art form (music) has infiltrated the other (fiction) as part of what Jean-Jacques Nattiez calls the poietic process. My study demonstrates that the literary techniques used in fiction to imitate music, regardless of genre, are shared. These traits include references to pop and classical music embedded in the text, imitation of motifs and numerical musical patterns associated with a particular piece of music, and individual pieces of music that underpin the construction of a literary work.

Published
2022

16. Exome sequencing in bipolar disorder identifies AKAP11 as a risk gene shared with schizophrenia

Author

Palmer, Duncan S, Howrigan, Daniel P, Chapman, Sinéad B, Adolfsson, Rolf, Bass, Nick, Blackwood, Douglas, Boks, Marco PM, Chen, Chia-Yen, Churchhouse, Claire, Corvin, Aiden P, Craddock, Nicholas, Curtis, David, Di Florio, Arianna, Dickerson, Faith, Freimer, Nelson B, Goes, Fernando S, Jia, Xiaoming, Jones, Ian, Jones, Lisa, Jonsson, Lina, Kahn, Rene S, Landén, Mikael, Locke, Adam E, McIntosh, Andrew M, McQuillin, Andrew, Morris, Derek W, O’Donovan, Michael C, Ophoff, Roel A, Owen, Michael J, Pedersen, Nancy L, Posthuma, Danielle, Reif, Andreas, Risch, Neil, Schaefer, Catherine, Scott, Laura, Singh, Tarjinder, Smoller, Jordan W, Solomonson, Matthew, Clair, David St, Stahl, Eli A, Vreeker, Annabel, Walters, James TR, Wang, Weiqing, Watts, Nicholas A, Yolken, Robert, Zandi, Peter P, and Neale, Benjamin M

Subjects
Biotechnology, Human Genome, Clinical Research, Serious Mental Illness, Schizophrenia, Brain Disorders, Bipolar Disorder, Mental Health, Genetics, 2.1 Biological and endogenous factors, Aetiology, Mental health, A Kinase Anchor Proteins, Exome, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Exome Sequencing, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

We report results from the Bipolar Exome (BipEx) collaboration analysis of whole-exome sequencing of 13,933 patients with bipolar disorder (BD) matched with 14,422 controls. We find an excess of ultra-rare protein-truncating variants (PTVs) in patients with BD among genes under strong evolutionary constraint in both major BD subtypes. We find enrichment of ultra-rare PTVs within genes implicated from a recent schizophrenia exome meta-analysis (SCHEMA; 24,248 cases and 97,322 controls) and among binding targets of CHD8. Genes implicated from genome-wide association studies (GWASs) of BD, however, are not significantly enriched for ultra-rare PTVs. Combining gene-level results with SCHEMA, AKAP11 emerges as a definitive risk gene (odds ratio (OR) = 7.06, P = 2.83 × 10-9). At the protein level, AKAP-11 interacts with GSK3B, the hypothesized target of lithium, a primary treatment for BD. Our results lend support to BD's polygenicity, demonstrating a role for rare coding variation as a significant risk factor in BD etiology.

Published
2022

17. Evaluating the Impact of a Youth-Led Sexual Violence Prevention Program: Youth Leadership Retreat Outcomes

Author

Edwards, Katie M., Banyard, Victoria L., Waterman, Emily A., Mitchell, Kimberly J., Jones, Lisa M., Kollar, Laura M. Mercer, Hopfauf, Skyler, and Simon, Briana

Abstract

Involving youth in developing and implementing prevention programs to reduce sexual violence (SV) has the potential to improve prevention outcomes. However, there has been little focus on youth-led SV prevention programs, and limited evaluation research to help guide efforts. The current study examined the effectiveness of Youth Voices in Prevention (Youth VIP) leadership retreats on SV victimization and perpetration, forms of violence related to SV (e.g., bullying), SV bystander behaviors and readiness, and perceptions of norms related to SV prevention. Results identified mixed findings for program impact, with variations in outcomes that can help guide future youth-led prevention program initiatives. Youth attending a large "kick-off" leadership retreat (that was less youth-led that subsequent smaller retreats) later reported more bystander behaviors, but also reported increased perpetration and victimization, compared to non-attending youth. However, youth attending smaller, more focused leadership retreats held during the school year, reported reductions in sexual harassment perpetration and improved bystander behaviors and attitudes compared to non-attending youth. Evaluation of moderator variables suggests that program impact was generally stronger for younger participants, sexual minority youth, and non-White youth (which were largely Native American youth in this sample). Findings suggest promise for youth-led prevention work but also highlight the need for testing the impact of different training structures and modalities.

Published
2022
Full Text
View/download PDF

18. Voices of Youth and Emerging Adults on Suicide Prevention: Experiences and Expectations

Author

Banyard, Victoria, Mitchell, Kimberly J., Jones, Lisa M., and Ybarra, Michele L.

Abstract

Self-directed violence (SDV) is a significant public health issue for adolescents and emerging adults, and yet youth exposure to prevention messaging and youth perspectives on SDV prevention needs are understudied. The current study sought to better understand the ways in which a national sample of youth and emerging adults were exposed to suicide prevention programs or conversations. A sample of 1031 young people ages 13-23 were recruited nationally through social media. Survey questions asked about SDV prevention exposure. Open-ended questions asked youth to suggest additional information they desired about SDV. A majority of participants (87%) reported that they had received prevention exposure from at least one source (i.e., family, online, attending a talk, or formal program) with few differences by demographic characteristics. However, sexual and gender minority (SGM) youth reported accessing more SDV prevention information online compared to other youth. Overall, youth had many ideas about what additional information they needed, including how to help someone at risk for SDV and how to access information about mental health. While the majority of youth are receiving some SDV prevention messages, there is variation in how they get this information, and survey participants still felt they were missing important information. Findings highlight the need to resource more comprehensive SDV prevention for youth and young adults.

Published
2022
Full Text
View/download PDF

19. The Contributing Role of Family, School, and Peer Supportive Relationships in Protecting the Mental Wellbeing of Children and Adolescents

Author

Butler, Nadia, Quigg, Zara, Bates, Rebecca, Jones, Lisa, Ashworth, Emma, Gowland, Steve, and Jones, Margaret

Abstract

Globally, mental disorders are the leading cause of disability in children and adolescents. Previous research has demonstrated that supportive relationships are a key protective factor against poor mental health in children, particularly amongst those who have experienced adversity. However, fewer studies have examined the relative impact of different types of supportive relationships. The current study examined the association between level of family adult support, school adult support, and school peer support and mental wellbeing in a sample of children (age 8-15 years, N = 2,074) from schools in the UK. All three sources of support were independently associated with mental wellbeing. Analyses demonstrated a graded relationship between the number of sources of support and the odds of low mental wellbeing (LMWB), reflecting a cumulative protective effect. While all three sources of support were best, it was not vital, and analyses demonstrated a protective effect of school sources of support on LMWB amongst children with low family support. Peer support was found to be particularly important, with prevalence of LMWB similar amongst children who had high peer support (but low family and school adult support), and those who had high family and school adult support, (but low peer support), indicating that high peer support has an equivalent impact of two other protective factors. Findings from the study highlight the crucial context schools provide in fostering positive peer relationships and supportive teacher--student relationships to promote mental health and resilience for all children, including both those with and without supportive home environments.

