188 results on '"Joo-Hee Zo"'
Search Results
2. Association between invasively measured central aortic pulse pressure and diameter of ascending aorta
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Hack-Lyoung Kim, Hyun Sung Joh, Woo-Hyun Lim, Jae-Bin Seo, Sang-Hyun Kim, Joo-Hee Zo, and Myung-A Kim
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Medicine ,Science - Abstract
Abstract Data on the relationship between arterial pulsatile hemodynamics and aortic root geometry, using invasive hemodynamic measurement, has been scarce. Thus, this study aimed to assess the relationship between invasively measured aortic pulse pressure (aPP) and the diameter of ascending aorta (AoD). We analyzed 665 subjects (64.3 ± 11.0 years; 34.6% female) who underwent elective invasive coronary angiography (ICA) for the evaluation of coronary artery disease. Transthoracic echocardiography was performed on the same day, and AoD was measured at the level of 1 cm above the sinotubular junction at the end-diastole. Body surface area (BSA)-adjusted AoD (AoD/BSA) was used for the analysis. A pig-tail catheter was used to measure aortic pressures at a level approximately 3 cm above the aortic valve just before ICA. aPP was calculated as the difference between systolic and diastolic pressures of the aorta. In multiple linear regression analyses, aPP (β = 0.259; P
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- 2023
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3. Arterial stiffness and its associations with left ventricular diastolic function according to heart failure types
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Hack-Lyoung Kim, Jaehoon Chung, Seokmoon Han, Hyun Sung Joh, Woo-Hyun Lim, Jae-Bin Seo, Sang-Hyun Kim, Joo-Hee Zo, and Myung-A Kim
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Vascular stiffness ,Diastolic function ,Heart failure ,Pulse wave analysis ,Medicine ,Internal medicine ,RC31-1245 - Abstract
Abstract Background Little is known about the characteristics of arterial stiffness in heart failure (HF). This study was performed to compare the degree of arterial stiffness and its association with left ventricular (LV) diastolic function among three groups: control subjects, patients with HF with reduced ejection fraction (HFrEF), and patients with HF with preserved ejection fraction (HFpEF). Methods A total of 83 patients with HFrEF, 68 patients with HFpEF, and 84 control subjects were analyzed. All HF patients had a history of hospitalization for HF treatment. Brachial-ankle pulse wave velocity (baPWV) measurement and transthoracic echocardiography were performed at the same day in a stable condition. Results The baPWV was significantly higher in patients with both HFrEF and HFpEF compared to control subjects (1,661 ± 390, 1,909 ± 466, and 1,477 ± 296 cm/sec, respectively; P
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- 2023
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4. Influence of Socioeconomic Status on the Presence of Obstructive Coronary Artery Disease and Cardiovascular Outcomes in Patients Undergoing Invasive Coronary Angiography
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Jaehoon Chung, Woo-Hyun Lim, Hack-Lyoung Kim, Hyun Sung Joh, Jae-Bin Seo, Sang-Hyun Kim, Joo-Hee Zo, and Myung-A Kim
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cardiovascular disease ,coronary angiography ,coronary artery disease ,medical aid beneficiary ,national health insurance beneficiary ,socioeconomic status ,Medicine - Abstract
This retrospective study investigated the impact of socioeconomic status (SES) on patients at high risk of cardiovascular disease, focusing on obstructive coronary artery disease (CAD) presence and long-term cardiovascular outcomes in individuals undergoing invasive coronary angiography (ICA). Analyzing data from 9530 patients categorized by health insurance type (medical aid beneficiaries (MABs) as the low SES group; national health insurance beneficiaries (NHIBs) as the high SES group), this research explores the relationship between SES and outcomes. Despite a higher prevalence of cardiovascular risk factors, the MAB group exhibited similar rates of obstructive CAD compared to the NHIB group. However, over a median 3.5-year follow-up, the MAB group experienced a higher incidence of composite cardiovascular events, including cardiac death, acute myocardial infarction, coronary revascularization, and ischemic stroke, compared with the NHIB group (20.2% vs. 16.2%, p < 0.001). Multivariable Cox regression analysis, adjusting for potential confounders, revealed independently worse clinical outcomes for the MAB group (adjusted odds ratio 1.28; 95% confidence interval 1.07–1.54; p = 0.006). Despite comparable CAD rates, this study underscores the fact that individuals with low SES encounter an elevated risk of composite cardiovascular events, emphasizing the association between socioeconomic disadvantage and heightened susceptibility to cardiovascular disease, even among those already at high risk.
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- 2024
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5. Associations of Estimated Pulse Wave Velocity with Body Mass Index and Waist Circumference among General Korean Adults
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Hack-Lyoung Kim, Hyun Sung Joh, Woo-Hyun Lim, Jae-Bin Seo, Sang-Hyun Kim, Joo-Hee Zo, and Myung-A Kim
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arterial stiffness ,body mass index ,pulse wave velocity ,obesity ,waist circumference ,Microbiology ,QR1-502 - Abstract
The correlation between body fat parameters and arterial stiffness is still under debate. This study aimed to examine the associations of body mass index (BMI) and waist circumference (WC) with estimated pulse wave velocity (ePWV). We utilized data from 14,228 subjects (mean age 53.4 ± 16.8 years; 56.9% were female) from the Korean National Health and Nutrition Examination Survey. The ePWV was calculated using a formula based on age and blood pressure. Simple linear correlation analyses revealed significant associations between both BMI and ePWV (r = 0.098; p < 0.001) and WC and ePWV (r = 0.291; p < 0.001), with a stronger correlation observed between WC and ePWV. Multiple linear regression analysis demonstrated that WC remained significantly associated with ePWV after adjusting for potential confounders (β = 0.020; p = 0.001). However, a statistically significant association was not found between BMI and ePWV (β = 0.011; p = 0.076). Multiple binary logistic regression analysis further indicated that both higher BMI and WC were independently associated with higher ePWV, but the association was more pronounced between WC and ePWV than between BMI and ePWV. These findings underscore a stronger correlation between visceral obesity (as indicated by WC) and arterial stiffness (as indicated by ePWV) compared to overall obesity (as indicated by BMI). This highlights the potential significance of abdominal obesity in assessing cardiovascular risk.
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- 2023
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6. Efficacy, safety and clinical outcome associated with statin use for primary prevention in Korean patients with low-density lipoprotein cholesterol level ≥ 190 mg/dL: A retrospective cohort study.
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Hack-Lyoung Kim, Woo-Hyun Lim, Jae-Bin Seo, Joo-Hee Zo, Myung-A Kim, and Sang-Hyun Kim
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Medicine ,Science - Abstract
BackgroundAlthough the current guideline recommends the use of high-intensity statin to reduce the low-density lipoprotein cholesterol (LDL-C) level by 50% in patients with baseline value of ≥ 190 mg/dL, direct application of this recommendation to Asian populations is still questionable. This study was performed to investigate the statin response of LDL-C in Korean patients with LDL-C ≥ 190 mg/dL.MethodsA total of 1,075 Korean patients (age 60.7 ± 12.2 years, women 68%) with baseline LDL-C ≥ 190 mg/dL without cardiovascular disease was retrospectively reviewed. Lipid profiles at 6 months, side effects and clinical outcomes during the follow-up period after statin treatment were assessed according to statin intensity.ResultsMost of the patients (76.3%) were treated with moderate-intensity statins, 11.4% with high-intensity statins, and 12.3% with a statin + ezetimibe. The reductions in LDL-C percentage at 6 months were 48.0%, 56.0% and 53.3% in patients treated with moderate-intensity statins, high-intensity statins and statin + ezetimibe, respectively (P < 0.001). Side effects requiring dose reduction, medication switch or drug interruption were observed in 1.3%, 4.9% and 2.3% of patients treated with moderate-intensity statin, high-intensity statin and statin + ezetimibe, respectively (P = 0.024). During the median follow-duration of 815 days (interquartile range, 408-1,361 days), the incidences of cardiovascular events were not different among the 3 groups (log-rank P = 0.823).ConclusionsCompared to high-intensity statin, moderate-intensity statin was effective enough in reaching target goal of LDL-C without increase in cardiovascular risk and with fewer side effects in Korean patients with LDL-C ≥ 190 mg/dL.
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- 2023
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7. Associations between measurements of central blood pressure and target organ damage in high-risk patients
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Ki-Hyun Jeon, Hack-Lyoung Kim, Woo-Hyun Lim, Jae-Bin Seo, Sang-Hyun Kim, Joo-Hee Zo, and Myung-A Kim
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Aortic blood pressure ,Arterial pressure ,Atherosclerosis ,Hypertension ,Pulse pressure ,Medicine ,Internal medicine ,RC31-1245 - Abstract
Abstract Background It is not well-known which components of central blood pressure (CBP) are more influential to target organ damage (TOD). This study aimed to determine the relationship between CBP measurements and various types of TOD in high-risk patients. Methods A total of 148 patients who had documented atherosclerotic cardiovascular disease or its multiple risk factors were prospectively enrolled. CBP was measured by using applanation tonometry of the radial artery. The following nine TOD parameters were evaluated: left ventricular mass index, relative wall thickness, septal e′ velocity, septal E/e′, brachial-ankle pulse wave velocity, ankle-brachial index, estimated glomerular filtration rate, urine protein and obstructive coronary artery disease. Results The mean age of the study population was 67.1 ± 9.0 years and 108 (73 %) were male. Among four CBP measurements (systolic, diastolic, mean, and pulse pressures), central pulse pressure (CPP) was associated with the largest number of TOD parameters. As CPP increased, the number of TOD increased (P = 0.010), but this association was not observed in other CBP measurements (P > 0.05 for each). Conclusions CPP had a stronger correlation with TOD than other CBP measurements. Non-invasive CPP could be a useful indicator for predicting TOD in patients at high coronary risk.
