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9. Phenolic Compounds from the Aerial Parts of Malva verticillataand their Anti-diabetic Effect

Author

Ko, Jung-Hwan, Nuankaew, Wanlapa, Joo, Sun-Woo, Kim, Hyoung-Geun, Thi, Nhan Nguyen, Lee, Yeong-Geun, Kang, Tong Ho, and Baek, Nam-In

Abstract

The EtOAc, n-BuOH, and aqueous fractions from the aerial parts of Malva verticillatahave been shown to promote significant recovery from alloxan-induced pancreatic islet (PI) damage in zebrafish larvae at 10 μg/mL. Therefore, this study aimed to identify the principal active components of these plant parts and their pharmacological properties. Repeated SiO2and octadecyl SiO2column chromatography with the aerial parts of M. verticillataled to isolation of four phenolic compounds; these compounds were identified as benzyl-α-D-galactopyranoside (1), (-)-secoisolariciresinol-9'-O-β-D-glucopyranoside (2), transferulic acid (3), and trans-ferulic acid methyl ester (4) on the basis of physicochemical and spectroscopic analyses including infrared, nuclear magnetic resonance, and fast atom bombardment-mass spectroscopy. Compounds 14were first isolated from M. verticillatain this study. Furthermore, compounds 1–4recovered alloxan-induced PI damage in zebrafish. Especially, compound 3recovered the size of the injured PIs by 83.8% (p=0.0007) compared to the alloxan-induced group, while compound 4by 33.4% (p=0.0072). It is the first report that trans-ferulic acid (3) exhibited the protective effect on zebrafish larvae PIs damaged by alloxan.

Published
2018
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