Published
2022
Full Text
View/download PDF

20. Characterisation of age and polarity at onset in bipolar disorder.

Author

Kalman, Janos L, Olde Loohuis, Loes M, Vreeker, Annabel, McQuillin, Andrew, Stahl, Eli A, Ruderfer, Douglas, Grigoroiu-Serbanescu, Maria, Panagiotaropoulou, Georgia, Ripke, Stephan, Bigdeli, Tim B, Stein, Frederike, Meller, Tina, Meinert, Susanne, Pelin, Helena, Streit, Fabian, Papiol, Sergi, Adams, Mark J, Adolfsson, Rolf, Adorjan, Kristina, Agartz, Ingrid, Aminoff, Sofie R, Anderson-Schmidt, Heike, Andreassen, Ole A, Ardau, Raffaella, Aubry, Jean-Michel, Balaban, Ceylan, Bass, Nicholas, Baune, Bernhard T, Bellivier, Frank, Benabarre, Antoni, Bengesser, Susanne, Berrettini, Wade H, Boks, Marco P, Bromet, Evelyn J, Brosch, Katharina, Budde, Monika, Byerley, William, Cervantes, Pablo, Chillotti, Catina, Cichon, Sven, Clark, Scott R, Comes, Ashley L, Corvin, Aiden, Coryell, William, Craddock, Nick, Craig, David W, Croarkin, Paul E, Cruceanu, Cristiana, Czerski, Piotr M, Dalkner, Nina, Dannlowski, Udo, Degenhardt, Franziska, Del Zompo, Maria, DePaulo, J Raymond, Djurovic, Srdjan, Edenberg, Howard J, Eissa, Mariam Al, Elvsåshagen, Torbjørn, Etain, Bruno, Fanous, Ayman H, Fellendorf, Frederike, Fiorentino, Alessia, Forstner, Andreas J, Frye, Mark A, Fullerton, Janice M, Gade, Katrin, Garnham, Julie, Gershon, Elliot, Gill, Michael, Goes, Fernando S, Gordon-Smith, Katherine, Grof, Paul, Guzman-Parra, Jose, Hahn, Tim, Hasler, Roland, Heilbronner, Maria, Heilbronner, Urs, Jamain, Stephane, Jimenez, Esther, Jones, Ian, Jones, Lisa, Jonsson, Lina, Kahn, Rene S, Kelsoe, John R, Kennedy, James L, Kircher, Tilo, Kirov, George, Kittel-Schneider, Sarah, Klöhn-Saghatolislam, Farah, Knowles, James A, Kranz, Thorsten M, Lagerberg, Trine Vik, Landen, Mikael, Lawson, William B, Leboyer, Marion, Li, Qingqin S, Maj, Mario, Malaspina, Dolores, Manchia, Mirko, and Mayoral, Fermin

Subjects
Psychiatric Genomics Consortium (PGC) Bipolar Disorder Working Group, International Consortium on Lithium Genetics, Colombia-US Cross Disorder Collaboration in Psychiatric Genetics, Humans, Bipolar Disorder, Depressive Disorder, Major, Age of Onset, Multifactorial Inheritance, Genome-Wide Association Study, Autism Spectrum Disorder, Bipolar disorder, GWAS, age at onset, polarity at onset, polygenic score, Genetics, Mental Health, Prevention, Brain Disorders, Serious Mental Illness, 2.1 Biological and endogenous factors, Aetiology, Mental health, Good Health and Well Being, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract

BackgroundStudying phenotypic and genetic characteristics of age at onset (AAO) and polarity at onset (PAO) in bipolar disorder can provide new insights into disease pathology and facilitate the development of screening tools.AimsTo examine the genetic architecture of AAO and PAO and their association with bipolar disorder disease characteristics.MethodGenome-wide association studies (GWASs) and polygenic score (PGS) analyses of AAO (n = 12 977) and PAO (n = 6773) were conducted in patients with bipolar disorder from 34 cohorts and a replication sample (n = 2237). The association of onset with disease characteristics was investigated in two of these cohorts.ResultsEarlier AAO was associated with a higher probability of psychotic symptoms, suicidality, lower educational attainment, not living together and fewer episodes. Depressive onset correlated with suicidality and manic onset correlated with delusions and manic episodes. Systematic differences in AAO between cohorts and continents of origin were observed. This was also reflected in single-nucleotide variant-based heritability estimates, with higher heritabilities for stricter onset definitions. Increased PGS for autism spectrum disorder (β = -0.34 years, s.e. = 0.08), major depression (β = -0.34 years, s.e. = 0.08), schizophrenia (β = -0.39 years, s.e. = 0.08), and educational attainment (β = -0.31 years, s.e. = 0.08) were associated with an earlier AAO. The AAO GWAS identified one significant locus, but this finding did not replicate. Neither GWAS nor PGS analyses yielded significant associations with PAO.ConclusionsAAO and PAO are associated with indicators of bipolar disorder severity. Individuals with an earlier onset show an increased polygenic liability for a broad spectrum of psychiatric traits. Systematic differences in AAO across cohorts, continents and phenotype definitions introduce significant heterogeneity, affecting analyses.

Published
2021

21. Patient-Level Pooled Analysis of Endovascular Ultrasound Renal Denervation or a Sham Procedure 6 Months After Medication Escalation: The RADIANCE Clinical Trial Program