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- 2021
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8. Association between body fat parameters and arterial stiffness
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Hack-Lyoung Kim, Dong-Won Ahn, Su Hwan Kim, Dong Seok Lee, Soon Ho Yoon, Joo-Hee Zo, Myung-A. Kim, and Ji Bong Jeong
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Medicine ,Science - Abstract
Abstract The influence of body fat on arterial stiffness remains controversial. This study was performed to investigate the associations between four different types of body fat parameters and brachial-ankle pulse wave velocity (baPWV). A total of 3758 subjects (mean age, 53.4 ± 8.8 years; females, 36.3%) who underwent health check-up were retrospectively analyzed. Anthropometric parameters including body mass index (BMI), waist circumference (WC) and waist–hip ratio (WHR) were assessed, and visceral fat area (VFA) was calculated by bioelectrical impedance analysis. In simple linear correlation analyses, baPWV was associated with WC, WHR and VFA (P 0.05 for each). Even after controlling for potential confounders, higher baPWV was significantly associated not only with higher WHR [for > 0.90 in men and > 0.85 in women: odds ratio (OR), 1.23; 95% confidence interval (CI), 1.06–1.42; P = 0.005; for the highest tertile compared to the lowest tertile: OR, 1.38; 95% CI, 1.15–1.66; P
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- 2021
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9. Association between arterial stiffness and left ventricular diastolic function: A large population-based cross-sectional study
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Minkwan Kim, Hack-Lyoung Kim, Woo-Hyun Lim, Jae-Bin Seo, Sang-Hyun Kim, Myung-A Kim, and Joo-Hee Zo
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pulse wave velocity ,diastolic function ,ventricular-vascular coupling ,arterial stiffness ,heart failure with a preserved ejection fraction ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
BackgroundThe association between arterial stiffness and left ventricular (LV) diastolic function has been demonstrated in several studies, but the samples size in those studies was small. This study aims to verify this issue in a large number of study subjects.MethodsA total of 7,013 consecutive participants (mean age 60.6 years and 43.3% female) who underwent both baPWV and transthoracic echocardiography were retrospectively analyzed. Subjects with significant cardiac structural abnormalities were excluded.ResultsThere were significant correlations of baPWV with septal e′ velocity (r = – 0.408; P < 0.001), septal E/e′ (r = 0.349; P < 0.001), left atrial volume index (LAVI) (r = 0.122; P < 0.001) and maximal velocity of tricuspid valve regurgitation (TR Vmax) (r = 0.322; P < 0.001). The baPWV values increased proportionally with an increase in the number of LV diastolic indices meeting LV diastolic dysfunction criteria (P-for-trend < 0.001). In multivariable analyses with adjustment for confounding effects of various clinical covariates, higher baPWV was independently associated with septal e′ < 7 (odds ratio [OR], 1.30; 95% confidence interval [CI] 1.20–1.60; P < 0.001), septal E/e′ ≥ 15 (OR, 1.46; 95% CI, 1.21–1.78; P < 0.001), and TR Vmax > 2.8 m/s (OR, 1.60; 95% CI, 1.23–2.09; P < 0.001) but not with LAVI ≥ 34 mL/m2 (OR, 0.89; 95% CI, 0.76–1.03; P = 0.123).ConclusionsIncreased arterial stiffness, as measured by baPWV, was associated with abnormal diastolic function parameters in a large number of study participants, providing strong evidence to the existing data about ventricular-vascular coupling.
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- 2022
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10. Age-specific association between invasively measured central blood pressure and left ventricular mass index
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Tae-Min Rhee, Hack-Lyoung Kim, Woo-Hyun Lim, Jae-Bin Seo, Sang-Hyun Kim, Joo-Hee Zo, and Myung-A Kim
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age ,central blood pressure ,left ventricular mass index ,invasive catheterization ,young adults ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: The impact of age on the association between central aortic hemodynamics and left ventricular (LV) remodeling has not been well elucidated. We compared the relationship between measurements of central blood pressure (CBP) and LV mass index (LVMI) according to their ages ( .05 for each). In the younger age group (≤50 years), multivariable analysis showed that aSBP (β = 0.457, P= .021) and aPP (β = 0.610, P= .006) had a significant association with LVMI after adjusting for possible confounding factors. The results remained consistent even when analyzed in a 1:1 propensity score-matched cohort. In conclusion, invasively measured aPP showed the closest association with LVMI in subjects aged
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- 2021
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11. Association between household income and pulse pressure: data from the Korean National Health and Nutrition Examination Survey
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Hack-Lyoung Kim, Jaehoon Chung, Woo-Hyun Lim, Jae-Bin Seo, Sang-Hyun Kim, Joo-Hee Zo, and Myung-A Kim
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arterial stiffness ,household income ,pulse pressure ,socioeconomic status ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Purpose There has been limited evidence for the association between socioeconomic status (SES) and arterial stiffness. This study was performed to investigate the association between household income and brachial pulse pressure (PP) in the general Korean population. Materials and methods This study was based on data acquired in the 2018 Korea National Health and Nutrition Examination Survey (2018 KNHANES). A total of 13004 subjects at the age of 20 years or older analysed. The information on monthly household income was obtained through the questionnaire, and was stratified into 5 groups for each quintile. Brachial blood pressure (BP) was measured 3 times, and the average of the second and third measured BPs were used. PP was calculated as the difference between systolic and diastolic BPs. Results A lower household income was associated with a higher prevalence of cardiovascular risk factors. As household income increased, PP decreased proportionally (p
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- 2021
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12. Prognostic value of serum soluble ST2 in stable coronary artery disease: a prospective observational study
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Hack-Lyoung Kim, Jung Pyo Lee, Nathan Wong, Woo-Hyun Lim, Jae-Bin Seo, Joo-Hee Zo, Myung-A Kim, and Sang-Hyun Kim
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Medicine ,Science - Abstract
Abstract The role of ST2 in stable coronary artery disease (CAD) has not yet been well defined. This study was performed to investigate baseline serum soluble ST2 (sST2) level can predict clinical outcomes in patients with stable CAD. A total of 388 consecutive patients with suspected CAD (65 years and 63.7% male) in stable condition referred for elective invasive coronary angiography (ICA) was prospectively recruited. Major adverse cardiovascular event (MACE), including cardiac death, non-fatal myocardial infarction, coronary revascularization (90 days after ICA), and ischemic stroke during clinical follow-up was assessed. Most of the patients (88.0%) had significant CAD (stenosis ≥ 50%). During median follow-up of 834 days, there was 29 case of MACE (7.5%). The serum sST2 level was significantly higher in patients with MACE than those without (47.3 versus 30.6 ng/ml, P
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- 2021
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13. Associations of Brachial-Ankle Pulse Wave Velocity With Left Ventricular Geometry and Diastolic Function in Untreated Hypertensive Patients
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Soongu Kwak, Hack-Lyoung Kim, Minjae In, Woo-Hyun Lim, Jae-Bin Seo, Sang-Hyun Kim, Joo-Hee Zo, and Myung-A Kim
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arterial stiffness ,diastolic function ,hypertension ,left ventricular remodeling ,pulse wave velocity ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: Although brachial-ankle pulse wave velocity (baPWV) is simple and convenient, its usefulness as an initial screening test for hypertensive patients is not well-known. This study aimed to investigate the association of baPWV with left ventricular (LV) geometry and diastolic function in treatment-naive hypertensive patients.Methods: A total of 202 untreated hypertensive patients (mean age, 62 years; males, 51.5%) without documented cardiovascular diseases were prospectively enrolled. Both baPWV and transthoracic echocardiography were performed on the same day before antihypertensive treatment.Results: In multiple linear regression analysis after adjustment for potential confounders, baPWV had significant correlations with structural measurements of LV including relative wall thickness (β = 0.219, P = 0.021) and LV mass index (β = 0.286, P = 0.002), and four diastolic parameters including septal e′ velocity (β = −0.199, P = 0.018), E/e′ (β = 0.373, P < 0.001), left atrial volume index (β = 0.334, P < 0.001), and maximal velocity of tricuspid regurgitation (β = 0.401, P < 0.001). The baPWV was significantly increased in patients with LV hypertrophy, abnormal LV remodeling, or diastolic dysfunction, compared to those without (P = 0.008, P = 0.035, and P < 0.001, respectively). In the receiver operating characteristic curve analysis, the discriminant ability of baPWV in predicting LV hypertrophy and diastolic dysfunction had an area under the curve of 0.646 (95% confidence interval 0.544–0.703, P = 0.004) and 0.734 (95% confidence interval 0.648–0.800, P < 0.001), respectively.Conclusion: baPWV was associated with parameters of LV remodeling and diastolic function in untreated hypertensive patients. The baPWV could be a useful screening tool for the early detection of adverse cardiac features among untreated hypertensive patients.
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- 2021
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14. Gender difference in the association between brachial-ankle pulse wave velocity and cardiovascular risk scores
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Tae-Min Rhee, Hack-Lyoung Kim, Sohee Oh, Woo-Hyun Lim, Jae-Bin Seo, Woo-Young Chung, Sang-Hyun Kim, Myung-A Kim, and Joo-Hee Zo
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cardiovascular diseases ,risk assessment ,pulse wave analysis ,sex characteristics ,Medicine - Abstract
Background/Aims Although brachial-ankle pulse wave velocity (baPWV) has been validated as a novel method to predict the cardiovascular risk in general population, the relevance of baPWV to the traditional risk scores has not been clearly revealed. This study investigated the relationship between baPWV and four different cardiovascular risk-predicting scores in men and women. Methods A total of 539 subjects (58.1 ± 12.2 years, 50.1% men) without cardiovascular disease (CVD) who underwent health examinations including baPWV measurement were retrospectively analyzed. Four cardiovascular risk scores (Framingham risk score [FRS; 1998], Adult Treatment Panel [ATP] III revised FRS [2002], generalized FRS [2008], and American College of Cardiology/American Heart Association [ACC/AHA] CVD risk [2013]) were calculated in each subject. Results In a total population, baPWV was moderately correlated with four cardiovascular risk scores (r = 0.577 for FRS; r = 0.594 for ATP III revised FRS; r = 0.589 for generalized FRS; r = 0.571 for ACC/AHA CVD risk; p < 0.001 for each). These correlations were stronger in women than in men (r = 0.649 vs. 0.451 for FRS; r = 0.719 vs. 0.411 for ATP III revised FRS; r = 0.735 vs. 0.540 for generalized FRS; r = 0.699 vs. 0.552 for ACC/AHA CVD risk; p for gender difference ≤ 0.005 for each). Conclusions In middle-aged and elderly Koreans without CVD, baPWV was identified as having a moderately positive correlation with four different risk scores. The correlation was stronger in women than in men, implying the better performance of baPWV in women for predicting cardiovascular risk of healthy population.
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- 2019
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15. Association between dental health and obstructive coronary artery disease: an observational study
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Ho Lee, Hack-Lyoung Kim, Kwang Nam Jin, Sohee Oh, Yoon-Sic Han, Da-Un Jung, Hye-Young Sim, Hee-Sun Kim, Woo-Hyun Lim, Jae-Bin Seo, Sang-Hyun Kim, Joo-Hee Zo, and Myung-A Kim
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Coronary artery disease ,Dental health ,Inflammation ,Tooth loss ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Background The association between dental health and coronary artery disease (CAD) remains a topic of debate. This study aimed to investigate the association between dental health and obstructive CAD using multiple dental indices. Methods Eighty-eight patients (mean age: 65 years, 86% male) were prospectively enrolled before undergoing coronary CT angiography (n = 52) or invasive coronary angiography (n = 36). Obstructive CAD was defined as luminal stenosis of ≥50% for the left main coronary artery or ≥ 70% for the other epicardial coronary arteries. All patients underwent thorough dental examinations to evaluate 7 dental health indices, including the sum of decayed and filled teeth, the ratio of no restoration, the community periodontal index of treatment needs, clinical attachment loss, the total dental index, the panoramic topography index, and number of lost teeth. Results Forty patients (45.4%) had obstructive CAD. Among the 7 dental health indices, only the number of lost teeth was significantly associated with obstructive CAD, with patients who had obstructive CAD having significantly more lost teeth than patients without obstructive CAD (13.08 ± 10.4 vs. 5.44 ± 5.74, p
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- 2019
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16. Association between inter-leg blood pressure difference and cardiovascular outcome in patients undergoing percutaneous coronary intervention
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Inki Moon, Hack-Lyoung Kim, Woo-Hyun Lim, Jae-Bin Seo, Joo-Hee Zo, Myung-A Kim, and Sang-Hyun Kim
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Medicine ,Science - Abstract
Background Although the inter-arm blood pressure (BP) difference has been advocated to be associated with cardiovascular events, the implication of inter-leg BP difference has not been well established. This study was conducted to investigate whether inter-arm and -leg BP differences have prognostic value in patients undergoing percutaneous coronary intervention (PCI). Methods In this prospective study, we consecutively enrolled 667 patients who underwent PCI. Both arm and leg BPs were measured at the day after PCI. The primary outcome was a major adverse cardiovascular event (MACE) including cardiac death, acute coronary syndrome, coronary revascularization, stroke, and hospitalization for heart failure during the follow-up period. Results Mean age was 64.0±11.1 years old, and males were predominant (70.5%). During a mean follow-up period of 3.0 years, MACE occurred in 209 (31.3%) patients. The inter-leg systolic BP difference (ILSBPD) was significantly higher in patients with MACE than those without (9.9±12.3 vs. 7.2±7.5 mmHg, P = 0.004). The inter-arm systolic BP difference was not significantly different between patients with and without MACE (P = 0.403). In multivariable Cox regression analysis, increased ILSBPD was independently associated with the development of MACE (per 5 mmHg; hazard ratio, 1.07; 95% confidence interval, 1.01–1.14). The inter-arm systolic BP difference was not associated with MACE in the multivariable analysis. Conclusion Increased ILSBPD was independently associated with worse cardiovascular outcomes after PCI. As ILSBPD is easy to measure, it may be helpful in the risk stratification of patients undergoing PCI.
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- 2021
17. Data on the clinical usefulness of brachial-ankle pulse wave velocity in patients with suspected coronary artery disease
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In-Chang Hwang, Kwang Nam Jin, Hack-Lyoung Kim, You-Nui Kim, Moon-Sun Im, Woo-Hyun Lim, Jae-Bin Seo, Sang-Hyun Kim, Joo-Hee Zo, and Myung-A Kim
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Computer applications to medicine. Medical informatics ,R858-859.7 ,Science (General) ,Q1-390 - Abstract
Brachial-artery pulse wave velocity (baPWV) is a simple and reliable tool for measurement of arterial stiffness. Our previous studies suggested that baPWV is associated with the presence and severity of coronary artery disease (CAD) and the risk of cardiovascular events. In the present data article, we provided supplementary data supporting the independent prognostic value of arterial stiffness, assessed by baPWV, in patients with suspected CAD (Hwang et al., 2017) [1]. The data was obtained from 523 patients undergoing coronary CT angiography (CCTA), and baPWV was measured at the time of CCTA. Patients with vulnerable coronary plaque or obstructive CAD on CCTA had higher age, more cardiovascular risk factors, and higher baPWV values. Given the significant association between high baPWV and the presence of vulnerable plaque or obstructive CAD as shown in this data article, the prognostic value of baPWV was further assessed in subgroups divided according to the CCTA findings (vulnerable plaque or obstructive CAD). In each subgroup by CCTA findings, multivariable Cox proportional hazard model analysis showed that high baPWV was an independent risk factor for cardiovascular events even after adjusting for clinical risk factors.
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- 2018
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18. Subclinical alterations in left ventricular structure and function according to obesity and metabolic health status.
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Hyun-Jung Lee, Hack-Lyoung Kim, Woo-Hyun Lim, Jae-Bin Seo, Sang-Hyun Kim, Joo-Hee Zo, and Myung-A Kim
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Medicine ,Science - Abstract
BackgroundObesity and metabolic syndrome (MetS) are associated with high risk of cardiac dysfunction and heart failure. We assessed the effect of obesity and metabolic health status on left ventricular (LV) structure and function in subjects without overt heart disease.MethodsIn 789 subjects (58.8±13.0 years, 50.7% males) without overt heart disease, LV morphology and function were compared among 6 groups stratified by body mass index (BMI) (normal weight, overweight and obese) and metabolic health status (meeting ≤1 criterion of MetS excluding waist circumference defined as metabolically healthy; otherwise, metabolically unhealthy).ResultsLV ejection fraction (LVEF) was not different among the 6 groups (P>0.05). However, high BMI and poor metabolic health were associated with poorer global longitudinal strain (GLS), higher LV mass index (LVMI) and higher E/e' (PConclusionsObesity and poor metabolic health status were associated with subclinical decrement in LV systolic and diastolic function, and higher LV mass, but not with LVEF, in subjects without overt heart disease.
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- 2019
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19. Huge Left Ventricular Thrombus and Apical Ballooning associated with Recurrent Massive Strokes in a Septic Shock Patient
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Hyun-Jung Lee, Hack-Lyoung Kim, Doyeon Hwang, Chan-Soon Park, Jae-Sung Lim, Eungyu Kang, and Joo-Hee Zo
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echocardiography ,sepsis ,stroke ,thrombosis ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
The most feared complication of left ventricular thrombus (LVT) is the occurrence of systemic thromboembolic events, especially in the brain. Herein, we report a patient with severe sepsis who suffered recurrent devastating embolic stroke. Transthoracic echocardiography revealed apical ballooning of the left ventricle with a huge LVT, which had not been observed in chest computed tomography before the stroke. This case emphasizes the importance of serial cardiac evaluation in patients with stroke and severe medical illness.
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- 2016
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20. The Incremental Prognostic Value of Cardiac Computed Tomography in Comparison with Single-Photon Emission Computed Tomography in Patients with Suspected Coronary Artery Disease.
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Heesun Lee, Yeonyee E Yoon, Jun-Bean Park, Hack-Lyoung Kim, Hyo Eun Park, Seung-Pyo Lee, Hyung-Kwan Kim, Su-Yeon Choi, Yong-Jin Kim, Goo-Yeong Cho, Joo-Hee Zo, and Dae-Won Sohn
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Medicine ,Science - Abstract
Coronary computed tomographic angiography (CCTA) facilitates comprehensive evaluation of coronary artery disease (CAD), including plaque characterization, and can provide additive diagnostic value to single-photon emission computed tomography (SPECT). However, data regarding the incremental prognostic value of CCTA to SPECT remain sparse. We evaluated the independent and incremental prognostic value of CCTA, as compared with clinical risk factors and SPECT.A total of 1,077 patients with suspected CAD who underwent both SPECT and cardiac CT between 2004 and 2012 were enrolled retrospectively. Presence of reversible or fixed perfusion defect (PD) and summed stress score were evaluated on SPECT. Presence, extent of coronary atherosclerosis and diameter stenosis (DS) were evaluated on CCTA. Plaque composition was categorized as non-calcified, mixed, or calcified according to the volume of calcified component (>130 Hounsfield Units). Patients were followed up for the occurrence of adverse cardiac events including cardiac death, non-fatal myocardial infarction, unstable angina, and late revascularization (>90 days after imaging studies).During follow-up (median 23 months), adverse cardiac events were observed in 71 patients (6.6%). When adjusted for clinical risk factors and SPECT findings, the presence of any coronary plaque, any plaque in ≥3 segments, coronary artery calcium score (CACS) ≥400, a plaque ≥50% DS, presence of non-calcified plaque (NCP) or mixed plaque (MP), and NCP/MP in ≥2 segments were independent predictors of adverse cardiac events; however, the presence of calcified plaque (CP) was not. Conventional CCTA findings, including CACS ≥400 and a plaque ≥50% DS, demonstrated incremental prognostic value over clinical risk factors and SPECT (χ² 54.19 to 101.03; p
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- 2016
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21. Left Atrial Mechanical Function and Global Strain in Hypertrophic Cardiomyopathy.
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Kyung-Jin Kim, Hong-Mi Choi, Yeonyee E Yoon, Hack-Lyoung Kim, Seung-Pyo Lee, Hyung-Kwan Kim, Yong-Jin Kim, Goo-Yeong Cho, Joo-Hee Zo, and Dae-Won Sohn
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Medicine ,Science - Abstract
Atrial fibrillation is the most common arrhythmia and is associated with adverse outcomes in hypertrophic cardiomyopathy (HCM). Although left atrial (LA) remodeling and dysfunction are known to associate with the development of atrial fibrillation in HCM, the changes of the LA in HCM patients remain unclear. This study aimed to evaluate the changes in LA size and mechanical function in HCM patients compared to control subjects and to determine the characteristics of HCM associated with LA remodeling and dysfunction.Seventy-nine HCM patients (mean age, 54 ± 11 years; 76% were men) were compared to 79 age- and sex-matched controls (mean age, 54 ± 11 years; 76% were men) and 20 young healthy controls (mean age, 33 ± 5 years; 45% were men). The LA diameter, volume, and mechanical function, including global strain (ε), were evaluated by 2D-speckle tracking echocardiography. The phenotype of HCM, maximal left ventricular (LV) wall thickness, LV mass, and presence and extent of late gadolinium enhancement (LGE) were evaluated with cardiac magnetic resonance imaging.HCM patients showed increased LA volume index, impaired reservoir function, and decreased LA ε compared to the control subjects. When we divided the HCM group according to a maximal LA volume index (LAVImax) of 38.7 ml/m2 or LA ε of 21%, no significant differences in the HCM phenotype and maximal LV wall thickness were observed for patients with LAVImax >38.7 ml/m2 or LA ε ≤21%. Conversely, the LV mass index was significantly higher both in patients with maximal LA volume index >38.7 ml/m2 and with LA ε ≤21% and was independently associated with LAVImax and LA ε. Although the LGE extent was increased in patients with LA ε ≤21%, it was not independently associated with either LAVImax or LA ε.HCM patients showed progressed LA remodeling and dysfunction; the determinant of LA remodeling and dysfunction was LV mass index rather than LV myocardial fibrosis by LGE-magnetic resonance imaging.
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- 2016
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22. The association of brachial-ankle pulse wave velocity with coronary artery disease evaluated by coronary computed tomography angiography.