Author

Azizi, Michel, Sharp, Andrew S.P., Fisher, Naomi D.L., Weber, Michael A., Lobo, Melvin D., Daemen, Joost, Lurz, Philipp, Mahfoud, Felix, Schmieder, Roland E., Basile, Jan, Bloch, Michael J., Saxena, Manish, Wang, Yale, Sanghvi, Kintur, Jenkins, J. Stephen, Devireddy, Chandan, Rader, Florian, Gosse, Philippe, Claude, Lisa, Augustin, Dimitri A., McClure, Candace K., Kirtane, Ajay J., Wang, Yale, Skeik, Nedaa, Bae, Richard, McMeans, Amy, Goldman, JoAnne, Peterson, Rose, Stephen Jenkins, James, Tutor, Isabelle, Harrison, Michael, Penning, Angel, Devireddy, Chandan, Lea, Janice, Fiebach, Amanda, Merlin, Claudia, Rader, Florian, Dohad, Suhail, Tran, Anne, Bhatia, Kirin, Fisher, Naomi D.L., Sobieszczyk, Piotr, Halliday, Ian, Munson, Tay, Lindsey, Jason, Laster, Steven, Bunte, Mathew, Hart, Anthony, King, Dana, Hall, Jamie, Sanghvi, Kintur, Krathen, Courtney, Lewis, Luot, Willitts, Ashley, Todoran, Thomas, Basile, Jan, Awkar, Anthony, Palmer, Casey, Tecklenburg, Anna, Schindler, John, Pacella, John, Muldoon, Matthew, Albright, MaryJo, Nicholson, Tracy, Flack, John, Chami, Youseff, Hafiz, Abdul Moiz, Starkey, Emily, Adams, Kristal, Bernardo, Nelson, Veis, Judith, Hashim, Hayder, Singh, Suman, Whitman, Donna, Stouffer, Rick, Hinderliter, Alan, Allen, Meghan, Scholl, Tatum, Fong, Pete, Gainer, James, Crook, Sherron, Hatchcock, Ellen, Cohen, Debbie, Giri, Jay, Kobayashi, Taisei, Neubauer, Robin, Naidu, Suveeksha, Kirtane, Ajay J., Radhakrishnan, Jai, Batres, Candido, Edwards, Suzanne, Khuddus, Matheen, Zentko, Suzanne, Touchton, Abby, Roberson, Marti, Bloch, Michael J., Akinapelli, Abhilash, English, Lisa, Neumann, Bridget, Mendelsohn, Farrel, Brantley, Hutton, Cawthon, Thomas, DeRamus, Susan, Wade, Wesley, Fishman, Robert, Tuohy, Edward, LeBlanc, Jessica, McCurry, Tina, Krishnaswamy, Amar, Laffin, Luke, Bajzer, Christopher, Boros, Marilyn, Branche, Monica, Abraham, Josephine, Abraham, Anu, Stijleman, Inge, Hsi, David, Martin, Scott, Portnay, Edward, Fiebach, Maryann, Garavito, Carolina, Adams, Todd, Teklinski, Andrew, Leech, Adam, Drilling, Patrick, Tulik, Lynda, Benzuly, Keith, Paparello, James, Fintel, Dan, Ramirez, Haydee, Kats, Lauren, Huang, Paul, Biswas, Santanu, Risher, Serena, Pratt, Kristina, Ibebuogu, Uzoma, Johnson, Karen, Cushman, William, Jones, Lisa, Jackson, Leigh, Landers, David, Pasala, Tilak, Salazer, Thomas, Canino, Peter, Arakelian, Patricia, Yang, Yi-Ming, Khaliq, Asma, Weinberg, Mitchell, Abetu, Yihenew, Gulliver, Alana, Reilly, J.P., Garasic, Joseph, Chugh, Atul, Bertolet, Barry, Go, Brian, Gallapudi, Raghava, Cohn, Joel, Rogers, Kevin, Saxena, Manish, Mathur, Anthony, Jain, Ajay, Balawon, Armida, Zongo, Oliver, Topham, Christine, Sharp, Andrew, Anderson, Richard, Thompson, Elizabeth, Spiro, Nikki, Hodges, Elizabeth, Holder, Jaqueline, Ellam, Timothy, Bagnall, Alan, Jackson, Ralph, Bridgett, Victoria, Wilson, Peter, Das, Neelanjan, Doulton, Timothy, Loader, David, Hector, Gemma, Levy, Terry, Bent, Clare, Kodoth, Vivek, Horler, Stephanie, Nix, Sara, Robinson, Nicholas, Al-Janabi, Firas, Sayer, Jeremy, Ganesh Iyer, Sudha, Redman, Emily, Ramirez, Jonaifah, Padmanabhan, Sandosh, Sharif, Faisal, Alhmoudi, Aishah, Lunardi, Mattia, Coen, Eileen, Glynn, Nicola, Mahfoud, Felix, Lauder, Lucas, Kulenthiran, Saarraaken, Koch, Christina, Wachter, Angelika, Schmieder, Roland, Schmid, Axel, Kannenkeril, Dennis, Heinritz, Ulrike, Endres-Frohlich, Kerstin, Lurz, Philipp, Rommel, Karl, Fengler, Petzold, Martin, Büttner, Margit, Weil, Joachim, Agdirlioglu, Tolga, Köllner, Tanja, Stephan, Jeannine, Dagkonakis, Nikolaos, Hamann, Frank, Ettl, Ute, Petzsche, Ulrike, Reimer, Peter, Hausberg, Martin, Hinrichs, Ralf, Di Ponio-Voit, Isabella, Lutz, Matthias, Gosse, Philippe, Cremer, Antoine, Papadopoulos, Panteleimon, Gaudissard, Julie, Maire, Florent, Azizi, Michel, Sapoval, Marc, Livrozet, Marine, Regrag, Asma, Paquet, Valerie, Delsart, Pascal, Hennicaux, Justin, Sommeville, Coralie, Bertrand, Fabien, Daemen, Joost, Lafeber, Melvin, Zeijen, Victor, Ruiter, Amo, Huijskens, Elisabeth, van Ramshorst, Jan, Xaplanteris, Panagiotis, Briki, Rachid, de Hemptinne, Quentin, Pascal, Severine, Renard, Katty, Ferdinande, Bert, Iglesias, Juan F., Ehert, Georg, Gallego, Laetitia, Dobretz, Kevin, Bottone, Sylviane, Sanghvi, Kintur, Costello, Josh, Krathan, Courtney, Lewis, Luot, McElvarr, Andrew, Reilly, John, Jenkins, Stephen, Cash, Michael, Williams, Shannon, Jarvis, Maria, Fong, Pete, Laffer, Cheryl, Gainer, James, Robbins, Mark, Crook, Sherron, Maddel, Sarita, Hsi, David, Martin, Scott, Portnay, Edward, Ducey, Maryanne, Rose, Suzanne, DelMastro, Elizabeth, Bangalore, Sripal, Williams, Stephen, Cabos, Stanley, Rodriguez Alvarez, Carolina, Todoran, Thomas, Basile, Jan, Powers, Eric, Hodskins, Emily, Paladugu, Vijay, Tecklenburg, Anna, Devireddy, Chandan, Lea, Janice, Wells, Bryan, Fiebach, Amanda, Merlin, Claudia, Rader, Florian, Dohad, Suhail, Kim, Hyun-Min, Rashid, Mohammad, Abraham, Josephine, Owan, Theophilus, Abraham, Anu, Lavasani, Iran, Neilson, Hailey, Calhoun, David, McElderry, Thomas, Maddox, William, Oparil, Suzanne, Kinder, Sheila, Kirtane, Ajay J., Radhakrishnan, Jai, Batres, Candido, Edwards, Suzanne, Garasic, Joseph, Drachman, Doug, Zusman, Randy, Rosenfield, Kenneth, Do, Danny, Khuddus, Matheen, Zentko, Suzanne, O’Meara, James, Barb, Ilie, Foster, Abby, Boyette, Alice, Wang, Yale, Jay, Desmond, Skeik, Nedaa, Schwartz, Robert, Peterson, Rose, Goldman, Jo Anne, Goldman, Jessie, Ledley, Gary, Katof, Nancy, Potluri, Srinivasa, Biedermann, Scott, Ward, Jacquelyn, White, Megan, Fisher, Naomi D.L., Mauri, Laura, Sobieszczky, Piotr, Smith, Alex, Aseltine, Laura, Stouffer, Rick, Hinderliter, Alan, Pauley, Eric, Wade, Tyrone, Zidar, David, Shishehbor, Mehdi, Effron, Barry, Costa, Marco, Semenec, Terence, Bloch, Michael J., Roongsritong, Chanwit, Nelson, Priscilla, Neumann, Bridget, Cohen, Debbie, Giri, Jay, Neubauer, Robin, Vo, Thu, Chugh, Atul R., Huang, Pei-Hsiu, Jose, Powell, Flack, John, Fishman, Robert, Jones, Michael, Adams, Todd, Bajzer, Christopher, Saxena, Manish, Lobo, Melvin D., Mathur, Anthony, Jain, Ajay, Balawon, Armida, Zongo, Olivier, Levy, Terry, Bent, Clare, Beckett, David, Lakeman, Nicki, Kennard, Sarah, Sharp, Andrew, D’Souza, Richard J., Statton, Sarah, Wilkes, Lindsay, Anning, Christine, Sayer, Jeremy, Ganesh Iyer, Sudha, Robinson, Nicholas, Sevillano, Annaliza, Ocampo, Madelaine, Gerber, Robert, Faris, Mohamad, John Marshall, Andrew, Sinclair, Janet, Pepper, Hayley, Davies, Justin, Chapman, Neil, Burak, Paula, Carvelli, Paula, Jadhav, Sachin, Quinn, Jane, Christian Rump, Lars, Stegbauer, Johannes, Schimmöller, Lars, Potthoff, Sebastian, Schmid, Claudia, Roeder, Sylvia, Weil, Joachim, Hafer, Lukas, Agdirlioglu, Tolga, Köllner, Tanja, Mahfoud, Felix, Böhm, Michael, Ewen, Sebastian, Kulenthiran, Saarraaken, Wachter, Angelika, Koch, Christina, Lurz, Philipp, Fengler, Karl, Rommel, Karl-Philipp, Trautmann, Kai, Petzold, Martin, Schmieder, Roland E., Ott, Christian, Schmid, Axel, Uder, Michael, Heinritz, Ulrike, Fröhlich-Endres, Kerstin, Genth-Zotz, Sabine, Kämpfner, Denise, Grawe, Armin, Höhne, Johannes, Kaesberger, Bärbel, von zur Mühlen, Constantin, Wolf, Dennis, Welzel, Markus, Gosse, Philippe, Cremer, Antoine, Trillaud, Hervé, Papadopoulos, Panteleimon, Maire, Florent, Gaudissard, Julie, Azizi, Michel, Sapoval, Marc, Cornu, Erika, Fouassier, David, Livrozet, Marine, Lorthioir, Aurélien, Paquet, Valérie, Pathak, Atul, Honton, Benjamin, Cottin, Marianne, Petit, Frédéric, Lantelme, Pierre, Berge, Constance, Courand, Pierre-Yves, Langevin, Fatou, Delsart, Pascal, Longere, Benjamin, Ledieu, Guillaume, Pontana, François, Sommeville, Coralie, Bertrand, Fabien, Daemen, Joost, Feyz, Lida, Zeijen, Victor, Ruiter, Arno, Huyskens, Elisabeth, Blankestijn, Peter, Voskuil, Michiel, Rittersma, Zwaantina, Dolmans, Helma, Kroon, A.A., van Zwam, W.H., Vranken, Jeannique, de Haan, Claudia, Persu, Alexandre, Renkin, Jean, Maes, Frédéric, Beauloye, Christophe, Lengelé, Jean-Philippe, Huyberechts, Dominique, Bouvier, Anne, Witkowski, Adam, Januszewicz, Andrzej, Kądziela, Jacek, Prejbisj, Aleksander, Hering, Dagmara, Ciecwierz, Dariusz, Jaguszewski, Milosz J., Owczuk, Radoslaw, Ciecwierz, Dariusz, Jaguszewski, Milosz J., Wang, Yale, Jay, Desmond, Skeik, Nedaa, Schwartz, Robert, Rader, Florian, Dohad, Suhail, Victor, Ronald, Sanghvi, Kintur, Costello, Josh, Walsh, Courtney, Abraham, Josephine, Owan, Theophilus, Abraham, Anu, Fisher, Naomi D.L., Mauri, Laura, Sobieszczky, Piotr, Williams, Jonathan, Bloch, Michael J., Roongsritong, Chanwit, Todoran, Thomas, Basile, Jan, Powers, Eric, Hodskins, Emily, Fong, Pete, Laffer, Cheryl, Gainer, James, Robbins, Mark, Reilly, John, Cash, Michael, Goldman, Jessie, Aggarwal, Sandeep, Ledley, Gary, Hsi, David, Martin, Scott, Portnay, Edward, Calhoun, David, McElderry, Thomas, Maddox, William, Oparil, Suzanne, Huang, Pei-Hsiu, Jose, Powell, Khuddus, Matheen, Zentko, Suzanne, O’Meara, James, Barb, Ilie, Garasic, Joseph, Drachman, Doug, Zusman, Randy, Rosenfield, Kenneth, Devireddy, Chandan, Lea, Janice, Wells, Bryan, Stouffer, Rick, Hinderliter, Alan, Pauley, Eric, Potluri, Srinivasa, Biedermann, Scott, Bangalore, Sripal, Williams, Stephen, Zidar, David, Shishehbor, Mehdi, Effron, Barry, Costa, Marco, Kirtane, Ajay J., Radhakrishnan, Jai, Lobo, Melvin D., Mathur, Anthony, Jain, Ajay, Sayer, Jeremy, Ganesh Iyer, Sudha, Robinson, Nicholas, Ali Edroos, Sadat, Levy, Terry, Patel, Amit, Beckett, David, Bent, Clare, Davies, Justin, Chapman, Neil, Shun Shin, Matthew, Howard, James, Sharp, Andrew S.P., Joseph, Anil, D’Souza, Richard, Gerber, Robert, Faris, Mohamad, John Marshall, Andrew, Elorz, Cristina, Lurz, Philipp, Höllriegel, Robert, Fengler, Karl, Rommel, Karl-Philipp, Mahfoud, Felix, Böhm, Michael, Ewen, Sebastian, Lucic, Jelena, Schmieder, Roland E., Ott, Christian, Schmid, Axel, Uder, Michael, Rump, Christian, Stegbauer, Johannes, Kröpil, Patric, Azizi, Michel, Sapoval, Marc, Cornu, Erika, Fouassier, David, Gosse, Philippe, Cremer, Antoine, Trillaud, Hervé, Papadopoulos, Panteleimon, Pathak, Atul, Honton, Benjamin, Lantelme, Pierre, Berge, Constance, Courand, Pierre-Yves, Daemen, Joost, Feyz, Lida, Blankestijn, Peter, Voskuil, Michiel, Rittersma, Zwaantina, Kroon, A.A., van Zwam, W.H., Persu, Alexandre, and Renkin, Jean