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Hack-Lyoung Kim, Kwang Nam Jin, Jae-Bin Seo, Young Ho Choi, Woo-Young Chung, Sang-Hyun Kim, Myung-A Kim, and Joo-Hee Zo
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Medicine ,Science - Abstract
The aim of this study was to investigate whether brachial-ankle pulse wave velocity (baPWV) is associated with the severity of coronary artery disease (CAD) assessed by coronary computed tomography angiography (CCTA), and to evaluate baPWV as a predictor of obstructive CAD on CCTA. A total of 470 patients who underwent both baPWV and CCTA were included. We evaluated stenosis degree and plaque characteristics on CCTA. To estimate the severity of CAD, we calculated the number of segment with plaque (segment involvement score; SIS), stenosis degree-weighted plaque score (segment stenosis score; SSS), and coronary artery calcium score (CACS). The mean baPWV was 1,485 ± 315 cm/s (range, 935-3,175 cm/s). Non-obstructive (stenosis < 50%) and obstructive (stenosis ≥ 50%) CAD was found in 129 patients (27.4%) and 144 (30.6%), respectively. baPWV in patients with obstructive CAD was higher than that of patients with non-obstructive (1,680 ± 396 cm/s versus 1,477 ± 244 cm/s, P < 0.001) or no CAD (1,680 ± 396 cm/s versus ± 196 1,389 cm/s, P < 0.001). baPWV showed significant correlation with SSS (r = 0.429, P < 0.001), SIS (r = 0.395, P < 0.001), CACS (r 0.346, P < 0.001), and the number of segment with non-calcified plaque (r 0.092, P = 0.047), mixed plaque (r = 0.267, P < 0.001), and calcified plaque (r = 0.348, P < 0.001), respectively. The optimal baPWV cut-off value for the detection of obstructive CAD was 1,547 cm/s. baPWV ≥ 1,547 cm/s was independent predictor for the obstructive CAD. In conclusion, baPWV is well correlated with the severity of CAD evaluated by CCTA. baPWV has the potential to predict severity of coronary artery atherosclerosis.
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- 2015
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23. One-month changes in blood pressure-adjusted pulse wave velocity for predicting long-term cardiovascular outcomes in patients undergoing percutaneous coronary intervention
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Hack-Lyoung Kim, Hyun Sung Joh, Woo-Hyun Lim, Jae-Bin Seo, Sang-Hyun Kim, Joo-Hee Zo, and Myung-A Kim
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Physiology ,Internal Medicine ,Cardiology and Cardiovascular Medicine - Published
- 2022
24. Influence of socioeconomic status on the presence of obstructive coronary artery disease and cardiovascular outcomes in patients undergoing invasive coronary angiography
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Jaehoon Chung, Hack-Lyoung Kim, Hyun Sung Joh, Woo-Hyun Lim, Jae-Bin Seo, Sang-Hyun Kim, Joo-Hee Zo, and Myung-A Kim
- Abstract
BackgroundAlthough it has been documented that low socioeconomic status (SES) is associated with increased risk of mortality and cardiovascular disease (CVD), this issue has not been addressed in patients at high CVD risk. This study was performed to investigate the association of the patient’s SES with the presence of obstructive coronary artery disease (CAD) and long-term cardiovascular outcomes who undergo invasive coronary angiography (ICA).MethodsA total of 9,530 patients who underwent ICA for the evaluation and treatment of CAD (66.0±12.3 years and 60.2% male) were retrospectively reviewed. The patients were divided into two groups according to the health insurance type: those with low SES who had the Medical aid program (Medical aid beneficiary [MAB] group; n=1,436) and those with high SES who had the National Health Insurance program (National Health Insurance beneficiary [NHIB] group; n=8,094). The primary outcome was a composite of cardiac death, acute myocardial infarction, coronary revascularization, and ischemic stroke.ResultsOf the study patients, 1,436 (15.1%) were in the MAB group. The prevalence of cardiovascular risk factors was higher in the MAB group compared to the NHIB group. However, the prevalence of obstructive CAD was similar between the two groups (62.8% vs. 64.2%;P=0.306). During a median follow-up period of 3.5 years (interquartile range, 1.0 to 5.9 years), the incidence of the composite cardiovascular event was significantly higher in the MAB group than in the NHIB group (20.2% vs. 16.2%,PP=0.006).ConclusionsAlthough CAD prevalence was similar, MABs showed an increased risk of composite cardiovascular events than NHIBs in Korean adults undergoing ICA. This provides additional evidence for the association between low SES and an increased risk of CVD, even in high-risk subjects.Clinical perspectiveWhat is new?This study provided evidence for a relationship between low socioeconomic status and increased cardiovascular disease risk in a high-risk population.What are the clinical implications?Subjects with low socioeconomic status are more likely to develop cardiovascular disease and to have a higher frequency of related risk factors, so cardiovascular disease tests and treatments should be performed more aggressively.Appropriate risk stratification of low socioeconomic status patients with traditional risk factors for cardiovascular disease is important for identifying high-risk patients.
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- 2023
25. Age-specific association between invasively measured central blood pressure and left ventricular mass index
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Myung A. Kim, Joo Hee Zo, Woo Hyun Lim, Sang-Hyun Kim, Tae Min Rhee, Hack Lyoung Kim, and Jae Bin Seo
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Adult ,Male ,Aging ,medicine.medical_specialty ,Physiology ,Heart Ventricles ,Blood Pressure ,030204 cardiovascular system & hematology ,Cohort Studies ,Left ventricular mass ,03 medical and health sciences ,0302 clinical medicine ,Central blood pressure ,Internal medicine ,Internal Medicine ,Humans ,Medicine ,Arterial Pressure ,030212 general & internal medicine ,Young adult ,Propensity Score ,Aged ,Aortic hemodynamics ,business.industry ,Age Factors ,Hemodynamics ,Organ Size ,General Medicine ,Middle Aged ,Age specific ,Echocardiography ,Hypertension ,cardiovascular system ,Cardiology ,Female ,Hypertrophy, Left Ventricular ,business - Abstract
Background: The impact of age on the association between central aortic hemodynamics and left ventricular (LV) remodeling has not been well elucidated. We compared the relationship between measurements of central blood pressure (CBP) and LV mass index (LVMI) according to their ages (Methods: A total of 305 consecutive subjects (64.4 ± 10.9 years, 60.7% males) who underwent invasive coronary angiography (ICA) for the evaluation of coronary artery disease were prospectively enrolled. Just before ICA, CBP was measured at the aortic root using a pig-tail catheter, and CBP indices, including aortic systolic blood pressure (aSBP), aortic pulse pressure (aPP), aortic fractional pulse pressure (=aPP/mean aortic pressure), and aortic pulsatility index (=aPP/diastolic aortic pressure), were recorded. All subjects underwent transthoracic echocardiography, and LVMI was measured on the same day of ICA. Results: In simple linear correlation analyses, LVMI was associated with all CBP indices in subjects aged P P > .05 for each). In the younger age group (≤50 years), multivariable analysis showed that aSBP (β = 0.457, P= .021) and aPP (β = 0.610, P= .006) had a significant association with LVMI after adjusting for possible confounding factors. The results remained consistent even when analyzed in a 1:1 propensity score-matched cohort. In conclusion, invasively measured aPP showed the closest association with LVMI in subjects aged Conclusion: Aortic pulsatile hemodynamic status appears to have a greater effect on LV remodeling in younger people than in older people.
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- 2021
26. Association between Aging and Changes in the Ankle-Brachial Index after Exercise in Patients with Chest Pain
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Myung-A Kim, Joo-Hee Zo, Hack-Lyoung Kim, Woo Hyun Lim, Jae-Bin Seo, and Sang-Hyun Kim
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medicine.medical_specialty ,medicine.anatomical_structure ,Index (economics) ,business.industry ,medicine ,Physical therapy ,In patient ,medicine.symptom ,Ankle ,Chest pain ,Association (psychology) ,business - Published
- 2020
27. Prognostic value of arterial stiffness according to the cardiovascular risk profiles
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Myung A. Kim, Jae Bin Seo, Sang-Hyun Kim, Woo Hyun Lim, Hack Lyoung Kim, and Joo Hee Zo
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Male ,medicine.medical_specialty ,Pulse Wave Analysis ,030204 cardiovascular system & hematology ,03 medical and health sciences ,Vascular Stiffness ,0302 clinical medicine ,Risk Factors ,Interquartile range ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Ankle Brachial Index ,030212 general & internal medicine ,Myocardial infarction ,Risk factor ,Pulse wave velocity ,Mass screening ,Retrospective Studies ,Proportional hazards model ,business.industry ,Confounding ,Prognosis ,medicine.disease ,Cardiovascular Diseases ,Heart Disease Risk Factors ,Cardiology ,Arterial stiffness ,Female ,business - Abstract
It is not clear whether the influence of arterial stiffness depends on the subject’s cardiovascular risk status. This study was performed to assess the prognostic value of arterial stiffness according to different cardiovascular risk profiles. A total of 11,767 subjects (61 years and 58% males) who underwent brachial-ankle pulse wave velocity (baPWV) measurement were retrospectively analyzed. Subjects were stratified into three groups: (1) those with traditional risk factor ≤1 and without atherosclerotic cardiovascular disease (ASCVD), (2) those with traditional risk factors ≥2 and without ASCVD, or (3) those with documented ASCVD. Composite events of cardiac death, non-fatal myocardial infarction, coronary revascularization and stroke were assessed during the clinical follow-up period. Compared to patients with risk factor ≤1, those with risk factor ≥2 and those with ASCVD were older, and more frequently had unfavorable laboratory findings, and higher baPWV values. During the median follow-up of 1329 days (interquartile range, 570–1,965 days), there were 350 composite events (3.0%). In multivariable Cox regression analyses, higher baPWV value was independently associated with higher incidence rate of composite events even after controlling for potential confounders in all three groups (P
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- 2020
28. Prognostic value of arterial stiffness in menopausal women
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Minkwan Kim, Hack-Lyoung Kim, Yuna Cho, Woo-Hyun Lim, Jae-Bin Seo, Sang-Hyun Kim, Joo-Hee Zo, and Myung-A Kim
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Applied Mathematics ,General Mathematics ,Myocardial Infarction ,Obstetrics and Gynecology ,Middle Aged ,Pulse Wave Analysis ,Prognosis ,Vascular Stiffness ,Humans ,Ankle Brachial Index ,Female ,Menopause ,Aged ,Retrospective Studies - Abstract
Because menopausal women have an increased cardiovascular risk, risk stratification is very crucial in this population. This study aimed to verify the prognostic value of arterial stiffness in menopausal women.We retrospectively analyzed 2,917 menopausal women (age55y) without overt cardiovascular disease who underwent brachial-ankle pulse wave velocity measurement. The primary endpoint was a composite of clinical events, including all-cause death, nonfatal myocardial infarction, coronary revascularization, and stroke, hereafter referred to as major adverse cardiovascular events. Propensity score matching and inverse probability-treatment weighting analysis were used to balance differences in baseline participant characteristics.The mean participant age was 66.8 ± 7.7 years. During a median follow-up period of 4.0 (interquartile range of 1.9-6.3) years, the primary outcome was noted in 56 cases (1.9%). Pulse wave velocity was significantly higher in participants with the primary outcome than in those without (1,947 ± 388 vs 1,690 ± 348 cm/s; P 0.001). For every 100 cm/s increase in pulse wave velocity, the hazard ratio for the primary endpoint increased by 1.15 times (95% confidence interval, 1.08-1.22; P 0.001) in multivariable Cox regression analysis. A pulse wave velocity1,613 cm/s was associated with increased risk of the primary endpoint in the same multivariable analysis (hazard ratio, 3.06; 95% confidence interval, 1.40-6.68; P = 0.005). The results were consistent after propensity score matching and inverse probability-treatment weighting analysis.Elevated brachial-ankle pulse wave velocity was associated with the occurrence of major adverse cardiovascular events in menopausal women without cardiovascular disease and may represent a useful screening tool.
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- 2022
29. Association Between Metabolic Syndrome and Parameters of Subclinical Target Organ Damage in Urban Subjects Without Documented Cardiovascular Disease
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Do Sun Lim, Sang-Hyun Kim, Hyung Joon Joo, Myung A. Kim, Hack Lyoung Kim, Jae Bin Seo, Woo Hyun Lim, and Joo Hee Zo
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Adult ,Male ,Risk ,medicine.medical_specialty ,Databases, Factual ,Urban Population ,Endocrinology, Diabetes and Metabolism ,Disease ,Pulse Wave Analysis ,Carotid Intima-Media Thickness ,Risk Factors ,Internal medicine ,Republic of Korea ,Prevalence ,Internal Medicine ,medicine ,Humans ,Ankle Brachial Index ,Prospective Studies ,Stage (cooking) ,Subclinical infection ,Metabolic Syndrome ,business.industry ,Middle Aged ,medicine.disease ,Target organ damage ,Cardiovascular Diseases ,Hypertension ,Linear Models ,Cardiology ,Female ,Metabolic syndrome ,Tomography, X-Ray Computed ,business ,Glomerular Filtration Rate - Abstract
Background: Identification of subclinical target organ damage (TOD) at early stage is important for the reduction in cardiovascular risk. This study was performed to assess the association between ...
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- 2020
30. Association Between Serum Adropin Level and Cardiac Target Organ Damages in Patients Undergoing Invasive Coronary Angiography
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Hack-Lyoung Kim, Jaehoon Chung, Hyun Sung Joh, Woo-Hyun Lim, Jae-Bin Seo, Sang-Hyun Kim, Joo-Hee Zo, and Myung-A Kim
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General Engineering - Published
- 2023
31. Associations between measurements of central blood pressure and target organ damage in high-risk patients
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Joo-Hee Zo, Sang-Hyun Kim, Jae-Bin Seo, Myung A. Kim, Hack-Lyoung Kim, Woo Hyun Lim, and Ki-Hyun Jeon
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medicine.medical_specialty ,Diastole ,Renal function ,Coronary artery disease ,Internal medicine ,medicine.artery ,Aortic blood pressure ,Internal Medicine ,medicine ,Radial artery ,Pulse wave velocity ,Arterial pressure ,Angiology ,business.industry ,Research ,Atherosclerosis ,medicine.disease ,RC31-1245 ,Pulse pressure ,Blood pressure ,Hypertension ,Cardiology ,Medicine ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background It is not well-known which components of central blood pressure (CBP) are more influential to target organ damage (TOD). This study aimed to determine the relationship between CBP measurements and various types of TOD in high-risk patients. Methods A total of 148 patients who had documented atherosclerotic cardiovascular disease or its multiple risk factors were prospectively enrolled. CBP was measured by using applanation tonometry of the radial artery. The following nine TOD parameters were evaluated: left ventricular mass index, relative wall thickness, septal e′ velocity, septal E/e′, brachial-ankle pulse wave velocity, ankle-brachial index, estimated glomerular filtration rate, urine protein and obstructive coronary artery disease. Results The mean age of the study population was 67.1 ± 9.0 years and 108 (73 %) were male. Among four CBP measurements (systolic, diastolic, mean, and pulse pressures), central pulse pressure (CPP) was associated with the largest number of TOD parameters. As CPP increased, the number of TOD increased (P = 0.010), but this association was not observed in other CBP measurements (P > 0.05 for each). Conclusions CPP had a stronger correlation with TOD than other CBP measurements. Non-invasive CPP could be a useful indicator for predicting TOD in patients at high coronary risk.
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- 2021
32. Brachial-ankle pulse wave velocity as a predictor of long-term cardiovascular events in 2174 subjects with type 2 diabetes mellitus: A retrospective cohort study
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Hack-Lyoung, Kim, Won Kyeong, Jeon, Hyun Sung, Joh, Woo-Hyun, Lim, Jae-Bin, Seo, Sang-Hyun, Kim, Joo-Hee, Zo, and Myung-A, Kim
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Male ,Stroke ,Diabetes Mellitus, Type 2 ,Predictive Value of Tests ,Myocardial Infarction ,Humans ,Ankle Brachial Index ,General Medicine ,Middle Aged ,Pulse Wave Analysis ,Retrospective Studies - Abstract
The prognostic value of arterial stiffness in patients with diabetes mellitus (DM) remains unclear. The aim of this study was to investigate the association between brachial-ankle pulse wave velocity (baPWV) and the occurrence of cardiovascular events in people with DM. A total of 2714 subjects (mean age, 63.6 years; males, 59.3%) with type 2 DM and without documented cardiovascular disease and stroke were analyzed. The primary end-point of this study was composite cardiovascular events of cardiac death, non-fatal myocardial infarction, coronary revascularization and stroke. There were 118 composite events (4.3%) during a median follow-up period of 3.84 years (interquartile range, 1.60-5.52 years). In multivariable Cox regression analysis, higher baPWV (≥1672 cm/s) was associated with composite events even after controlling for potential confounders (hazard ratio [HR], 2.00; 95% confidence interval [CI], 1.31-3.07; P = .001). Compared to the lowest baPWV tertile, both middle (HR, 1.84; 95% CI, 1.03-3.27; P = .037) and the highest (HR, 2.97; 95% CI, 1.69-5.22; P .001) tertile of baPWV were associated with increased risk of cardiovascular events in the same multivariable model. In conclusion, the baPWV was associated with cardiovascular events in people with type 2 DM. Considering the simplicity and convenience of baPWV measurement, baPWV may be useful for risk stratification of people with type 2 DM.
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- 2022
33. Association between body fat parameters and arterial stiffness
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Dong Seok Lee, Ji Bong Jeong, Soon Ho Yoon, Joo Hee Zo, Dong-Won Ahn, Myung A. Kim, Hack Lyoung Kim, and Su Hwan Kim
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Adult ,Male ,medicine.medical_specialty ,Waist ,Science ,Cardiology ,Intra-Abdominal Fat ,Pulse Wave Analysis ,Article ,Body Mass Index ,Medical research ,Vascular Stiffness ,Internal medicine ,medicine ,Humans ,Ankle Brachial Index ,Pulse wave velocity ,Abdominal obesity ,Adiposity ,Aged ,Retrospective Studies ,Waist-Height Ratio ,Multidisciplinary ,business.industry ,Middle Aged ,medicine.disease ,Obesity ,Confidence interval ,Risk factors ,Obesity, Abdominal ,Arterial stiffness ,Medicine ,Female ,Waist Circumference ,medicine.symptom ,business ,Bioelectrical impedance analysis ,Body mass index - Abstract
The influence of body fat on arterial stiffness remains controversial. This study was performed to investigate the associations between four different types of body fat parameters and brachial-ankle pulse wave velocity (baPWV). A total of 3758 subjects (mean age, 53.4 ± 8.8 years; females, 36.3%) who underwent health check-up were retrospectively analyzed. Anthropometric parameters including body mass index (BMI), waist circumference (WC) and waist–hip ratio (WHR) were assessed, and visceral fat area (VFA) was calculated by bioelectrical impedance analysis. In simple linear correlation analyses, baPWV was associated with WC, WHR and VFA (P P = 0.175). In multivariable analyses, BMI and WC were not associated with baPWV (P > 0.05 for each). Even after controlling for potential confounders, higher baPWV was significantly associated not only with higher WHR [for > 0.90 in men and > 0.85 in women: odds ratio (OR), 1.23; 95% confidence interval (CI), 1.06–1.42; P = 0.005; for the highest tertile compared to the lowest tertile: OR, 1.38; 95% CI, 1.15–1.66; P 2: OR, 1.39; 95% CI, 1.20–1.60; P P
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- 2021
34. Improved Prognostic Value in Predicting Long-Term Cardiovascular Events by a Combination of High-Sensitivity C-Reactive Protein and Brachial–Ankle Pulse Wave Velocity
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Myung A. Kim, Joo-Hee Zo, Hack-Lyoung Kim, Woo Hyun Lim, Jae-Bin Seo, and Sang-Hyun Kim
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medicine.medical_specialty ,pulse wave velocity ,risk stratification ,030204 cardiovascular system & hematology ,Article ,C-reactive protein ,03 medical and health sciences ,0302 clinical medicine ,Interquartile range ,Internal medicine ,Medicine ,030212 general & internal medicine ,Myocardial infarction ,Pulse wave velocity ,biology ,business.industry ,Hazard ratio ,General Medicine ,medicine.disease ,Confidence interval ,arterial stiffness ,Arterial stiffness ,Cardiology ,biology.protein ,business ,major adverse cardiovascular event ,Mace - Abstract
Background: Both C-reactive protein (CRP) and arterial stiffness are associated with the development of cardiovascular disease (CVD). This study was performed to investigate whether a combination of these two measurements could improve cardiovascular risk stratification. Methods: A total of 6572 consecutive subjects (mean age, 60.8 ± 11.8 years, female, 44.2%) who underwent both high-sensitivity CRP (hs-CRP) and brachial–ankle pulse wave velocity (baPWV) measurement within 1 week were retrospectively analyzed. Major adverse cardiovascular events (MACE), including cardiovascular death, acute myocardial infarction, coronary revascularization, and stroke were assessed during the clinical follow-up. Results: During a mean follow-up period of 3.75 years (interquartile range, 1.78–5.31 years), there were 182 cases of MACE (2.8%). The elevated baPWV (≥1505 cm/s) (hazard ratio (HR), 4.21, 95% confidence interval (CI), 2.73–6.48, p <, 0.001) and hs-CRP (≥3 mg/L) (HR, 1.57, 95% CI, 1.12–2.21, 0.001) levels were associated with MACE even after controlling for potential confounders. The combination of baPWV and hs-CRP further stratified the subjects’ risk (subjects with low baPWV and hs-CRP vs. subjects with high baPWV and hs-CRP, HR, 7.08, 95% CI, 3.76−13.30, 0.001). Adding baPWV information to clinical factors and hs-CRP had an incremental prognostic value (global Chi-square score, from 126 to 167, p <, 0.001). Conclusions: The combination of hs-CRP and baPWV provided a better prediction of future CVD than either one by itself. Taking these two simple measurements simultaneously is clinically useful in cardiovascular risk stratification.