Published
2024
Full Text
View/download PDF

25. The role of shifting baseline syndrome in conservation : linked local ecological knowledge and biological datasets

Author

Jones, Lisa (Lizzie) P.

Subjects
Local Ecological Knowledge, Shifting Baseline Syndrome, Generational Amnesia, Personal Amnesia, Shifting Baselines
Abstract

Local ecological knowledge (LEK) is increasingly recognised as an important source of information for conservation, especially when long-term scientific datasets are inaccessible or non-existent. However, local knowledge and perceptions of environmental change are fundamentally personal and subjective, due to a variety of social and psychological factors. Cognitive biases and phenomena, such as Shifting Baseline Syndrome (SBS) can threaten the exclusion of valuable anecdotal knowledge in conservation research, practice and policy. Under SBS, perceived environmental baselines used to measure change may not accurately represent the true ecological 'starting point', potentially leading to the consistent downgrading of perceived 'normal' conditions with every sequential generation. SBS is therefore considered an increasingly critical issue in the face of accelerating global change, as people are unable to perceive the true extent of ecological degradation, yet very little empirical evidence for SBS exists. This thesis provides a thorough review of the SBS literature (Chapter 1), regarding current evidence for SBS and the causes, consequences, and proposed combat methods of SBS in the context of conservation management, participation, education and environmental policy. The review aims to define key terminology from a multidisciplinary perspective and distinguish SBS from other similar phenomena, combining the fields of social science, psychology, and ecology to reveal key gaps in the SBS literature. Tackling a key research gap identified by the literature review, this thesis provides early empirical evidence for SBS in the context of garden bird population change in the UK (Chapter 3). Following the widely accepted criteria for defining evidence of SBS, social perceptions of local ecological change were statistically compared to long-term biological data to create a measure of paired 'agreement'. Variation in paired agreement was used to identify evidence of both generational and personal amnesia, the two mechanisms thought to drive evidence of SBS. This thesis also offers the first evidence of negative impacts of SBS on public perceptions of conservation priority for species in decline, confirming previous hypotheses regarding the detrimental effects of SBS on conservation support. In investigating differences in evidence of SBS between the UK and Finland, evidence of the impacts of data range restriction and reduced sample size were identified. Data range restriction (hereafter 'range restriction') is a statistical phenomenon, characterised by weakened statistical relationships due to limited variation in the dataset as the observed sample data do not represent the full data range of interest. The effects of data range restriction are explored using comparative modelling of variance in experience of biological change across three unrestricted and range restricted samples. The chapter concludes that range restricted sample size increases of up to 45% to achieve power equivalent to an unrestricted dataset. Combining data in the UK and Finland, areas of agreement and disagreement between perceptions and the biological data are explored across multiple bird species, time points and population parameters (relative abundance and population trends). Patterns in agreement between data sources were identified, revealing situations where the effects of underlying socio-psychological phenomena may be more prominent and where collecting species relative abundance may be more effective than collecting species trends and vice versa. This study indicated that agreement was more likely to vary between species, countries and participants when collecting species relative abundance, and when asking for personal perceptions of species relative abundance, agreement tended to be higher for male participants, those recognised a greater number of species from those who reported a greater number of years birding experience. By contrast, trend agreement varied only between species, indicating that for poorly known species, research on long-term trends may be a more reliable measure of species status than relative abundance. Finally, Chapter 7 provides one of very few studies to investigate the potential implications of SBS on conservation target-setting and decision-making. Previous hypotheses and evidence for SBS in this area are conflicted. There has been speculation as to the presence and impacts of SBS within conservation management since Daniel Pauly's seminal paper on SBS in 1995, however, recent studies have not found evidence for the syndrome. In this study, paired tests investigated experience-related differences in personal perceptions of current, maximum and target abundance (as pairs or territories), long-term trends, and perceived conservation priority for six bird species on participant's local bird or nature reserves. No significant effect of experience was found for all species and power analysis indicated that even if SBS was statistically detectible with a larger sample, the practical implications of the syndrome would be minimal due to small effect sizes, suggesting that SBS may not be as significant a threat in conservation management as first thought.

Published
2021

26. Sentinel Surveillance System Implementation and Evaluation for SARS-CoV-2 Genomic Data, Washington, USA, 2020-2021

Author

Oltean, Hanna N., Allen, Krisandra J., Frisbie, Lauren, Lunn, Stephanie M., Torres, Laura Marcela, Manahan, Lillian, Painter, Ian, Russel, Denny, Singh, Avi, Aric, JohnAric MoonDance, Grant, Kristin, Peter, Cara, Cao, Rebecca, Garcia, Katelynn, Mackellar, Drew, Jones, Lisa, Halstead, Holly, Gray, Hannah, Melly, Geoff, Nickerson, Deborah, Starita, Lea, Frazar, Chris, Greninger, Alexander L., Roychoudhury, Pavitra, Mathias, Patrick C., Kalnoski, Michael H., Ting, Chao-Nan, Lykken, Marisa, and Rice, Tana

Subjects
Washington -- Health aspects, Epidemics -- Statistics -- Genetic aspects, Sentinel health events -- Methods, Data entry -- Methods, Health
Abstract

Virus genome data can provide useful information for public health practice, particularly when combined with epidemiologic data in real time. Goals of genomic surveillance can include monitoring circulating and emerging [...]

Published
2023
Full Text
View/download PDF

27. Lipid intensive drug therapy for sepsis pilot: A Bayesian phase I clinical trial

Author

Guirgis, Faheem W, Black, Lauren Page, DeVos, Elizabeth, Henson, Morgan, Ferreira, Jason, Miller, Taylor, Rosenthal, Martin, Leeuwenburgh, Christiaan, Kalynych, Colleen, Moldawer, Lyle, Jones, Lisa, Crandall, Marie, Reddy, Srinivasa T, Gao, Hanzhi, Wu, Sam, and Moore, Frederick

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Neurosciences, Infectious Diseases, Clinical Research, Sepsis, Hematology, Clinical Trials and Supportive Activities, Patient Safety, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Inflammatory and immune system, Infection, cholesterol, lipid emulsion, lipids, organ failure, parenteral nutrition, sepsis, septic shock
Abstract

ObjectivesCholesterol may be protective in sepsis. Patients with early sepsis may have critically low cholesterol levels that are associated with poor outcomes. The study objective was to test the safety of a fish oil-containing lipid injectable emulsion for stabilizing early cholesterol levels in sepsis.MethodsPhase I Bayesian optimal interval design trial of adult patients with septic shock (Sequential Organ Failure Assessment score ≥4 or vasopressor dependence). Using sequential dose escalation, participants received 2 doses of 1.0 to 1.6 g/kg of lipid emulsion (Smoflipid 20% lipid emulsion) within 48 hours of enrollment. Cholesterol levels, function, and organ failure were assessed serially during the first 7 days of hospital admission.Measurements and main resultsA total of 10 patients with septic shock were enrolled. One patient withdrew for social reasons. Another patient had an unrelated medical complication and received 1 drug dose. Of 9 patients, mean age was 58 years (SD 16), median Sequential Organ Failure Assessment was 8, and 28-day mortality was 30%. No serious adverse events related to lipid infusion occurred. The six occurrences of non-serious adverse events possibly related to lipid infusion included hyperglycemia (1), elevated triglycerides (3), anemia (1), and vascular access redness/pain (1) for all doses. The mean change in total cholesterol levels from enrollment was -7 (SD 16.6) at 48 hours and 14 (SD 25.2) at 7 days.ConclusionsFish oil-containing lipid emulsion administration during early septic shock was safe. Further studies are needed to assess effects on cholesterol levels, function, and organ failure.Clinical trial registrationNCT03405870.

Published
2020

28. Black Fish in a White Pond: Identity Development of African American Students in Predominately White Suburban Schools

Author

Jones, Lisa A.

Abstract

The issues that African American students face daily in suburban schools are different from what their White counterparts as well as other African American students living in urban areas face. Such issues are grounded in the cultural and social identity development of individuals. Not only do African American students have to learn to deal with the pitfalls of school but they must navigate the murky waters of identity development at the same time. This notion is underscored by Tatum (1997), who pointed out that "the search for personal identity that intensifies in adolescence can involve several dimensions of an adolescent's life: vocational plans, religious beliefs, values, and preferences, political affiliations and beliefs, gender roles, and ethnic identities." This article briefly explores the sociopolitical context of school as it applies to the cultural identity development of African American students and their education in predominately White, middle-class, suburban schools. Topics of discussion include: (1) cultural and social identity development; (2) sociopolitical context of schooling and multicultural education; (3) minority students and the classroom; and (4) addressing the needs of students of color, particularly African Americans, in predominately White, middle-class, suburban schools.

Published
2018

36. Association of Occupational Dysfunction and Hospital Admissions With Different Polygenic Profiles in Bipolar Disorder

Author

Jonsson, Lina, primary, Hörbeck, Elin, additional, Primerano, Amedeo, additional, Song, Jie, additional, Karlsson, Robert, additional, Smedler, Erik, additional, Gordon-Smith, Katherine, additional, Jones, Lisa, additional, Craddock, Nicholas, additional, Jones, Ian, additional, Sullivan, Patrick F., additional, Pålsson, Erik, additional, Di Florio, Arianna, additional, Sparding, Timea, additional, and Landén, Mikael, additional

Published
2024
Full Text
View/download PDF

37. LIPid Intensive Drug therapy for Sepsis Pilot (LIPIDS-P): Phase I/II clinical trial protocol of lipid emulsion therapy for stabilising cholesterol levels in sepsis and septic shock.

Author

Guirgis, Faheem, Black, Lauren, Rosenthal, Martin, Henson, Morgan, Ferreira, Jason, Leeuwenburgh, Christiaan, Kalynych, Colleen, Moldawer, Lyle, Miller, Taylor, Jones, Lisa, Crandall, Marie, Reddy, Srinivasa, Wu, Samuel, and Moore, Frederick

Subjects
cholesterol, lipid emulsion, lipids, organ failure, parenteral nutrition, sepsis, Cholesterol, Clinical Trials, Phase I as Topic, Clinical Trials, Phase II as Topic, Fat Emulsions, Intravenous, Humans, Sepsis, Shock, Septic
Abstract

INTRODUCTION: Sepsis is a life-threatening, dysregulated response to infection. Both high-density lipoprotein and low-density lipoprotein cholesterol should protect against sepsis by several mechanisms; however, for partially unknown reasons, cholesterol levels become critically low in patients with early sepsis who experience poor outcomes. An anti-inflammatory lipid injectable emulsion containing fish oil is approved by the Food and Drug Administration as parenteral nutrition for critically ill patients and may prevent this decrease in serum cholesterol levels by providing substrate for cholesterol synthesis and may favourably modulate inflammation. This LIPid Intensive Drug therapy for Sepsis Pilot clinical trial is the first study to attempt to stabilise early cholesterol levels using lipid emulsion as a treatment modality for sepsis. METHODS AND ANALYSIS: This is a two-centre, phase I/II clinical trial. Phase I is a non-randomised dose-escalation study using a Bayesian optimal interval design in which up to 16 patients will be enrolled to evaluate the safest and most efficacious dose for stabilising cholesterol levels. Based on phase I results, the two best doses will be used to randomise 48 patients to either lipid injectable emulsion or active control (no treatment). Twenty-four patients will be randomised to one of two doses of the study drug, while 24 control group patients will receive no drug and will be followed during their hospitalisation. The control group will receive all standard treatments mandated by the institutional sepsis alert protocol. The phase II study will employ a permuted blocked randomisation technique, and the primary endpoint will be change in serum total cholesterol level (48 hours - enrolment). Secondary endpoints include change in cholesterol level from enrolment to 7 days, change in Sequential Organ Failure Assessment score over the first 48 hours and 7 days, in-hospital and 28-day mortality, lipid oxidation status, inflammatory biomarkers, and high-density lipoprotein function. ETHICS AND DISSEMINATION: Investigators are trained and follow good clinical practices, and each phase of the study was reviewed and approved by the institutional review boards of each institution. Results of each phase will be disseminated through presentations at national meetings and publication in peer-reviewed journals. If promising, data from the pilot study will be used for a larger, multicentre, phase II clinical trial. TRIAL REGISTRATION NUMBER: NCT03405870.