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- 2021
35. Associations of Brachial-Ankle Pulse Wave Velocity With Left Ventricular Geometry and Diastolic Function in Untreated Hypertensive Patients
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Myung A. Kim, Joo Hee Zo, Woo Hyun Lim, Hack Lyoung Kim, Soongu Kwak, Jae Bin Seo, Sang-Hyun Kim, and Minjae In
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medicine.medical_specialty ,hypertension ,pulse wave velocity ,Diastole ,Cardiovascular Medicine ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Diseases of the circulatory (Cardiovascular) system ,Medicine ,Mass index ,030212 general & internal medicine ,Pulse wave velocity ,Original Research ,left ventricular remodeling ,Receiver operating characteristic ,business.industry ,diastolic function ,Confounding ,Area under the curve ,medicine.disease ,Confidence interval ,arterial stiffness ,RC666-701 ,Arterial stiffness ,Cardiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background: Although brachial-ankle pulse wave velocity (baPWV) is simple and convenient, its usefulness as an initial screening test for hypertensive patients is not well-known. This study aimed to investigate the association of baPWV with left ventricular (LV) geometry and diastolic function in treatment-naive hypertensive patients.Methods: A total of 202 untreated hypertensive patients (mean age, 62 years; males, 51.5%) without documented cardiovascular diseases were prospectively enrolled. Both baPWV and transthoracic echocardiography were performed on the same day before antihypertensive treatment.Results: In multiple linear regression analysis after adjustment for potential confounders, baPWV had significant correlations with structural measurements of LV including relative wall thickness (β = 0.219, P = 0.021) and LV mass index (β = 0.286, P = 0.002), and four diastolic parameters including septal e′ velocity (β = −0.199, P = 0.018), E/e′ (β = 0.373, P < 0.001), left atrial volume index (β = 0.334, P < 0.001), and maximal velocity of tricuspid regurgitation (β = 0.401, P < 0.001). The baPWV was significantly increased in patients with LV hypertrophy, abnormal LV remodeling, or diastolic dysfunction, compared to those without (P = 0.008, P = 0.035, and P < 0.001, respectively). In the receiver operating characteristic curve analysis, the discriminant ability of baPWV in predicting LV hypertrophy and diastolic dysfunction had an area under the curve of 0.646 (95% confidence interval 0.544–0.703, P = 0.004) and 0.734 (95% confidence interval 0.648–0.800, P < 0.001), respectively.Conclusion: baPWV was associated with parameters of LV remodeling and diastolic function in untreated hypertensive patients. The baPWV could be a useful screening tool for the early detection of adverse cardiac features among untreated hypertensive patients.
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- 2021
36. Clinical factors associated with reduced global longitudinal strain in subjects with normal left ventricular ejection fraction
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Joo-Hee Zo, Hack-Lyoung Kim, Woo Hyun Lim, Sang-Hyun Kim, Myung A. Kim, and Jae-Bin Seo
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Male ,medicine.medical_specialty ,Longitudinal strain ,Cardiovascular risk factors ,030204 cardiovascular system & hematology ,Ventricular Function, Left ,03 medical and health sciences ,Ventricular Dysfunction, Left ,0302 clinical medicine ,Cigarette smoking ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Binary logistic regression analysis ,030212 general & internal medicine ,Retrospective Studies ,Ejection fraction ,business.industry ,Mean age ,Stroke Volume ,Odds ratio ,Middle Aged ,Confidence interval ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Characteristics of subjects with reduced GLS but no overt left ventricular dysfunction have been poorly characterized. We sought to find clinical factors associated with reduced GLS despite having normal LVEF. Subjects without documented cardiovascular disease who underwent measurement of GLS using 2D speckle-tracking echocardiography were retrospectively reviewed. All subjects had normal LVEF (≥ 55%). Because GLS is a negative value, we took the absolute value |x| for a simpler interpretation. Reduced GLS was defined as
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- 2021
37. Association between inter-leg blood pressure difference and cardiovascular outcome in patients undergoing percutaneous coronary intervention
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Myung A. Kim, Jae Bin Seo, Inki Moon, Joo Hee Zo, Sang-Hyun Kim, Woo Hyun Lim, and Hack Lyoung Kim
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Male ,medicine.medical_treatment ,Blood Pressure ,Cardiovascular Medicine ,Vascular Medicine ,Medical Conditions ,Endocrinology ,Risk Factors ,Atrial Fibrillation ,Chronic Kidney Disease ,Medicine and Health Sciences ,Coronary Heart Disease ,Prospective Studies ,Stroke ,Multidisciplinary ,Hazard ratio ,Middle Aged ,Prognosis ,Treatment Outcome ,Neurology ,Cardiovascular Diseases ,Nephrology ,Hypertension ,Cardiology ,Medicine ,Female ,Arrhythmia ,Research Article ,medicine.medical_specialty ,Acute coronary syndrome ,Endocrine Disorders ,Cerebrovascular Diseases ,Science ,Percutaneous Coronary Intervention ,Internal medicine ,medicine ,Renal Diseases ,Diabetes Mellitus ,Humans ,cardiovascular diseases ,Aged ,Leg ,business.industry ,Percutaneous coronary intervention ,Cardiovascular Disease Risk ,medicine.disease ,Blood pressure ,Heart failure ,Metabolic Disorders ,Conventional PCI ,business ,Mace ,Follow-Up Studies - Abstract
Background Although the inter-arm blood pressure (BP) difference has been advocated to be associated with cardiovascular events, the implication of inter-leg BP difference has not been well established. This study was conducted to investigate whether inter-arm and -leg BP differences have prognostic value in patients undergoing percutaneous coronary intervention (PCI). Methods In this prospective study, we consecutively enrolled 667 patients who underwent PCI. Both arm and leg BPs were measured at the day after PCI. The primary outcome was a major adverse cardiovascular event (MACE) including cardiac death, acute coronary syndrome, coronary revascularization, stroke, and hospitalization for heart failure during the follow-up period. Results Mean age was 64.0±11.1 years old, and males were predominant (70.5%). During a mean follow-up period of 3.0 years, MACE occurred in 209 (31.3%) patients. The inter-leg systolic BP difference (ILSBPD) was significantly higher in patients with MACE than those without (9.9±12.3 vs. 7.2±7.5 mmHg, P = 0.004). The inter-arm systolic BP difference was not significantly different between patients with and without MACE (P = 0.403). In multivariable Cox regression analysis, increased ILSBPD was independently associated with the development of MACE (per 5 mmHg; hazard ratio, 1.07; 95% confidence interval, 1.01–1.14). The inter-arm systolic BP difference was not associated with MACE in the multivariable analysis. Conclusion Increased ILSBPD was independently associated with worse cardiovascular outcomes after PCI. As ILSBPD is easy to measure, it may be helpful in the risk stratification of patients undergoing PCI.
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- 2021
38. Association between household income and pulse pressure: data from the Korean National Health and Nutrition Examination Survey
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Jae-Bin Seo, Myung A. Kim, Jae Hoon Chung, Sang-Hyun Kim, Hack-Lyoung Kim, Woo Hyun Lim, and Joo-Hee Zo
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Adult ,National Health and Nutrition Examination Survey ,Blood Pressure ,030204 cardiovascular system & hematology ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Risk Factors ,Republic of Korea ,Internal Medicine ,medicine ,Humans ,030212 general & internal medicine ,Socioeconomic status ,business.industry ,General Medicine ,Odds ratio ,medicine.disease ,Nutrition Surveys ,Confidence interval ,Pulse pressure ,Blood pressure ,Logistic Models ,Arterial stiffness ,Income ,Household income ,Cardiology and Cardiovascular Medicine ,business ,Demography - Abstract
PURPOSE There has been limited evidence for the association between socioeconomic status (SES) and arterial stiffness. This study was performed to investigate the association between household income and brachial pulse pressure (PP) in the general Korean population. MATERIALS AND METHODS This study was based on data acquired in the 2018 Korea National Health and Nutrition Examination Survey (2018 KNHANES). A total of 13004 subjects at the age of 20 years or older analysed. The information on monthly household income was obtained through the questionnaire, and was stratified into 5 groups for each quintile. Brachial blood pressure (BP) was measured 3 times, and the average of the second and third measured BPs were used. PP was calculated as the difference between systolic and diastolic BPs. RESULTS A lower household income was associated with a higher prevalence of cardiovascular risk factors. As household income increased, PP decreased proportionally (p
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- 2021
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39. Association of the Serum Osteoprotegerin Level With Target Organ Damage in Patients at High Risk of Coronary Artery Disease
- Author
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Joo Hee Zo, Woo Hyun Lim, Sang-Hyun Kim, Jung Pyo Lee, Hack Lyoung Kim, Myung A. Kim, Jae Bin Seo, and Jae Hoon Chung
- Subjects
musculoskeletal diseases ,medicine.medical_specialty ,Renal function ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Pulse Wave Analysis ,Coronary Angiography ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,Osteoprotegerin ,Risk Factors ,Internal medicine ,medicine ,Humans ,Ankle Brachial Index ,030212 general & internal medicine ,Pulse wave velocity ,business.industry ,Confounding ,General Medicine ,Odds ratio ,medicine.disease ,Target organ damage ,Confidence interval ,Cardiology ,Cardiology and Cardiovascular Medicine ,business ,Glomerular Filtration Rate - Abstract
BACKGROUND There is little data as to whether osteoprotegerin (OPG) is associated with target organ damage (TOD), so we evaluated the association in patients at high risk of coronary artery disease (CAD).Methods and Results:A total of 349 patients who underwent invasive coronary angiography (ICA) for suspected CAD were prospectively recruited. During the index admission, 6 TOD parameters were collected: extent of CAD, glomerular filtration rate (GFR), left ventricular mass index (LVMI), E/e', brachial-ankle pulse wave velocity (baPWV), and ankle-brachial index (ABI). Serum OPG levels were measured using enzyme-linked immunosorbent assay. The OPG level was significantly higher in patients with ≥1 TOD parameter than in those without (314±186 vs. 202±74 pg/mL, P
- Published
- 2020
40. Echocardiographic parameters determining cardiovascular outcomes in patients after acute ischemic stroke
- Author