Published
2019

38. GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores

Author

Mullins, Niamh, Bigdeli, Tim B, Børglum, Anders D, Coleman, Jonathan RI, Demontis, Ditte, Mehta, Divya, Power, Robert A, Ripke, Stephan, Stahl, Eli A, Starnawska, Anna, Anjorin, Adebayo, Corvin, Aiden, Sanders, Alan R, Forstner, Andreas J, Reif, Andreas, Koller, Anna C, Świątkowska, Beata, Baune, Bernhard T, Müller-Myhsok, Bertram, Penninx, Brenda WJH, Pato, Carlos, Zai, Clement, Rujescu, Dan, Hougaard, David M, Quested, Digby, Levinson, Douglas F, Binder, Elisabeth B, Byrne, Enda M, Agerbo, Esben, Streit, Fabian, Mayoral, Fermin, Bellivier, Frank, Degenhardt, Franziska, Breen, Gerome, Morken, Gunnar, Turecki, Gustavo, Rouleau, Guy A, Grabe, Hans J, Völzke, Henry, Jones, Ian, Giegling, Ina, Agartz, Ingrid, Melle, Ingrid, Lawrence, Jacob, Walters, James TR, Strohmaier, Jana, Shi, Jianxin, Hauser, Joanna, Biernacka, Joanna M, Vincent, John B, Kelsoe, John, Strauss, John S, Lissowska, Jolanta, Pimm, Jonathan, Smoller, Jordan W, Guzman-Parra, José, Berger, Klaus, Scott, Laura J, Jones, Lisa A, Azevedo, M Helena, Trzaskowski, Maciej, Kogevinas, Manolis, Rietschel, Marcella, Boks, Marco, Ising, Marcus, Grigoroiu-Serbanescu, Maria, Hamshere, Marian L, Leboyer, Marion, Frye, Mark, Nöthen, Markus M, Alda, Martin, Preisig, Martin, Nordentoft, Merete, Boehnke, Michael, O’Donovan, Michael C, Owen, Michael J, Pato, Michele T, Renteria, Miguel E, Budde, Monika, Weissman, Myrna M, Wray, Naomi R, Bass, Nicholas, Craddock, Nicholas, Smeland, Olav B, Andreassen, Ole A, Mors, Ole, Gejman, Pablo V, Sklar, Pamela, McGrath, Patrick, Hoffmann, Per, McGuffin, Peter, Lee, Phil H, Mortensen, Preben Bo, Kahn, René S, Ophoff, Roel A, Adolfsson, Rolf, Van der Auwera, Sandra, Djurovic, Srdjan, Kloiber, Stefan, and Heilmann-Heimbach, Stefanie

Subjects
Prevention, Suicide, Serious Mental Illness, Schizophrenia, Human Genome, Depression, Mental Health, Genetics, Brain Disorders, Aetiology, 2.3 Psychological, social and economic factors, 2.1 Biological and endogenous factors, Mental health, Good Health and Well Being, Bipolar Disorder, Case-Control Studies, Depressive Disorder, Major, Female, Genome-Wide Association Study, Humans, Male, Multifactorial Inheritance, Risk Factors, Suicide, Attempted, M.R.C.Psych, Dr.Med.Sc, Dipl.-Psych, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Mood Disorders, Polygenic Risk Scoring, Psychiatric Genomics Consortium, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract

ObjectiveMore than 90% of people who attempt suicide have a psychiatric diagnosis; however, twin and family studies suggest that the genetic etiology of suicide attempt is partially distinct from that of the psychiatric disorders themselves. The authors present the largest genome-wide association study (GWAS) on suicide attempt, using cohorts of individuals with major depressive disorder, bipolar disorder, and schizophrenia from the Psychiatric Genomics Consortium.MethodsThe samples comprised 1,622 suicide attempters and 8,786 nonattempters with major depressive disorder; 3,264 attempters and 5,500 nonattempters with bipolar disorder; and 1,683 attempters and 2,946 nonattempters with schizophrenia. A GWAS on suicide attempt was performed by comparing attempters to nonattempters with each disorder, followed by a meta-analysis across disorders. Polygenic risk scoring was used to investigate the genetic relationship between suicide attempt and the psychiatric disorders.ResultsThree genome-wide significant loci for suicide attempt were found: one associated with suicide attempt in major depressive disorder, one associated with suicide attempt in bipolar disorder, and one in the meta-analysis of suicide attempt in mood disorders. These associations were not replicated in independent mood disorder cohorts from the UK Biobank and iPSYCH. No significant associations were found in the meta-analysis of all three disorders. Polygenic risk scores for major depression were significantly associated with suicide attempt in major depressive disorder (R2=0.25%), bipolar disorder (R2=0.24%), and schizophrenia (R2=0.40%).ConclusionsThis study provides new information on genetic associations and demonstrates that genetic liability for major depression increases risk for suicide attempt across psychiatric disorders. Further collaborative efforts to increase sample size may help to robustly identify genetic associations and provide biological insights into the etiology of suicide attempt.

Published
2019

39. Contribution of Rare Copy Number Variants to Bipolar Disorder Risk Is Limited to Schizoaffective Cases

Author

Charney, Alexander W, Stahl, Eli A, Green, Elaine K, Chen, Chia-Yen, Moran, Jennifer L, Chambert, Kimberly, Belliveau, Richard A, Forty, Liz, Gordon-Smith, Katherine, Lee, Phil H, Bromet, Evelyn J, Buckley, Peter F, Escamilla, Michael A, Fanous, Ayman H, Fochtmann, Laura J, Lehrer, Douglas S, Malaspina, Dolores, Marder, Stephen R, Morley, Christopher P, Nicolini, Humberto, Perkins, Diana O, Rakofsky, Jeffrey J, Rapaport, Mark H, Medeiros, Helena, Sobell, Janet L, Backlund, Lena, Bergen, Sarah E, Juréus, Anders, Schalling, Martin, Lichtenstein, Paul, Knowles, James A, Burdick, Katherine E, Jones, Ian, Jones, Lisa A, Hultman, Christina M, Perlis, Roy, Purcell, Shaun M, McCarroll, Steven A, Pato, Carlos N, Pato, Michele T, Di Florio, Ariana, Craddock, Nick, Landén, Mikael, Smoller, Jordan W, Ruderfer, Douglas M, and Sklar, Pamela

Subjects
Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Genetics, Serious Mental Illness, Bipolar Disorder, Mental Health, Prevention, Brain Disorders, Schizophrenia, 2.1 Biological and endogenous factors, Aetiology, Mental health, Good Health and Well Being, Case-Control Studies, Cohort Studies, DNA Copy Number Variations, Gene Duplication, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Multifactorial Inheritance, Psychotic Disorders, Bipolar disorder, Copy number variant, Polygenic risk score, Rare variant burden, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Biological sciences, Biomedical and clinical sciences, Psychology
Abstract

BackgroundGenetic risk for bipolar disorder (BD) is conferred through many common alleles, while a role for rare copy number variants (CNVs) is less clear. Subtypes of BD including schizoaffective disorder bipolar type (SAB), bipolar I disorder (BD I), and bipolar II disorder (BD II) differ according to the prominence and timing of psychosis, mania, and depression. The genetic factors contributing to the combination of symptoms among these subtypes are poorly understood.MethodsRare large CNVs were analyzed in 6353 BD cases (3833 BD I [2676 with psychosis, 850 without psychosis, and 307 with unknown psychosis history], 1436 BD II, 579 SAB, and 505 BD not otherwise specified) and 8656 controls. CNV burden and a polygenic risk score (PRS) for schizophrenia were used to evaluate the relative contributions of rare and common variants to risk of BD, BD subtypes, and psychosis.ResultsCNV burden did not differ between BD and controls when treated as a single diagnostic entity. However, burden in SAB was increased relative to controls (p = .001), BD I (p = .0003), and BD II (p = .0007). Burden and schizophrenia PRSs were increased in SAB compared with BD I with psychosis (CNV p = .0007, PRS p = .004), and BD I without psychosis (CNV p = .0004, PRS p = 3.9 × 10-5). Within BD I, psychosis was associated with increased schizophrenia PRSs (p = .005) but not CNV burden.ConclusionsCNV burden in BD is limited to SAB. Rare and common genetic variants may contribute differently to risk for psychosis and perhaps other classes of psychiatric symptoms.