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You Nui Kim, Sang-Hyun Kim, Kyung Taek Park, Jae-Sung Lim, Joo Hee Zo, Hack Lyoung Kim, Myung A. Kim, Minkwan Kim, Woo Hyun Lim, and Jae Bin Seo
- Subjects
Male ,medicine.medical_specialty ,Time Factors ,Heart Valve Diseases ,030204 cardiovascular system & hematology ,Risk Assessment ,Ventricular Function, Left ,Brain Ischemia ,03 medical and health sciences ,Ventricular Dysfunction, Left ,0302 clinical medicine ,Interquartile range ,Predictive Value of Tests ,Risk Factors ,Internal medicine ,Cause of Death ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Myocardial infarction ,Stroke ,Aged ,Retrospective Studies ,Aged, 80 and over ,Ejection fraction ,Sclerosis ,business.industry ,Proportional hazards model ,Hazard ratio ,Confounding ,Stroke Volume ,Middle Aged ,medicine.disease ,Confidence interval ,Echocardiography, Doppler, Color ,Treatment Outcome ,Aortic Valve ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,030217 neurology & neurosurgery - Abstract
Previous studies have focused on only 1 or 2 echocardiographic parameters as prognostic markers in patients with acute ischemic stroke (AIS). A total of 900 patients with AIS who underwent transthoracic echocardiography (72.6 ± 12.0 years and 60% males) were retrospectively reviewed. Composite clinical events, including all-cause mortality, non-fatal stroke, non-fatal myocardial infarction, and coronary revascularization, were assessed during clinical follow-ups. During a median follow-up of 3.3 years (interquartile range 0.6–5.1 years), there were 151 (16.8%) composite events. In the multivariable analyses after controlling for potential confounders, left ventricular ejection fraction (LVEF)
- Published
- 2020
41. P1348 Impact of left ventricular ejection fraction and aortic valve sclerosis on cardiovascular outcome in patients with acute ischemic stroke
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W H Lim, K T Park, H L Kim, M A Kim, Joo Hee Zo, J B Seo, M Kim, and S H Kim
- Subjects
medicine.medical_specialty ,Ejection fraction ,business.industry ,Internal medicine ,Aortic valve sclerosis ,medicine ,Cardiology ,Radiology, Nuclear Medicine and imaging ,In patient ,General Medicine ,Cardiology and Cardiovascular Medicine ,business ,Acute ischemic stroke - Abstract
Background/Introduction Previous studies have focused on only 1 or 2 echocardiographic parameters as prognostic marker in patients with acute ischemic stroke (AIS). Purpose Various echocardiographic parameters in the same patient were systemically evaluated for their prognostic significance in AIS. Methods A total of 900 patients with AIS who underwent transthoracic echocardiography (TTE) (72.6 ± 12.0 years and 60% male) were retrospectively reviewed. Composite events including all-cause mortality, non-fatal stroke, non-fatal myocardial infarction, and coronary revascularization were assessed during clinical follow-up. Results During a median follow-up of 3.3 years (interquartile range, 0.6-5.1 years), there were 151 (16.8%) composite events. Univariable analyses showed that low left ventricular ejection fraction (LVEF) (< 60%), increased peak tricuspid regurgitation (TR) velocity (> 2.8 m/s) and aortic valve (AV) sclerosis were associated with composite events (P < 0.05 for each). In the multivariable analyses after controlling for potential confounders, LVEF < 60% (hazard ratio [HR], 1.90; 95% confidence interval [CI], 1.30-2.77; P = 0.001) and AV sclerosis (HR, 1.56; 95% CI, 1.10-2.21; P = 0.013) were independent prognostic factors associated with composite events. Multivariable analysis showed that HR for composite events gradually increased according to LVEF and AV sclerosis: HR was 2.8-fold higher in the highest-risk group than in the lowest group (P = 0.001). Conclusions In patients with AIS, LVEF < 60% and the presence of AV sclerosis predicts the future vascular events. Patients with AIS exhibiting reduced LVEF and AV sclerosis may benefit from aggressive secondary prevention Abstract P1348 Figure. COX plot for composite event
- Published
- 2020
42. Association Between Body Mass Index and Arterial Stiffness
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Hack-Lyoung Kim, Woo-Hyun Lim, Jae-Bin Seo, Sang-Hyun Kim, Joo-Hee Zo, and Myung-A Kim
- Subjects
General Engineering - Published
- 2022
43. Prognosis of anatomic coronary artery disease without myocardial ischemia: Coronary computed tomography angiography detects high-risk patients even in cases of negative single-photon emission computed tomography findings
- Author
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Yeonyee E. Yoon, Su Yeon Choi, Hong Mi Choi, Heesun Lee, Wonjae Lee, Yong Jin Kim, Joo Hee Zo, Seung Pyo Lee, Goo Yeong Cho, Hyo Eun Park, Hyung Kwan Kim, Hack Lyoung Kim, Dae Won Sohn, and Jun Bean Park
- Subjects
Male ,Risk ,medicine.medical_specialty ,Computed Tomography Angiography ,medicine.medical_treatment ,Myocardial Ischemia ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Single-photon emission computed tomography ,Anterior Descending Coronary Artery ,Revascularization ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Angina, Unstable ,030212 general & internal medicine ,Myocardial infarction ,Aged ,Retrospective Studies ,Tomography, Emission-Computed, Single-Photon ,medicine.diagnostic_test ,business.industry ,Unstable angina ,Middle Aged ,Prognosis ,medicine.disease ,Plaque, Atherosclerotic ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Perfusion ,Emission computed tomography - Abstract
Background While coronary computed tomography angiography (CCTA) provides comprehensive anatomic evaluation of coronary artery disease (CAD) with prognostic implications, clinically, the focus is usually placed on presence or absence of functionally significant CAD. Herein, we aimed to suggest a new risk stratification strategy using CCTA in patients with anatomic CAD but without myocardial ischemia on single-photon emission computed tomography (SPECT). Methods Consecutive patients (n = 798) with CAD on CCTA who underwent SPECT for evaluation of myocardial ischemia were retrospectively evaluated. The primary outcome was the occurrence of adverse cardiac events, including cardiac death, nonfatal myocardial infarction, unstable angina, and late revascularization. Results Of the enrolled patients, 542 (68%) showed no perfusion defect (PD) on SPECT. During the follow-up (median, 22.6 months), adverse cardiac events occurred in 23 patients without PD (4.6%). Presence of plaque in ≥4 coronary segments, plaque in the left main or proximal left anterior descending coronary artery, and partially calcified plaque presence were independent predictors of adverse events. When we defined the CCTA score based on these 3 predictors (0–3 points), the annualized event rates increased with increasing CCTA scores. Patients with a CCTA score of 3 were associated with a 23-fold risk increase (adjusted HR 23.18; p = 0.003) and showed unfavorable event-free survival, comparable to those with PD on SPECT (p = 0.191). Conclusion Anatomic CAD patients without evidence of myocardial ischemia on SPECT but with high-risk characteristics on CCTA showed unfavorable outcomes, comparable to those with PD. CCTA allows further risk stratification even in patients with negative SPECT findings.
- Published
- 2018
44. Association between aortic knob width and invasively measured aortic pulse pressure
- Author
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Tae Min Rhee, Hack Lyoung Kim, Woo Hyun Lim, Myung A. Kim, Jae Bin Seo, You Jeong Ki, Won Kyeong Jeon, Sang-Hyun Kim, and Joo Hee Zo
- Subjects
Aortic arch ,medicine.medical_specialty ,Blood Pressure ,030204 cardiovascular system & hematology ,Assessment and Diagnosis ,Coronary Angiography ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine.artery ,Heart rate ,Ascending aorta ,Internal Medicine ,medicine ,Humans ,030212 general & internal medicine ,Aortic Pulse Pressure ,Pulse ,Aorta ,Aged ,Advanced and Specialized Nursing ,Ejection fraction ,business.industry ,Blood Pressure Determination ,General Medicine ,Middle Aged ,medicine.disease ,Blood pressure ,Cardiology ,Aortic stiffness ,Cardiology and Cardiovascular Medicine ,business - Abstract
BACKGROUND Aortic knob width (AKW), which can be measured easily in simple radiography, is associated with the degree of dilatation and tortuosity of the aortic arch. Pulsatile stress influences aortic geometry. This study was carried out to investigate whether AKW can represent invasively measured aortic pulse pressure (APP). METHODS A total of 252 patients who underwent invasive coronary angiography (ICA) for the evaluation of coronary artery disease were enrolled. AKW was defined as the perpendicular length from the lateral margin of the main bronchus to the most prominent edge of the aortic knob on chest radiography. APP was measured at the ascending aorta using a pigtail catheter immediately before ICA. RESULTS When patients were divided into two groups according to the median value of APP (69 mmHg), AKW was significantly greater in patients with higher APP (≥69 mmHg) than in those with lower APP (
- Published
- 2018
45. Data on the clinical usefulness of brachial-ankle pulse wave velocity in patients with suspected coronary artery disease
- Author
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You Nui Kim, Moon Sun Im, Jae Bin Seo, In Chang Hwang, Kwang Nam Jin, Sang-Hyun Kim, Joo Hee Zo, Myung A. Kim, Hack Lyoung Kim, and Woo Hyun Lim
- Subjects
medicine.medical_specialty ,030204 cardiovascular system & hematology ,lcsh:Computer applications to medicine. Medical informatics ,medicine.disease_cause ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Ankle pulse ,In patient ,030212 general & internal medicine ,Risk factor ,lcsh:Science (General) ,Pulse wave velocity ,Multidisciplinary ,Proportional hazards model ,business.industry ,Medicine and Dentistry ,medicine.disease ,Vulnerable plaque ,Cardiology ,Arterial stiffness ,lcsh:R858-859.7 ,business ,lcsh:Q1-390 - Abstract
Brachial-artery pulse wave velocity (baPWV) is a simple and reliable tool for measurement of arterial stiffness. Our previous studies suggested that baPWV is associated with the presence and severity of coronary artery disease (CAD) and the risk of cardiovascular events. In the present data article, we provided supplementary data supporting the independent prognostic value of arterial stiffness, assessed by baPWV, in patients with suspected CAD (Hwang et al., 2017) [1]. The data was obtained from 523 patients undergoing coronary CT angiography (CCTA), and baPWV was measured at the time of CCTA. Patients with vulnerable coronary plaque or obstructive CAD on CCTA had higher age, more cardiovascular risk factors, and higher baPWV values. Given the significant association between high baPWV and the presence of vulnerable plaque or obstructive CAD as shown in this data article, the prognostic value of baPWV was further assessed in subgroups divided according to the CCTA findings (vulnerable plaque or obstructive CAD). In each subgroup by CCTA findings, multivariable Cox proportional hazard model analysis showed that high baPWV was an independent risk factor for cardiovascular events even after adjusting for clinical risk factors.
- Published
- 2018
46. Interaction of Metabolic Health and Obesity on Subclinical Target Organ Damage
- Author
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Hack Loyung Kim, Jae Bin Seo, Woo Hyun Lim, Jae Hoon Chung, Myung A. Kim, Sang-Hyun Kim, Joo Hee Zo, and Hyun Jung Lee
- Subjects
Male ,medicine.medical_specialty ,Cross-sectional study ,Health Status ,Endocrinology, Diabetes and Metabolism ,030204 cardiovascular system & hematology ,Kidney ,Left ventricular hypertrophy ,Risk Assessment ,Ventricular Function, Left ,Body Mass Index ,Ventricular Dysfunction, Left ,03 medical and health sciences ,Vascular Stiffness ,0302 clinical medicine ,Risk Factors ,Internal medicine ,Metabolically healthy obesity ,Internal Medicine ,medicine ,Humans ,030212 general & internal medicine ,Aged ,Retrospective Studies ,Subclinical infection ,Obesity, Metabolically Benign ,business.industry ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Obesity ,Cross-Sectional Studies ,Cardiovascular Diseases ,Cardiology ,Arterial stiffness ,Female ,Hypertrophy, Left Ventricular ,Kidney Diseases ,Waist Circumference ,business ,Body mass index - Abstract
Metabolically healthy obese (MHO) individuals generally show better cardiovascular prognosis compared with metabolically unhealthy counterparts, which may be related to different patterns of target organ damage (TOD). We aimed to investigate the patterns of TOD related to obesity and metabolic unhealthiness.A total of 659 Korean adults (mean age, 60.0 ± 11.8 years; male, 51.1%) undergoing health examinations were stratified into four groups according to obesity (body mass index ≥25.0 kg/mIn multivariable analyses, compared with the MHNO group, the MHO group showed 2.31 times higher odds for LVH, whereas, the MUNO group showed 3.14 and 6.28 times higher odds for increased arterial stiffness and renal dysfunction, respectively. Metabolic unhealthiness was associated with increased arterial stiffness [odds ratio (OR) 2.73; confidence interval (95% CI) 1.72-4.34], renal dysfunction (OR 4.02; 95% CI 1.54-10.49), and LV diastolic dysfunction (OR 2.28; 95% CI 1.14-4.55). Meanwhile, obesity showed weaker association with LVH and LV diastolic dysfunction, and was not associated with increased arterial stiffness and renal dysfunction in multivariable analyses.Metabolic unhealthiness shows more association with TOD than obesity, which may contribute to the higher risk of cardiometabolic abnormalities in MUNO compared with MHO.
- Published
- 2018
47. Relationship between brachial-ankle pulse wave velocity and invasively measured aortic pulse pressure
- Author
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Jeehoon Kang, Hack Loyung Kim, Jae Bin Seo, Myung A. Kim, Joo Hee Zo, Sang-Hyun Kim, and Woo Hyun Lim
- Subjects
medicine.medical_specialty ,Univariate analysis ,business.industry ,Endocrinology, Diabetes and Metabolism ,Wave velocity ,030204 cardiovascular system & hematology ,medicine.disease ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,mental disorders ,Internal Medicine ,Cardiology ,Arterial stiffness ,Ankle pulse ,Medicine ,Aortic stiffness ,030212 general & internal medicine ,Aortic Pulse Pressure ,Cardiology and Cardiovascular Medicine ,business ,Pulse wave velocity - Abstract
Although brachial-ankle pulse wave velocity (baPWV) has been widely used as an index of arterial stiffness, no consensus exists about whether baPWV can reflect central aortic stiffness. The authors investigated the association between baPWV and invasively measured aortic pulse pressure (APP) in a total of 109 consecutive patients (mean age, 62.3 ± 11.3 years; 67.9% men). Most patients (91%) had obstructive coronary artery disease, and mean baPWV and APP values were 1535 ± 303 cm/s and 66.8 ± 22.5 mm Hg, respectively. In univariate analysis, there was a significant linear correlation between baPWV and APP (r = .635, P < .001). The correlation between baPWV and APP remained significant even after controlling for potential confounders (β = 0.574, P < .001; R2 = .469). Arterial stiffness measured by baPWV showed a strong positive correlation with invasively measured APP, independent of clinical confounders. Therefore, baPWV can be a good marker of central aortic stiffness.
- Published
- 2018
48. Additional prognostic value of brachial-ankle pulse wave velocity to coronary computed tomography angiography in patients with suspected coronary artery disease
- Author
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Sang-Hyun Kim, In Chang Hwang, Joo Hee Zo, You Nui Kim, Myung A. Kim, Jae Bin Seo, Hack Lyoung Kim, Woo Hyun Lim, Moon Sun Im, and Kwang Nam Jin
- Subjects
Male ,medicine.medical_specialty ,Time Factors ,Computed Tomography Angiography ,Seoul ,Population ,Myocardial Infarction ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Coronary Angiography ,Risk Assessment ,Coronary artery disease ,Peripheral Arterial Disease ,03 medical and health sciences ,Patient Admission ,Vascular Stiffness ,0302 clinical medicine ,Predictive Value of Tests ,Risk Factors ,Interquartile range ,Internal medicine ,Multidetector Computed Tomography ,Humans ,Medicine ,Ankle Brachial Index ,030212 general & internal medicine ,Myocardial infarction ,education ,Pulse wave velocity ,Aged ,Retrospective Studies ,education.field_of_study ,business.industry ,Hazard ratio ,Reproducibility of Results ,Middle Aged ,Prognosis ,medicine.disease ,Confidence interval ,Stroke ,Cardiology ,Arterial stiffness ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Increased arterial stiffness is associated with a higher risk of future cardiovascular events. We aimed to investigate whether information about arterial stiffness provides additional prognostic value to coronary computed tomography angiography (CCTA) findings.A total of 523 consecutive patients (mean age, 58.0 ± 10.3 years; male, 60.6%) with suspected coronary artery disease (CAD), who underwent CCTA and brachial-ankle pulse wave velocity (baPWV) measurement within a month, were retrospectively analyzed. A composite of cardiovascular death, nonfatal myocardial infarction (MI), coronary revascularization, nonfatal stroke, and hospitalization for cardiovascular causes was assessed.During a median 43.9 months of follow-up (interquartile range, 11.6-66.9 months), the composite endpoint occurred in 66 patients (3 cardiovascular deaths, 1 nonfatal MI, 35 coronary revascularizations, 16 nonfatal strokes, and 45 hospitalizations for cardiovascular causes). After adjustment for clinical risk factors and CCTA findings, higher baPWV was an independent prognostic factor for the composite endpoint (adjusted hazard ratio, 4.717; 95% confidence interval, 2.675-8.319; p 0.001). The addition of baPWV to clinical risk factors and CCTA findings significantly improved the prediction of cardiovascular events (global χArterial stiffness provides additional prognostic information to CCTA findings in patients with suspected CAD. The baPWV can serve as a useful clinical tool for risk stratification in this population.
- Published
- 2018
49. Association between reduced arterial stiffness and preserved diastolic function of the left ventricle in middle-aged and elderly patients
- Author
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Jae Bin Seo, Sang-Hyun Kim, Joo Hee Zo, Woo-Young Chung, Hack Loyung Kim, Woo Hyun Lim, Myung A. Kim, Kyung Taek Park, and Sohee Oh
- Subjects
medicine.medical_specialty ,business.industry ,Endocrinology, Diabetes and Metabolism ,Confounding ,Odds ratio ,030204 cardiovascular system & hematology ,medicine.disease ,Confidence interval ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Ventricle ,Left atrial ,Internal medicine ,Internal Medicine ,medicine ,Arterial stiffness ,Cardiology ,Diastolic function ,030212 general & internal medicine ,Cardiology and Cardiovascular Medicine ,business ,Pulse wave velocity - Abstract
The aim of this study was to investigate whether arterial stiffness plays a role in retaining normal diastolic function in a middle-aged and elderly Korean population. A total of 267 patients without documented cardiovascular disease, 50 years and older (mean age, 57.3±6.3 years; 69.8% men) were retrospectively analyzed. All patients underwent both transthoracic echocardiography and brachial-ankle pulse wave velocity measurement on the same day. Patients with septal annular peak velocity (e') ≥8 cm/s and left atrial volume index
- Published
- 2017
50. Additional Value of Brachial-Ankle Pulse Wave Velocity to Single-Photon Emission Computed Tomography in the Diagnosis of Coronary Artery Disease
- Author
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Kyeongmin Jang, So Won Oh, Miri Park, Jae Bin Seo, Sohee Oh, Sang-Hyun Kim, Joo Hee Zo, Myung A. Kim, Hack Loyung Kim, and Woo Hyun Lim
- Subjects
Male ,medicine.medical_specialty ,Ischemia ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Single-photon emission computed tomography ,Pulse Wave Analysis ,Coronary Angiography ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,Vascular Stiffness ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Ankle Brachial Index ,030212 general & internal medicine ,cardiovascular diseases ,Pulse wave velocity ,Aged ,Retrospective Studies ,Tomography, Emission-Computed, Single-Photon ,medicine.diagnostic_test ,Receiver operating characteristic ,business.industry ,Biochemistry (medical) ,Middle Aged ,medicine.disease ,Prognosis ,Arterial stiffness ,SSS ,ROC Curve ,Cardiology ,Original Article ,Female ,Cardiology and Cardiovascular Medicine ,business ,Emission computed tomography ,Follow-Up Studies - Abstract
Aim: The aim of this study was to investigate whether information on arterial stiffness can improve the value of single-photon emission computed tomography (SPECT) in the detection of obstructive coronary artery disease (CAD). Methods: A total of 233 patients (age: 62.2 ± 10.8 years, 60.3% males) with detected ischemia on SPECT undergoing invasive coronary angiography (ICA) and brachial-ankle pulse wave velocity (baPWV) measurement within a month was retrospectively reviewed. Results: Of the 233 patients, 190 (81.5%) had obstructive CAD (≥ 50% luminal stenosis). The difference in baPWV according to the presence of obstructive CAD was significant in patients in the mild ischemia group [summed stress score (SSS): 4–8] (1,770 ± 364 cm versus 1,490 ± 328 cm, p < 0.001) but not in the moderate (SSS: 9–13) or severe (SSS: ≥14) ischemia groups (p > 0.05 for each). Receiver operating characteristic curve analyses showed that the diagnostic value of baPWV for obstructive CAD was significant only in patients in the mild ischemia group (area under curve: 0.714; p = 0.001) but not in the moderate or severe ischemia groups (p > 0.05 for each). Adding information on baPWV to SPECT results and clinical parameters significantly increased diagnostic accuracy in the detection of obstructive CAD in patients with mild ischemia (integrated discrimination improvement p = 0.006) but not in those with moderate or severe ischemia on SPECT (p > 0.05 for each). Conclusions: The results of this study suggest that baPWV may have additional value to SPECT for the detection of obstructive CAD, especially in patients with mild ischemia on SPECT.
- Published
- 2017
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