Published
2019

40. ACR Appropriateness Criteria® Fibroids

Author

Ascher, Susan M., Wasnik, Ashish P., Robbins, Jessica B., Adelman, Marisa, Brook, Olga R., Feldman, Myra K., Jones, Lisa P., Knavel Koepsel, Erica M., Patel-Lippmann, Krupa K., Patlas, Michael N., VanBuren, Wendaline, and Maturen, Katherine E.

Published
2022
Full Text
View/download PDF

41. Investing Ourselves: The Role of Space and Place in Being a Working-Class Female Academic

Author

Jones, Lisa and Maguire, Meg

Abstract

As working-class female academics, this paper examines the constructions of our identities focusing on both what unites and differentiates us as working-class women. We focus on the structuring forces in our lives such as our class, our whiteness and our gender, but we also discuss how our experiences have been shaped by space and place as a complex set of time-sensitive inter-relationships involving domination and subordination. Here, our different stories of "where," "when" and "how" we grew up are discussed as we attempt to make sense of these in relation to our construction of class and its intersectionality with these important aspects of our lives. We examine how these shaping features of our identities influence the personal investment we place in our work and how the middle-class 'status' inferred upon us by our educational 'success' and engagement within academia almost always feels contradictory to our own subjectivities and working-class loyalties.

Published
2021
Full Text
View/download PDF

42. Engaging or Disengaging: Understanding the Differences between Actionists and Unhelpful Bystanders among Youth Reacting to Peer Sexual Violence

Author

Banyard, Victoria, Edwards, Katie, Greenberg, Patricia, Waterman, Emily, Jones, Lisa, and Mitchell, Kimberly J.

Abstract

A growing body of research examines variables that may improve or impede helpful bystander action to prevent peer sexual assault among adolescents. The current study examines how individual and relational variables distinguish youth who respond to sexual violence in unhelpful versus helpful ways. Students were given a survey to assess frequency of actions taken in response to four peer sexual violence situations. Helpful actions were more likely among students who endorsed positive bystander attitudes and who reported more proactive prevention behaviors and less likely among students who self-reported peer violence perpetration. The findings support bystander prevention efforts that change social norms, increase proactive behaviors, and promote responsibility for intervening. Effectiveness may be enhanced through tailored approaches for youth most at risk for unhelpful bystander responses.

Published
2021
Full Text
View/download PDF

45. The influence of early life vitamin D deficiency on offspring skeletal muscle development, structure and function

Author

Jones, Lisa Ellen, Green, Lucy, Newland, Philip, Cleal, Jane, Poore, Kirsten, and Rustighi, Emiliano

Subjects
618.3
Abstract

Vitamin D deficiency (VDD) is highly prevalent in pregnant women, and may impair early life skeletal muscle development, and consequently influence muscle structure and function in adulthood and its rate of decline with aging. The profound decline in muscle mass and strength with age (sarcopenia) is associated with an increased risk of morbidity and mortality. Vitamin D status is determined by dietary intake, sunlight exposure and a deficiency in vitamin D is associated with obesity in humans. There is very little research on how VDD during pregnancy impacts the offspring’s skeletal muscle development, structure and function across the life course. Thus, this thesis aimed to test the hypothesis that pregnancy VDD will impair offspring skeletal muscle development, structure and function across its life course, and this was investigated in animal models of obesity and dietary specific VDD. In the first study, female C57BL/6J mice were fed a control (C; 7% kcal fat) or high-fat obesogenic (HF; 45% kcal fat) diet 6 weeks prior to mating and throughout pregnancy until weaning. Offspring were fed the C or HF diet postnatally. At 30 weeks of age, offspring isometric muscle contractile parameters, myofibre structure and mRNA levels of genes associated with muscle growth, contraction and insulin signalling were evaluated. In the second study, female C57BL/6J mice were fed a control (C; 1 IU/g vitamin D3) or VDD (0 IU/g vitamin D3) diet from 6 weeks prior to mating until weaning. All offspring were then weaned onto the C diet. At 15-weeks, offspring isometric muscle contractile force, grip strength, overall strength and open-field activity was assessed. In the third study, Welsh mountain ewes were fed a control (C, 2000 IU/kg vitamin D3), or a vitamin D deficient (VDD, 0 IU/kg vitamin D3) diet 17 days prior to conception until 127 days of gestation. In the late-gestation fetus, skeletal muscle radiolabelled glucose uptake, myofibre structure and mRNA levels of insulin signalling genes were quantified. A pre-weaning obesogenic diet was associated with some effects on muscle contractile peak force and potential fatigability in the adult offspring, and vitamin D homeostasis was affected by maternal obesity. A gestational VDD diet did not alter the skeletal muscle peak force, grip strength or overall strength in the young adult mouse, or glucose uptake in the fetal muscle. However, activity levels were reduced in the VDD mouse adult offspring. Fetal muscle structure did not change following a VDD diet, but some changes to skeletal muscle mass were observed in adulthood in the VDD mouse model. Overall, the results suggest that VDD during pregnancy is not as detrimental to the offspring’s skeletal muscle as hypothesised at the outset of this thesis. However, reduction in activity levels following a prenatal VDD diet may predispose the offspring to health complications such as obesity and metabolic disorders in later life. Considering there are some changes in muscle mass of offspring following a prenatal VDD diet, determining any myofibre structural changes is required. These data are a novel addition to a small pre-existing body of evidence for a role of pregnancy vitamin D on later life skeletal muscle function, and pave the way for future analysis with the aim to understand how the underlying mechanisms in the offspring muscle are influenced following a VDD diet during pregnancy.

Published
2018

46. Identifying the Common Genetic Basis of Antidepressant Response

Author

Kasper, Siegfried, Zohar, Joseph, Souery, Daniel, Montgomery, Stuart, Albani, Diego, Forloni, Gianluigi, Ferentinos, Panagiotis, Rujescu, Dan, Mendlewicz, Julien, Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Adams, Mark J., Agerbo, Esben, Air, Tracy M., Andlauer, Till F.M., Bacanu, Silviu-Alin, Bækvad-Hansen, Marie, Beekman, Aartjan T.F., Bigdeli, Tim B., Binder, Elisabeth B., Bryois, Julien, Buttenschøn, Henriette N., Bybjerg-Grauholm, Jonas, Cai, Na, Castelao, Enrique, Christensen, Jane Hvarregaard, Clarke, Toni-Kim, Coleman, Jonathan R.I., Colodro-Conde, Lucía, Couvy-Duchesne, Baptiste, Craddock, Nick, Crawford, Gregory E., Davies, Gail, Deary, Ian J., Degenhardt, Franziska, Derks, Eske M., Direk, Nese, Dolan, Conor V., Dunn, Erin C., Eley, Thalia C., Escott-Price, Valentina, Hassan Kiadeh, Farnush Farhadi, Finucane, Hilary K., Foo, Jerome C., Forstner, Andreas J., Frank, Josef, Gaspar, Héléna A., Gill, Michael, Goes, Fernando S., Gordon, Scott D., Grove, Jakob, Hall, Lynsey S., Hansen, Christine Søholm, Hansen, Thomas F., Herms, Stefan, Hickie, Ian B., Hoffmann, Per, Homuth, Georg, Horn, Carsten, Hottenga, Jouke-Jan, Hougaard, David M., Howard, David M., Ising, Marcus, Jansen, Rick, Jones, Ian, Jones, Lisa A., Jorgenson, Eric, Knowles, James A., Kohane, Isaac S., Kraft, Julia, Kretzschmar, Warren W., Kutalik, Zoltán, Li, Yihan, Lind, Penelope A., MacIntyre, Donald J., MacKinnon, Dean F., Maier, Robert M., Maier, Wolfgang, Marchini, Jonathan, Mbarek, Hamdi, McGrath, Patrick, McGuffin, Peter, Medland, Sarah E., Mehta, Divya, Middeldorp, Christel M., Mihailov, Evelin, Milaneschi, Yuri, Milani, Lili, Mondimore, Francis M., Montgomery, Grant W., Mostafavi, Sara, Mullins, Niamh, Nauck, Matthias, Ng, Bernard, Nivard, Michel G., Nyholt, Dale R., O’Reilly, Paul F., Oskarsson, Hogni, Owen, Michael J., Painter, Jodie N., Pedersen, Carsten Bøcker, Pedersen, Marianne Giørtz, Peterson, Roseann E., Peyrot, Wouter J., Pistis, Giorgio, Posthuma, Danielle, Quiroz, Jorge A., Qvist, Per, Rice, John P., Riley, Brien P., Rivera, Margarita, Mirza, Saira Saeed, Schoevers, Robert, Schulte, Eva C., Shen, Ling, Shi, Jianxin, Shyn, Stanley I., Sigurdsson, Engilbert, Sinnamon, Grant C.B., Smit, Johannes H., Smith, Daniel J., Stefansson, Hreinn, Steinberg, Stacy, Streit, Fabian, Strohmaier, Jana, Tansey, Katherine E., Teismann, Henning, Teumer, Alexander, Thompson, Wesley, Thomson, Pippa A., Thorgeirsson, Thorgeir E., Traylor, Matthew, Treutlein, Jens, Trubetskoy, Vassily, Uitterlinden, André G., Umbricht, Daniel, Van der Auwera, Sandra, van Hemert, Albert M., Viktorin, Alexander, Visscher, Peter M., Wang, Yunpeng, Webb, Bradley T., Weinsheimer, Shantel Marie, Wellmann, Jürgen, Willemsen, Gonneke, Witt, Stephanie H., Wu, Yang, Xi, Hualin S., Yang, Jian, Zhang, Futao, Arolt, Volker, Baune, Bernhard T., Berger, Klaus, Boomsma, Dorret I., Cichon, Sven, Dannlowski, Udo, de Geus, E.J.C., DePaulo, J. Raymond, Domenici, Enrico, Domschke, Katharina, Esko, Tõnu, Grabe, Hans J., Hamilton, Steven P., Hayward, Caroline, Heath, Andrew C., Kendler, Kenneth S., Kloiber, Stefan, Lewis, Glyn, Li, Qingqin S., Lucae, Susanne, Madden, Pamela A.F., Magnusson, Patrik K., Martin, Nicholas G., McIntosh, Andrew M., Metspalu, Andres, Mors, Ole, Mortensen, Preben Bo, Müller-Myhsok, Bertram, Nordentoft, Merete, Nöthen, Markus M., O’Donovan, Michael C., Paciga, Sara A., Pedersen, Nancy L., Penninx, Brenda W.J.H., Perlis, Roy H., Porteous, David J., Potash, James B., Preisig, Martin, Rietschel, Marcella, Schaefer, Catherine, Schulze, Thomas G., Smoller, Jordan W., Stefansson, Kari, Tiemeier, Henning, Uher, Rudolf, Völzke, Henry, Weissman, Myrna M., Werge, Thomas, Lewis, Cathryn M., Levinson, Douglas F., Breen, Gerome, Børglum, Anders D., Sullivan, Patrick F., Pain, Oliver, Hodgson, Karen, Marshe, Victoria S., Campos, Adrian I., Carrillo-Roa, Tania, Cattaneo, Annamaria, Als, Thomas D., Dernovsek, Mojca Z., Fabbri, Chiara, Henigsberg, Neven, Hauser, Joanna, Kennedy, James L., Lenze, Eric J., Müller, Daniel J., Mulsant, Benoit H., Perroud, Nader, Rentería, Miguel E., Reynolds, Charles F., III, Wigmore, Eleanor M., Aitchison, Katherine J., Biernacka, Joanna M., Bondolfi, Guido, Kato, Masaki, Liu, Yu-Li, Serretti, Alessandro, Tsai, Shih-Jen, Turecki, Gustavo, and Weinshilboum, Richard

Published
2022
Full Text
View/download PDF

47. ACR Appropriateness Criteria® Endometriosis.

Author

Feldman, Myra K., Wasnik, Ashish P., Adamson, Megan, Dawkins, Adrian A., Dibble, Elizabeth H., Jones, Lisa P., Joshi, Gayatri, Melamud, Kira, Patel-Lippmann, Krupa K., Shampain, Kimberly, VanBuren, Wendaline, and Kang, Stella K.

Abstract

Endometriosis is a common condition impacting individuals assigned female at birth. Though incompletely understood, the disorder is caused by endometrial-like tissue located outside of the endometrial cavity, associated with inflammation and fibrosis. Clinical presentation is variable, ranging from asymptomatic to severe pelvic pain and infertility. Treatment is determined by the patient's individualized goals and can include medical therapies to temporize symptoms or definitive surgical excision. Imaging is used to help diagnose endometriosis and for treatment planning. The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision process support the systematic analysis of the medical literature from peer reviewed journals. Established methodology principles such as Grading of Recommendations Assessment, Development, and Evaluation or GRADE are adapted to evaluate the evidence. The RAND/UCLA Appropriateness Method User Manual provides the methodology to determine the appropriateness of imaging and treatment procedures for specific clinical scenarios. In those instances where peer reviewed literature is lacking or equivocal, experts may be the primary evidentiary source available to formulate a recommendation. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

49. Depressive symptoms are associated with clinical outcomes in heart failure with reduced ejection fraction.

Author

Sherwood, Andrew, Blumenthal, James A., Mentz, Robert J., Koch, Gary G., Rogers, Joseph G., Chang, Patricia P., Chien, Christopher, Adams, Kirkwood F., Rose‐Jones, Lisa J., Jensen, Brian C., Donahue, Mark, Johnson, Kristy S., and Hinderliter, Alan L.

Subjects
PROPORTIONAL hazards models, SYMPTOMS, MENTAL depression, HEART failure patients, HEALTH behavior, HEART failure
Abstract

Aims: The objective of this study was to examine associations between elevated depressive symptoms and increased risk of adverse clinical events patients with heart failure and reduced ejection fraction (HFrEF), as well as the potential contribution of health behaviours. Methods and results: One hundred forty‐two men and women with HFrEF were enrolled through heart failure (HF) clinics and followed over time. At baseline and 6 months, depressive symptoms were assessed by the Beck Depression Inventory‐II (BDI‐II) and HFrEF disease activity by B‐type natriuretic peptide (BNP). The Self‐Care of Heart Failure Index (SCHFI) was used to assess HF self‐care behaviours. Proportional hazards regression models assessed the contribution of depressive symptoms and HFrEF disease biomarkers on death or cardiovascular hospitalization. Over a median follow‐up period of 4 years, 42 patients (30%) died, and 84 (60%) had cardiovascular hospitalizations. A 10‐point higher baseline BDI‐II score was associated with a 35% greater risk of death or cardiovascular hospitalization. Higher baseline BDI‐II scores were associated with poorer HF self‐care maintenance behaviours (R = −0.30, P < 0.001) and fewer daily steps (R = −0.19, P = 0.04), suggesting that elevated depressive symptoms may diminish important health behaviours. Increases in plasma BNP over 6 months were associated with worse outcomes. Changes in BDI‐II and plasma BNP over 6 months were positively related (R = 0.25, P = 0.004). Conclusions: This study confirms that elevated depressive symptoms are associated with an increased likelihood of adverse clinical outcomes in patients with HFrEF. Poor health behaviours may contribute to the adverse association of elevated depressive symptoms with the increased hazard of adverse clinical outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results